Patient and graft survival after liver transplantation for hereditary hemochromatosis: Implications for pathogenesis

Hepatology

Volumn 39, Issue 6, 2004, Pages 1655-1662

  Crawford, Darrell H G ^a   Fletcher, Linda M ^a   Hubscher, Stefan G ^b   Stuart, Katherine A ^a   Gane, Edward ^c   Angus, Peter W ^d   Jeffrey, Gary P ^e   McCaughan, Geoffrey W ^f   Kerlin, Paul ^a   Powell, Lawrie W ^g   Elias, Elwyn E ^b,h  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^c New Zealand Liver Transplant Unit   (New Zealand)

^d AUSTIN HOSPITAL   (Australia)

^e SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^f ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^g QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^h PRINCESS ALEXANDRA HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; CYCLOSPORIN; FERRITIN; IRON; TACROLIMUS;

ADULT; ARTICLE; CAUSE OF DEATH; CLINICAL ARTICLE; FERRITIN BLOOD LEVEL; GENETIC DISORDER; GRAFT SURVIVAL; HEALTH CARE UTILIZATION; HEMOCHROMATOSIS; HEREDITARY HEMOCHROMATOSIS; HUMAN; INTESTINE ABSORPTION; IRON ABSORPTION; IRON KINETICS; IRON LOADED LIVER GRAFT; IRON METABOLISM; IRON STORAGE; LIVER CELL CARCINOMA; LIVER DISEASE; LIVER FIBROSIS; LIVER FUNCTION; LIVER GRAFT; LIVER GRAFT FUNCTION; LIVER HEMOSIDEROSIS; LIVER TRANSPLANTATION; MALE; PRIORITY JOURNAL; RECURRENT CANCER; RISK FACTOR; SURVIVAL;

ADULT; FOLLOW-UP STUDIES; GRAFT SURVIVAL; HEMOCHROMATOSIS; HUMANS; IRON; LIVER; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; SURVIVAL RATE; TIME FACTORS;

EID: 2542511670     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20242     Document Type: Article

References (23)

1. Powell LW, Leggett BA, Crawford DH. Hemochromatosis and other iron storage disorders. In: Schiff ER, Sorrell MF, Maddrey WC, eds. Schiff's Diseases of the Liver. 8th ed. Philadelphia: Lippincott-Raven, 1999:1107-1130.
2. Wiesner RH. A long-term comparison of tacrolimus (FK506) versus cyclosporine in liver transplantation: a report of the United States FK506 group. Transplantation 1998;66:493-499.
3. 2000 Annual Report of the U.S. Scientific Registry of Transplant Recipients and the Organ Procurement and Transplantation Network. Transplant data 1989-1998. Available at: http://optn.org/AR2003/survival_rates.htm. Accessed April 19, 2004.
4. Stuart K, Fletcher L, Clouston A, Lynch SV, Purdie D, Lynch S, et al. Increased hepatic iron and cirrhosis: no evidence for an adverse effect on patient outcome following liver transplantation. HEPATOLOGY 2000;32:1200-1206.
5. Brandhagen DJ, Alvarez W, Therneau TM, Kruckeberg KE, Thibodeau SN, Ludwig J, et al. Iron overload in cirrhosis-HFE genotypes and outcome after liver transplantation. HEPATOLOGY 2000;31:456-460.
6. Kowdley K, Hassanein T, Kaur S, Farrell F, Van Thiel D, Keeffe E, et al. Primary liver cancer and survival in patients undergoing liver transplantation for hemochromatosis. Liver Transpl Surg 1995;1:237-241.
7. Britton RS. Metal-induced hepatotoxicity. Semin Liver Dis 1996;16:3-12.
8. Adams PC, Ghent CN, Grant DR, Frei JV, Wall WJ. Transplantation of a donor liver with haemochromatosis: evidence against an inhetited intrahepatic defect. Gut 1997;32:1082-1083.
9. Adams PC, Jeffrey G, Alanen K, Chakrabarti S, Preshaw R, Howson W, et al. Transplantation of haemochromatosis liver and intestine into a normal recipient. Gut 1999;45:783.
10. Dabkowski PL, Angus PW, Smallwood RA, Ireton J, Jones RM. Site of principal metabolic defect in idiopathic haemochromatosis: insights from transplantation of an affected organ. BMJ 1993;306:1726.
11. Scheuer PJ, Williams R, Muir AR. Hepatic pathology in relatives of patients with haemochromatosis. J Pathol Bacteriol 1962;84:53-64.
12. Torrance JD, Bothwell TH. A simple technique for measuring storage iron concentrations in formalinised liver samples. S Afr J Med Sci 1968;33:9-11.
13. Jazwinska EC, Cullen LM, Busfield F, Pyper WR, Webb SI, Powell LW, et al. Haemochromatosis and HLA-H. Nat Genet 1996;14:249-251.
14. Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996;334:693-699.
15. Cullen LM, Summerville L, Glassick TV, Crawford DHG, Powell LW, Jazwinska EC. Neonatal screening for the haemochromatosis defect. Blood 1997;90:4236-4237.
16. Olynyk JK, Cullen DJ, Aquilia S, Rossi E, Summerville L, Powell LW. A population-based study of the clinical expression of the hemochromatosis gene. N Engl J Med 1999;341:718-724.
17. Phatak PD, Sham RL, Raubertas RF, Dunnigan K, O'Leary MT, Braggins C, et al. Prevalence of hereditary hemochromatosis in 16031 primary care patients. Ann Intern Med 1998;129:954-961.
18. McCune CA, Al-Jader LN, May A, Hayes SL, Jackson HA, Worwood M. Hereditary haemochromatosis: only 1% of adult HFEC282Y homozygotes in South Wales have a clinical diagnosis of iron overload. Hum Genet 2002;111:538-543.
19. Fletcher LM, Dixon JL, Purdie DM, Powell LW, Crawford DHG. Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis: quantifying the risk. Gastroenterology 2002;122:281-289.
20. Pillay P, Tzoracoleftherakis E, Tzakis A, Kakis AK, Van Thiel DH, Starzl TE. Orthotopic liver transplantation for hemochromatosis. Transpl Proc 1991;23:1888-1889.
21. Kilpe VE, Krakauer H, Wren RE. An analysis of liver transplant experience from 37 transplant centers as reported to Medicare. Transplantation 1993;56:554-561.
22. Niederau C, Fischer R, Purschel A, Stremmel W, Haussinger D, Strohmeyer G. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology 1996;110:1107-1119.
23. Parolin MB, Batts KP, Wiesner RH, Bernstein PS, Zinsmeister AR, Harmsen WS, et al. Liver allograft iron accumulation in patients with and without pretransplantation hepatic hemosiderosis. Liver Transpl 2002;8:331-339.