-
1
-
-
12444341944
-
Toll-like receptors in innate immunity
-
Takeda K., and Akira S. Toll-like receptors in innate immunity. Int Immunol 17 1 (2005) 1-14
-
(2005)
Int Immunol
, vol.17
, Issue.1
, pp. 1-14
-
-
Takeda, K.1
Akira, S.2
-
2
-
-
30044442866
-
How Toll-like receptors signal: what we know and what we don't know
-
O'Neill L.A. How Toll-like receptors signal: what we know and what we don't know. Curr Opin Immunol 18 1 (2006) 3-9
-
(2006)
Curr Opin Immunol
, vol.18
, Issue.1
, pp. 3-9
-
-
O'Neill, L.A.1
-
3
-
-
0028174061
-
Function and activation of NF-kappa B in the immune system
-
Baeuerle P.A., and Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 12 (1994) 141-179
-
(1994)
Annu Rev Immunol
, vol.12
, pp. 141-179
-
-
Baeuerle, P.A.1
Henkel, T.2
-
4
-
-
0022481133
-
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
-
Sen R., and Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46 5 (1986) 705-716
-
(1986)
Cell
, vol.46
, Issue.5
, pp. 705-716
-
-
Sen, R.1
Baltimore, D.2
-
5
-
-
0022930702
-
Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism
-
Sen R., and Baltimore D. Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell 47 6 (1986) 921-928
-
(1986)
Cell
, vol.47
, Issue.6
, pp. 921-928
-
-
Sen, R.1
Baltimore, D.2
-
6
-
-
0342742310
-
Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B
-
Osborn L., Kunkel S., and Nabel G.J. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci USA 86 7 (1989) 2336-2340
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, Issue.7
, pp. 2336-2340
-
-
Osborn, L.1
Kunkel, S.2
Nabel, G.J.3
-
7
-
-
0024516201
-
The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction
-
Lenardo M.J., Fan C.M., Maniatis T., and Baltimore D. The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell 57 2 (1989) 287-294
-
(1989)
Cell
, vol.57
, Issue.2
, pp. 287-294
-
-
Lenardo, M.J.1
Fan, C.M.2
Maniatis, T.3
Baltimore, D.4
-
8
-
-
0023946662
-
Multiple actions of interleukin 6 within a cytokine network
-
Wong G.G., and Clark S.C. Multiple actions of interleukin 6 within a cytokine network. Immunol Today 9 5 (1988) 137-139
-
(1988)
Immunol Today
, vol.9
, Issue.5
, pp. 137-139
-
-
Wong, G.G.1
Clark, S.C.2
-
9
-
-
0025343895
-
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor
-
Libermann T.A., and Baltimore D. Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol 10 5 (1990) 2327-2334
-
(1990)
Mol Cell Biol
, vol.10
, Issue.5
, pp. 2327-2334
-
-
Libermann, T.A.1
Baltimore, D.2
-
10
-
-
0021603716
-
Information for the dorsal-ventral pattern of the Drosophila embryo is stored as maternal mRNA
-
Anderson K.V., and Nusslein-Volhard C. Information for the dorsal-ventral pattern of the Drosophila embryo is stored as maternal mRNA. Nature 311 5983 (1984) 223-227
-
(1984)
Nature
, vol.311
, Issue.5983
, pp. 223-227
-
-
Anderson, K.V.1
Nusslein-Volhard, C.2
-
11
-
-
0025774776
-
Drosophila Toll and IL-1 receptor
-
Gay N.J., and Keith F.J. Drosophila Toll and IL-1 receptor. Nature 351 6325 (1991) 355-356
-
(1991)
Nature
, vol.351
, Issue.6325
, pp. 355-356
-
-
Gay, N.J.1
Keith, F.J.2
-
12
-
-
0025078530
-
Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal
-
Ghosh S., Gifford A.M., Riviere L.R., Tempst P., Nolan G.P., and Baltimore D. Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell 62 5 (1990) 1019-1029
-
(1990)
Cell
, vol.62
, Issue.5
, pp. 1019-1029
-
-
Ghosh, S.1
Gifford, A.M.2
Riviere, L.R.3
Tempst, P.4
Nolan, G.P.5
Baltimore, D.6
-
13
-
-
0029865142
-
IRAK: a kinase associated with the interleukin-1 receptor
-
Cao Z., Henzel W.J., and Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science 271 5252 (1996) 1128-1131
-
(1996)
Science
, vol.271
, Issue.5252
, pp. 1128-1131
-
-
Cao, Z.1
Henzel, W.J.2
Gao, X.3
-
14
-
-
0023724778
-
I kappa B: a specific inhibitor of the NF-kappa B transcription factor
-
Baeuerle P.A., and Baltimore D. I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 242 4878 (1988) 540-546
-
(1988)
Science
, vol.242
, Issue.4878
, pp. 540-546
-
-
Baeuerle, P.A.1
Baltimore, D.2
-
15
-
-
0028075756
-
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
-
Grosshans J., Bergmann A., Haffter P., and Nusslein-Volhard C. Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo. Nature 372 6506 (1994) 563-566
-
(1994)
Nature
, vol.372
, Issue.6506
, pp. 563-566
-
-
Grosshans, J.1
Bergmann, A.2
Haffter, P.3
Nusslein-Volhard, C.4
-
16
-
-
0030595339
-
The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
-
Lemaitre B., Nicolas E., Michaut L., Reichhart J.M., and Hoffmann J.A. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86 6 (1996) 973-983
-
(1996)
Cell
, vol.86
, Issue.6
, pp. 973-983
-
-
Lemaitre, B.1
Nicolas, E.2
