Selective regulation of cytokine induction by adenoviral gene transfer, of IκBα into human macrophages: Lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-κB independent

Journal of Immunology

Volumn 162, Issue 5, 1999, Pages 2939-2945

  Bondeson, Jan ^a   Browne, Kylie A ^a   Brennan, Fionula M ^a   Foxwell, Brian M J ^a   Feldmann, Marc ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA; ZYMOSAN;

ADENOVIRUS; ARTICLE; AUTOCRINE EFFECT; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE OVEREXPRESSION; GENE TARGETING; GENE TRANSFER; HUMAN; HUMAN CELL; MACROPHAGE; PARACRINE SIGNALING; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIOCYTE; ULTRAVIOLET IRRADIATION;

ADENOVIRIDAE; CYTOKINES; DNA-BINDING PROTEINS; GENE TRANSFER TECHNIQUES; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; MACROPHAGES; NF-KAPPA B; TETRADECANOYLPHORBOL ACETATE; ULTRAVIOLET RAYS; ZYMOSAN;

EID: 0033104615     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Feldmann, M., F. M. Brennan, and R. N. Maini. 1996. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14:397.
2. Feldmann, M., M. J. Elliott, J. N. Woody, and R. N. Maini. 1997. Anti-tumour necrosis factor α therapy of rheumatoid arthritis. Adv. Immunol. 64:283.
3. Elliott, M. J., R. N. Maini, M. Feldmann, A. Long-Fox, P. Charles, P. Katsikis, F. M. Brennan, J. Walker, H. Bijl, J. Ghrayeb, and J. Woody. 1993. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to TNFα. Arthritis Rheum. 36:1681.
4. Moreland, L. W., S. W. Baumgartner, M. H. Schiff, E. A. Tindall, R. M. Fleischmann, A. L. Weaver, R. E. Ettlinger, S. Cohen, W. J. Koopman, K. Mohler, M. B. Widmer, and C. M. Blosch. 1997. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N. Engl. J. Med. 337:141.
5. Elliott, M. J., R. N. Maini, M. Feldmann, J. R. Kalden, C. Antoni, J. S. Smolen, B. Leeb, F. C. Breedveld, J. D. Macfarlane, H. Bijl, and J. N. Woody. 1994. Randomised double blind comparison of a chimaeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis. Lancet 344:1105.
6. Van Dullemen, H. M., S. J. H. Van Deventer, D. W. Hommes, H. A. Bijl, J. Jansen, G. N. J. Tytgat, and J. Woody. 1995. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 109:129.
7. Foxwell, B. M. J., K. Browne, J. Bondeson, C. Clarke, R. de Martin, F. M. Brennan, and M. Feldmann. 1998. Efficient adenoviral infection with IκBα reveals that TNFα production in rheumatoid arthritis is NFκB dependent. Proc. Natl. Acad. Sci. USA 95:8211.
8. Wrighton, C. J., R. Hofer-Warbinek, T. Moll, R. Eytner, F. H. Bach, and R. de Martin. 1996. Inhibition of endothelial cell activation by adenovirus-mediated expression of IκBα, an inhibitor of the transcription factor NFκB. J. Exp. Med. 183:1013.
9. Han, J., and B. Beutler. 1990. The essential role of the UA-rich sequence in endotoxin-induced cachectin/TNF synthesis. Eur. Cytokine Network 1:71.
10. Shakov, A. N., M. A. Collart, and P. Vassalli. 1990. Kappa-B enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumour necrosis factor α gene in primary macrophages. J. Exp. Med. 171:35.
11. Cogswell, Y., M. M. Godlevski, G. B. Wisely, W. C. Clay, L. M. Leesnitzer, J. P. Ways, and J. G. Gray. 1994. NF-κB regulates IL-1β transcription through a consensus NF-κB binding site and a nonconsensus CRE-like site. J. Immunol. 153:712.
