Serum ferritin in Danes: Studies of iron status from infancy to old age, during blood donation and pregnancy

International Journal of Hematology

Volumn 63, Issue 2, 1996, Pages 103-135

  Milman, Nils ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NAESTVED HOSPITAL   (Denmark)

Author keywords

adolescents; blood donation; children; ferritin; hemoglobin; iron deficiency; iron metabolism; iron overload; iron status; men; newborn; pregnancy; women

Indexed keywords

IRON;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CLINICAL TRIAL; CONTRACEPTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENMARK; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; INFANT; MALE; MENSTRUATION; NEWBORN; NORMAL HUMAN; PREGNANCY; PRIORITY JOURNAL;

EID: 0029965281     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1016/0925-5710(95)00426-2     Document Type: Article

References (151)

1. Munro HN, Linder MC. Ferritin: structure, biosynthesis, and role in iron metabolism. Physiol Rev 1978;58:317-396.
2. Laufberger V. Sur la cristallisation de la ferritine. Bull Soc Chim Biol 1937;19:1575-1582.
3. Bomford AB, Munro HN. Biosynthesis of ferritin and isoferritins. In: Jacobs A, Worwood M. (eds). Iron in Biochemistry and Medicine II. London: Academic Press 1980:173-202.
4. Drysdale JW, Adelman TG, Arosio P, Casareale D, Fitzpatrick P, Hazard JT, Yokota M. Human isoferritins in normal and disease states. Sem Hematol 1977;14:71-88.
5. Harrison PM, Hoare RJ, Hoy TG, Macara IG. Ferritin and haemosiderin: structure and function. In: Jacobs A, Worwood M. (eds). Iron in Biochemistry and Medicine. London: Academic Press, 1974;73-114.
6. Weinfeld A. Storage iron in man. Acta Med Scand 1964;suppl 427.
7. Bothwell TH, Charlton RW, Cook JD, Finch CA. Iron Metabolism in Man. Oxford: Blackwell Scientific Publications, 1979;88-104.
8. Mazur A, Shorr E. A quantitative immunochemical study of ferritin and its relation to the vasodepressor material. J Biol Chem 1950;182:607-627.
9. Addison G, Beamish MR, Hales CN, Hodgkins M, Jacobs A, Llewllin P. An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. J Clin Pathol 1972;25:326-329.
10. Worwood M. Serum ferritin. In: Jacobs A, Worwood M. (eds). Iron in Biochemistry and Medicine II. London: Academic Press, 1980;204-244.
11. Wood WG. Comparison of eleven commercial kits for determination of serum ferritin levels. J Clin Chem Clin Biochem 1981;19:947-952.
12. Albertini A, Iacobello C, Belloli S, Ruggeri G, Arosio P. Standardization of serum ferritin determination. In: Albertini Arosio P, Chiancone E, Drysdale J (eds). Ferritins and Isoferritins as Biochemical Markers. Amsterdam: Elsevier Science Publishers, 1984;1311-1342.
13. International Committee for Standardisation in Haematology. Standard for serum ferritin assay. Lancet 1986;2:409.
14. Milman N, Christensen TE, Pedersen NS, Visfeldt J. Serum ferritin and bone marrow iron in non-dialysis, peritoneal dialysis and hemodialysis patients with chronic renal failure. Acta Med Scand 1980;207:201-205.
15. Milman N, Christensen TE, Bartels U, Pedersen NS. Iron status in patients undergoing regular peritoneal dialysis. Dan Med Bulletin 1980;27:291-295.
16. Milman N, Christensen TE, Visfeldt J. Diagnostic efficiency of various laboratory tests in the assessment of bone marrow iron stores in patients with chronic uraemia. Scand J Haematol 1981;26:257-264.
17. Milman N. Plasma transferrin and the relation to iron status in patients with chronic uremia. Clin Nephrol 1981;16:314-320.
18. Milman N. Iron absorption in patients with chronic uraemia. A comparative study using whole body counting and red cell incorporation of radioiron. Scand J Haematol 1982;29:5-17.