Michaut, L.3
Reichhart, J.M.4
Hoffmann, J.A.5
-
17
-
-
0027443688
-
Dif, a dorsal-related gene that mediates an immune response in Drosophila
-
Ip Y.T., Reach M., Engstrom Y., Kadalayil L., Cai H., Gonzalez-Crespo S., et al. Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell 75 4 (1993) 753-763
-
(1993)
Cell
, vol.75
, Issue.4
, pp. 753-763
-
-
Ip, Y.T.1
Reach, M.2
Engstrom, Y.3
Kadalayil, L.4
Cai, H.5
Gonzalez-Crespo, S.6
-
18
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
Medzhitov R., Preston-Hurlburt P., and Janeway Jr. C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 6640 (1997) 394-397
-
(1997)
Nature
, vol.388
, Issue.6640
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway Jr., C.A.3
-
19
-
-
0031905311
-
A family of human receptors structurally related to Drosophila Toll
-
Rock F.L., Hardiman G., Timans J.C., Kastelein R.A., and Bazan J.F. A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci USA 95 2 (1998) 588-593
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.2
, pp. 588-593
-
-
Rock, F.L.1
Hardiman, G.2
Timans, J.C.3
Kastelein, R.A.4
Bazan, J.F.5
-
20
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
-
Poltorak A., He X., Smirnova I., Liu M.Y., Huffel C.V., Du X., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 5396 (1998) 2085-2088
-
(1998)
Science
, vol.282
, Issue.5396
, pp. 2085-2088
-
-
Poltorak, A.1
He, X.2
Smirnova, I.3
Liu, M.Y.4
Huffel, C.V.5
Du, X.6
-
21
-
-
16844379118
-
The role of Toll-like receptors in the host response to viruses
-
Bowie A.G., and Haga I.R. The role of Toll-like receptors in the host response to viruses. Mol Immunol 42 8 (2005) 859-867
-
(2005)
Mol Immunol
, vol.42
, Issue.8
, pp. 859-867
-
-
Bowie, A.G.1
Haga, I.R.2
-
22
-
-
0030240062
-
Macrophages ingest and are activated by bacterial DNA
-
Stacey K.J., Sweet M.J., and Hume D.A. Macrophages ingest and are activated by bacterial DNA. J Immunol 157 5 (1996) 2116-2122
-
(1996)
J Immunol
, vol.157
, Issue.5
, pp. 2116-2122
-
-
Stacey, K.J.1
Sweet, M.J.2
Hume, D.A.3
-
23
-
-
0030816325
-
Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock
-
Sparwasser T., Miethke T., Lipford G., Erdmann A., Hacker H., Heeg K., et al. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock. Eur J Immunol 27 7 (1997) 1671-1679
-
(1997)
Eur J Immunol
, vol.27
, Issue.7
, pp. 1671-1679
-
-
Sparwasser, T.1
Miethke, T.2
Lipford, G.3
Erdmann, A.4
Hacker, H.5
Heeg, K.6
-
24
-
-
0030008234
-
Analysis of the signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages
-
Kengatharan M., De Kimpe S.J., and Thiemermann C. Analysis of the signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages. Br J Pharmacol 117 6 (1996) 1163-1170
-
(1996)
Br J Pharmacol
, vol.117
, Issue.6
, pp. 1163-1170
-
-
Kengatharan, M.1
De Kimpe, S.J.2
Thiemermann, C.3
-
25
-
-
0034075754
-
The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense
-
O'Neill L.A., and Dinarello C.A. The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunol Today 21 5 (2000) 206-209
-
(2000)
Immunol Today
, vol.21
, Issue.5
, pp. 206-209
-
-
O'Neill, L.A.1
Dinarello, C.A.2
-
26
-
-
0028237775
-
Macrophage differentiation marker MyD88 is a member of the Toll/IL-1 receptor family
-
Hultmark D. Macrophage differentiation marker MyD88 is a member of the Toll/IL-1 receptor family. Biochem Biophys Res Commun 199 1 (1994) 144-146
-
(1994)
Biochem Biophys Res Commun
, vol.199
, Issue.1
, pp. 144-146
-
-
Hultmark, D.1
-
27
-
-
0031423761
-
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
-
Wesche H., Henzel W.J., Shillinglaw W., Li S., and Cao Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7 6 (1997) 837-847
-
(1997)
Immunity
, vol.7
, Issue.6
, pp. 837-847
-
-
Wesche, H.1
Henzel, W.J.2
Shillinglaw, W.3
Li, S.4
Cao, Z.5
-
28
-
-
0035817925
-
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
-
Fitzgerald K.A., Palsson-McDermott E.M., Bowie A.G., Jefferies C.A., Mansell A.S., Brady G., et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413 6851 (2001) 78-83
-
(2001)
Nature
, vol.413
, Issue.6851
, pp. 78-83
-
-
Fitzgerald, K.A.1
Palsson-McDermott, E.M.2
Bowie, A.G.3
Jefferies, C.A.4
Mansell, A.S.5
Brady, G.6
-
29
-
-
0035555301
-
TIRAP: an adapter molecule in the Toll signaling pathway
-
Horng T., Barton G.M., and Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol 2 9 (2001) 835-841
-
(2001)
Nat Immunol
, vol.2
, Issue.9
, pp. 835-841
-
-
Horng, T.1
Barton, G.M.2
Medzhitov, R.3
-
30
-
-
0345991221
-
TICAM-2: a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-beta
-
Oshiumi H., Sasai M., Shida K., Fujita T., Matsumoto M., and Seya T. TICAM-2: a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem (2003)
-