12. Hiscott, J., J. Marois, J. Garoufalis, M. D'Addario, A. Roulston, I. Kwan, N. Pepin, J. Lacoste, H. Nguyen, G. Bensi, and M. Fenton. 1993. Characterization of a functional NF-κB site in the human interleukin 1β promoter: evidence for a positive autoregulatory loop. Mol. Cell. Biol. 13:6231.
13. Libermann, T. A., and D. Baltimore. 1990. Activation of interleukin-6 gene expression through the NF-κB transcription factor. J. Clin. Invest. 97:1890.
14. Platzer, C., C. Meisel, K. Vogt, M. Platzer, and H. D. Volk. 1995. Up-regulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs. Int. Immunol. 7:517.
15. Bazzoni, F., A. Kruys, C. V. Shakhov, C. V. Jongeneel, and B. Beutler. 1994. Analysis of tumor necrosis factor promoter responses to ultraviolet light. J. Clin. Invest. 93:56.
16. Hohmann, H.-P., R. Remy, C. Scheidereit, and A. P. G. M. van Loon. 1991. Maintenance of NF-κB activity is dependent on protein synthesis and the continuous presence of external stimuli. Mol. Cell. Biol. 11:259.
17. Kaufman, P. A., J. B. Weinberg, and W. C. Greene. 1992. Nuclear expression of the 50- and 65-kD Rel-related subunits of nuclear factor-κB is differentially regulated in human monocytic cells. J. Clin. Invest. 90:121.
18. Tran-Thi, T. A., K. Decker, and P. A. Baeuerle. 1995. Differential activation of transcription factors NF-κB and AP-1 in rat liver macrophages. Hepatology 22: 613.
19. Makarov, S. S., W. N. Johnston, J. C. Olsen, J. M. Watson, K. Mondal, C. Rinehart, and J. S. Haskill. 1997. NF-κB as a target for anti-inflammatory gene therapy: suppression of inflammatory responses in monocytic and stromal cells by stable gene transfer of IκBa cDNA. Gene Ther. 4:846.
20. Tapper, H., and R. Sundler. 1995. Glucan receptor and zymosan-induced lysosomal enzyme secretion in macrophages. Biochem. J. 306:829.
21. Green, S. P., J. A. Hamilton, and W. A. Phillips. 1992. Zymosan-triggered tyrosine phosphorylation in mouse bone marrow-derived macrophages is enhanced by respiratory burst priming agents. Biochem. J. 288:427.
22. Sangeudolce, M. V., V. C. Capo, M. Bouhamdan, P. Bongrand, C. K. Huang, and J. L. Mege. 1993. Zymosan-induced tyrosine phosphorylation in human monocytes: role of protein kinase C. J. Immunol. 151:405.
23. Zaffran, Y., J. C. Escalier, S. Ruta, C. Capo, and J. L. Mege. 1995. Zymosan triggered association of tyrosine phosphoproteins and lyn kinase with cytoskeleton in human monocytes. J. Immunol. 154:3488.
24. Glaser, K. B., A. Sung, J. Bauer, and B. M. Weichman. 1993. Regulation of eicosanoid biosynthesis in the macrophage. Biochem. Pharmacol. 45:1567.
25. Pierce, R. A., S. Sandefur, G. A. R. Doyle, and H. G. Weygus. 1996. Monocytic cell type-specific transcriptional induction of collagenase. J. Clin. Invest. 97: 1890.
26. Graham, F. L., and L. Prevec. 1995. Methods for construction of adenovirus vectors. Mol. Biotechnol. 3:207.
27. 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery. J. Virol. 69:2257.
28. Buchan, G., K. Barrett, M. Turner, D. Chantry, R. N. Maini, and M. Feldmann. 1988. Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1α. Clin. Exp. Immunol. 73:449.
29. Engelberts, I., A. Moller, G. J. M. Schoen, C. J. van der Linden, and W. A. Buurman. 1991. Evaluation of human TNF in plasma by ELISA. Lymphokine Cytokine Res. 10:60.
