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Volumn 56, Issue 3, 2004, Pages 351-369

Opioids as modulators of cell death and survival - Unraveling mechanisms and revealing new indications

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; CALMODULIN; CHEMOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; NALOXONE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OPIATE; OPIATE RECEPTOR; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE;

EID: 4143066901     PISSN: 00316997     EISSN: None     Source Type: Journal    
DOI: 10.1124/pr.56.3.2     Document Type: Review
Times cited : (190)

References (261)
  • 2
    • 0037424828 scopus 로고    scopus 로고
    • The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha
    • Adayev T, Ray I, Sondhi R, Sobocki T, and Banerjee P (2003) The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha. Biochim Biophys Acta 7:85-96.
    • (2003) Biochim Biophys Acta , vol.7 , pp. 85-96
    • Adayev, T.1    Ray, I.2    Sondhi, R.3    Sobocki, T.4    Banerjee, P.5
  • 3
    • 0034659718 scopus 로고    scopus 로고
    • Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C
    • Aley KO, Messing RO, Mochly-Rosen D, and Levine JD (2000) Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C. J Neurosci 20:4680-4685.
    • (2000) J Neurosci , vol.20 , pp. 4680-4685
    • Aley, K.O.1    Messing, R.O.2    Mochly-Rosen, D.3    Levine, J.D.4
  • 4
    • 0030019450 scopus 로고    scopus 로고
    • Inhibition of primary murine macrophage cytokine production in vitro following treatment with the kappa-opioid agonist U50,488H
    • Alicea C, Belkowski S, Eisenstein TK, Adler MW, and Rogers TJ (1996) Inhibition of primary murine macrophage cytokine production in vitro following treatment with the kappa-opioid agonist U50,488H. J Neuroimmunol 64:83-90.
    • (1996) J Neuroimmunol , vol.64 , pp. 83-90
    • Alicea, C.1    Belkowski, S.2    Eisenstein, T.K.3    Adler, M.W.4    Rogers, T.J.5
  • 6
    • 0036041621 scopus 로고    scopus 로고
    • Endomorphins 1 and 2 inhibit IL-10 and IL-12 production and innate immune functions and potentiate NF-kappaB DNA binding in THP-1 differentiated to macrophage-like cells
    • Azuma Y and Ohura K (2002) Endomorphins 1 and 2 inhibit IL-10 and IL-12 production and innate immune functions and potentiate NF-kappaB DNA binding in THP-1 differentiated to macrophage-like cells. Scand J Immunol 56:260-269.
    • (2002) Scand J Immunol , vol.56 , pp. 260-269
    • Azuma, Y.1    Ohura, K.2
  • 7
    • 0036962461 scopus 로고    scopus 로고
    • Expression of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1 in human brain tumors and their involvement in glial proliferation in vitro
    • Barbero S, Bajetto A, Bonavia R, Porcile C, Piccioli P, Pirani P, Ravetti JL, Zona G, Spaziante R, Florio T, et al. (2002) Expression of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1 in human brain tumors and their involvement in glial proliferation in vitro. Ann N Y Acad Sci 973:60-69.
    • (2002) Ann N Y Acad Sci , vol.973 , pp. 60-69
    • Barbero, S.1    Bajetto, A.2    Bonavia, R.3    Porcile, C.4    Piccioli, P.5    Pirani, P.6    Ravetti, J.L.7    Zona, G.8    Spaziante, R.9    Florio, T.10
  • 8
    • 0037447318 scopus 로고    scopus 로고
    • Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt
    • Barbero S, Bonavia R, Bajetto A, Porcile C, Pirani P, Ravetti JL, Zona GL, Spaziante R, Florio T, and Schettini G (2003) Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt. Cancer Res 63:1969-1974.
    • (2003) Cancer Res , vol.63 , pp. 1969-1974
    • Barbero, S.1    Bonavia, R.2    Bajetto, A.3    Porcile, C.4    Pirani, P.5    Ravetti, J.L.6    Zona, G.L.7    Spaziante, R.8    Florio, T.9    Schettini, G.10
  • 9
    • 1642579498 scopus 로고    scopus 로고
    • Systemic morphine administration suppresses genes involved in antigen presentation
    • Beagles K, Wellstein A, and Bayer B (2004) Systemic morphine administration suppresses genes involved in antigen presentation. Mol Pharmacol 65:437-442.
    • (2004) Mol Pharmacol , vol.65 , pp. 437-442
    • Beagles, K.1    Wellstein, A.2    Bayer, B.3
  • 10
    • 0036895875 scopus 로고    scopus 로고
    • The fibroblast growth factor receptor is at the site of convergence between mu-opioid receptor and growth factor signaling pathways in rat C6 glioma cells
    • Belcheva MM, Haas PD, Tan Y, Heaton VM, and Coscia CJ (2002) The fibroblast growth factor receptor is at the site of convergence between mu-opioid receptor and growth factor signaling pathways in rat C6 glioma cells. J Pharmacol Exp Ther 303:909-918.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 909-918
    • Belcheva, M.M.1    Haas, P.D.2    Tan, Y.3    Heaton, V.M.4    Coscia, C.J.5
  • 11
    • 0035823506 scopus 로고    scopus 로고
    • mu-Opioid receptor-mediated ERK activation involves calmodulin-dependent epidermal growth factor receptor transactivation
    • Belcheva MM, Szucs M, Wang D, Sadee W, and Coscia CJ (2001) mu-Opioid receptor-mediated ERK activation involves calmodulin-dependent epidermal growth factor receptor transactivation. J Biol Chem 276:33847-33853.
    • (2001) J Biol Chem , vol.276 , pp. 33847-33853
    • Belcheva, M.M.1    Szucs, M.2    Wang, D.3    Sadee, W.4    Coscia, C.J.5
  • 13
    • 0029053172 scopus 로고
    • Inhibition of interleukin-1 and tumor necrosis factor-alpha synthesis following treatment of macrophages with the kappa opioid agonist U50,488H
    • Belkowski SM, Alicea C, Eisenstein TK, Adler MW, and Rogers TJ (1995) Inhibition of interleukin-1 and tumor necrosis factor-alpha synthesis following treatment of macrophages with the kappa opioid agonist U50,488H. J Pharmacol Exp Ther 273:1491-1496.
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 1491-1496
    • Belkowski, S.M.1    Alicea, C.2    Eisenstein, T.K.3    Adler, M.W.4    Rogers, T.J.5
  • 14
    • 0029954749 scopus 로고    scopus 로고
    • Regulation of ERK (extracellular signal regulated kinase), part of the neurotrophin signal transduction cascade, in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine
    • Berhow MT, Hiroi N, and Nestler EJ (1996) Regulation of ERK (extracellular signal regulated kinase), part of the neurotrophin signal transduction cascade, in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine. J Neurosci 16:4707-4715.
    • (1996) J Neurosci , vol.16 , pp. 4707-4715
    • Berhow, M.T.1    Hiroi, N.2    Nestler, E.J.3
  • 15
    • 1342304124 scopus 로고    scopus 로고
    • Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: Implications for epithelial secretory responses
    • Bertelsen LS, Barrett KE, and Keely SJ (2004) Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses. J Biol Chem 279:6271-6279.
    • (2004) J Biol Chem , vol.279 , pp. 6271-6279
    • Bertelsen, L.S.1    Barrett, K.E.2    Keely, S.J.3
  • 17
    • 0037242116 scopus 로고    scopus 로고
    • Different expression of mu-opiate receptor in chronic and acute wounds and the effect of beta-endorphin on transforming growth factor beta type II receptor and cytokeratin 16 expression
    • Bigliardi PL, Sumanovski LT, Buchner S, Rufli T, and Bigliardi-Qi M (2003) Different expression of mu-opiate receptor in chronic and acute wounds and the effect of beta-endorphin on transforming growth factor beta type II receptor and cytokeratin 16 expression. J Investig Dermatol 120:145-152.
    • (2003) J Investig Dermatol , vol.120 , pp. 145-152
    • Bigliardi, P.L.1    Sumanovski, L.T.2    Buchner, S.3    Rufli, T.4    Bigliardi-Qi, M.5
  • 18
    • 0034044916 scopus 로고    scopus 로고
    • beta-endorphin stimulates cytokeratin 16 expression and downregulates mu-opiate receptor expression in human epidermis
    • Bigliardi-Qi M, Bigliardi PL, Eberle AN, Buchner S, and Rufli T (2000) beta-endorphin stimulates cytokeratin 16 expression and downregulates mu-opiate receptor expression in human epidermis. J Investig Dermatol 114:527-532.
    • (2000) J Investig Dermatol , vol.114 , pp. 527-532
    • Bigliardi-Qi, M.1    Bigliardi, P.L.2    Eberle, A.N.3    Buchner, S.4    Rufli, T.5
  • 19
    • 0032580184 scopus 로고    scopus 로고
    • Morphine's immunoregulatory actions are not shared by fentanyl
    • Bilfinger TV, Fimiani C, and Stefano GB (1998) Morphine's immunoregulatory actions are not shared by fentanyl. Int J Cardiol 64 (Suppl 1):S61-S66.
    • (1998) Int J Cardiol , vol.64 , Issue.SUPPL. 1
    • Bilfinger, T.V.1    Fimiani, C.2    Stefano, G.B.3
  • 20
    • 0036895747 scopus 로고    scopus 로고
    • Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice
    • Bohn LM, Lefkowitz EJ, and Caron MG (2002) Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. J Neurosci 22:10494-10500.
    • (2002) J Neurosci , vol.22 , pp. 10494-10500
    • Bohn, L.M.1    Lefkowitz, E.J.2    Caron, M.G.3
  • 22
    • 0035192385 scopus 로고    scopus 로고
    • Chronic morphine induces up-regulation of the pro-apoptotic Fas receptor and down-regulation of the anti-apoptotic Bcl-2 oncoprotein in rat brain
    • Boronat MA, Garcia-Fuster MJ, and Garcia-Sevilla JA (2001) Chronic morphine induces up-regulation of the pro-apoptotic Fas receptor and down-regulation of the anti-apoptotic Bcl-2 oncoprotein in rat brain. Br J Pharmacol 134:1263-1270.
