Inhibition of IKK-2 by 2-[(aminocarbonyl)amino]-5-acetylenyl-3- thiophenecarboxamides

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 11, 2005, Pages 2870-2875

  Bonafoux, Dominique ^a   Bonar, Sheri ^a   Christine, Lori ^a   Clare, Michael ^a   Donnelly, Ann ^a   Guzova, Julia ^a   Kishore, Nandini ^a   Lennon, Patrick ^a   Libby, Adam ^a   Mathialagan, Sumathy ^a   McGhee, William ^a   Rouw, Sharon ^a   Sommers, Cindy ^a   Tollefson, Michael ^a   Tripp, Catherine ^a,b   Weier, Richard ^a   Wolfson, Serge ^a   Min, Yao ^a  

^a PFIZER INC   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

2 (Aminocarbonyl)amino 5 acetylenyl 3 thiophenecarboxamides; IKK 2 inhibition; NF B regulation

Indexed keywords

I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; THIOPHENE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

CELLS, CULTURED; FIBROBLASTS; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-8; PROTEIN-SERINE-THREONINE KINASES; THIOPHENES;

EID: 21144447164     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.090     Document Type: Article

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