High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis

Diabetologia

Volumn 49, Issue 7, 2006, Pages 1661-1669

  McClain, D A ^a,b   Abraham, D ^a   Rogers, J ^a   Brady, R ^a   Gault, P ^a   Ajioka, R ^a   Kushner, J P ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Diabetes; Haemochromatosis; Impaired glucose tolerance; Insulin resistance; Insulin secretion

Indexed keywords

GLUCOSE; INSULIN;

ADULT; ARTICLE; COMORBIDITY; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; DISEASE ASSOCIATION; FEMALE; FREQUENCY ANALYSIS; GENETIC DISORDER; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; HEMOCHROMATOSIS; HUMAN; HYPOINSULINEMIA; INSULIN RELEASE; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; MEDICAL RECORD; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OUTPATIENT DEPARTMENT; PATIENT REFERRAL; PHLEBOTOMY; PREVALENCE; PRIORITY JOURNAL; SAMPLE; SCREENING;

ADULT; AGED; BLOOD GLUCOSE; DIABETES COMPLICATIONS; DIABETES MELLITUS; FEMALE; GLUCOSE INTOLERANCE; HEMOCHROMATOSIS; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; PREVALENCE;

EID: 33744919003     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0200-0     Document Type: Article

References (49)

1. Edwards C (1999) Hemochromatosis. In: Lee GR, Foerster J, Lukens J, Paraskevas F, Greer JP, Rodgers GM (eds) Wintrobe's Clinical Hematology. Williams & Wilkins, Baltimore, Massachusetts, pp 1056-1070
2. Bothwell THCR, Motulsky AG (1995) Hemochromatosis. In: Scriver CR, Beaudet A, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease. McGraw-Hill, New York, pp 2237-2269
3. Feder JN, Gnirke A, Thomas W et al (1996) A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 13:399-408
4. Feder JN, Tsuchihashi Z, Irrinki A et al (1997) The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression. J Biol Chem 272:14025-14028
5. Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C (2005) Hepcidin is decreased in TFR2 hemochromatosis. Blood 105(4):1803-1806
6. Nemeth E, Tuttle MS, Powelson J et al (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090-2093
7. Edwards CQ, Dadone MM, Skolnick MH, Kushner JP (1982) Hereditary haemochromatosis. Clin Haematol 11:411-435
8. Buysschaert M, Paris I, Selvais P, Hermans MP (1997) Clinical aspects of diabetes secondary to idiopathic haemochromatosis in French-speaking Belgium. Diabetes Metab 23:308-313
9. Moirand R, Adams PC, Bicheler V, Brissot P, Deugnier Y (1997) Clinical features of genetic hemochromatosis in women compared with men. Ann Intern Med 127:105-110
10. Hramiak IM, Finegood DT, Adams PC (1997) Factors affecting glucose tolerance in hereditary hemochromatosis. Clin Invest Med 20:110-118
11. Merkel PA, Simonson DC, Amiel SA et al (1988) Insulin resistance and hyperinsulinemia in patients with thalassemia major treated by hypertransfusion. N Engl J Med 318:809-814
12. Mendler MH, Turlin B, Moirand R et al (1999) Insulin resistance- associated hepatic iron overload. Gastroenterology 117:1155-1163
13. Rossetti L, Giaccari A, DeFronzo RA (1990) Glucose toxicity. Diabetes Care 13:610-630
14. Bugianesi E, Manzini P, D'Antico S et al (2004) Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver. Hepatology 39:179-187
15. Cooksey RC, Jouihan HA, Ajioka RS et al (2004) Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. Endocrinology 145:5305-5312
16. Adams PC, Reboussin DM, Barton JC et al (2005) Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med 352:1769-1778
17. Guttridge MG, Thompson J, Worwood M, Darke C (1998) Rapid detection of genetic mutations associated with haemochromatosis. Vox Sang 75:253-256
18. Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539-553
19. Saad MF, Steil GM, Riad-Gabriel M et al 1997 Method of insulin administration has no effect on insulin sensitivity estimates from the insulin-modified minimal model protocol. Diabetes 46:2044-2048
20. Boston RC, Stefanovski D, Moate PJ, Sumner AE, Watanabe RM, Bergman RN (2003) MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test. Diabetes Technol Ther 5:1003-1015
21. Kenny S, Aubert RE, Geiss LS (1995) Prevalence and incidence of non-insulin-dependent diabetes. In: Health NIo, Diseases NIoDaDaK (eds) National Diabetes Data Group. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, pp 47-68
22. Bulaj ZJ, Ajioka RS, Phillips JD et al (2000) Disease-related conditions in relatives of patients with hemochromatosis. N Engl J Med 343:1529-1535
23. Kahn SE, Prigeon RL, McCulloch DK et al (1993) Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 42:1663-1672