    • (2001) Br J Pharmacol , vol.134 , pp. 1263-1270
    • Boronat, M.A.1    Garcia-Fuster, M.J.2    Garcia-Sevilla, J.A.3
  • 23
    • 0035889932 scopus 로고    scopus 로고
    • Chronic ethanol inhibits NK cell cytolytic activity: Role of opioid peptide beta-endorphin
    • Boyadjieva N, Dokur M, Advis JP, Meadows GG, and Sarkar DK (2001) Chronic ethanol inhibits NK cell cytolytic activity: role of opioid peptide beta-endorphin. J Immunol 167:5645-5652.
    • (2001) J Immunol , vol.167 , pp. 5645-5652
    • Boyadjieva, N.1    Dokur, M.2    Advis, J.P.3    Meadows, G.G.4    Sarkar, D.K.5
  • 24
    • 0347993738 scopus 로고    scopus 로고
    • Mobilization of opioid-containing polymorphonuclear cells by hematopoietic growth factors and influence on inflammatory pain
    • Brack A, Rittner HL, Machelska H, Beschmann K, Sitte N, Schafer M, and Stein C (2004) Mobilization of opioid-containing polymorphonuclear cells by hematopoietic growth factors and influence on inflammatory pain. Anesthesiology 100:149-157.
    • (2004) Anesthesiology , vol.100 , pp. 149-157
    • Brack, A.1    Rittner, H.L.2    Machelska, H.3    Beschmann, K.4    Sitte, N.5    Schafer, M.6    Stein, C.7
  • 26
    • 0041816104 scopus 로고    scopus 로고
    • Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor
    • Buchanan FG, Wang D, Bargiacchi F, and DuBois RN (2003) Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor. J Biol Chem 278:35451-35457.
    • (2003) J Biol Chem , vol.278 , pp. 35451-35457
    • Buchanan, F.G.1    Wang, D.2    Bargiacchi, F.3    DuBois, R.N.4
  • 27
    • 0345687920 scopus 로고    scopus 로고
    • Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation and adhesion to stromal cells
    • Burger M, Glodek A, Hartmann T, Schmitt-Graff A, Silberstein LE, Fujii N, Kipps TJ, and Burger JA (2003) Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation and adhesion to stromal cells. Oncogene 22:8093-8101.
    • (2003) Oncogene , vol.22 , pp. 8093-8101
    • Burger, M.1    Glodek, A.2    Hartmann, T.3    Schmitt-Graff, A.4    Silberstein, L.E.5    Fujii, N.6    Kipps, T.J.7    Burger, J.A.8
  • 28
  • 29
    • 0034893236 scopus 로고    scopus 로고
    • Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain
    • Cabot PJ, Carter L, Schafer M, and Stein C (2001) Methionine-enkephalin- and Dynorphin A-release from immune cells and control of inflammatory pain. Pain 93:207-212.
    • (2001) Pain , vol.93 , pp. 207-212
    • Cabot, P.J.1    Carter, L.2    Schafer, M.3    Stein, C.4
  • 30
    • 0042860142 scopus 로고    scopus 로고
    • Activation of delta- and kappa-opioid receptors by opioid peptides protects cardiomyocytes via KATP channels
    • Cao Z, Liu L, and Van Winkle DM (2003) Activation of delta- and kappa-opioid receptors by opioid peptides protects cardiomyocytes via KATP channels. Am J Physiol Heart Circ Physiol 285:H1032-H1039.
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Cao, Z.1    Liu, L.2    Van Winkle, D.M.3
  • 33
    • 0029063055 scopus 로고
    • Endogenous opioid peptides suppress cytokine-mediated up-regulation of HIV-1 expression in the chronically infected promonocyte clone U1
    • Chao CC, Gekker G, Sheng WS, Hu S, Portoghese PS, and Peterson PK (1995) Endogenous opioid peptides suppress cytokine-mediated up-regulation of HIV-1 expression in the chronically infected promonocyte clone U1. Adv Exp Med Biol 373:65-72.
    • (1995) Adv Exp Med Biol , vol.373 , pp. 65-72
    • Chao, C.C.1    Gekker, G.2    Sheng, W.S.3    Hu, S.4    Portoghese, P.S.5    Peterson, P.K.6
  • 34
    • 0033990594 scopus 로고    scopus 로고
    • U50,488 protection against HIV-1-related neurotoxicity: Involvement of quinolinic acid suppression
    • Chao CC, Hu S, Gekker G, Lokensgard JR, Heyes MP, and Peterson PK (2000) U50,488 protection against HIV-1-related neurotoxicity: involvement of quinolinic acid suppression. Neuropharmacology 39:150-160.
    • (2000) Neuropharmacology , vol.39 , pp. 150-160
    • Chao, C.C.1    Hu, S.2    Gekker, G.3    Lokensgard, J.R.4    Heyes, M.P.5    Peterson, P.K.6
  • 35
    • 0026643507 scopus 로고
    • Morphine potentiates transforming growth factor-beta release from human peripheral blood mononuclear cell cultures
    • Chao CC, Hu S, Molitor TW, Zhou Y, Murtaugh MP, Tsang M, and Peterson PK (1992) Morphine potentiates transforming growth factor-beta release from human peripheral blood mononuclear cell cultures. J Pharmacol Exp Ther 262:19-24.
    • (1992) J Pharmacol Exp Ther , vol.262 , pp. 19-24
    • Chao, C.C.1    Hu, S.2    Molitor, T.W.3    Zhou, Y.4    Murtaugh, M.P.5    Tsang, M.6    Peterson, P.K.7
  • 36
    • 0020029345 scopus 로고
    • Dynorphin is a specific endogenous ligand of the kappa opioid receptor
    • Chavkin C, James IF, and Goldstein A (1982) Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science (Wash DC) 215:413-415.
    • (1982) Science (Wash DC) , vol.215 , pp. 413-415
    • Chavkin, C.1    James, I.F.2    Goldstein, A.3
  • 37
    • 0346056873 scopus 로고    scopus 로고
    • Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor
    • Chen C, Li J, Bot G, Szabo I, Rogers TJ, and Liu-Chen LY (2004) Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor. Eur J Pharmacol 483:175-186.
    • (2004) Eur J Pharmacol , vol.483 , pp. 175-186
    • Chen, C.1    Li, J.2    Bot, G.3    Szabo, I.4    Rogers, T.J.5    Liu-Chen, L.Y.6
  • 38
    • 0142188718 scopus 로고    scopus 로고
    • Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells
    • Cheng K, Zimniak P, and Raufman JP (2003) Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells. Cancer Res 63:6744-6750.
    • (2003) Cancer Res , vol.63 , pp. 6744-6750
    • Cheng, K.1    Zimniak, P.2    Raufman, J.P.3
  • 40
    • 0030859482 scopus 로고    scopus 로고
    • Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist
    • Chu P, Murray S, Lissin D, and von Zastrow M (1997) Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist. J Biol Chem 272:27124-27130.
    • (1997) J Biol Chem , vol.272 , pp. 27124-27130
    • Chu, P.1    Murray, S.2    Lissin, D.3    Von Zastrow, M.4
  • 41
    • 0030870905 scopus 로고    scopus 로고
    • Induction and activation of mitogen-activated protein kinases of human lymphocytes as one of the signaling pathways of the immunomodulatory effects of morphine sulfate
    • Chuang LF, Killam KF Jr, and Chuang RY (1997) Induction and activation of mitogen-activated protein kinases of human lymphocytes as one of the signaling pathways of the immunomodulatory effects of morphine sulfate. J Biol Chem 272:26815-26817.
    • (1997) J Biol Chem , vol.272 , pp. 26815-26817
    • Chuang, L.F.1    Killam Jr., K.F.2    Chuang, R.Y.3
  • 42
    • 0030296744 scopus 로고    scopus 로고
    • G protein-coupled receptors: Heterologous regulation of homologous desensitization and its implications
    • Chuang TT, Iacovelli L, Sallese M, and De Blasi A (1996) G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications. Trends Pharmacol Sci 17:416-421.
    • (1996) Trends Pharmacol Sci , vol.17 , pp. 416-421
    • Chuang, T.T.1    Iacovelli, L.2    Sallese, M.3    De Blasi, A.4
  • 43
    • 0028804902 scopus 로고
    • Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment
    • Crain SM and Shen KF (1995) Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment. Proc Natl Acad Sci USA 92:10540-10544.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10540-10544
    • Crain, S.M.1    Shen, K.F.2
  • 44
    • 0037501368 scopus 로고    scopus 로고
    • Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma
    • Czupalla C, Culo M, Muller EC, Brock C, Reusch HP, Spicher K, Krause E, and Nurnberg B (2003) Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma. J Biol Chem 278: 11536-11545.
    • (2003) J Biol Chem , vol.278 , pp. 11536-11545
    • Czupalla, C.1    Culo, M.2    Muller, E.C.3    Brock, C.4    Reusch, H.P.5    Spicher, K.6    Krause, E.7    Nurnberg, B.8
  • 45
    • 0034689003 scopus 로고    scopus 로고
    • beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2
    • DeFea KA, Zalevsky J, Thoma MS, Dery O, Mullins RD, and Bunnett NW (2000) beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol 148:1267-1281.
    • (2000) J Cell Biol , vol.148 , pp. 1267-1281
    • DeFea, K.A.1    Zalevsky, J.2    Thoma, M.S.3    Dery, O.4    Mullins, R.D.5    Bunnett, N.W.6
  • 46
    • 0036308503 scopus 로고    scopus 로고
    • Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemotherapy-induced apoptosis
    • Deng W, Balazs L, Wang DA, Van Middlesworth L, Tigyi G, and Johnson LR (2002) Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemotherapy-induced apoptosis. Gastroenterology 123:206-216.
