Transferrin receptor 2 mediates a biphasic pattern of transferrin uptake associated with ligand delivery to multivesicular bodies

American Journal of Physiology - Cell Physiology

Volumn 287, Issue 6 56-6, 2004, Pages

  Robb, Aeisha B ^a   Ericsson, Maria ^b   Wessling Resnick, Marianne ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

HepG2 cells; Iron transport

Indexed keywords

CD71 ANTIGEN; IRON; LIGAND; TRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CELL STRAIN HEPG2; CELL SURFACE; CELL VACUOLE; ENDOCYTOSIS; ENDOSOME; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT;

ANTIGENS, CD; CARCINOMA, HEPATOCELLULAR; CELL MEMBRANE; ENDOCYTOSIS; ENDOSOMES; HELA CELLS; HUMANS; IODINE RADIOISOTOPES; IRON; LIGANDS; MICROSCOPY, IMMUNOELECTRON; RECEPTORS, TRANSFERRIN; TRANSFERRIN;

EID: 8644221378     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00337.2004     Document Type: Article

References (42)

1. Blight GD and Morgan EH. Ferritin and iron uptake by reticulocytes. Br J Haematol 55: 59-71, 1983.
2. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
3. Calzolari A, Deaglio S, Sposi NM, Petrucci E, Morsilli O, Gabbianelli M, Malavasi F, Peschle C, and Testa U. Transferrin receptor 2 protein is not expressed in normal erythroid cells. Biochem J 381: 629-634, 2004.
4. Camaschella C, Roetto A, Cali A, De Gobbi M, Garozzo G, Carella M, Majorano N, Totaro A, and Gasparini P. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat Genet 25: 14-15, 2000.
5. Chan RY, Ponka P, and Schulman HM. Transferrin-receptor-independent but iron-dependent proliferation of variant Chinese hamster ovary cells. Exp Cell Res 202: 326-336, 1992.
6. Ciechanover A, Schwartz AL, Dautry-Varsat A, and Lodish HF. Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line: effect of lysosomotropic agents. J Biol Chem 258: 9681-9689, 1983.
7. Deaglio S, Capobianco A, Cali A, Bellora F, Alberti F, Righi L, Sapino A, Camaschella C, and Malavasi F. Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum. Blood 100: 3782-3789, 2002.
8. Fischbach K, Lu Y, Tiffany-Castiglioni E, Minter A, Bowman BH, and Adrian GS. Expression of chimeric human transferrin genes in vitro. J Neurosci Res 27: 633-641, 1990.
9. Fleming RE, Ahmann JR, Migas MC, Waheed A, Koeffler HP, Kawabata H, Britton RS, Bacon BR, and Sly WS. Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc Natl Acad Sci USA 99: 10653-10658, 2002.
10. Futter CE, Pearse A, Hewlett LJ, and Hopkins CR. Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes. J Cell Biol 132: 1011-1023, 1996.
11. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102: 783-788, 2003.
12. Gehrke SG, Kulaksiz H, Herrmann T, Riedel HD, Bents K, Veltkamp C, and Stremmel W. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood 102: 371-376, 2003.
13. Griffiths G. Fine Structure Immunocytochemistry. Heidelberg, Germany: Springer-Verlag, 1993.
14. Hattori A, Wakusawa S, Hayashi H, Harashima A, Sanae F, Kawanaka M, Yamada G, Yano M, and Yoshioka K. AVAQ 594-597 deletion of the TfR2 gene in a Japanese family with hemochromatosis. Hepatol Res 26: 154-156, 2003.
15. Ikuta K, Zak O, and Aisen P. Recycling, degradation and sensitivity to the synergistic anion of transferrin in the receptor-independent route of iron uptake by human hepatoma (HuH-7) cells. Int J Biochem Cell Biol 36: 340-352, 2004.
16. Katzmann DJ, Odorizzi G, and Emr SD. Receptor downregulation and multivesicular-body sorting. Nat Rev Mol Cell Biol 3: 893-905, 2002.
17. Kawabata H, Germain RS, Ikezoe T, Tong X, Green EM, Gombart AF, and Koeffler HP. Regulation of expression of murine transferrin receptor 2. Blood 98: 1949-1954, 2001.
18. Kawabata H, Germain RS, Vuong PT, Nakamaki T, Said JW, and Koeffler HP. Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo. J Biol Chem 275: 16618-16625, 2000.
19. Kawabata H, Yang R, Hirama T, Vuong PT, Kawano S, Gombart AF, and Koeffler HP. Molecular cloning of transferrin receptor 2: a new member of the transferrin receptor-like family. J Biol Chem 274: 20826-20832, 1999.
