IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages

Blood

Volumn 102, Issue 12, 2003, Pages 4123-4129

  Kuwata, Hirotaka ^b   Watanabe, Yasuyuki ^b   Miyoshi, Hiroyuki ^b   Yamamoto, Masahiro ^b   Kaisho, Tsuneyasu ^b   Takeda, Kiyoshi ^b   Akira, Shizuo ^a  

^a OSAKA UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PROTEIN BCL 3; SYNAPTOTAGMIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; DNA BINDING; GENE OVEREXPRESSION; LENTIVIRINAE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

EID: 0242433137     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-04-1228     Document Type: Article

References (45)

1. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683-765.
2. Kühn R, Lohler J, Rennick D, Rajewsky K, Müller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 1993;75:263-274.
3. + TH1-like responses. J Clin Invest. 1996;98:1010-1020.
4. Spencer SD, Di Marco F, Hooley J, et al. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J Exp Med. 1998;187:571-578.
5. Steidler L, Hans W, Schotte L, et al. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science. 2000;289:1352-1355.
6. Fedorak RN, Gangl A, Elson CO, et al. Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease: the Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group. Gastroenterology. 2000;119:1473-1482.
7. Schottelius AJ, Mayo MW, Sartor RB, Baldwin AS Jr. Interleukin-10 signaling blocks inhibitor of κB kinase activity and nuclear factor κB DNA binding. J Biol Chem. 1999;274:31868-31874.
8. Kontoyiannis D, Kotlyarov A, Carballo E, et al. Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology. EMBO J. 2001;20:3760-3770.
9. Donnelly RP, Freeman SL, Hayes MP. Inhibition of IL-10 expression by IFN-γ up-regulates transcription of TNF-α in human monocytes. J Immunol. 1995;155:1420-1427.
10. Bogdan C, Paik J, Vodovotz Y, Nathan C. Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10. J Biol Chem. 1992;267:23301-23308.
11. Rodig SJ, Meraz MA, White JM, et al. Disruption of the Jakl gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell. 1998;93:373-383.
12. Riley JK, Takeda K, Akira S, Schreiber RD. Interleukin-10 receptor signaling through the JAK-STAT pathway: requirement for two distinct receptor-derived signals for anti-inflammatory action. J Biol Chem. 1999;274:16513-16521.
13. Takeda K, Clausen B, Kaisho T, et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity. 1999;10:39-49.
14. Kobayashi M, Kweon M, Kuwata H, Kiyono H, Takeda K, Akira S. Toll-like receptor-dependent IL-12p40 production causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest. 2003;111:1297-1308.
15. Wang P, Wu P, Siegel MI, Egan RW, Billah MM. IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells. J Immunol. 1994;153:811-816.
16. Aste-Amezaga M, Ma X, Sartori A, Trinchieri G. Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. J Immunol. 1998;160:5936-5944.
17. Lee TS, Chau LY. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med. 2002;8:240-246.
18. Berlato C, Cassatella MA, Kinjyo I, Gatto L, Yoshimura A, Bazzoni F. Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation. J Immunol. 2002;168:6404-6411.
19. Lang R, Patel D, Morris JJ, Rutschman RL, Murray P. Shaping gene expression in activated and resting primary macrophages by IL-10. J Immunol. 2002;169:2253-2263.
20. INK4D by IL-10 contributes to inhibition of macrophage proliferation. J Immunol. 2000;164:4607-4615.
21. Naldini L, Blomer U, Gallay P, et al. In vivo gene delivery and stable transduction of non-dividing cells by a lentiviral vector. Science. 1996;272:263-267.