    • (2002) Gastroenterology , vol.123 , pp. 206-216
    • Deng, W.1    Balazs, L.2    Wang, D.A.3    Van Middlesworth, L.4    Tigyi, G.5    Johnson, L.R.6
  • 48
    • 0033518005 scopus 로고    scopus 로고
    • Oncogenic mutant of Galpha12 stimulates cell proliferation through cycloxygenase-2 signaling pathway
    • Dermott JM, Reddy MR, Onesime D, Reddy EP, and Dhanasekaran N (1999) Oncogenic mutant of Galpha12 stimulates cell proliferation through cycloxygenase-2 signaling pathway. Oncogene 18:7185-7189.
    • (1999) Oncogene , vol.18 , pp. 7185-7189
    • Dermott, J.M.1    Reddy, M.R.2    Onesime, D.3    Reddy, E.P.4    Dhanasekaran, N.5
  • 49
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, and Zeiher AM (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature (Lond) 399:601-605.
    • (1999) Nature (Lond) , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 51
    • 0032573386 scopus 로고    scopus 로고
    • Expression of an oncogenic mutant G alpha i2 activates Ras in Rat-1 fibroblast cells
    • Edamatsu H, Kaziro Y, and Itoh H (1998) Expression of an oncogenic mutant G alpha i2 activates Ras in Rat-1 fibroblast cells. FEBS Lett 440:231-234.
    • (1998) FEBS Lett , vol.440 , pp. 231-234
    • Edamatsu, H.1    Kaziro, Y.2    Itoh, H.3
  • 52
    • 0031748909 scopus 로고    scopus 로고
    • Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests
    • Elmer GI, Pieper JO, Negus SS, and Woods JH (1998) Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests. Pain 75:129-140.
    • (1998) Pain , vol.75 , pp. 129-140
    • Elmer, G.I.1    Pieper, J.O.2    Negus, S.S.3    Woods, J.H.4
  • 53
    • 0347297582 scopus 로고    scopus 로고
    • The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity. Mechanism and regulation
    • Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, and Iuvone T (2002) The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity. Mechanism and regulation. J Biol Chem 277:50348-50354.
    • (2002) J Biol Chem , vol.277 , pp. 50348-50354
    • Esposito, G.1    Ligresti, A.2    Izzo, A.A.3    Bisogno, T.4    Ruvo, M.5    Di Rosa, M.6    Di Marzo, V.7    Iuvone, T.8
  • 54
    • 0033039909 scopus 로고    scopus 로고
    • Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence
    • Fan GH, Wang LZ, Qiu HC, Ma L, and Pei G (1999) Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence. Mol Pharmacol 56:39-45.
    • (1999) Mol Pharmacol , vol.56 , pp. 39-45
    • Fan, G.H.1    Wang, L.Z.2    Qiu, H.C.3    Ma, L.4    Pei, G.5
  • 55
    • 0345304250 scopus 로고    scopus 로고
    • Chronic morphine treatment and withdrawal induce up-regulation of c-Jun N-terminal kinase 3 gene expression in rat brain
    • Fan XL, Zhang JS, Zhang XQ, and Ma L (2003) Chronic morphine treatment and withdrawal induce up-regulation of c-Jun N-terminal kinase 3 gene expression in rat brain. Neuroscience 122:997-1002.
    • (2003) Neuroscience , vol.122 , pp. 997-1002
    • Fan, X.L.1    Zhang, J.S.2    Zhang, X.Q.3    Ma, L.4
  • 56
    • 0034659116 scopus 로고    scopus 로고
    • Heroin-induced alterations in leukocyte numbers and apoptosis in the rat spleen
    • Fecho K and Lysle DT (2000) Heroin-induced alterations in leukocyte numbers and apoptosis in the rat spleen. Cell Immunol 202:113-123.
    • (2000) Cell Immunol , vol.202 , pp. 113-123
    • Fecho, K.1    Lysle, D.T.2
  • 57
    • 0028358875 scopus 로고
    • Macrophage-derived nitric oxide is involved in the depressed concanavalin A responsiveness of splenic lymphocytes from rats administered morphine in vivo
    • Fecho K, Maslonek KA, Coussons-Read ME, Dykstra LA, and Lysle DT (1994) Macrophage-derived nitric oxide is involved in the depressed concanavalin A responsiveness of splenic lymphocytes from rats administered morphine in vivo. J Immunol 152:5845-5852.
    • (1994) J Immunol , vol.152 , pp. 5845-5852
    • Fecho, K.1    Maslonek, K.A.2    Coussons-Read, M.E.3    Dykstra, L.A.4    Lysle, D.T.5
  • 58
    • 0942301172 scopus 로고    scopus 로고
    • Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells
    • Fernandis AZ, Prasad A, Band H, Klosel R, and Ganju RK (2004) Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells. Oncogene 23:157-167.
    • (2004) Oncogene , vol.23 , pp. 157-167
    • Fernandis, A.Z.1    Prasad, A.2    Band, H.3    Klosel, R.4    Ganju, R.K.5
  • 60
    • 0033007857 scopus 로고    scopus 로고
    • Morphine and anandamide stimulate intracellular calcium transients in human arterial endothelial cells: Coupling to nitric oxide release
    • Fimiani C, Mattocks D, Cavani F, Salzet M, Deutsch DG, Pryor S, Bilfinger TV, and Stefano GB (1999b) Morphine and anandamide stimulate intracellular calcium transients in human arterial endothelial cells: coupling to nitric oxide release. Cell Signal 11:189-193.
    • (1999) Cell Signal , vol.11 , pp. 189-193
    • Fimiani, C.1    Mattocks, D.2    Cavani, F.3    Salzet, M.4    Deutsch, D.G.5    Pryor, S.6    Bilfinger, T.V.7    Stefano, G.B.8
  • 61
    • 0030907987 scopus 로고    scopus 로고
    • PI3K: Downstream AKTion blocks apoptosis
    • Franke TF, Kaplan DR, and Cantley LC (1997) PI3K: downstream AKTion blocks apoptosis. Cell 88:435-437.
    • (1997) Cell , vol.88 , pp. 435-437
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3
  • 62
    • 0027493099 scopus 로고
    • Morphine-induced alterations in thymocyte sub-populations of B6C3F1 mice
    • Freier DO and Fuchs BA (1993) Morphine-induced alterations in thymocyte sub-populations of B6C3F1 mice. J Pharmacol Exp Ther 265:81-88.
    • (1993) J Pharmacol Exp Ther , vol.265 , pp. 81-88
    • Freier, D.O.1    Fuchs, B.A.2
  • 63
    • 0027504413 scopus 로고
    • Morphine induces apoptosis in murine thymocytes in vivo but not in vitro: Involvement of both opiate and glucocorticoid receptors
    • Fuchs BA and Pruett SB (1993) Morphine induces apoptosis in murine thymocytes in vivo but not in vitro: involvement of both opiate and glucocorticoid receptors. J Pharmacol Exp Ther 266:417-423.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 417-423
    • Fuchs, B.A.1    Pruett, S.B.2
  • 65
    • 0027087225 scopus 로고
    • Beta-endorphin inhibits interleukin-2 release and expression of interleukin-2 receptors in concanavalin A-stimulated splenic lymphocytes
    • Garcia I, Perez-Castillo A, Moreno J, and Alemany S (1992) Beta-endorphin inhibits interleukin-2 release and expression of interleukin-2 receptors in concanavalin A-stimulated splenic lymphocytes. Lymphokine Cytokine Res 11:339-345.
    • (1992) Lymphokine Cytokine Res , vol.11 , pp. 339-345
    • Garcia, I.1    Perez-Castillo, A.2    Moreno, J.3    Alemany, S.4
  • 67
    • 0033622132 scopus 로고    scopus 로고
    • Distinct roles for Galpha(i)2 and Gbetagamma in signaling to DNA synthesis and Galpha(i)3 in cellular transformation by dopamine D2S receptor activation in BALB/c 3T3 cells
    • Ghahremani MH, Forget C, and Albert PR (2000) Distinct roles for Galpha(i)2 and Gbetagamma in signaling to DNA synthesis and Galpha(i)3 in cellular transformation by dopamine D2S receptor activation in BALB/c 3T3 cells. Mol Cell Biol 20:1497-1506.
    • (2000) Mol Cell Biol , vol.20 , pp. 1497-1506
    • Ghahremani, M.H.1    Forget, C.2    Albert, P.R.3
  • 68
    • 0033876844 scopus 로고    scopus 로고
    • Beta-endorphin concentrations in peripheral blood mononuclear cells of patients with multiple sclerosis: Effects of treatment with interferon beta
    • Gironi M, Martinelli V, Brambilla E, Furlan R, Panerai AE, Comi G, and Sacerdote P (2000) Beta-endorphin concentrations in peripheral blood mononuclear cells of patients with multiple sclerosis: effects of treatment with interferon beta. Arch Neurol 57:1178-1181.
    • (2000) Arch Neurol , vol.57 , pp. 1178-1181
    • Gironi, M.1    Martinelli, V.2    Brambilla, E.3    Furlan, R.4    Panerai, A.E.5    Comi, G.6    Sacerdote, P.7
  • 69
    • 0037184060 scopus 로고    scopus 로고
    • Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway
    • Gomez Del Pulgar T, De Ceballos ML, Guzman M, and Velasco G (2002) Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 277:36527-36533.
    • (2002) J Biol Chem , vol.277 , pp. 36527-36533
    • Gomez Del Pulgar, T.1    De Ceballos, M.L.2    Guzman, M.3    Velasco, G.4
  • 70
    • 0036893646 scopus 로고    scopus 로고
    • The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase
    • Grey A, Chen Q, Callon K, Xu X, Reid IR, and Cornish J (2002) The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase. Endocrinology 143:4755-4763.