(2003)
J Biol Chem
-
-
Oshiumi, H.1
Sasai, M.2
Shida, K.3
Fujita, T.4
Matsumoto, M.5
Seya, T.6
-
31
-
-
0037320451
-
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3- mediated interferon-beta induction
-
Oshiumi H., Matsumoto M., Funami K., Akazawa T., and Seya T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3- mediated interferon-beta induction. Nat Immunol 4 2 (2003) 161-167
-
(2003)
Nat Immunol
, vol.4
, Issue.2
, pp. 161-167
-
-
Oshiumi, H.1
Matsumoto, M.2
Funami, K.3
Akazawa, T.4
Seya, T.5
-
32
-
-
0037114185
-
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling
-
Yamamoto M., Sato S., Mori K., Hoshino K., Takeuchi O., Takeda K., et al. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol 169 12 (2002) 6668-6672
-
(2002)
J Immunol
, vol.169
, Issue.12
, pp. 6668-6672
-
-
Yamamoto, M.1
Sato, S.2
Mori, K.3
Hoshino, K.4
Takeuchi, O.5
Takeda, K.6
-
33
-
-
0141959224
-
LPS-TLR4 Signaling to IRF-3/7 and NF-KB Involves the Toll Adapters TRAM and TRIF
-
Fitzgerald K.A., Rowe D.C., Barnes B.J., Caffrey D.R., Visintin A., Latz E., et al. LPS-TLR4 Signaling to IRF-3/7 and NF-KB Involves the Toll Adapters TRAM and TRIF. J Exp Med (2003)
-
(2003)
J Exp Med
-
-
Fitzgerald, K.A.1
Rowe, D.C.2
Barnes, B.J.3
Caffrey, D.R.4
Visintin, A.5
Latz, E.6
-
34
-
-
0346340104
-
TIRP: a novel TIR domain-containing adapter protein involved in Toll/interleukin-1 receptor signalling
-
Bin L.H., Xu L.G., and Shu H.B. TIRP: a novel TIR domain-containing adapter protein involved in Toll/interleukin-1 receptor signalling. J Biol Chem 28 (2003) 28
-
(2003)
J Biol Chem
, vol.28
, pp. 28
-
-
Bin, L.H.1
Xu, L.G.2
Shu, H.B.3
-
35
-
-
0037505362
-
The Toll-IL-1 receptor adaptor family grows to five members
-
O'Neill L.A., Fitzgerald K.A., and Bowie A.G. The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol 24 6 (2003) 286-290
-
(2003)
Trends Immunol
, vol.24
, Issue.6
, pp. 286-290
-
-
O'Neill, L.A.1
Fitzgerald, K.A.2
Bowie, A.G.3
-
36
-
-
0033583034
-
Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes
-
Zhang F.X., Kirschning C.J., Mancinelli R., Xu X.P., Jin Y., Faure E., et al. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J Biol Chem 274 12 (1999) 7611-7614
-
(1999)
J Biol Chem
, vol.274
, Issue.12
, pp. 7611-7614
-
-
Zhang, F.X.1
Kirschning, C.J.2
Mancinelli, R.3
Xu, X.P.4
Jin, Y.5
Faure, E.6
-
37
-
-
0032133278
-
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
-
Medzhitov R., Preston-Hurlburt P., Kopp E., Stadlen A., Chen C., Ghosh S., et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 2 2 (1998) 253-258
-
(1998)
Mol Cell
, vol.2
, Issue.2
, pp. 253-258
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Kopp, E.3
Stadlen, A.4
Chen, C.5
Ghosh, S.6
-
38
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
-
Alexopoulou L., Holt A.C., Medzhitov R., and Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 6857 (2001) 732-738
-
(2001)
Nature
, vol.413
, Issue.6857
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
39
-
-
0037117543
-
IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase
-
Li S., Strelow A., Fontana E.J., and Wesche H. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci USA 99 8 (2002) 5567-5572
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.8
, pp. 5567-5572
-
-
Li, S.1
Strelow, A.2
Fontana, E.J.3
Wesche, H.4
-
40
-
-
0029761275
-
TRAF6 is a signal transducer for interleukin-1
-
Cao Z., Xiong J., Takeuchi M., Kurama T., and Goeddel D.V. TRAF6 is a signal transducer for interleukin-1. Nature 383 6599 (1996) 443-446
-
(1996)
Nature
, vol.383
, Issue.6599
, pp. 443-446
-
-
Cao, Z.1
Xiong, J.2
Takeuchi, M.3
Kurama, T.4
Goeddel, D.V.5
-
41
-
-
0037129212
-
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
-
Suzuki N., Suzuki S., Duncan G.S., Millar D.G., Wada T., Mirtsos C., et al. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 416 6882 (2002) 750-756
-
(2002)
Nature
, vol.416
, Issue.6882
, pp. 750-756
-
-
Suzuki, N.1
Suzuki, S.2
Duncan, G.S.3
Millar, D.G.4
Wada, T.5
Mirtsos, C.6
-
42
-
-
2942748292
-
IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness
-
Qin J., Jiang Z., Qian Y., Casanova J.L., and Li X. IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness. J Biol Chem 279 25 (2004) 26748-26753
-
(2004)
J Biol Chem
, vol.279
, Issue.25
, pp. 26748-26753
-
-
Qin, J.1
Jiang, Z.2
Qian, Y.3
Casanova, J.L.4
Li, X.5
-
43
-
-
4644333526
-
The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling
-
Lye E., Mirtsos C., Suzuki N., Suzuki S., and Yeh W.C. The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem 279 39 (2004) 40653-40658
-
(2004)
J Biol Chem
, vol.279
, Issue.39
, pp. 40653-40658
-
-
Lye, E.1
Mirtsos, C.2
Suzuki, N.3
