HFE mutations are not strongly associated with sporadic ALS

Neurology

Volumn 62, Issue 9, 2004, Pages 1611-1612

  Yen, A A ^a   Simpson, E P ^a   Henkel, J S ^a   Beers, D R ^a   Appel, S H ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENE; GENE MUTATION; GENETIC ASSOCIATION; HFE GENE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; OXIDATIVE STRESS; PREVALENCE; PRIORITY JOURNAL;

EID: 2342662119     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000123114.04644.CC     Document Type: Article

References (10)

1. Simpson EP, Yen AA, Appel SH. Oxidative stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis. Curr Opin Rheumatol 2003;15:730-736.
2. Carri MT, Ferri A, Cozzolino M, Calabrese L, Rotilio G. Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals. Brain Res Bull 2003;61:365-374.
3. Kasarskis EJ, Tandon L, Lovell MA, Ehmann WD. Aluminum, calcium, and iron in the spinal cord of patients with sporadic amyotrophic lateral sclerosis using laser microprobe mass spectroscopy: a preliminary study. J Neurol Sci 1995;130:203-208.
4. Qian SY, Buettner GR. Iron and dioxygen chemistry is an important route to initiation of biological free radical oxidations: an electron paramagnetic resonance spin trapping study. Free Rad Biol Med 1999;26:1447-1456.
5. Burt MJ, George PM, Upton JD, et al. The significance of haemochromatosis gene mutations in the general population: implications for screening. Gut 1998;43:830-836.
6. Burke W, Imperatore G, McDonnell SM, Baron RC, Khoury MJ. Contribution of different HFE genotypes to iron overload disease: a pooled analysis. Genet Med 2000;2:271-277.
7. Njajou OT, Houwing-Duistermaat JJ, Osborne RH, et al. A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism. Eur J Hum Genet 2003;11:225-231.
8. Pulliam JF, Jennings CD, Kryscio RJ, et al. Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE. Am J Med Genet 2003;119:48-53.
9. Borie C, Gasparini F, Verpillat P, et al. French Parkinson's Disease Genetic Study Group. Association study between iron-related genes polymorphisms and Parkinson's disease. J Neurol 2002;249:801-804.
10. Steinberg KK, Cogswell ME, Chang JC, et al. Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States. JAMA 2001;285:2216-2222.