19. Pedersen NS, Axelsen NH, Bock E, Nørgaard-Pedersen B. A paper disc two-site immunoradiometric assay for ferritin. Prot Biol Fluids 1976;24:659-662.
20. Milman N, Pedersen NS, Visfeldt J. Serum ferritin in healthy Danes: relation to marrow haemosiderin iron stores. Dan Med Bull 1983;30:115-120.
21. Milman N, Bangsbøll S, Pedersen NS, Visfeldt J. Serum ferritin in non-dialysis patients with chronic renal failure: relation to bone marrow iron stores. Scand J Haematol 1983;30:337-344.
22. Milman N, Graudal N. Serum ferritin in acute viral hepatitis. Scand J Gastroenterol 1984;19:38-40.
23. Milman N, Cohn J, Pedersen NS. Serum ferritin and iron status of children in the Faroe Islands. Eur J Pediatr 1984;142:89-92.
24. Milman N, Pedersen NS, Visfeldt J. Serum ferritin in patients on regular peritoneal and haemodialysis treatment: relation to marrow haemosiderin iron stores. Dan Med Bull 1984;31:245-248.
25. Milman N, Ibsen KK. Serum ferritin in Danish children and adolescents. Scand J Haematol 1984;33:260-266.
26. Milman N, Cohn J. Serum iron, serum transferrin and transferrin saturation in healthy children without iron deficiency. Eur J Pediatr 1984;143:96-98.
27. Milman N, Søndergaard M. Iron stores in male blood donors evaluated by serum ferritin. Transfusion 1984;24:464-468.
28. Milman N, Søndergaard M, Sørensen CM. Iron stores in female blood donors evaluated by serum ferritin. Blut 1985;51:337-345.
29. Milman N, Andersen HC, Pedersen NS. Serum ferritin and iron status in 'healthy' elderly individuals. Scand J Clin Lab Invest 1986;46:19-26.
30. Milman N, Ibsen KK, Christensen JM. Serum ferritin and iron status in mothers and newborn infants. Acta Obstet Gynecol Scand 1987;66:205-211.
31. Milman N, Ingerslev J, Graudal N. Serum ferritin and iron status in a Danish population of healthy 85-year-old individuals. Scand J Clin Lab Invest 1990;50:77-83.
32. Milman N, Kirchhoff M. Iron stores in 1433 30- to 60-year-old Danish males. Evaluation by serum ferritin and haemoglobin. Scand J Clin Lab Invest 1991;51:635-641.
33. Milman N, Kirchhoff M. Iron stores in 1359 30- to 60-year-old Danish women: evaluation by serum ferritin and hemoglobin. Ann Hematol 1992;64:22-27.
34. Milman N, Kirchhoff M, Jørgensen T. Iron status markers, serum ferritin and hemoglobin in 1359 Danish women in relation to menstruation, hormonal contraception, parity, and postmenopausal hormone treatment. Ann Hematol 1992;65:96-102.
35. Milman N, Kirchhoff M. Influence of blood donation on iron stores assessed by serum ferritin and haemoglobin in a population survey of 1433 Danish males. Eur J Haematol 1991;47:134-139.
36. Milman N, Kirchhoff M. The influence of blood donation on iron stores assessed by serum ferritin and hemoglobin in a population survey of 1359 Danish women. Ann Hematol 1991;62:27-32.
37. Milman N, Schultz-Larsen K. Iron stores in 70-year-old Danish men and women. Evaluation in 469 individuals by serum ferritin and hemoglobin. Aging Clin Exp Res 1994;6:97-103.
38. Milman N, Graudal N, Hegnhøj J, Visfeldt J, Christoffersen P, Pedersen NS. Relation between bone marrow haemosiderin iron, serum iron status markers, and chemical and histochemical liver iron content in 82 patients with alcoholic and nonalcoholic hepatic disease. Ann Hematol 1993;66:203-207.
39. Milman N, Graudal N, Hegnhøj J, Christoffersen P, Pedersen NS. Relationships among serum iron status markers, chemical and histochemical liver iron content in 117 patients with alcoholic and non-alcoholic hepatic disease. Hepato-Gastroenterol 1994;41:20-24.