Suzuki, S.4
Yeh, W.C.5
-
44
-
-
0035836638
-
IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)
-
Li X., Commane M., Jiang Z., and Stark G.R. IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK). Proc Natl Acad Sci USA 98 8 (2001) 4461-4465
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.8
, pp. 4461-4465
-
-
Li, X.1
Commane, M.2
Jiang, Z.3
Stark, G.R.4
-
45
-
-
0034655280
-
IL-1 receptor-associated kinase modulates host responsiveness to endotoxin
-
Swantek J.L., Tsen M.F., Cobb M.H., and Thomas J.A. IL-1 receptor-associated kinase modulates host responsiveness to endotoxin. J Immunol 164 8 (2000) 4301-4306
-
(2000)
J Immunol
, vol.164
, Issue.8
, pp. 4301-4306
-
-
Swantek, J.L.1
Tsen, M.F.2
Cobb, M.H.3
Thomas, J.A.4
-
46
-
-
0035913278
-
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
-
Wang C., Deng L., Hong M., Akkaraju G.R., Inoue J., and Chen Z.J. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412 6844 (2001) 346-351
-
(2001)
Nature
, vol.412
, Issue.6844
, pp. 346-351
-
-
Wang, C.1
Deng, L.2
Hong, M.3
Akkaraju, G.R.4
Inoue, J.5
Chen, Z.J.6
-
47
-
-
0035834672
-
IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B
-
Qian Y., Commane M., Ninomiya-Tsuji J., Matsumoto K., and Li X. IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. J Biol Chem 276 45 (2001) 41661-41667
-
(2001)
J Biol Chem
, vol.276
, Issue.45
, pp. 41661-41667
-
-
Qian, Y.1
Commane, M.2
Ninomiya-Tsuji, J.3
Matsumoto, K.4
Li, X.5
-
48
-
-
0036788753
-
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol
-
Jiang Z., Ninomiya-Tsuji J., Qian Y., Matsumoto K., and Li X. Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol 22 20 (2002) 7158-7167
-
(2002)
Mol Cell Biol
, vol.22
, Issue.20
, pp. 7158-7167
-
-
Jiang, Z.1
Ninomiya-Tsuji, J.2
Qian, Y.3
Matsumoto, K.4
Li, X.5
-
49
-
-
0034084163
-
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity
-
Karin M., and Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18 (2000) 621-663
-
(2000)
Annu Rev Immunol
, vol.18
, pp. 621-663
-
-
Karin, M.1
Ben-Neriah, Y.2
-
50
-
-
0030685825
-
IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation
-
Mercurio F., Zhu H., Murray B.W., Shevchenko A., Bennett B.L., Li J., et al. IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 278 5339 (1997) 860-866
-
(1997)
Science
, vol.278
, Issue.5339
, pp. 860-866
-
-
Mercurio, F.1
Zhu, H.2
Murray, B.W.3
Shevchenko, A.4
Bennett, B.L.5
Li, J.6
-
51
-
-
0031586174
-
Identification and characterization of an IkappaB kinase
-
Regnier C.H., Song H.Y., Gao X., Goeddel D.V., Cao Z., and Rothe M. Identification and characterization of an IkappaB kinase. Cell 90 2 (1997) 373-383
-
(1997)
Cell
, vol.90
, Issue.2
, pp. 373-383
-
-
Regnier, C.H.1
Song, H.Y.2
Gao, X.3
Goeddel, D.V.4
Cao, Z.5
Rothe, M.6
-
52
-
-
0030611595
-
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
-
Woronicz J.D., Gao X., Cao Z., Rothe M., and Goeddel D.V. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 278 5339 (1997) 866-869
-
(1997)
Science
, vol.278
, Issue.5339
, pp. 866-869
-
-
Woronicz, J.D.1
Gao, X.2
Cao, Z.3
Rothe, M.4
Goeddel, D.V.5
-
53
-
-
0030613551
-
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
-
Zandi E., Rothwarf D.M., Delhase M., Hayakawa M., and Karin M. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91 2 (1997) 243-252
-
(1997)
Cell
, vol.91
, Issue.2
, pp. 243-252
-
-
Zandi, E.1
Rothwarf, D.M.2
Delhase, M.3
Hayakawa, M.4
Karin, M.5
-
54
-
-
0035817925
-
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
-
Fitzgerald K.A., Palsson-McDermott E.M., Bowie A.G., Jefferies C.A., Mansell A.S., Brady G., et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413 6851 (2001) 78-83
-
(2001)
Nature
, vol.413
, Issue.6851
, pp. 78-83
-
-
Fitzgerald, K.A.1
Palsson-McDermott, E.M.2
Bowie, A.G.3
Jefferies, C.A.4
Mansell, A.S.5
Brady, G.6
-
55
-
-
0037153130
-
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
-
Horng T., Barton G.M., Flavell R.A., and Medzhitov R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420 6913 (2002) 329-333
-
(2002)
Nature
, vol.420
, Issue.6913
, pp. 329-333
-
-
Horng, T.1
Barton, G.M.2
Flavell, R.A.3
Medzhitov, R.4
-
56
-
-
0033166472
-
Unresponsiveness of MyD88-deficient mice to endotoxin
-
Kawai T., Adachi O., Ogawa T., Takeda K., and Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11 1 (1999) 115-122
-
(1999)
Immunity
, vol.11
, Issue.1
, pp. 115-122
-
-
Kawai, T.1
Adachi, O.2
Ogawa, T.3
Takeda, K.4
Akira, S.5
-
57
-
-
0037153191
-
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
-
Yamamoto M., Sato S., Hemmi H., Sanjo H., Uematsu S., Kaisho T., et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420 6913 (2002) 324-329
-