22. Miyoshi H, Blomer U, Takahashi M, Gage FH, Verma IM. Development of a self-inactivating lentivirus vector. J Virol. 1998;72:8150-8157.
23. + cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Science. 1999;283:682-686.
24. Simeonidis S, Liang S, Chen G, Thanos D. Cloning and functional characterization of mouse IκBε. Proc Natl Acad Sci U S A. 1997;94:14372-14377.
25. Nolan GP, Fujita T, Bhatia K, et al. The bcl-3 proto-oncogene encodes a nuclear IκB-like molecule that preferentially interacts with NF-κB p50 and p52 in a phosphorylation-dependent manner. Mol Cell Biol. 1993;13:3557-3566.
26. Franzoso G, Bours V, Azarenko V, et al. The oncoprotein Bcl-3 can facilitate NF-κB-mediated transactivation by removing inhibiting p50 homodimers from select κB sites. EMBO J. 1993;12:3893-3901.
27. Zhang Q, DiDonato JA, Karin M, McKeithan TW, BCL3 encodes a nuclear protein which can alter the subcellular location of NF-κB proteins. Mol Cell Biol. 1994;14:3915-3926.
28. Wulczyn FG, Naumann M, Scheidereit C. Candidate proto-oncogene bcl-3 encodes a subunitspecific inhibitor of transcription factor NF-κB. Nature, 1992;358:597-599.
29. Franzoso G, Bours V, Park S, Tomita-Yamaguchi M, Kelly K, Siebenlist U. The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-κB-mediated inhibition. Nature. 1992;359:339-342.
30. Cassatella MA, Gasperini S, Bovolenta C, et al. Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation. Blood. 1999;94:2880-2889.
31. Yasukawa H, Sasaki A, Yoshimura A. Negative regulation of cytokine signaling pathways. Annu Rev Immunol. 2000;18:143-164.
32. Kinjyo I, Hanada T, Inagaki-Ohara K, et al. SOCS 1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity. 2002;17:583-591.
33. Nakagawa R, Naka T, Tsutsui H, et al. SOCS-1 participates in negative regulation of LPS responses. Immunity. 2002;17:677-687.
34. Bours V, Franzoso G, Azarenko V, et al. The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers. Cell. 1993;72:729-739.
35. Kerr LD, Duckett CS, Wamsley P, et al. The protooncogene bcl-3 encodes an IκB protein. Genes Dev. 1992;6:2352-2363.
36. Hatada EN, Nieters A, Wulczyn FG, et al. The ankyrin repeat domains of the NF-κB precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-κB DNA binding. Proc Natl Acad Sci U S A. 1992;89:2489-2493.
37. Brasier AR, Lu M, Hai T, Lu Y, Boldogh I. NF-κB-inducible BCL-3 expression is an autoregulatory loop controlling nuclear p50/NF-κB1 residence. J Biol Chem. 2001;276:32080-32093.
38. Franzoso G, Carlson L, Scharton-Kersten T, et al. Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions. Immunity. 1997;6:479-490.
39. Schwarz EM, Krimpenfort P, Berns A, Verma IM. Immunological defects in mice with a targeted disruption in Bcl-3. Genes Dev. 1997;11:187-197.
40. Fujita T, Nolan GP, Liou HC, Scott ML, Baltimore D. The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-κB p50 homodimers. Genes Dev. 1993;7:1354-1363.
41. Sanjabi S, Hoffmann A, Liou HC, Baltimore D, Smale ST. Selective requirement for c-Rel during IL-12 p40 gene induction in macrophages. Proc Natl Acad Sci U S A. 2000;97:12705-12710.
42. Sha WC, Liou HC, Tuomanen EI, Baltimore D. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell. 1995;80:321-330.
43. Haruta H, Kato A, Todokoro K. Isolation of a novel interleukin-1 nuclear protein bearing ankyrin-repeat motifs. J Biol Chem. 2001;276:12485-12488.
44. Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M. MAIL, a novel nuclear IκB protein that potentiates LPS-induced IL-6 production. FEBS Lett. 2001;485:53-56.
45. Yamazaki S, Muta T, Takeshige K. A novel IκB protein, IκB-ζ, induced by proinflammatory stimuli, negatively regulates nuclear factor-κB in the nuclei. J Biol Chem. 2001;276:27657-27662.