20. Kleijmeer M, Ramm G, Schuurhuis D, Griffith J, Rescigno M, Ricciardi-Castagnoli P, Rudensky AY, Ossendorp F, Melief CJ, Stoorvogel W, and Geuze HJ. Reorganization of multivesicular bodies regulates MHC Class II antigen presentation by dendritic cells. J Cell Biol 155: 53-63, 2001.
21. Knowles BB, Howe CC, and Aden DP. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209: 497-499, 1980.
22. Kozyraki R, Fyfe J, Verroust PJ, Jacobsen C, Dautry-Varsat A, Gburek J, Willnow TE, Christensen EI, and Moestrup SK. Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia. Proc Natl Acad Sci USA 98: 12491-12496, 2001.
23. Lamb JE, Ray F, Ward JH, Kushner JP, and Kaplan J. Internalization and subcellular localization of transferrin and transferrin receptors in HeLa cells. J Biol Chem 258: 8751-8758, 1983.
24. Lee AW, Oates PS, and Trinder D. Effects of cell proliferation on the uptake of transferrin-bound iron by human hepatoma cells. Hepatology 38: 967-977, 2003.
25. Levy JE, Jin O, Fujiwara Y, Kuo F, and Andrews NC. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet 21: 396-399, 1999.
26. Mattman A, Huntsman D, Lockitch G, Langlois S, Buskard N, Ralston D, Butterfield Y, Rodrigues P, Jones S, Porto G, Marra M, De Sousa M, and Vatcher G. Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation. Blood 100: 1075-1077, 2002.
27. Morgan EH and Baker E. Role of transferrin receptors and endocytosis in iron uptake by hepatic and erythroid cells. Ann NY Acad Sci 526: 65-82, 1988.
28. Neumannova V, Richardson DR, Kriegerbeckova K, and Kovar J. Growth of human tumor cell lines in transferrin-free, low-iron medium. In Vitro Cell Dev Biol Anim 31: 625-632, 1995.
29. Penhallow RC, Brown-Mason A, and Woodworth RC. Comparative studies of the binding and growth-supportive ability of mammalian transferrins in human cells. J Cell Physiol 128: 251-260, 1986.
30. Pietrangelo A. Non-HFE hemochromatosis. Hepatology 39: 21-29, 2004.
31. Ponka P and Lok CN. The transferrin receptor: role in health and disease. Int J Biochem Cell Biol 31: 1111-1137, 1999.
32. Roetto A, Totaro A, Piperno A, Piga A, Longo F, Garozzo G, Cali A, De Gobbi M, Gasparini P, and Camaschella C. New mutations inactivating transferrin receptor 2 in hemochromatosis type 3. Blood 97: 2555-2560, 2001.
33. Slordahl S, Romslo I, and Lamvik J. Binding of transferrin and uptake of iron by K-562 cells. Scand J Clin Lab Invest 44: 549-553, 1984.
34. Stoorvogel W, Geuze HJ, Griffith JM, and Strous GJ. The pathways of endocytosed transferrin and secretory protein are connected in the trans-Golgi reticulum. J Cell Biol 106: 1821-1829, 1988.
35. Stoorvogel W, Geuze HJ, and Strous GJ. Sorting of endocytosed transferrin and asialoglycoprotein occurs immediately after internalization in HepG2 cells. J Cell Biol 104: 1261-1268, 1987.
36. Trinder D, Morgan EH, and Baker E. The effects of an antibody to the rat transferrin receptor and of rat serum albumin on the uptake of diferric transferrin by rat hepatocytes. Biochim Biophys Acta 943: 440-446, 1988.
37. Trinder D, Zak O, and Aisen P. Transferrin receptor-independent uptake of diferric transferrin by human hepatoma cells with antisense inhibition of receptor expression. Hepatology 23: 1512-1520, 1996.
38. Vogt TM, Blackwell AD, Giannetti AM, Bjorkman PJ, and Enns CA. Heterotypic interactions between transferrin receptor and transferrin receptor 2. Blood 101: 2008-2014, 2003.
39. Warren RA, Green FA, and Enns CA. Saturation of the endocytic pathway for the transferrin receptor does not affect the endocytosis of the epidermal growth factor receptor. J Biol Chem 272: 2116-2121, 1997.
40. Welch S. Transferrin: The Iron Carrier. Boca Raton, FL: CRC, 1992.
41. Youssefian T and Cramer EM. Megakaryocyte dense granule components are sorted in multivesicular bodies. Blood 95: 4004-4007, 2000.
42. Zhang AS, Xiong S, Tsukamoto H, and Enns CA. Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes. Blood 103: 1509-1514, 2004.