(2002)
Nature
, vol.420
, Issue.6913
, pp. 324-329
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
Sanjo, H.4
Uematsu, S.5
Kaisho, T.6
-
58
-
-
0037114185
-
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling
-
Yamamoto M., Sato S., Mori K., Hoshino K., Takeuchi O., Takeda K., et al. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol 169 12 (2002) 6668-6672
-
(2002)
J Immunol
, vol.169
, Issue.12
, pp. 6668-6672
-
-
Yamamoto, M.1
Sato, S.2
Mori, K.3
Hoshino, K.4
Takeuchi, O.5
Takeda, K.6
-
59
-
-
0141959224
-
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF
-
Fitzgerald K.A., Rowe D.C., Barnes B.J., Caffrey D.R., Visintin A., Latz E., et al. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med 198 7 (2003) 1043-1055
-
(2003)
J Exp Med
, vol.198
, Issue.7
, pp. 1043-1055
-
-
Fitzgerald, K.A.1
Rowe, D.C.2
Barnes, B.J.3
Caffrey, D.R.4
Visintin, A.5
Latz, E.6
-
60
-
-
0037227992
-
Deletion of IFN-gamma reduces fumonisin-induced hepatotoxicity in mice via alterations in inflammatory cytokines and apoptotic factors
-
Sharma R.P., He Q., and Johnson V.J. Deletion of IFN-gamma reduces fumonisin-induced hepatotoxicity in mice via alterations in inflammatory cytokines and apoptotic factors. J Interferon Cytokine Res 23 1 (2003) 13-23
-
(2003)
J Interferon Cytokine Res
, vol.23
, Issue.1
, pp. 13-23
-
-
Sharma, R.P.1
He, Q.2
Johnson, V.J.3
-
61
-
-
0141923690
-
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling
-
Sato S., Sugiyama M., Yamamoto M., Watanabe Y., Kawai T., Takeda K., et al. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J Immunol 171 8 (2003) 4304-4310
-
(2003)
J Immunol
, vol.171
, Issue.8
, pp. 4304-4310
-
-
Sato, S.1
Sugiyama, M.2
Yamamoto, M.3
Watanabe, Y.4
Kawai, T.5
Takeda, K.6
-
62
-
-
0038714270
-
Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR
-
Jiang Z., Zamanian-Daryoush M., Nie H., Silva A.M., Williams B.R., and Li X. Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem 278 19 (2003) 16713-16719
-
(2003)
J Biol Chem
, vol.278
, Issue.19
, pp. 16713-16719
-
-
Jiang, Z.1
Zamanian-Daryoush, M.2
Nie, H.3
Silva, A.M.4
Williams, B.R.5
Li, X.6
-
63
-
-
1542723466
-
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta
-
Jiang Z., Mak T.W., Sen G., and Li X. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci USA 101 10 (2004) 3533-3538
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.10
, pp. 3533-3538
-
-
Jiang, Z.1
Mak, T.W.2
Sen, G.3
Li, X.4
-
64
-
-
2442642691
-
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation
-
Meylan E., Burns K., Hofmann K., Blancheteau V., Martinon F., Kelliher M., et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol 5 5 (2004) 503-507
-
(2004)
Nat Immunol
, vol.5
, Issue.5
, pp. 503-507
-
-
Meylan, E.1
Burns, K.2
Hofmann, K.3
Blancheteau, V.4
Martinon, F.5
Kelliher, M.6
-
65
-
-
0035889228
-
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
-
Kawai T., Takeuchi O., Fujita T., Inoue J., Muhlradt P.F., Sato S., et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 167 10 (2001) 5887-5894
-
(2001)
J Immunol
, vol.167
, Issue.10
, pp. 5887-5894
-
-
Kawai, T.1
Takeuchi, O.2
Fujita, T.3
Inoue, J.4
Muhlradt, P.F.5
Sato, S.6
-
66
-
-
4344613405
-
Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling
-
Gohda J., Matsumura T., and Inoue J. Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. J Immunol 173 5 (2004) 2913-2917
-
(2004)
J Immunol
, vol.173
, Issue.5
, pp. 2913-2917
-
-
Gohda, J.1
Matsumura, T.2
Inoue, J.3
-
67
-
-
0043176281
-
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
-
Yamamoto M., Sato S., Hemmi H., Hoshino K., Kaisho T., Sanjo H., et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301 5633 (2003) 640-643
-
(2003)
Science
, vol.301
, Issue.5633
, pp. 640-643
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
Hoshino, K.4
Kaisho, T.5
Sanjo, H.6
-
68
-
-
24944586285
-
Achieving stability of lipopolysaccharide-induced NF-kappaB activation
-
Covert M.W., Leung T.H., Gaston J.E., and Baltimore D. Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 309 5742 (1854-) 7
-
(1854)
Science
, vol.309
, Issue.5742
, pp. 7
-
-
Covert, M.W.1
Leung, T.H.2
Gaston, J.E.3
Baltimore, D.4
-
69
-
-
24944489952
-
Stimulus specificity of gene expression programs determined by temporal control of IKK activity
-
Werner S.L., Barken D., and Hoffmann A. Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science 309 5742 (2005) 1857-1861
-
(2005)
Science
, vol.309
, Issue.5742
, pp. 1857-1861
-
-
Werner, S.L.1
Barken, D.2
Hoffmann, A.3
-
70
-
-
0024269038
-
Augmented expression of a myeloid-specific protein tyrosine kinase gene (hck) after macrophage activation
-