40. Crichton RR, Millar JA, Cumming RCL, Bryce CFA. The organ specificity of ferritin in human and horse liver and spleen. Biochem J 1973;131:51-59.
41. Milman N, Thomsen H, Mathiassen B. Serum ferritin, iron status and plasma ascorbic acid in 40- to 49-year old males in the Faroe Islands. Scand J Clin Lab Invest 1990;50:559-564.
42. Milman N, Sengeløv H, Dombernowsky P. Iron status markers in patients with small cell carcinoma of the lung. Relation to survival. Br J Cancer 1991;64:895-898.
43. Milman N, Mellemgaard A, Hansen SH, Dombernowsky P. Bone marrow haemosiderin iron and serum iron status markers in small cell carcinoma of the lung. Int J Oncol 1993;3:29-32.
44. Milman N, Agger AO, Nielsen OJ. Iron supplementation during pregnancy. Effect on iron status markers, serum erythropoietin and human placental lactogen. A placebo controlled study in 207 Danish women. Dan Med Bull 1991:38:471-476.
45. Milman N, Heitmann BL, Lyhne N, Rosdahl N, Jensen KH. Iron status in 1113 Danish men and women aged 35 to 65 years. Relation to dietary and supplemental iron intake. Scand J Nutr 1993;37:98-103.
46. Milman N, Rosdahl N, Lyhne N, Jørgensen T. Iron status in 883 Danish women aged 35-65 years. Relation to menstruation and method of contraception. Acta Obstet Gynecol Scand 1993;72:601-605.
47. Michaelsen KF, Milman N, Samuelson G. A longitudinal study of iron status in healthy Danish infants: effects of early iron status, growth velocity and dietary factors. Acta Paediatr Scand 1995;84:1035-1044.
48. Milman N, Graudal N, Agger AO. Iron status markers during pregnancy. No relationship between levels in the beginning of the second trimester, prior to delivery and post partum. J Int Med 1995;237:261-267.
49. Milman N, Bentzon MW, Graudal N, Juul-Jørgensen B. Statistical pitfalls in the comparison between two commercial serum ferritin kits, Pharmacia and Amersham. Dan Med Bull 1993;40:508-510.
50. Lowry OH, Rosebough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:265-275.
51. Milman N, Graudal N, Juul-Jørgensen B, Bentzon MW. Calibration of the Amersham Ferritin RIA kit using the WHO human liver ferritin international standard. Eur J Clin Chem Clin Biochem 1994;32:41-42.
52. Birgegård G. Serum ferritin: physiological and methodological studies. Clin Chim Acta 1980;103:277-285.
53. Siimes MA, Dallman PR. New kinetic role for serum ferritin in iron metabolism. Br J Haematol 1974;28:7-18.
54. Finch CA, Huebers HA, Cazzola M, Bergamaschi G, Belloti V. Storage iron. In: Albertini A, Arosio P, Chiancone E, Drysdale J (eds). Ferritins and Isoferritins as Biochemical Markers. Amsterdam: Elsevier Science Publishers, 1984;3-21.
55. Hershko C, Cook JD, Finch CA. Storage iron kinetics III. Study of desferrioxamine action by selective radioiron labels of RE and parenchymal cell. J Lab Clin Med 1973;81:876-886.
56. Milman N. Idiopathic haemochromatosis in Denmark 1950-1985. Clinical, histological and biochemical features in 179 patients and 13 preclinical cases. Dan Med Bull 1991;38:385-393.
57. Worwood M, Cragg SJ, Wagstaff M, Jacobs A. Binding of human serum ferritin to concanavalin A. Clin Sci 1979;56:83-87.
58. Cragg SJ, Wagstaff M, Worwood M. Detection of a glycosylated subunit in human serum ferritin. Biochem J 1981;199:565-571.
59. 131]-human plasma ferritin in man. Blood 1982;60:827-833.
60. Linder MC, Munro HN. Assay of tissue ferritin. Anal Biochem 1972;48:266-278.
61. Cook JD, Lipschitz DA, Miles LEM, Finch CA. Serum ferritin as a measure of iron stores in normal subjects. Am J Clin Nutr 1974;27:681-687.