30. Butler, D. M., R. N. Maini, M. Feldmann, and F. M. Brennan. 1995. Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures: comparison of monoclonal anti-TNFα antibody with the IL-1 receptor antagonist. Eur. Cytokine Network 6:225.
31. Abrams, J. S., M. G. Ronocarlo, H. Yssel, U. Andersson, G. I. Gleich, and J. E. Silver. 1993. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 125:5.
32. Foey, A. D., S. L. Parry, L. M. Williams, M. Feldmann, B. M. J. Foxwell, and F. M. Brennan. 1998. Regulation of monocyte IL-10 production by endogenous IL-1 and TNF: role of the p38 and p42/44 MAP kinases. J. Immunol. 160:920.
33. Williams, L., D. L. Gibbons, A. Gearing, M. Feldmann, and F. M. Brennan. 1996. The synthetic metalloproteinase inhibitor BB-2275 blocks both p55 and p75 receptor shedding, independent of its inhibitory effect on TNF processing. J. Clin. Invest. 97:2833.
34. Clarke, C. P. J., D. A. Taylor-Fishwick, A. Hales, Y. Chernajovsky, K. Sugamura, M. Feldmann, and B. M. J. Foxwell. 1995. Interleukin-4 inhibits κ light chain expression and NFκB degradation in 70Z/3 murine pre-B cells. Eur. J. Immunol. 25:2961.
35. Morrison, D. F. 1981. Multivariate Statistical Methods. McGraw-Hill, London, p. 32.
36. Bondeson, J., and R. Sundler. 1995. Auranofin inhibits the induction of interleukin 1β and tumor necrosis factor α in macrophages. Biochem. Pharmacol. 50: 1753.
37. -/- mice: an overview. J. Leukocyte Biol. 61:389.
38. Moore, K. W., A. O'Garra, R. de Waal Malefyt, P. Vieira, and T. R. Mosmann. 1993. Interleukin-10. Annu. Rev. Immunol. 11:165.
39. Wanidworanun, C., and W. Strober. 1993. Predominant role of tumour necrosis factor α in human monocyte IL-10 synthesis. J. Immunol. 151:6853.
40. Parry, S. L., M. Sebbag, F. M. Brennan, and M. Feldmann. 1997. Contact with T cells modulates monocyte IL-10 production by TNFα-dependent mechanisms. J. Immunol. 158:3673.
41. Traenckner, E. B., and P. A. Baeuerle. 1995. Appearance of apparently ubiquitin-conjugated I kappa B-alpha during its phosphorylation-induced degradation in intact cells. J. Cell Sci. Suppl. 19:79.
42. Haas, M., S. Page, M. Page, F. J. Neumann, N. Marx, M. Adam, H. W. Ziegler-Heitbrock, D. Neumeier, and K. Brand. 1998. Effect of proteasome inhibitors on monocytic Iκ-Bα and β depletion, NF-κB activation and cytokine production. J. Leukocyte Biol. 63:395.
43. Bassuk, A., and J. M. Leiden. 1997. The role of Ets transcription factors in the development and function of the mammalian immune system. Adv. Immunol. 64:65.
44. Katsikis, P., C. Q. Chu, F. M. Brennan, R. N. Maini, and M. Feldmann. 1994. Immunoregulatory role of interleukin 10 (IL-10) in rheumatoid arthritis. J. Exp. Med. 179:1517.
45. Brennan, F. M., D. Chantry, A. Jackson, R. Maini, and M. Feldmann. 1989. Inhibitory effect of TNF α antibodies on synovial cell interleukin-1 production in rheumatoid arthritis. Lancet 2:244.
46. Haworth, C., F. M. Brennan, D. Chantry, M. Turner, R. N. Maini, and M. Feldmann. 1991. Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor α. Eur. J. Immunol. 21:2575.
47. Goldfeld, A. E., J. L. Strominger, and C. Doyle. 1991. Human tumor necrosis factor α gene regulation in phorbol ester-stimulated T and B cell lines. J. Exp. Med. 174:73.
48. Tsai, E. Y., J. Jain, P. A. Pesavento, A. Rao, and A. E. Goldfeld. 1996. Tumor necrosis factor α gene regulation in activated T cells involves ATF-2/Jun and NFATp. Mol. Cell. Biol. 16:459.