    • (2002) Endocrinology , vol.143 , pp. 4755-4763
    • Grey, A.1    Chen, Q.2    Callon, K.3    Xu, X.4    Reid, I.R.5    Cornish, J.6
  • 73
    • 0021076929 scopus 로고
    • Comparison of the analgesic actions of THIP and morphine
    • Grognet A, Hertz F, and DeFeudis FV (1983) Comparison of the analgesic actions of THIP and morphine. Gen Pharmacol 14:585-589.
    • (1983) Gen Pharmacol , vol.14 , pp. 585-589
    • Grognet, A.1    Hertz, F.2    DeFeudis, F.V.3
  • 74
    • 0030975325 scopus 로고    scopus 로고
    • Inhibition of T cell superantigen responses following treatment with the kappa-opioid agonist U50,488H
    • Guan L, Eisenstein TK, Adler MW, and Rogers TJ (1997) Inhibition of T cell superantigen responses following treatment with the kappa-opioid agonist U50,488H. J Neuroimmunol 75:163-168.
    • (1997) J Neuroimmunol , vol.75 , pp. 163-168
    • Guan, L.1    Eisenstein, T.K.2    Adler, M.W.3    Rogers, T.J.4
  • 75
    • 0036840219 scopus 로고    scopus 로고
    • Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptor
    • Guo CJ, Li Y, Tian S, Wang X, Douglas SD, and Ho WZ (2002) Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptor. J Investig Med 50:435-442.
    • (2002) J Investig Med , vol.50 , pp. 435-442
    • Guo, C.J.1    Li, Y.2    Tian, S.3    Wang, X.4    Douglas, S.D.5    Ho, W.Z.6
  • 76
    • 0036682055 scopus 로고    scopus 로고
    • Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth
    • Gupta K, Kshirsagar S, Chang L, Schwartz R, Law PY, Yee D, and Hebbel RP (2002) Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth. Cancer Res 62:4491-4498.
    • (2002) Cancer Res , vol.62 , pp. 4491-4498
    • Gupta, K.1    Kshirsagar, S.2    Chang, L.3    Schwartz, R.4    Law, P.Y.5    Yee, D.6    Hebbel, R.P.7
  • 77
    • 0035808842 scopus 로고    scopus 로고
    • Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro
    • Gurwell JA, Nath A, Sun Q, Zhang J, Martin KM, Chen Y, and Hauser KF (2001) Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro. Neuroscience 102:555-563.
    • (2001) Neuroscience , vol.102 , pp. 555-563
    • Gurwell, J.A.1    Nath, A.2    Sun, Q.3    Zhang, J.4    Martin, K.M.5    Chen, Y.6    Hauser, K.F.7
  • 78
    • 0037058648 scopus 로고    scopus 로고
    • Potential ability of morphine to inhibit the adhesion, invasion and metastasis of metastatic colon 26-L5 carcinoma cells
    • Harimaya Y, Koizumi K, Andoh T, Nojima H, Kuraishi Y, and Saiki I (2002) Potential ability of morphine to inhibit the adhesion, invasion and metastasis of metastatic colon 26-L5 carcinoma cells. Cancer Lett 187:121-127.
    • (2002) Cancer Lett , vol.187 , pp. 121-127
    • Harimaya, Y.1    Koizumi, K.2    Andoh, T.3    Nojima, H.4    Kuraishi, Y.5    Saiki, I.6
  • 79
    • 1542510624 scopus 로고    scopus 로고
    • Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor
    • Hart S, Fischer OM, and Ullrich A (2004) Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor. Cancer Res 64:1943-1950.
    • (2004) Cancer Res , vol.64 , pp. 1943-1950
    • Hart, S.1    Fischer, O.M.2    Ullrich, A.3
  • 80
    • 0030051996 scopus 로고    scopus 로고
    • The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors
    • Hatzoglou A, Bakogeorgou E, and Castanas E (1996) The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors. Eur J Pharmacol 296:199-207.
    • (1996) Eur J Pharmacol , vol.296 , pp. 199-207
    • Hatzoglou, A.1    Bakogeorgou, E.2    Castanas, E.3
  • 81
    • 0033538342 scopus 로고    scopus 로고
    • Gi proteins use a novel beta gamma- and Ras-independent pathway to activate extracellular signal-regulated kinase and mobilize AP-1 transcription factors in Jurkat T lymphocytes
    • Hedin KE, Bell MP, Huntoon CJ, Karnitz LM, and McKean DJ (1999) Gi proteins use a novel beta gamma- and Ras-independent pathway to activate extracellular signal-regulated kinase and mobilize AP-1 transcription factors in Jurkat T lymphocytes. J Biol Chem 274:19992-20001.
    • (1999) J Biol Chem , vol.274 , pp. 19992-20001
    • Hedin, K.E.1    Bell, M.P.2    Huntoon, C.J.3    Karnitz, L.M.4    McKean, D.J.5
  • 82
    • 0035952657 scopus 로고    scopus 로고
    • G(z) signaling: Emerging divergence from G(i) signaling
    • Ho MK and Wong YH (2001) G(z) signaling: emerging divergence from G(i) signaling. Oncogene 20:1615-1625.
    • (2001) Oncogene , vol.20 , pp. 1615-1625
    • Ho, M.K.1    Wong, Y.H.2
  • 83
    • 0032796333 scopus 로고    scopus 로고
    • beta-Endorphin binding and regulation of cytokine expression in Langerhans cells
    • Hosoi J, Ozawa H, and Granstein RD (1999) beta-Endorphin binding and regulation of cytokine expression in Langerhans cells. Ann N Y Acad Sci 885:405-413.
    • (1999) Ann N Y Acad Sci , vol.885 , pp. 405-413
    • Hosoi, J.1    Ozawa, H.2    Granstein, R.D.3
  • 84
    • 0028924486 scopus 로고
    • Expression of the conditioned NK cell activity is beta-endorphin dependent
    • Hsueh CM, Chen SF, Ghanta VK, and Hiramoto RN (1995) Expression of the conditioned NK cell activity is beta-endorphin dependent. Brain Res 678:76-82.
    • (1995) Brain Res , vol.678 , pp. 76-82
    • Hsueh, C.M.1    Chen, S.F.2    Ghanta, V.K.3    Hiramoto, R.N.4
  • 85
    • 0030596919 scopus 로고    scopus 로고
    • Activation of mu-opioid receptors are required for the conditioned enhancement of NK cell activity
    • Hsueh CM, Chen SF, Huang HJ, Ghanta VK, and Hiramoto RN (1996) Activation of mu-opioid receptors are required for the conditioned enhancement of NK cell activity. Brain Res 737:263-268.
    • (1996) Brain Res , vol.737 , pp. 263-268
    • Hsueh, C.M.1    Chen, S.F.2    Huang, H.J.3    Ghanta, V.K.4    Hiramoto, R.N.5
  • 86
    • 0033728872 scopus 로고    scopus 로고
    • Morphine inhibits human microglial cell production of and migration towards, RANTES
    • Hu S, Chao CC, Hegg CC, Thayer S, and Peterson PK (2000) Morphine inhibits human microglial cell production of and migration towards, RANTES. J Psychopharmacol 14:238-243.
    • (2000) J Psychopharmacol , vol.14 , pp. 238-243
    • Hu, S.1    Chao, C.C.2    Hegg, C.C.3    Thayer, S.4    Peterson, P.K.5
  • 88
    • 0035049085 scopus 로고    scopus 로고
    • Changes in the expression of G protein-coupled receptor kinases and beta-arrestin 2 in rat brain during opioid tolerance and supersensitivity
    • Hurle MA (2001) Changes in the expression of G protein-coupled receptor kinases and beta-arrestin 2 in rat brain during opioid tolerance and supersensitivity. J Neurochem 77:486-492.
    • (2001) J Neurochem , vol.77 , pp. 486-492
    • Hurle, M.A.1
  • 89
    • 0031469732 scopus 로고    scopus 로고
    • Effect of beta-endorphin on cell growth and cell death in human peripheral blood lymphocytes
    • Ientile R, Ginoprelli T, Cannavo G, Picerno I, and Piedimonte G (1997) Effect of beta-endorphin on cell growth and cell death in human peripheral blood lymphocytes. J Neuroimmunol 80:87-92.
    • (1997) J Neuroimmunol , vol.80 , pp. 87-92
    • Ientile, R.1    Ginoprelli, T.2    Cannavo, G.3    Picerno, I.4    Piedimonte, G.5
  • 90
    • 0037333912 scopus 로고    scopus 로고
    • Mu-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via phosphatidylinositol 3-kinase
    • Iglesias M, Segura MF, Cornelia JX, and Olmos G (2003) Mu-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via phosphatidylinositol 3-kinase. Neuropharmacology 44:482-492.
    • (2003) Neuropharmacology , vol.44 , pp. 482-492
    • Iglesias, M.1    Segura, M.F.2    Cornelia, J.X.3    Olmos, G.4
  • 91
    • 0027490626 scopus 로고
    • Enhancement of tumor growth by morphine and its possible mechanism in mice
    • Ishikawa M, Tanno K, Kamo A, Takayanagi Y, and Sasaki K (1993) Enhancement of tumor growth by morphine and its possible mechanism in mice. Biol Pharm Bull 16:762-766.
    • (1993) Biol Pharm Bull , vol.16 , pp. 762-766
    • Ishikawa, M.1    Tanno, K.2    Kamo, A.3    Takayanagi, Y.4    Sasaki, K.5
  • 92
    • 10744231064 scopus 로고    scopus 로고
    • Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy
    • Jankowski K, Kucia M, Wysoczynski M, Reca R, Zhao D, Trzyna E, Trent J, Peiper S, Zembala M, Ratajczak J, et al. (2003) Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy. Cancer Res 63:7926-7935.