Ziegler S.F., Wilson C.B., and Perlmutter R.M. Augmented expression of a myeloid-specific protein tyrosine kinase gene (hck) after macrophage activation. J Exp Med 168 5 (1988) 1801-1810
-
(1988)
J Exp Med
, vol.168
, Issue.5
, pp. 1801-1810
-
-
Ziegler, S.F.1
Wilson, C.B.2
Perlmutter, R.M.3
-
71
-
-
0026530288
-
Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages
-
Boulet I., Ralph S., Stanley E., Lock P., Dunn A.R., Green S.P., et al. Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages. Oncogene 7 4 (1992) 703-710
-
(1992)
Oncogene
, vol.7
, Issue.4
, pp. 703-710
-
-
Boulet, I.1
Ralph, S.2
Stanley, E.3
Lock, P.4
Dunn, A.R.5
Green, S.P.6
-
72
-
-
0027144465
-
Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes
-
Geng Y., Zhang B., and Lotz M. Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes. J Immunol 151 12 (1993) 6692-6700
-
(1993)
J Immunol
, vol.151
, Issue.12
, pp. 6692-6700
-
-
Geng, Y.1
Zhang, B.2
Lotz, M.3
-
73
-
-
0033228567
-
The src family-selective tyrosine kinase inhibitor PP1 blocks LPS and IFN-gamma-mediated TNF and iNOS production in murine macrophages
-
Orlicek S.L., Hanke J.H., and English B.K. The src family-selective tyrosine kinase inhibitor PP1 blocks LPS and IFN-gamma-mediated TNF and iNOS production in murine macrophages. Shock 12 5 (1999) 350-354
-
(1999)
Shock
, vol.12
, Issue.5
, pp. 350-354
-
-
Orlicek, S.L.1
Hanke, J.H.2
English, B.K.3
-
74
-
-
0030912071
-
Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn
-
Meng F., and Lowell C.A. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med 185 9 (1997) 1661-1670
-
(1997)
J Exp Med
, vol.185
, Issue.9
, pp. 1661-1670
-
-
Meng, F.1
Lowell, C.A.2
-
75
-
-
0037087438
-
Macrophage effector functions controlled by Bruton's tyrosine kinase are more crucial than the cytokine balance of T cell responses for microfilarial clearance
-
Mukhopadhyay S., Mohanty M., Mangla A., George A., Bal V., Rath S., et al. Macrophage effector functions controlled by Bruton's tyrosine kinase are more crucial than the cytokine balance of T cell responses for microfilarial clearance. J Immunol 168 6 (2002) 2914-2921
-
(2002)
J Immunol
, vol.168
, Issue.6
, pp. 2914-2921
-
-
Mukhopadhyay, S.1
Mohanty, M.2
Mangla, A.3
George, A.4
Bal, V.5
Rath, S.6
-
76
-
-
1842814062
-
Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling?
-
Jefferies C.A., and O'Neill L.A. Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling?. Immunol Lett 92 1-2 (2004) 15-22
-
(2004)
Immunol Lett
, vol.92
, Issue.1-2
, pp. 15-22
-
-
Jefferies, C.A.1
O'Neill, L.A.2
-
77
-
-
0037492123
-
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4
-
Jefferies C.A., Doyle S., Brunner C., Dunne A., Brint E., Wietek C., et al. Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4. J Biol Chem 278 28 (2003) 26258-26264
-
(2003)
J Biol Chem
, vol.278
, Issue.28
, pp. 26258-26264
-
-
Jefferies, C.A.1
Doyle, S.2
Brunner, C.3
Dunne, A.4
Brint, E.5
Wietek, C.6
-
78
-
-
21244503601
-
Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide
-
Doyle S.L., Jefferies C.A., and O'Neill L.A. Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide. J Biol Chem 280 25 (2005) 23496-23501
-
(2005)
J Biol Chem
, vol.280
, Issue.25
, pp. 23496-23501
-
-
Doyle, S.L.1
Jefferies, C.A.2
O'Neill, L.A.3
-
79
-
-
33744543517
-
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
-
Gray P., Dunne A., Brikos C., Jefferies C.A., Doyle S.L., and O'Neill L.A. MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J Biol Chem 281 15 (2006) 10489-10495
-
(2006)
J Biol Chem
, vol.281
, Issue.15
, pp. 10489-10495
-
-
Gray, P.1
Dunne, A.2
Brikos, C.3
Jefferies, C.A.4
Doyle, S.L.5
O'Neill, L.A.6
-
80
-
-
0028151080
-
NF-kappa B/Rel family members are physically associated phosphoproteins
-
Li C.C., Korner M., Ferris D.K., Chen E., Dai R.M., and Longo D.L. NF-kappa B/Rel family members are physically associated phosphoproteins. Biochem J 303 Pt 2 (1994) 499-506
-
(1994)
Biochem J
, vol.303
, Issue.PART 2
, pp. 499-506
-
-
Li, C.C.1
Korner, M.2
Ferris, D.K.3
Chen, E.4
Dai, R.M.5
Longo, D.L.6
-
81
-
-
0028170265
-
Activation of NF-kappa B in vivo is regulated by multiple phosphorylations
-
Naumann M., and Scheidereit C. Activation of NF-kappa B in vivo is regulated by multiple phosphorylations. EMBO J 13 19 (1994) 4597-4607
-
(1994)
EMBO J
, vol.13
, Issue.19
, pp. 4597-4607
-
-
Naumann, M.1
Scheidereit, C.2
-
82
-
-
0033199348
-
NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes
-
Heissmeyer V., Krappmann D., Wulczyn F.G., and Scheidereit C. NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes. EMBO J 18 17 (1999) 4766-4778
-
(1999)
EMBO J
, vol.18
, Issue.17
, pp. 4766-4778
-
-
Heissmeyer, V.1
Krappmann, D.2