62. Walters GO, Jacobs A, Worwood M, Trevett D, Thomson W. Iron absorption in normal subjects and patients with idiopathic haemochromatosis: relationship with serum ferritin concentration. Gut 1975;16:188-192.
63. Heinrich HC. Diagnostik, Å tiologie und Therapie des Eisenmangels unter besonderen Berücksichtigung der 59Fe-Retentionsmessung in Gesamt-körperRadioaktivitätsdetektor. Nuklearmediziner 1983;6:137-269.
64. Magnusson B, Björn-Rasmussen E, Hallberg L, Rossander L. Iron absorption in relation to iron status. Scand J Haematol 1981;27:201-208.
65. Bezwoda WR, Bothwell TH, Torrance JD, MacPhail AP, Charlton RW, Kay G, Levin J. The relationship between marrow iron stores, plasma ferritin concentrations and iron absorption. Scand J Haematol 1979;22:113-120.
66. Greenman J, Jacobs A. The effect of iron stores on iron absorption in the rat: the possible role of circulating ferritin. Gut 1975;16:613-616.
67. Gale E, Torrance J, Bothwell T. The quantitative estimation of total iron stores in human bone marrow. J Clin Invest 1963;42:1076-1082.
68. Pritchard JA, Scott DE. Iron demands during pregnancy. In: Hallberg L, Harwerth H-G, Vanotti A. (eds). Iron Deficiency. Pathogenesis, Clinical Aspects, Therapy. London: Academic Press, 1970;173-182.
69. Barry M. Liver iron concentration, stainable iron, and total body storage iron. Gut 1974;15:411-415.
70. Brissot P, Bourel M, Herry D et al. Assessment of liver iron content in 271 patients: a reevaluation of direct and indirect methods. Gastroenterol 1981;80:557-565.
71. Bothwell TH, Charlton RW, Cook JD, Finch CA. Iron Metabolism in Man. Oxford: Blackwell Scientific Publications, 1979:121-155.
72. Heinrich HC. Intestinal iron absorption in man. Methods of measurement, dose relationship, diagnostic and therapeutic implications. In: Hallberg L, Harwerth HG, Vanotti A (eds). Iron Deficiency. Pathogenesis, Clinical Aspects, Therapy. London: Academic Press, 1970;213-294.
73. Cook JD, Lipschitz DA. Clinical measurement of iron absorption. Clin Haematol 1977;6:567-581.
74. Bainton DF, Finch CA. The diagnosis of iron deficiency anaemia. Am J Med 1964;37:62-70.
75. Finch CA, Smith NJ, Cook JD, Labbe RF, Lipschitz DA. Laboratory parameters in the diagnosis of iron deficiency. Haematologia 1974;8:177-182.
76. Bothwell TH, Charlton RW, Cook JD, Finch CA. Iron Metabolism in Man. Oxford: Blackwell Scientific Publications, 1979;284-309.
77. Lee GR. The anaemia of chronic disease. Sem Hematol 1983;20:61-80.
78. Walters GO, Miller FM, Worwood M. Serum ferritin concentration and iron stores in normal subjects. J Clin Pathol 1973;26:770-772.
79. Jacob RA, Sandstead HH, Klevay LM, Johnson LK. Utility of serum ferritin as a measure of iron deficiency in normal males undergoing repetitive phlebotomy. Blood 1980;56:786-791.
80. Charlton RW, Derman D, Skikne B et al. Iron stores, serum ferritin and iron absorption. In: Brown EB, Aisen P, Fielding J et al. (eds). Proteins of Iron Metabolism. New York: Grune & Stratton, 1977;387-392.
81. Birgegård G, Högman C, Killander A, Levander H, Simonsson B, Wide L. Serum ferritin and erythrocyte 2,3-DPG during quantitated phlebotomy and iron treatment. Scand J Haematol 1977;19:327-333.
82. Bassett ML, Halliday JW, Ferris RA, Powell LW. Diagnosis of hemochromatosis in young subjects: predictive accuracy of biochemical screening tests. Gastroenterology 1984;87:628-633.
83. Jacobs A, Miller F, Worwood M, Beamish MR, Wardrop CA. Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. Br Med J 1972;4:206-208.