    • (2003) Cancer Res , vol.63 , pp. 7926-7935
    • Jankowski, K.1    Kucia, M.2    Wysoczynski, M.3    Reca, R.4    Zhao, D.5    Trzyna, E.6    Trent, J.7    Peiper, S.8    Zembala, M.9    Ratajczak, J.10
  • 93
    • 0036300956 scopus 로고    scopus 로고
    • Opioid peptides endomorphin-1 and endomorphin-2 in the immune system in humans and in a rodent model of inflammation
    • Jessop DS, Richards LJ, and Harbuz MS (2002) Opioid peptides endomorphin-1 and endomorphin-2 in the immune system in humans and in a rodent model of inflammation. Ann N Y Acad Sci 966:456-463.
    • (2002) Ann N Y Acad Sci , vol.966 , pp. 456-463
    • Jessop, D.S.1    Richards, L.J.2    Harbuz, M.S.3
  • 94
    • 1642417380 scopus 로고    scopus 로고
    • Up-regulation of murine double minute clone 2 (MDM2) gene expression in rat brain after morphine, heroin and cocaine administrations
    • Jiang Y, Yang W, Zhou Y, and Ma L (2003) Up-regulation of murine double minute clone 2 (MDM2) gene expression in rat brain after morphine, heroin and cocaine administrations. Neurosci Lett 352:216-220.
    • (2003) Neurosci Lett , vol.352 , pp. 216-220
    • Jiang, Y.1    Yang, W.2    Zhou, Y.3    Ma, L.4
  • 95
    • 0020519807 scopus 로고
    • The binding to rat brain homogenates of Mr2034, a universal opiate
    • Johnson N and Pasternak GW (1983) The binding to rat brain homogenates of Mr2034, a universal opiate. Life Sci 33:985-991.
    • (1983) Life Sci , vol.33 , pp. 985-991
    • Johnson, N.1    Pasternak, G.W.2
  • 96
    • 1942423629 scopus 로고    scopus 로고
    • Phosphatidylinositol-3 kinase is distinctively required for micro-, but not kappa-opioid receptor-induced activation of c-Jun N-terminal kinase
    • Kam AY, Chan AS, and Wong YH (2004) Phosphatidylinositol-3 kinase is distinctively required for micro-, but not kappa-opioid receptor-induced activation of c-Jun N-terminal kinase. J Neurochem 89:391-402.
    • (2004) J Neurochem , vol.89 , pp. 391-402
    • Kam, A.Y.1    Chan, A.S.2    Wong, Y.H.3
  • 97
    • 0030823262 scopus 로고    scopus 로고
    • Opioid alkaloids and casomorphin peptides decrease the proliferation of prostatic cancer cell lines (LNCaP, PC3 and DU145) through a partial interaction with opioid receptors
    • Kampa M, Bakogeorgou E, Hatzoglou A, Damianaki A, Martin PM, and Castanas E (1997) Opioid alkaloids and casomorphin peptides decrease the proliferation of prostatic cancer cell lines (LNCaP, PC3 and DU145) through a partial interaction with opioid receptors. Eur J Pharmacol 335:255-265.
    • (1997) Eur J Pharmacol , vol.335 , pp. 255-265
    • Kampa, M.1    Bakogeorgou, E.2    Hatzoglou, A.3    Damianaki, A.4    Martin, P.M.5    Castanas, E.6
  • 98
    • 0034874425 scopus 로고    scopus 로고
    • Opioids are non-competitive inhibitors of nitric oxide synthase in T47D human breast cancer cells
    • Kampa M, Hatzoglou A, Notas G, Niniraki M, Kouroumalis E, and Castanas E (2001) Opioids are non-competitive inhibitors of nitric oxide synthase in T47D human breast cancer cells. Cell Death Differ 8:943-952.
    • (2001) Cell Death Differ , vol.8 , pp. 943-952
    • Kampa, M.1    Hatzoglou, A.2    Notas, G.3    Niniraki, M.4    Kouroumalis, E.5    Castanas, E.6
  • 100
    • 0035313417 scopus 로고    scopus 로고
    • Protective effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: Potential involvement of G protein and phosphatidylinositol 3-kinase (PI3 kinase)
    • Kim MS, Cheong YP, So HS, Lee KM, Kim TY, Oh J, Chung YT, Son Y, Kim BR, and Park R (2001) Protective effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and phosphatidylinositol 3-kinase (PI3 kinase). Biochem Pharmacol 61:779-786.
    • (2001) Biochem Pharmacol , vol.61 , pp. 779-786
    • Kim, M.S.1    Cheong, Y.P.2    So, H.S.3    Lee, K.M.4    Kim, T.Y.5    Oh, J.6    Chung, Y.T.7    Son, Y.8    Kim, B.R.9    Park, R.10
  • 101
    • 0033061113 scopus 로고    scopus 로고
    • Panax ginseng blocks morphine-induced thymic apoptosis by lowering plasma corticosterone level
    • Kim YR, Lee SY, Shin BA, and Kim KM (1999) Panax ginseng blocks morphine-induced thymic apoptosis by lowering plasma corticosterone level. Gen Pharmacol 32:647-652.
    • (1999) Gen Pharmacol , vol.32 , pp. 647-652
    • Kim, Y.R.1    Lee, S.Y.2    Shin, B.A.3    Kim, K.M.4
  • 102
    • 0030922877 scopus 로고    scopus 로고
    • Site mutation in the rat mu-opioid receptor demonstrates the involvement of calcium/calmodulin-dependent protein kinase II in agonist-mediated desensitization
    • Koch T, Kroslak T, Mayer P, Raulf E, and Hollt V (1997) Site mutation in the rat mu-opioid receptor demonstrates the involvement of calcium/calmodulin- dependent protein kinase II in agonist-mediated desensitization. J Neurochem 69:1767-1770.
    • (1997) J Neurochem , vol.69 , pp. 1767-1770
    • Koch, T.1    Kroslak, T.2    Mayer, P.3    Raulf, E.4    Hollt, V.5
  • 103
    • 0030968077 scopus 로고    scopus 로고
    • Inhibition of lipopolysaccharide-induced nitric oxide and cytokine production by ultralow concentrations of dynorphins in mixed glia cultures
    • Kong LY, McMillian MK, Hudson PM, Jin L, and Hong JS (1997) Inhibition of lipopolysaccharide-induced nitric oxide and cytokine production by ultralow concentrations of dynorphins in mixed glia cultures. J Pharmacol Exp Ther 280:61-66.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 61-66
    • Kong, L.Y.1    McMillian, M.K.2    Hudson, P.M.3    Jin, L.4    Hong, J.S.5
  • 104
    • 0030973504 scopus 로고    scopus 로고
    • Effect of enkephalins and endorphins on cytotoxic activity of natural killer cells and macrophages/monocytes in mice
    • Kowalski J (1997) Effect of enkephalins and endorphins on cytotoxic activity of natural killer cells and macrophages/monocytes in mice. Eur J Pharmacol 326: 251-255.
    • (1997) Eur J Pharmacol , vol.326 , pp. 251-255
    • Kowalski, J.1
  • 105
    • 2642533719 scopus 로고    scopus 로고
    • Delta opioid activation of the mitogen-activated protein kinase cascade does not require transphosphorylation of receptor tyrosine kinases
    • Kramer HK, Onoprishvili I, Andria ML, Hanna K, Sheinkman K, Haddad LB, and Simon EJ (2002) Delta opioid activation of the mitogen-activated protein kinase cascade does not require transphosphorylation of receptor tyrosine kinases. BMC Pharmacol 2:5.
    • (2002) BMC Pharmacol , vol.2 , pp. 5
    • Kramer, H.K.1    Onoprishvili, I.2    Andria, M.L.3    Hanna, K.4    Sheinkman, K.5    Haddad, L.B.6    Simon, E.J.7
  • 106
    • 0034126705 scopus 로고    scopus 로고
    • mu and delta-opioid receptor agonists induce mitogen-activated protein kinase (MAPK) activation in the absence of receptor internalization
    • Kramer HK and Simon EJ (2000) mu and delta-opioid receptor agonists induce mitogen-activated protein kinase (MAPK) activation in the absence of receptor internalization. Neuropharmacology 39:1707-1719.
    • (2000) Neuropharmacology , vol.39 , pp. 1707-1719
    • Kramer, H.K.1    Simon, E.J.2
  • 108
    • 0032540209 scopus 로고    scopus 로고
    • Buprenorphine hydrochloride induces apoptosis in NG108-15 nerve cells
    • Kugawa F, Arae K, Ueno A, and Aoki M (1998) Buprenorphine hydrochloride induces apoptosis in NG108-15 nerve cells. Eur J Pharmacol 347:105-112.
    • (1998) Eur J Pharmacol , vol.347 , pp. 105-112
    • Kugawa, F.1    Arae, K.2    Ueno, A.3    Aoki, M.4
  • 109
    • 0033835228 scopus 로고    scopus 로고
    • Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway
    • Kugawa F, Ueno A, and Aoki M (2000) Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. Biol Pharm Bull 23:930-935.
    • (2000) Biol Pharm Bull , vol.23 , pp. 930-935
    • Kugawa, F.1    Ueno, A.2    Aoki, M.3
  • 110
    • 0028871121 scopus 로고
    • Properties of delta opioid receptor in neuroblastoma NS20Y: Receptor activation and neuroblastoma proliferation
    • Law PY and Bergsbaken C (1995) Properties of delta opioid receptor in neuroblastoma NS20Y: receptor activation and neuroblastoma proliferation. J Pharmacol Exp Ther 272:322-332.
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 322-332
    • Law, P.Y.1    Bergsbaken, C.2
  • 111
    • 0034644652 scopus 로고    scopus 로고
    • Deltorphin II-induced rapid desensitization of delta-opioid receptor requires both phosphorylation and internalization of the receptor
    • Law PY, Kouhen OM, Solberg J, Wang W, Erickson LJ, and Loh HH (2000) Deltorphin II-induced rapid desensitization of delta-opioid receptor requires both phosphorylation and internalization of the receptor. J Biol Chem 275:32057-32065.