Wulczyn, F.G.3
Scheidereit, C.4
-
83
-
-
0029058962
-
Transactivation domain 2 (TA2) of p65 NF-kappa B. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells
-
Schmitz M.L., dos Santos Silva M.A., and Baeuerle P.A. Transactivation domain 2 (TA2) of p65 NF-kappa B. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells. J Biol Chem 270 26 (1995) 15576-15584
-
(1995)
J Biol Chem
, vol.270
, Issue.26
, pp. 15576-15584
-
-
Schmitz, M.L.1
dos Santos Silva, M.A.2
Baeuerle, P.A.3
-
84
-
-
0031437893
-
Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit
-
Bird T.A., Schooley K., Dower S.K., Hagen H., and Virca G.D. Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit. J Biol Chem 272 51 (1997) 32606-32612
-
(1997)
J Biol Chem
, vol.272
, Issue.51
, pp. 32606-32612
-
-
Bird, T.A.1
Schooley, K.2
Dower, S.K.3
Hagen, H.4
Virca, G.D.5
-
85
-
-
0033531795
-
Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells
-
Anrather J., Csizmadia V., Soares M.P., and Winkler H. Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. J Biol Chem 274 19 (1999) 13594-13603
-
(1999)
J Biol Chem
, vol.274
, Issue.19
, pp. 13594-13603
-
-
Anrather, J.1
Csizmadia, V.2
Soares, M.P.3
Winkler, H.4
-
86
-
-
0032589462
-
IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain
-
Sakurai H., Chiba H., Miyoshi H., Sugita T., and Toriumi W. IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J Biol Chem 274 43 (1999) 30353-30356
-
(1999)
J Biol Chem
, vol.274
, Issue.43
, pp. 30353-30356
-
-
Sakurai, H.1
Chiba, H.2
Miyoshi, H.3
Sugita, T.4
Toriumi, W.5
-
87
-
-
0032491485
-
Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529
-
Wang D., and Baldwin Jr. A.S. Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529. J Biol Chem 273 45 (1998) 29411-29416
-
(1998)
J Biol Chem
, vol.273
, Issue.45
, pp. 29411-29416
-
-
Wang, D.1
Baldwin Jr., A.S.2
-
88
-
-
0034693133
-
Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II
-
Wang D., Westerheide S.D., Hanson J.L., and Baldwin Jr. A.S. Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II. J Biol Chem 275 42 (2000) 32592-32597
-
(2000)
J Biol Chem
, vol.275
, Issue.42
, pp. 32592-32597
-
-
Wang, D.1
Westerheide, S.D.2
Hanson, J.L.3
Baldwin Jr., A.S.4
-
89
-
-
0025943986
-
The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B
-
Schmitz M.L., and Baeuerle P.A. The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B. EMBO J 10 12 (1991) 3805-3817
-
(1991)
EMBO J
, vol.10
, Issue.12
, pp. 3805-3817
-
-
Schmitz, M.L.1
Baeuerle, P.A.2
-
90
-
-
0035282213
-
I kappa B-independent control of NF-kappa B activity by modulatory phosphorylations
-
Schmitz M.L., Bacher S., and Kracht M. I kappa B-independent control of NF-kappa B activity by modulatory phosphorylations. Trends Biochem Sci 26 3 (2001) 186-190
-
(2001)
Trends Biochem Sci
, vol.26
, Issue.3
, pp. 186-190
-
-
Schmitz, M.L.1
Bacher, S.2
Kracht, M.3
-
91
-
-
0032039076
-
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
-
Zhong H., Voll R.E., and Ghosh S. Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell 1 5 (1998) 661-671
-
(1998)
Mol Cell
, vol.1
, Issue.5
, pp. 661-671
-
-
Zhong, H.1
Voll, R.E.2
Ghosh, S.3
-
92
-
-
0030991201
-
The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism
-
Zhong H., SuYang H., Erdjument-Bromage H., Tempst P., and Ghosh S. The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell 89 3 (1997) 413-424
-
(1997)
Cell
, vol.89
, Issue.3
, pp. 413-424
-
-
Zhong, H.1
SuYang, H.2
Erdjument-Bromage, H.3
Tempst, P.4
Ghosh, S.5
-
93
-
-
0036203419
-
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
-
Zhong H., May M.J., Jimi E., and Ghosh S. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell 9 3 (2002) 625-636
-
(2002)
Mol Cell
, vol.9
, Issue.3
, pp. 625-636
-
-
Zhong, H.1
May, M.J.2
Jimi, E.3
Ghosh, S.4
-
94
-
-
0037851769
-
IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide
-
Yang F., Tang E., Guan K., and Wang C.Y. IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J Immunol 170 11 (2003) 5630-5635
-
(2003)
J Immunol
, vol.170
, Issue.11
, pp. 5630-5635
-
-
Yang, F.1
Tang, E.2
Guan, K.3
Wang, C.Y.4
-
95
-
-
11244285329
-
Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription
-
Buss H., Dorrie A., Schmitz M.L., Hoffmann E., Resch K., and Kracht M. Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. J Biol Chem 279 53 (2004) 55633-55643
-
(2004)
J Biol Chem
, vol.279
, Issue.53
, pp. 55633-55643
-
-
Buss, H.1
Dorrie, A.2
Schmitz, M.L.3
Hoffmann, E.4
Resch, K.5
Kracht, M.6
-
96
-
-
13944253118
-
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway
-
Leitges M., Sanz L., Martin P., Duran A., Braun U., Garcia J.F., et al. Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol Cell 8 4 (2001) 771-780