84. Letsky EA, Miller F, Worwood M et al. Serum ferritin in children with thallassaemia regularly transfused. J Clin Pathol 1974;27:652-655.
85. Sorbie J, Valberg LS, Corbett WE, Ludwig J. Serum ferritin, cobalt excretion and body iron status. Can Med Assoc J 1975;112:201-208.
86. Oertel J, Bombik BM, Stephan M, Gerhartz H. Ferritin in bone marrow and serum in iron deficiency and iron overload. Blut 1978;37:113-117.
87. Brittenham GM, Danish EH, Harris JW. Assessment of bone marrow and body iron stores: old techniques and new technologies. Sem Hematol 1981;18:194-221.
88. Halliday JW, Powell LW. Serum ferritin and isoferritins in clinical medicine. In: Brown EB (ed.) Progress in Hematology XI. New York: Grune & Stratton, 1979;229-266.
89. Birgegård G, Hällgren R, Killander A, Strömberg A, Venge P, Wide L. Serum ferritin during infection. Scand J Haematol 1978;21:333-340.
90. Elin RJ, Wolff SM, Finch CA. Effect of induced fever on serum iron and ferritin concentration in man. Blood 1977;49:147-153.
91. Prieto J, Barry M, Sherlock S. Serum ferritin in patients with iron overload and with acute and chronic liver diseases. Gastroenterology 1975;68:525-533.
92. Kew MC, Torrance JD, Derman D, Simon M, Macnab GM, Charlton RW, Bothwell TH. Serum and tumour ferritins in primary liver cancer. Gut 1978;19:294-299.
93. Bothwell TH, Charlton RW, Cook JD, Finch CA. Iron Metabolism in Man. Oxford: Blackwell Scientific Publications, 1979;44-81.
94. Hausmann K, Drews J, Trampe R, Wedekind I, Göltner E, Kuse R, Düllmann J. Die Serumferritinbestimmung in der Diagnostik der Eisenmangels. In: Kaltwasser JP, Werner E (eds). Serumferritin. Berlin: Springer-Verlag, 1980;104-129.
95. Jacobs A, Miller E, Worwood M, Beamish MR, Wardrop CA. Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. Br Med J 1972;4:206-208.
96. Lipschitz DA, Cook JD, Finch CA. A clinical evaluation of serum ferritin. N Engl J Med 1974;290:1213-1216.
97. Hallberg L, Bengtsson C, Lapidus L, Lindstedt G, Lundberg PA, Hultén L. Screening for iron deficiency: an analysis based on bone-marrow examinations and serum ferritin determinations in a population sample of women. Br J Haematol 1993;85:787-798.
98. Worwood M. Laboratory determination of iron status. In Brock JH, Halliday JW, Pippard MJ, Powell LW (eds). Iron Metabolism in Health and Disease. London. WB Saunders Company Ltd., 1994;449-476.
99. Lindstedt G, Lundberg P-A, Björn-Rasmussen E, Magnussen B. Serum ferritin and iron deficiency anaemia in hospital patients. Lancet 1980;1:205-206.
100. Krause JR, Stole V. Serum ferritin and bone marrow iron stores. I. Correlation with absence of iron in biopsy specimens. Am J Clin Pathol 1979;72:817-820.
101. Valberg LS, Sorbie J, Ludwig J, Pelletier O. Serum ferritin and the iron status of Canadians. Can Med Assoc J 1976;114:417-421.
102. Dallman PR, Siimes MA, Stekel A. Iron deficiency in infancy and childhood. Am J Clin Nutr 1980;33:86-118.
103. World Health Organisation. Nutritional anaemias. Tech Rep Ser 1972;503.
104. Dallman PR, Siimes MA. Percentile curves for hemoglobin and red cell volume in infancy and childhood. J Pediatr 1979;94:26-31.
105. Bassett ML, Halliday J, Powell LW. Value of hepatic iron measurement in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 1986;6:24-29.
106. Milman N. Iron status markers in hereditary haemochromatosis. Distinction between subjects being homozygous and heterozygous for the haemochromatosis allele. Eur J Haematol 1991;47:292-298.