    • (2000) J Biol Chem , vol.275 , pp. 32057-32065
    • Law, P.Y.1    Kouhen, O.M.2    Solberg, J.3    Wang, W.4    Erickson, L.J.5    Loh, H.H.6
  • 112
    • 0031023556 scopus 로고    scopus 로고
    • Agonist activation of delta-opioid receptor but not mu-opioid receptor potentiates fetal calf serum or tyrosine kinase receptor-mediated cell proliferation in a cell-line-specific manner
    • Law PY, McGinn TM, Campbell KM, Erickson LE, and Loh HH (1997) Agonist activation of delta-opioid receptor but not mu-opioid receptor potentiates fetal calf serum or tyrosine kinase receptor-mediated cell proliferation in a cell-line-specific manner. Mol Pharmacol 51:152-160.
    • (1997) Mol Pharmacol , vol.51 , pp. 152-160
    • Law, P.Y.1    McGinn, T.M.2    Campbell, K.M.3    Erickson, L.E.4    Loh, H.H.5
  • 113
    • 0033597143 scopus 로고    scopus 로고
    • U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activation
    • Li JG, Luo LY, Krupnick JG, Benovic JL, and Liu-Chen LY (1999) U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activation. J Biol Chem 274: 12087-12094.
    • (1999) J Biol Chem , vol.274 , pp. 12087-12094
    • Li, J.G.1    Luo, L.Y.2    Krupnick, J.G.3    Benovic, J.L.4    Liu-Chen, L.Y.5
  • 115
    • 0036138197 scopus 로고    scopus 로고
    • Methadone enhances human immunodeficiency virus infection of human immune cells
    • Li Y, Wang X, Tian S, Guo CJ, Douglas SD, and Ho WZ (2002) Methadone enhances human immunodeficiency virus infection of human immune cells. J Infect Dis 185:118-122.
    • (2002) J Infect Dis , vol.185 , pp. 118-122
    • Li, Y.1    Wang, X.2    Tian, S.3    Guo, C.J.4    Douglas, S.D.5    Ho, W.Z.6
  • 116
    • 0034893945 scopus 로고    scopus 로고
    • Femtomolar concentrations of dynorphins protect rat mesencephalic dopaminergic neurons against inflammatory damage
    • Liu B, Qin L, Yang SN, Wilson BC, Liu Y, and Hong JS (2001) Femtomolar concentrations of dynorphins protect rat mesencephalic dopaminergic neurons against inflammatory damage. J Pharmacol Exp Ther 298:1133-1141.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 1133-1141
    • Liu, B.1    Qin, L.2    Yang, S.N.3    Wilson, B.C.4    Liu, Y.5    Hong, J.S.6
  • 117
    • 0033061108 scopus 로고    scopus 로고
    • Methadone-induced desensitization of the delta-opioid receptor is mediated by uncoupling of receptor from G protein
    • Liu JG, Liao XP, Gong ZH, and Qin BY (1999) Methadone-induced desensitization of the delta-opioid receptor is mediated by uncoupling of receptor from G protein. Eur J Pharmacol 374:301-308.
    • (1999) Eur J Pharmacol , vol.374 , pp. 301-308
    • Liu, J.G.1    Liao, X.P.2    Gong, Z.H.3    Qin, B.Y.4
  • 119
    • 0037087640 scopus 로고    scopus 로고
    • Kappa-opioid receptor agonist inhibition of HIV-1 envelope glycoprotein-mediated membrane fusion and CXCR4 expression on CD4(+) lymphocytes
    • Lokensgard JR, Gekker G, and Peterson PK (2002) Kappa-opioid receptor agonist inhibition of HIV-1 envelope glycoprotein-mediated membrane fusion and CXCR4 expression on CD4(+) lymphocytes. Biochem Pharmacol 63:1037-1041.
    • (2002) Biochem Pharmacol , vol.63 , pp. 1037-1041
    • Lokensgard, J.R.1    Gekker, G.2    Peterson, P.K.3
  • 120
    • 0031037296 scopus 로고    scopus 로고
    • Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma
    • Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, and Wetzker R (1997) Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science (Wash DC) 275:394-397.
    • (1997) Science (Wash DC) , vol.275 , pp. 394-397
    • Lopez-Ilasaca, M.1    Crespo, P.2    Pellici, P.G.3    Gutkind, J.S.4    Wetzker, R.5
  • 121
    • 0032586887 scopus 로고    scopus 로고
    • Modulation of Ca2+/calmodulin-dependent protein kinase II activity by acute and chronic morphine administration in rat hippocampus: Differential regulation of alpha and beta isoforms
    • Lou L, Zhou T, Wang P, and Pei G (1999) Modulation of Ca2+/calmodulin-dependent protein kinase II activity by acute and chronic morphine administration in rat hippocampus: differential regulation of alpha and beta isoforms. Mol Pharmacol 55:557-563.
    • (1999) Mol Pharmacol , vol.55 , pp. 557-563
    • Lou, L.1    Zhou, T.2    Wang, P.3    Pei, G.4
  • 122
    • 0030485090 scopus 로고    scopus 로고
    • Subchronic in vivo treatments of morphine inhibit T-cell proliferation by acting on macrophages
    • Lu ZW, Dai WJ, Wang GL, and Lin ZB (1996) Subchronic in vivo treatments of morphine inhibit T-cell proliferation by acting on macrophages. Brain Behav Immun 10:351-363.
    • (1996) Brain Behav Immun , vol.10 , pp. 351-363
    • Lu, Z.W.1    Dai, W.J.2    Wang, G.L.3    Lin, Z.B.4
  • 123
    • 0033965599 scopus 로고    scopus 로고
    • Heroin modulates the expression of inducible nitric oxide synthase
    • Lysle DT and How T (2000) Heroin modulates the expression of inducible nitric oxide synthase. Immunopharmacology 46:181-192.
    • (2000) Immunopharmacology , vol.46 , pp. 181-192
    • Lysle, D.T.1    How, T.2
  • 124
    • 0035783434 scopus 로고    scopus 로고
    • Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: An in vitro and in vivo study
    • Ma W, Zheng WH, Powell K, Jhamandas K, and Quirion R (2001) Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: an in vitro and in vivo study. Eur J Neurosci 14:1091-1104.
    • (2001) Eur J Neurosci , vol.14 , pp. 1091-1104
    • Ma, W.1    Zheng, W.H.2    Powell, K.3    Jhamandas, K.4    Quirion, R.5
  • 127
  • 128
    • 0029934759 scopus 로고    scopus 로고
    • Morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide
    • Magazine HI, Liu Y, Bilfinger TV, Fricchione GL, and Stefano GB (1996) Morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide. J Immunol 156:4845-4850.
    • (1996) J Immunol , vol.156 , pp. 4845-4850
    • Magazine, H.I.1    Liu, Y.2    Bilfinger, T.V.3    Fricchione, G.L.4    Stefano, G.B.5
  • 129
    • 0036786456 scopus 로고    scopus 로고
    • Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptor
    • Mahajan SD, Schwartz SA, Shanahan TC, Chawda RP, and Nair MP (2002) Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptor. J Immunol 169:3589-3599.
    • (2002) J Immunol , vol.169 , pp. 3589-3599
    • Mahajan, S.D.1    Schwartz, S.A.2    Shanahan, T.C.3    Chawda, R.P.4    Nair, M.P.5
  • 130
    • 0032828890 scopus 로고    scopus 로고
    • Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma
    • Maier U, Babich A, and Nurnberg B (1999) Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma. J Biol Chem 274:29311-29317.
    • (1999) J Biol Chem , vol.274 , pp. 29311-29317
    • Maier, U.1    Babich, A.2    Nurnberg, B.3
  • 131
    • 0022640769 scopus 로고
    • beta-Endorphin augments the cytolytic activity and interferon production of natural killer cells
    • Mandler RN, Biddison WE, Mandler R, and Serrate SA (1986) beta-Endorphin augments the cytolytic activity and interferon production of natural killer cells. J Immunol 136:934-939.
    • (1986) J Immunol , vol.136 , pp. 934-939
    • Mandler, R.N.1    Biddison, W.E.2    Mandler, R.3    Serrate, S.A.4
  • 132
    • 0025252232 scopus 로고
    • Binding of opioids to human MCF-7 breast cancer cells and their effects on growth
    • Maneckjee R, Biswas R, and Vonderhaar BK (1990) Binding of opioids to human MCF-7 breast cancer cells and their effects on growth. Cancer Res 50:2234-2238.
    • (1990) Cancer Res , vol.50 , pp. 2234-2238
    • Maneckjee, R.1    Biswas, R.2    Vonderhaar, B.K.3
  • 133
    • 0025341202 scopus 로고
    • Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines
    • Maneckjee R and Minna JD (1990) Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. Proc Natl Acad Sci USA 87:3294-3298.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3294-3298
    • Maneckjee, R.1    Minna, J.D.2
  • 134
    • 0026547233 scopus 로고
    • Nonconventional opioid binding sites mediate growth inhibitory effects of methadone on human lung cancer cells
    • Maneckjee R and Minna JD (1992) Nonconventional opioid binding sites mediate growth inhibitory effects of methadone on human lung cancer cells. Proc Natl Acad Sci USA 89:1169-1173.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1169-1173
    • Maneckjee, R.1    Minna, J.D.2
  • 135
    • 0027985282 scopus 로고
    • Opioids induce while nicotine suppresses apoptosis in human lung cancer cells
    • Maneckjee R and Minna JD (1994) Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ 5:1033-1040.
    • (1994) Cell Growth Differ , vol.5 , pp. 1033-1040
    • Maneckjee, R.1    Minna, J.D.2
  • 137
    • 0028215987 scopus 로고
    • Thermal hyperalgesia in association with the development of morphine tolerance in rats: Roles of excitatory amino acid receptors and protein kinase C
    • Mao J, Price DD, and Mayer DJ (1994) Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C. J Neurosci 14:2301-2312.
