Prevalence of hereditary haemochromatosis in premature atherosclerotic vascular disease

British Journal of Haematology

Volumn 102, Issue 5, 1998, Pages 1172-1175

  Franco, R F ^a,b   Zago, M A ^a   Trip, M D ^c   Ten Cate, H ^c   Van Den Ende, A ^c   Prins, M H ^c   Kastelein, J J P ^c   Reitsma, P H ^c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FUNDHERP   (Brazil)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Arterial thrombosis; Atherosclerosis; Haemochromatosis; HFE; Mutations

Indexed keywords

ADULT; ARTERY THROMBOSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; AUTOSOMAL RECESSIVE DISORDER; DISEASE ASSOCIATION; FEMALE; GENE AMPLIFICATION; GENE FREQUENCY; GENE MUTATION; HEMOCHROMATOSIS; HUMAN; IRON METABOLISM; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PREVALENCE; PRIORITY JOURNAL; VASCULAR DISEASE;

ADOLESCENT; ADULT; ARTERIOSCLEROSIS; CHILD; CHILD, PRESCHOOL; FEMALE; GENE FREQUENCY; HEMOCHROMATOSIS; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MALE; MIDDLE AGED; MUTATION; THROMBOSIS;

EID: 0031720168     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00898.x     Document Type: Article

References (20)

1. Beutler, E. (1997) Genetic irony beyond haemochromatosis: clinical effects of HLA-H mutations. Lancet, 349, 296-297.
2. Beutler, E., Gelbert, T., West, C., Lee, P., Adaras, M., Blackstone, R., Pockros, P., Kosty, M., Venditti, C.P., Phatak, P.D., Seese, N.K., Chorney, K.A., Ten Elshof, A.E., Gerhard, G.S. & Chorney, M. (1996) Mutation analysis in hereditary hemochromatosis. Blood Cells and Molecular Diseases, 22, 187-194.
3. Burt, M.J., Halliday, J.W. & Powell, L.W. (1993) Iron and coronary heart disease. British Medical Journal, 307, 575-576.
4. Corti, M.C., Gaziano, M. & Hennekens, C.H. (1997) Iron status and risk of cardiovascular disease. Annals of Epidemiology, 7, 62-68.
5. Dabbagh, A.J., Shwaery, G.T., Keaney, J.F., Jr & Frei, B. (1997) Effect of iron overload and iron deficiency on atherosclerosis in the hypercholesterolemic rabbit. Arteriosclerosis, Thrombosis and Vascular Biology, 17, 2638-2645.
6. Feder, J.N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D.A., Basava, A., Dormishian, F., Domingo, R., Jr, Ellis, M.C., Fullan, A., Hinton, L.M., Jones, N.L., Kimmel, B.E., Kronmal, G.S., Lauer, P., Lee, V.K., Loeb, D.B., Mapa, F.A., McClelland, K., Meyer, N.C., Mintier, G.A., Moeller, N., Moore, T., Morikang, E., Prass, C.E., Quintane, L., Starnes, S.M., Schatzman, R.C., Brunke, K.J., Drayna, D.T., Risen, N.J., Bacon, B.R. & Wolff, R.K. (1996) A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nature Genetics, 13, 399-408.
7. Figueiredo, M.S., Baffa, O., Barbieri-Neto, J. & Zago, M.A. (1993) Liver injury and generation of hydroxyl free radicals in experimental secondary hemochromatosis. Research in Experimental Medicine, 193, 27-37.
8. Kiechl, S., Aichner, F., Gerstenbrand, F., Egger, G., Mair, A., Rungger, G., Spogler, F., Jarosch, E., Oberhollenzer, F. & Willeit, J. (1994) Body iron stores and presence of carotid atherosclerosis. Arteriosclerosis and Thrombosis, 14, 1625-1630.
9. Kiechl, S., Willeit, J., Egger, G., Poewe, W. & Oberhollenzer, F. (1997) Body iron stores and the risk of carotid atherosclerosis: prospective results from the Bruneck Study. Circulation, 96, 3300-3307.
10. Lauffer, R.B. (1991) Iron stores and the international variation in mortality from coronary artery disease. Medical Hypotheses, 35, 96-102.
11. Martinez, P.A., Biron, C., Blanc, K. Masmejean, C., Jeanjean, P., Michel, H. & Schved, J. (1997) Compound heterozygotes for haemochromatosis gene mutations: may they help to understand the pathophysiology of the disease? Blood Cells and Molecular Diseases, 23, 269-276.
12. Merryweather-Clarke, A.T., Pointon, J.J., Shearman, J.D. & Robson, K.J.H. (1997) Global prevalence of putative haemochromatosis mutations. Journal of Medical Genetics, 34, 275-278.
13. Meyers, D.G. (1996) The iron hypothesis: does iron cause atherosclerosis? Clinical Cardiology, 19, 925-929.
14. Morrison, H.I., Semenciw, R.M., Mao, Y. & Wigle, D.T. (1994) Serum iron and risk of fatal acute myocardial infarction. Epidemiology, 5, 243-246.
15. Roberts, A.G., Whatley, S.D., Morgan, R.R., Worwood, M. & Elder, G.H. (1997) Increased frequency of the haemochromatosis Cys282Tyr mutation in sporadic porphyria cutanea tarda. Lancet, 349, 321-323.
16. Salonen, J.T., Korpela, H., Hyyssonen, K., Porkkala, E., Tuomainen, T.P., Belcher, J.D., Jacobs, D.R. & Salonen, R. (1995) Lowering of body iron stores by blood letting and oxidation resistance of serum lipoproteins: a randomized cross-over trial in male smokers. Journal of Internal Medicine, 237, 161-168.
17. Salonen, J.T., Nyyssonen, K., Korpela, H., Tuomilehto, J., Seppanen, R. & Salonen, R. (1992) High stored iron levels are associated with excessive risk of myocardial infarction in eastern Finnish men. Circulation, 86, 803-811.
18. Sampietro, M., Piperno, A., Lupica, L., Arosio, C., Vergani, A., Corbetta, N., Malosio, I., Mattioli, M., Fracanzani, A.L., Cappellini, M.D., Fiorelli, G. & Fargioni, S. (1998) High prevalence of the His63Asp HFE mutation in Italian patients with porphyria cutanea tarda. Hepatology, 27, 181-184.
19. Sempos, C.T., Looker, A.C. & Gillum, R.F. (1996) Iron and heart disease: the epidemiologic data. Nutrition Reviews, 54, 73-84.
20. Witte, D.L., Crosby, W.H., Edwards, C.Q., Fairbanks, V.F. & Mitros, FA. (1996) Practice parameter for hereditary hemochromatosis. Clinica Chimica Acta, 245, 139-200.