-
(2001)
Mol Cell
, vol.8
, Issue.4
, pp. 771-780
-
-
Leitges, M.1
Sanz, L.2
Martin, P.3
Duran, A.4
Braun, U.5
Garcia, J.F.6
-
97
-
-
0035896422
-
Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice
-
Yin L., Wu L., Wesche H., Arthur C.D., White J.M., Goeddel D.V., et al. Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science 291 5511 (2001) 2162-2165
-
(2001)
Science
, vol.291
, Issue.5511
, pp. 2162-2165
-
-
Yin, L.1
Wu, L.2
Wesche, H.3
Arthur, C.D.4
White, J.M.5
Goeddel, D.V.6
-
98
-
-
0038374178
-
IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli
-
Kravchenko V.V., Mathison J.C., Schwamborn K., Mercurio F., and Ulevitch R.J. IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli. J Biol Chem 278 29 (2003) 26612-26619
-
(2003)
J Biol Chem
, vol.278
, Issue.29
, pp. 26612-26619
-
-
Kravchenko, V.V.1
Mathison, J.C.2
Schwamborn, K.3
Mercurio, F.4
Ulevitch, R.J.5
-
99
-
-
0034643170
-
NAK is an IkappaB kinase-activating kinase
-
Tojima Y., Fujimoto A., Delhase M., Chen Y., Hatakeyama S., Nakayama K., et al. NAK is an IkappaB kinase-activating kinase. Nature 404 6779 (2000) 778-782
-
(2000)
Nature
, vol.404
, Issue.6779
, pp. 778-782
-
-
Tojima, Y.1
Fujimoto, A.2
Delhase, M.3
Chen, Y.4
Hatakeyama, S.5
Nakayama, K.6
-
100
-
-
0034665047
-
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription
-
Bonnard M., Mirtsos C., Suzuki S., Graham K., Huang J., Ng M., et al. Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J 19 18 (2000) 4976-4985
-
(2000)
EMBO J
, vol.19
, Issue.18
, pp. 4976-4985
-
-
Bonnard, M.1
Mirtsos, C.2
Suzuki, S.3
Graham, K.4
Huang, J.5
Ng, M.6
-
101
-
-
0034612636
-
Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
-
Hoeflich K.P., Luo J., Rubie E.A., Tsao M.S., Jin O., and Woodgett J.R. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406 6791 (2000) 86-90
-
(2000)
Nature
, vol.406
, Issue.6791
, pp. 86-90
-
-
Hoeflich, K.P.1
Luo, J.2
Rubie, E.A.3
Tsao, M.S.4
Jin, O.5
Woodgett, J.R.6
-
102
-
-
23944486750
-
Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
-
Martin M., Rehani K., Jope R.S., and Michalek S.M. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6 8 (2005) 777-784
-
(2005)
Nat Immunol
, vol.6
, Issue.8
, pp. 777-784
-
-
Martin, M.1
Rehani, K.2
Jope, R.S.3
Michalek, S.M.4
-
103
-
-
0035920176
-
A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei
-
Yamazaki S., Muta T., and Takeshige K. A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei. J Biol Chem 276 29 (2001) 27657-27662
-
(2001)
J Biol Chem
, vol.276
, Issue.29
, pp. 27657-27662
-
-
Yamazaki, S.1
Muta, T.2
Takeshige, K.3
-
104
-
-
12544255812
-
Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization
-
Yamazaki S., Muta T., Matsuo S., and Takeshige K. Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization. J Biol Chem 280 2 (2005) 1678-1687
-
(2005)
J Biol Chem
, vol.280
, Issue.2
, pp. 1678-1687
-
-
Yamazaki, S.1
Muta, T.2
Matsuo, S.3
Takeshige, K.4
-
105
-
-
14844293877
-
Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein
-
Motoyama M., Yamazaki S., Eto-Kimura A., Takeshige K., and Muta T. Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein. J Biol Chem 280 9 (2005) 7444-7451
-
(2005)
J Biol Chem
, vol.280
, Issue.9
, pp. 7444-7451
-
-
Motoyama, M.1
Yamazaki, S.2
Eto-Kimura, A.3
Takeshige, K.4
Muta, T.5
-
106
-
-
24144465889
-
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
-
Ogawa S., Lozach J., Benner C., Pascual G., Tangirala R.K., Westin S., et al. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell 122 5 (2005) 707-721
-
(2005)
Cell
, vol.122
, Issue.5
, pp. 707-721
-
-
Ogawa, S.1
Lozach, J.2
Benner, C.3
Pascual, G.4
Tangirala, R.K.5
Westin, S.6
-
107
-
-
0347065364
-
Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa
-
Wietek C., Miggin S.M., Jefferies C.A., and O'Neill L.A. Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa. J Biol Chem 278 51 (2003) 50923-50931
-
(2003)
J Biol Chem
, vol.278
, Issue.51
, pp. 50923-50931
-
-
Wietek, C.1
Miggin, S.M.2
Jefferies, C.A.3
O'Neill, L.A.4
-
108
-
-
4644252538
-
One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers
-
Leung T.H., Hoffmann A., and Baltimore D. One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell 118 4 (2004) 453-464
-
(2004)
Cell
, vol.118
, Issue.4
, pp. 453-464
-
-
Leung, T.H.1
Hoffmann, A.2
Baltimore, D.3
-
109
-
-
0142105387
-
Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities
-
Hoffmann A., Leung T.H., and Baltimore D. Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. EMBO J 22 20 (2003) 5530-5539
-
(2003)
EMBO J
, vol.22
, Issue.20
, pp. 5530-5539
-
-
Hoffmann, A.1
Leung, T.H.2
Baltimore, D.3
|