107. Fletcher J, Suter PEN. The transport of iron by the human placenta. Clin Sci 1969;36:209-220.
108. Saddi R, Shapira G. Iron requirements during growth. In: Hallberg L, Harwerth HG, Vanotti A (eds). Iron Deficiency. Pathogenesis, Clinical Aspects, Therapy. London: Academic Press, 1970;183-198.
109. Siimes MA, Addiego JE, Dallman PR. Ferritin in serum: diagnosis of iron deficiency and iron overload in infants and children. Blood 1974;43:581-590.
110. Rios E, Lipschitz DA, Cook JD, Smith NJ. Relationship of maternal and infant iron stores as assessed by determination of plasma ferritin. Pediatrics 1975;55:694-699.
111. Saarinen UM, Siimes MA. Serum ferritin in assessment of iron nutrition in healthy infants. Acta Paediatr Scand 1978;67:741-751.
112. Messer RD, Russo AM, McWhirter WR, Sprangemeyer D, Halliday JW. Serum ferritin in term and preterm infants. Aust Paediatr J 1980;16:185-188.
113. Weippl G. Die Serumferritinbestimmung im Kindesalter. In: Kaltwasser JP, Werner E (eds). Serumferritin. Berlin: Springer-Verlag, 1980;184-193.
114. Siimes ASI, Siimes MA. Changes in the concentration of ferritin in the serum during fetal life in singletons and twins. Early Hum Develop 1986;13:47-52.
115. Saarinen UM, Siimes MA. Iron absorption from breast milk, cow's milk, and iron-supplemented formula: an opportunistic use of changes in total body iron determined by hemoglobin, ferritin, and body weight in 132 infants. Pediatr Res 1979;13:143-147.
116. Fenton V, Cavill I, Fischer J. Iron stores in pregnancy. Br J Haematol 1977;37:145-149.
117. Kelly AM, Macdonald DJ, McDougall AN. Observations on maternal and fetal ferritin concentrations at term. Br J Obstet Gynaecol 1978;85:338-343.
118. Poulakka J, Janne O, Vihko R. Evaluation of serum ferritin assay and the influence of maternal iron stores on the iron status of newborns and infants. Acta Obstet Gynecol Scand 1980; suppl 95:53-56.
119. Macphail AP, Charlton RW, Bothwell TH, Torrance JD. The relationship between maternal and infant iron stores. Scand J Haematol 1980;25:141-150.
120. Bratlid D, Moe PJ. Hemoglobin and serum ferritin levels in mothers and infants at birth. Eur J Pediatr 1980;134:125-127.
121. Celada A, Busset R, Gutierrez J, Herreros V. Maternal and cord blood ferritin. Helv Paediatr Acta 1982;37:239-244.
122. Tanner JM, Whitehouse RH, Takaishi M. Standards from birth to maturity of height, weight, height velocity and weight velocity: British children 1965. Arch Dis Child 1966;41:454-462.
123. Andersen E, Andersen H, Hutchings B et al. Heights and weights in Danish schoolchildren in 1971-1972. Ugeskr Laeg 1974;136:2796-2802.
124. Cook JD, Finch CA, Smith NJ. Evaluation of the iron status of a population. Blood 1976;48:449-455.
125. Pilch SM, Senti FR (eds). Assessment of the iron nutritional status of the U.S. population based on data collected in the second National Health and Nutrition Examination Survey, 1976-1980. Prepared for the Food and Drug Administration under contract no. FDA 223â2384. Bethesda, Maryland: Life Sciences Research Office, Federation of American Societies for Experimental Biology, 1984.
126. Bothwell TH, Charlton RW, Cook JD, Finch CA. Iron Metabolism in Man. Oxford: Blackwell Scientific Publications, 1979;7-43.
127. Hallberg L, Hultén L, Lindstedt G, Lundberg PA, Mark A, Purens J, Svanberg B, Swolin B. Prevalence of iron deficiency in Swedish adolescents. Pediatr Res 1993;34:680-687.
128. Green R, Charlton R, Seftel H et al. Body iron excretion in man. A collaborative study. Am J Med 1968;45:336-353.
129. Milman N, Laursen J, Pødenphant J, Asnaes S. Trace elements in normal and cirrhotic human liver tissue I. Iron, copper, zinc, selenium, manganese, titanium and lead measured by X-ray fluorescence spectrometry. Liver 1986;6:111-117.