24. Chen H, Sullivan G, Quon MJ (2005) Assessing the predictive accuracy of QUICKI as a surrogate index for insulin sensitivity using a calibration model. Diabetes 54:1914-1925
25. Ajioka RS, Kushner JP (2002) Hereditary hemochromatosis. Semin Hematol 39:235-241
26. Kwan T, Leber B, Ahuja S, Carter R, Gerstein HC (1998) Patients with type 2 diabetes have a high frequency of the C282Y mutation of the hemochromatosis gene. Clin Invest Med 21:251-257
27. Moczulski DK, Grzeszczak W, Gawlik B (2001) Role of hemochromatosis C282Y and H63D mutations in HFE gene in development of type 2 diabetes and diabetic nephropathy. Diabetes Care 24:1187-1191
28. Braun J, Donner H, Plock K, Rau H, Usadel KH, Badenhoop K (1998) Hereditary haemochromatosis mutations (HFE) in patients with type II diabetes mellitus. Diabetologia 41:983-984
29. Dubois-Laforgue D, Caillat-Zucman S, Djilali-Saiah I et al (1998) Mutations in HFE, the hemochromatosis candidate gene, in patients with NIDDM. Diabetes Care 21:1371-1372
30. Frayling T, Ellard S, Grove J, Walker M, Hattersley AT (1998) C282Y mutation in HFE (haemochromatosis) gene and type 2 diabetes. Lancet 351:1933-1934
31. Halsall DJ, McFarlane I, Luan J, Cox TM, Wareham NJ (2003) Typical type 2 diabetes mellitus and HFE gene mutations: a population-based case-control study. Hum Mol Genet 12:1361-1365
32. Sampson MJ, Williams T, Heyburn PJ et al (2000) Prevalence of HFE (hemochromatosis gene) mutations in unselected male patients with type 2 diabetes. J Lab Clin Med 135:170-173
33. Conte D, Manachino D, Colli A et al (1998) Prevalence of genetic hemochromatosis in a cohort of Italian patients with diabetes mellitus. Ann Intern Med 128:370-373
34. Ellervik C, Mandrup-Poulsen T, Nordestgaard BG et al (2001) Prevalence of hereditary haemochromatosis in late-onset type 1 diabetes mellitus: a retrospective study. Lancet 358:1405-1409
35. Valenti L, Conte D, Piperno A et al (2004) The mitochondrial superoxide dismutase A16V polymorphism in the cardiomyopathy associated with hereditary haemochromatosis. J Med Genet 41:946-950
36. Bulaj ZJ, Griffen LM, Jorde LB, Edwards CQ, Kushner JP (1996) Clinical and biochemical abnormalities in people heterozygous for hemochromatosis. N Engl J Med 335:1799-1805
37. Van Lerberghe S, Hermans MP, Dahan K, Buysschaert M (2002) Clinical expression and insulin sensitivity in type 2 diabetic patients with heterozygous mutations for haemochromatosis. Diabetes Metab 28:33-38
38. Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB (2004) Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA 291:711-717
39. Wilson JG, Lindquist JH, Grambow SC, Crook ED, Maher JF (2003) Potential role of increased iron stores in diabetes. Am J Med Sci 325:332-339
40. Tuomainen TP, Nyyssonen K, Salonen R et al (1997) Body iron stores are associated with serum insulin and blood glucose concentrations. Population study in 1,013 eastern Finnish men. Diabetes Care 20:426-428
41. Mangiagli A, Italia S, Campisi S (1998) Glucose tolerance and beta-cell secretion in patients with thalassemia major. J Pediatr Endocrinol Metab 11:985-986
42. Pelot D, Zhou XJ, Carpenter P, Vaziri ND (1998) Effects of experimental hemosiderosis on pancreatic tissue iron content and structure. Dig Dis Sci 43:2411-2414
43. Andrews NC (1999) The iron transporter DMT1. Int J Biochem Cell Biol 31:991-994
44. MacDonald MJ, Cook JD, Epstein ML, Flowers CH (1994) Large amount of (apo)ferritin in the pancreatic insulin cell and its stimulation by glucose. FASEB J 8:777-781
45. Cario H, Holl RW, Debatin KM, Kohne E (2003) Insulin sensitivity and beta-cell secretion in thalassemia major with secondary haemochromatosis: assessment by oral glucose tolerance test. Eur J Pediatr 162:139-146
46. Fernandez-Real JM, Lopez-Bermejo A, Ricart W (2002) Cross-talk between iron metabolism and diabetes. Diabetes 51:2348-2354
47. Turlin B, Mendler MH, Moirand R, Guyader D, Guillygomarc'h A, Deugnier Y (2001) Histologic features of the liver in insulin resistance-associated iron overload. A study of 139 patients. Am J Clin Pathol 116:263-270
48. Dubois-Laforgue D, Caillat-Zucman S, Boitard C, Timsit J (2000) Clinical characteristics of type 2 diabetes in patients with mutations of HFE. Diabetes Metab 26:65-68
49. Caronia S, Taylor K, Pagliaro L et al (1999) Further evidence for an association between non-insulin-dependent diabetes mellitus and chronic hepatitis C virus infection. Hepatology 30:1059-1063