Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: Involvement of phosphatidylinositol 3-kinase and nuclear factor κB pathways in tumor necrosis factor α production in rheumatoid arthritis

Arthritis and Rheumatism

Volumn 46, Issue 1, 2002, Pages 31-41

  Brennan, Fionula M ^a,c   Hayes, Amanda L ^a   Ciesielski, Cathleen J ^b   Green, Patricia ^b   Foxwell, Brian M J ^b   Feldmann, Marc ^b  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; WORTMANNIN;

ARTICLE; CELL INFILTRATION; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIUM; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOVIRIDAE; ANDROSTADIENES; ANTIGENS, CD3; ARTHRITIS, RHEUMATOID; CELL COMMUNICATION; CHROMONES; COCULTURE TECHNIQUES; DNA-BINDING PROTEINS; ENZYME INHIBITORS; GENE EXPRESSION; GENETIC VECTORS; HUMANS; I-KAPPA B PROTEINS; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MACROPHAGES; MONOCYTES; MORPHOLINES; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036164274     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200201)46:1<31::AID-ART10029>3.0.CO;2-5     Document Type: Article

References (35)

1. Antigen-independent activation of naive and memory resting T cells by a cytokine combination
2. Cytokine stimulation of T lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor α but not interleukin-10: Possible relevance to pathophysiology of rheumatoid arthritis
3. Contact with T cells modulates monocyte IL-10 production: Role of T cell membrane TNFα
4. IL-15: A pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels
5. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis
6. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor α production in rheumatoid arthritis
7. Rheumatoid arthritis: A disease of T-lymphocyte/macrophage immunoregulation
8. The VLA-4/VCAM-1 pathway is involved in lymphocyte adhesion to endothelium in rheumatoid synovium
9. Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis
10. Alpha 4/beta 1 integrin (VLA-4) ligands in arthritis: Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes
11. Heterogeneity of T cell receptor idiotypes in rheumatoid arthritis
12. Restricted expression of T cell receptor V beta but not V alpha genes in rheumatoid arthritis
13. T cell receptor Vβ gene bias in rheumatoid arthritis
14. Targeting the T cell receptor in rheumatoid arthritis
15. Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis
16. How important are T cells in chronic rheumatoid synovitis?
17. Rheumatoid arthritis
18. Role of cytokines in rheumatoid arthritis
19. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α
20. Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis
21. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
22. Infiliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomised phase III trial
23. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
24. Cytokine production in culture by cells isolated from the synovial membrane
25. Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor α production in rheumatoid arthritis is NF-κB dependent
26. Identification of 6 novel factors that bind to the PRD I region of the human beta-interferon promoter
27. Cell surface glycoproteins expressed on activated human T cells induce production of interleukin-1β by monocytic cells: A possible role of CD69
28. Inhibitory effect of TNFα antibodies on synovial cell interleukin-1 production in rheumatoid arthritis
29. CD45-induced tumor necrosis factor α production in monocytes is phosphatidylinositol 3-kinase-dependent and nuclear factor-κB independent
30. Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP
31. Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells: Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase
32. The shared epitope hypothesis: An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
33. Selective regulation of cytokine induction by adenoviral gene transfer of IκBα into human macrophages: Lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-κB independent
34. Interleukin 15: A proinflammatory role in rheumatoid arthritis synovitis
35. Inhibition of T cell apoptosis in the rheumatoid synovium