130. Wiggers P, Dalhøj J, Kiaer H et al. Screening for haemochromatosis: prevalence among Danish blood donors. J Intern Med 1991;230:265-270.
131. Milman N, Graudal N, Nielsen LS, Sørensen SA. HLA determinants in idiopathic haemochromatosis. Dan Med Bull 1985;32:262-264.
132. Haraldsdottir J, Holm L, Jensen JH, Møller A. Dietary habits in Denmark 1985. Who Eats What. National Food Agency of Denmark, Publication no. 154, 1987.
133. Jørgensen LM, Kirchhoff M, Schultz-Larsen K, Schroll M. Food and nutrient intake in Denmark estimated by 7-days food records. III. Intake of vitamins, minerals and trace elements. Scand J Nutr 1992;36:8-11.
134. Finch CA, Cook JD, Labbe RF, Culala M. Effect of blood donation on iron stores as evaluated by serum ferritin. Blood 1977;50:441-447.
135. Birgegaard G, Högman C, Killander A, Wide L. Serum ferritin levels in male blood donors. Vox Sang 1978;34:65-70.
136. Pedersen NS, Morling N. Iron stores in blood donors evaluated by serum ferritin. Scand J Haematol 1978;20:70-76.
137. Simon TL, Garry PJ, Hooper EM. Iron stores in blood donors. J Am Med Ass 1981;245:2038-2043.
138. Heinrich HC, Oppitz KH, Busch H. Eisenmangel und Eisenprophylaxe bei Blutspendern. Klin Wochenschr 1973;51:107-117.
139. Hallberg L, Högdahl AM, Nilsson L, Rybo G. Menstrual blood loss - a population study. Variation at different ages and attempts to define normality. Acta Obstet Gynecol Scand 1966;45:320-351.
140. Cole SK, Billewicz WZ, Thomson AM. Sources of variation in menstrual blood loss. J Obstet Gynaecol Br Commonw 1971;78:933-939.
141. Beaton GH. Epidemiology of iron deficiency. In: Jacobs A, Worwood M (eds). Iron in Biochemistry and Medicine. London: Academic Press, 1974;477-528.
142. Hallberg L. Iron nutrition in women in industrialized countries. Bibl Nutr Dieta 1981;30:111-123.
143. Nilsson L, Sölvell L. Clinical studies on oral contraceptives - a randomized, doubleblind crossover study of four different populations. Acta Obstet Gynecol Scand 1967;46: suppl 8.
144. Frasinelli-Gunderson EP, Margen S, Brown JR. Iron stores in users of oral contraceptive agents. Am J Clin Nutr 1985;41:703-712.
145. Gillebaud J, Bonner J, Morehead J, Matthews A. Menstrual blood loss with intrauterine devices. Lancet 1976;1:387-390.
146. Riphagen FE, Lehert P. A survey of contraception in five West European countries. J Biosoc Sci 1989;21:23-46.
147. Danish Medicine Statistic. The consumption of medicine in Denmark 1991. Copenhagen 1992.
148. Kelton JG, Cruickshank M. Hematologic disorders of pregnancy. In: Burrow GN, Ferris TF (eds). Medical Complications during Pregnancy. 3rd ed. Philadelphia: WB Saunders Company, 1988;65-91.
149. Puolakka J, Jänne O, Pakarinen A, Järvinen PA, Vihko R. Serum ferritin as a measure of iron stores during and after normal pregnancy with and without iron supplements. Acta Obstet Gynecol Scand 1980; suppl. 95:43-51.
150. Taylor DJ, Mallen C, McDougall N, Lind T. Effect of iron supplementation on serum ferritin levels during and after pregnancy. Br J Obstet Gynaecol 1982;89: 1011-1017.
151. Romslo I, Haram K., Sagen N, Augensen K. Iron requirement in normal pregnancy as assessed by serum ferritin, serum transferrin saturation, and erythrocyte protoporfyrin determinations. Br J Obstet Gynaecol 1983;90: 101-107.