    • (1994) J Neurosci , vol.14 , pp. 2301-2312
    • Mao, J.1    Price, D.D.2    Mayer, D.J.3
  • 138
    • 0029162234 scopus 로고
    • Mechanisms of hyperalgesia and morphine tolerance: A current view of their possible interactions
    • Mao J, Price DD, and Mayer DJ (1995) Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions. Pain 62:259-274.
    • (1995) Pain , vol.62 , pp. 259-274
    • Mao, J.1    Price, D.D.2    Mayer, D.J.3
  • 139
    • 0036759656 scopus 로고    scopus 로고
    • Neuronal apoptosis associated with morphine tolerance: Evidence for an opioid-induced neurotoxic mechanism
    • Mao J, Sung B, Ji RR, and Lim G (2002) Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. J Neurosci 22:7650-7661.
    • (2002) J Neurosci , vol.22 , pp. 7650-7661
    • Mao, J.1    Sung, B.2    Ji, R.R.3    Lim, G.4
  • 142
    • 0037044783 scopus 로고    scopus 로고
    • Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha
    • McCole DF, Keely SJ, Coffey RJ, and Barrett KE (2002) Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha. J Biol Chem 277:42603-42612.
    • (2002) J Biol Chem , vol.277 , pp. 42603-42612
    • McCole, D.F.1    Keely, S.J.2    Coffey, R.J.3    Barrett, K.E.4
  • 144
    • 0034862452 scopus 로고    scopus 로고
    • Beta-Arrestins: New roles in regulating heptahelical receptors' functions
    • McDonald PH and Lefkowitz RJ (2001) Beta-Arrestins: new roles in regulating heptahelical receptors' functions. Cell Signal 13:683-689.
    • (2001) Cell Signal , vol.13 , pp. 683-689
    • McDonald, P.H.1    Lefkowitz, R.J.2
  • 145
    • 0028983944 scopus 로고
    • Beta-endorphin stimulates proliferation of small cell lung carcinoma cells in vitro via nonopioid binding sites
    • Melzig MF, Nylander I, Vlaskovska M, and Terenius L (1995) Beta-endorphin stimulates proliferation of small cell lung carcinoma cells in vitro via nonopioid binding sites. Exp Cell Res 219:471-476.
    • (1995) Exp Cell Res , vol.219 , pp. 471-476
    • Melzig, M.F.1    Nylander, I.2    Vlaskovska, M.3    Terenius, L.4
  • 146
    • 0026340654 scopus 로고
    • Endogenous opioids modulate neuronal survival in the developing avian ciliary ganglion
    • Meriney SD, Ford MJ, Oliva D, and Pilar G (1991) Endogenous opioids modulate neuronal survival in the developing avian ciliary ganglion. J Neurosci 11:3705-3717.
    • (1991) J Neurosci , vol.11 , pp. 3705-3717
    • Meriney, S.D.1    Ford, M.J.2    Oliva, D.3    Pilar, G.4
  • 147
    • 0021802754 scopus 로고
    • Morphine-induced delay of normal cell death in the avian ciliary ganglion
    • Meriney SD, Gray DB, and Pilar G (1985) Morphine-induced delay of normal cell death in the avian ciliary ganglion. Science (Wash DC) 228:1451-1453.
    • (1985) Science (Wash DC) , vol.228 , pp. 1451-1453
    • Meriney, S.D.1    Gray, D.B.2    Pilar, G.3
  • 148
    • 0029989296 scopus 로고    scopus 로고
    • Met-enkephalin induces cytolytic processes of apoptotic type in K562 human erythroid leukemia cells
    • Mernenko OA, Blishchenko EY, Mirkina II, and Karelin AA (1996) Met-enkephalin induces cytolytic processes of apoptotic type in K562 human erythroid leukemia cells. FEBS Lett 383:230-232.
    • (1996) FEBS Lett , vol.383 , pp. 230-232
    • Mernenko, O.A.1    Blishchenko, E.Y.2    Mirkina, I.I.3    Karelin, A.A.4
  • 149
    • 0028952242 scopus 로고
    • The human mu opioid receptor: Modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C
    • Mestek A, Hurley JH, Bye LS, Campbell AD, Chen Y, Tian M, Liu J, Schulman H, and Yu L (1995) The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C. J Neurosci 15 (Pt 2):2396-2406.
    • (1995) J Neurosci , vol.15 , Issue.PART 2 , pp. 2396-2406
    • Mestek, A.1    Hurley, J.H.2    Bye, L.S.3    Campbell, A.D.4    Chen, Y.5    Tian, M.6    Liu, J.7    Schulman, H.8    Yu, L.9
  • 150
    • 0020541272 scopus 로고
    • Multiple opiate binding sites in the central nervous system of the rabbit. Large predominance of a mu subtype in the cerebellum and characterization of a kappa subtype in the thalamus
    • Meunier JC, Kouakou Y, Puget A, and Moisand C (1983) Multiple opiate binding sites in the central nervous system of the rabbit. Large predominance of a mu subtype in the cerebellum and characterization of a kappa subtype in the thalamus. Mol Pharmacol 24:23-29.
    • (1983) Mol Pharmacol , vol.24 , pp. 23-29
    • Meunier, J.C.1    Kouakou, Y.2    Puget, A.3    Moisand, C.4
  • 152
    • 0037111841 scopus 로고    scopus 로고
    • Cannabinoids promote oligodendrocyte progenitor survival: Involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling
    • Molina-Holgado E, Vela JM, Arevalo-Martin A, Almazan G, Molina-Holgado F, Borrell J, and Guaza C (2002) Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/ Akt signaling. J Neurosci 22:9742-9753.
    • (2002) J Neurosci , vol.22 , pp. 9742-9753
    • Molina-Holgado, E.1    Vela, J.M.2    Arevalo-Martin, A.3    Almazan, G.4    Molina-Holgado, F.5    Borrell, J.6    Guaza, C.7
  • 153
    • 0023947636 scopus 로고
    • The effect of opiates upon prostatic carcinoma cell growth
    • Moon TD (1988) The effect of opiates upon prostatic carcinoma cell growth. Biochem Biophys Res Commun 153:722-727.
    • (1988) Biochem Biophys Res Commun , vol.153 , pp. 722-727
    • Moon, T.D.1
  • 154
    • 0035795077 scopus 로고    scopus 로고
    • beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue
    • Mousa SA, Zhang Q, Sitte N, Ji R, and Stein C (2001) beta-Endorphin- containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue. J Neuroimmunol 115:71-78.
    • (2001) J Neuroimmunol , vol.115 , pp. 71-78
    • Mousa, S.A.1    Zhang, Q.2    Sitte, N.3    Ji, R.4    Stein, C.5
  • 155
    • 0031974158 scopus 로고    scopus 로고
    • Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin
    • Murohara T, Horowitz JR, Silver M, Tsurumi Y, Chen D, Sullivan A, and Isner JM (1998) Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin. Circulation 97:99-107.
    • (1998) Circulation , vol.97 , pp. 99-107
    • Murohara, T.1    Horowitz, J.R.2    Silver, M.3    Tsurumi, Y.4    Chen, D.5    Sullivan, A.6    Isner, J.M.7
  • 156
    • 1342343122 scopus 로고    scopus 로고
    • Increased level of neuronal phosphoiositide 3-kinase gamma by the activation of mu-opioid receptor in the mouse periaqueductal gray matter: Further evidence for the implication in morphine-induced antinociception
    • Narita M, Imai S, Kasukawa A, Yajima Y, and Suzuki T (2004) Increased level of neuronal phosphoiositide 3-kinase gamma by the activation of mu-opioid receptor in the mouse periaqueductal gray matter: further evidence for the implication in morphine-induced antinociception. Neuroscience 124:515-521.
    • (2004) Neuroscience , vol.124 , pp. 515-521
    • Narita, M.1    Imai, S.2    Kasukawa, A.3    Yajima, Y.4    Suzuki, T.5
  • 157
    • 0029947776 scopus 로고    scopus 로고
    • Role of protein kinase C in desensitization of spinal delta-opioid-mediated antinociception in the mouse
    • Narita M, Mizoguchi H, Kampine JP, and Tseng LF (1996) Role of protein kinase C in desensitization of spinal delta-opioid-mediated antinociception in the mouse. Br J Pharmacol 118:1829-1835.
    • (1996) Br J Pharmacol , vol.118 , pp. 1829-1835
    • Narita, M.1    Mizoguchi, H.2    Kampine, J.P.3    Tseng, L.F.4
  • 159
    • 0037008883 scopus 로고    scopus 로고
    • Implications of phosphoinositide 3-kinase in the mu- and delta-opioid receptor-mediated supraspinal antinociception in the mouse
    • Narita M, Ohnishi O, Nemoto M, Yajima Y, and Suzuki T (2002) Implications of phosphoinositide 3-kinase in the mu- and delta-opioid receptor-mediated supraspinal antinociception in the mouse. Neuroscience 113:647-652.
    • (2002) Neuroscience , vol.113 , pp. 647-652
    • Narita, M.1    Ohnishi, O.2    Nemoto, M.3    Yajima, Y.4    Suzuki, T.5
  • 160
    • 0034863288 scopus 로고    scopus 로고
    • Dopamine D(2) receptor activation causes mitogenesis via p44/42 mitogen-activated protein kinase in opossum kidney cells
    • Narkar VA, Hussain T, Pedemonte C, and Lokhandwala MF (2001) Dopamine D(2) receptor activation causes mitogenesis via p44/42 mitogen-activated protein kinase in opossum kidney cells. J Am Soc Nephrol 12:1844-1852.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1844-1852
    • Narkar, V.A.1    Hussain, T.2    Pedemonte, C.3    Lokhandwala, M.F.4
  • 163
    • 0037015933 scopus 로고    scopus 로고
    • Endomorphin-1 alters interleukin-8 secretion in Caco-2 cells via a receptor mediated process
    • Neudeck BL and Loeb JM (2002) Endomorphin-1 alters interleukin-8 secretion in Caco-2 cells via a receptor mediated process. Immunol Lett 84:217-221.
    • (2002) Immunol Lett , vol.84 , pp. 217-221
    • Neudeck, B.L.1    Loeb, J.M.2
  • 164
    • 0033120644 scopus 로고    scopus 로고
    • Dynorphin A enhances mitogen-induced proliferative response and interleukin-2 production of rat splenocytes
    • Ni X, Lin BC, Song CY, and Wang CH (1999) Dynorphin A enhances mitogen-induced proliferative response and interleukin-2 production of rat splenocytes. Neuropeptides 33:137-143.
    • (1999) Neuropeptides , vol.33 , pp. 137-143
    • Ni, X.1    Lin, B.C.2    Song, C.Y.3    Wang, C.H.4
  • 165
    • 0028936331 scopus 로고
    • Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: Regional distribution and regulation by chronic morphine
    • Ortiz J, Harris HW, Guitart X, Terwilliger RZ, Haycock JW, and Nestler EJ (1995) Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: regional distribution and regulation by chronic morphine. J Neurosci 15: 1285-1297.
    • (1995) J Neurosci , vol.15 , pp. 1285-1297
    • Ortiz, J.1    Harris, H.W.2    Guitart, X.3    Terwilliger, R.Z.4    Haycock, J.W.5    Nestler, E.J.6
  • 167
    • 0027264039 scopus 로고
    • Morphine attenuates surgery-induced enhancement of metastatic colonization in rats
    • Page GG, Ben-Eliyahu S, Yirmiya R, and Liebeskind JC (1993) Morphine attenuates surgery-induced enhancement of metastatic colonization in rats. Pain 54:21-28.
    • (1993) Pain , vol.54 , pp. 21-28
    • Page, G.G.1    Ben-Eliyahu, S.2    Yirmiya, R.3    Liebeskind, J.C.4
  • 168
    • 0042916422 scopus 로고    scopus 로고
    • Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors
    • Pai R, Nakamura T, Moon WS, and Tarnawski AS (2003) Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors. FASEB J 17:1640-1647.
    • (2003) FASEB J , vol.17 , pp. 1640-1647
    • Pai, R.1    Nakamura, T.2    Moon, W.S.3    Tarnawski, A.S.4
  • 169
    • 0033600736 scopus 로고    scopus 로고
    • Agonist-induced, G protein-dependent and -independent down-regulation of the mu opioid receptor. The receptor is a direct substrate for protein-tyrosine kinase
    • Pak Y, O'Dowd BF, Wang JB, and George SR (1999) Agonist-induced, G protein-dependent and -independent down-regulation of the mu opioid receptor. The receptor is a direct substrate for protein-tyrosine kinase. J Biol Chem 274:27610-27616.
    • (1999) J Biol Chem , vol.274 , pp. 27610-27616
    • Pak, Y.1    O'Dowd, B.F.2    Wang, J.B.3    George, S.R.4
  • 170
    • 0028987312 scopus 로고
    • The beta-endorphin inhibition of mitogen-induced splenocytes proliferation is mediated by central and peripheral paracrine/autocrine effects of the opioid
    • Panerai AE, Manfredi B, Granucci F, and Sacerdote P (1995) The beta-endorphin inhibition of mitogen-induced splenocytes proliferation is mediated by central and peripheral paracrine/autocrine effects of the opioid. J Neuroimmunol 58:71-76.
    • (1995) J Neuroimmunol , vol.58 , pp. 71-76
    • Panerai, A.E.1    Manfredi, B.2    Granucci, F.3    Sacerdote, P.4
  • 171
    • 0037217709 scopus 로고    scopus 로고
    • Role of heme oxygenase-1 in morphine-modulated apoptosis and migration of macrophages
    • Patel K, Bhaskaran M, Dani D, Reddy K, and Singhal PC (2003) Role of heme oxygenase-1 in morphine-modulated apoptosis and migration of macrophages. J Infect Dis 187:47-54.
    • (2003) J Infect Dis , vol.187 , pp. 47-54
    • Patel, K.1    Bhaskaran, M.2    Dani, D.3    Reddy, K.4    Singhal, P.C.5
  • 172
    • 0038692926 scopus 로고    scopus 로고
    • Opioid-induced proliferation through the MAPK pathway in cultures of adult hippocampal progenitors
    • Persson AI, Thorlin T, Bull C, and Eriksson PS (2003) Opioid-induced proliferation through the MAPK pathway in cultures of adult hippocampal progenitors. Mol Cell Neurosci 23:360-372.
    • (2003) Mol Cell Neurosci , vol.23 , pp. 360-372
    • Persson, A.I.1    Thorlin, T.2    Bull, C.3    Eriksson, P.S.4
  • 173
    • 0032968784 scopus 로고    scopus 로고
    • Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: Implication of an atypical mu-opioid receptor
    • Peterson PK, Gekker G, Hu S, Lokensgard J, Portoghese PS, and Chao CC (1999) Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical mu-opioid receptor. Neuropharmacology 38:273-278.
    • (1999) Neuropharmacology , vol.38 , pp. 273-278
    • Peterson, P.K.1    Gekker, G.2    Hu, S.3    Lokensgard, J.4    Portoghese, P.S.5    Chao, C.C.6
  • 176
    • 0035487327 scopus 로고    scopus 로고
    • Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors
    • Pierce KL and Lefkowitz RJ (2001) Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors. Nat Rev Neurosci 2:727-733.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 727-733
    • Pierce, K.L.1    Lefkowitz, R.J.2
  • 177
    • 0032524665 scopus 로고    scopus 로고
    • A mitogen-activated protein kinase pathway is required for mu-opioid receptor desensitization
    • Polakiewicz KD, Schieferl SM, Dorner LF, Kansra V, and Comb MJ (1998a) A mitogen-activated protein kinase pathway is required for mu-opioid receptor desensitization. J Biol Chem 273:12402-12406.
    • (1998) J Biol Chem , vol.273 , pp. 12402-12406
    • Polakiewicz, K.D.1    Schieferl, S.M.2    Dorner, L.F.3    Kansra, V.4    Comb, M.J.5
  • 178
    • 0032483540 scopus 로고    scopus 로고
    • mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control
    • Polakiewicz RD, Schieferl SM, Gingras AC, Sonenberg N, and Comb MJ (1998b) mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control. J Biol Chem 273:23534-23541.
    • (1998) J Biol Chem , vol.273 , pp. 23534-23541
    • Polakiewicz, R.D.1    Schieferl, S.M.2    Gingras, A.C.3    Sonenberg, N.4    Comb, M.J.5
  • 179
    • 0030268354 scopus 로고    scopus 로고
    • Role of prolactin in the modulation of NK and LAK cell activity after short- or long-term morphine administration in neoplastic patients
    • Provinciali M, Di Stefane G, Stronati S, Raffaeli W, Pari G, and Fabris N (1996) Role of prolactin in the modulation of NK and LAK cell activity after short- or long-term morphine administration in neoplastic patients. Int J Immunopharmacol 18:577-586.
    • (1996) Int J Immunopharmacol , vol.18 , pp. 577-586
    • Provinciali, M.1    Di Stefane, G.2    Stronati, S.3    Raffaeli, W.4    Pari, G.5    Fabris, N.6
  • 180
    • 0026520443 scopus 로고
    • Gene expression and localization of opioid peptides in immune cells of inflamed tissue: Functional role in antinociception
    • Przewlocki R, Hassan AH, Lason W, Epplen C, Herz A, and Stein C (1992) Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception. Neuroscience 48:491-500.
    • (1992) Neuroscience , vol.48 , pp. 491-500
    • Przewlocki, R.1    Hassan, A.H.2    Lason, W.3    Epplen, C.4    Herz, A.5    Stein, C.6
  • 181
    • 0037112041 scopus 로고    scopus 로고
    • The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats
    • Raghavendra V, Rutkowski MD, and DeLeo JA (2002) The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats. J Neurosci 22:9980-9989.
    • (2002) J Neurosci , vol.22 , pp. 9980-9989
    • Raghavendra, V.1    Rutkowski, M.D.2    DeLeo, J.A.3
  • 183
    • 0034900301 scopus 로고    scopus 로고
    • Opioid peptide-expressing leukocytes: Identification, recruitment and simultaneously increasing inhibition of inflammatory pain
    • Rittner HL, Brack A, Machelska H, Mousa SA, Bauer M, Schafer M, and Stein C (2001) Opioid peptide-expressing leukocytes: identification, recruitment and simultaneously increasing inhibition of inflammatory pain. Anesthesiology 95:500-508.
    • (2001) Anesthesiology , vol.95 , pp. 500-508
    • Rittner, H.L.1    Brack, A.2    Machelska, H.3    Mousa, S.A.4    Bauer, M.5    Schafer, M.6    Stein, C.7
  • 185
    • 0037373707 scopus 로고    scopus 로고
    • Opioid G protein-coupled receptors: Signals at the crossroads of inflammation
    • Rogers TJ and Peterson PK (2003) Opioid G protein-coupled receptors: signals at the crossroads of inflammation. Trends Immunol 24:116-121.
    • (2003) Trends Immunol , vol.24 , pp. 116-121
    • Rogers, T.J.1    Peterson, P.K.2
  • 186
    • 0033670372 scopus 로고    scopus 로고
    • Bidirectional heterologous desensitization of opioid and chemokine receptors
    • Rogers TJ, Steele AD, Howard OM, and Oppenheim JJ (2000) Bidirectional heterologous desensitization of opioid and chemokine receptors. Ann N Y Acad Sci 917:19-28.
    • (2000) Ann N Y Acad Sci , vol.917 , pp. 19-28
    • Rogers, T.J.1    Steele, A.D.2    Howard, O.M.3    Oppenheim, J.J.4
  • 188
    • 1642493592 scopus 로고    scopus 로고
    • Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet
    • Roy S, Wang J, Gupta S, Charboneau R, Loh HH, and Barke RA (2004) Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet. J Neuroimmunol 147:78-81.
    • (2004) J Neuroimmunol , vol.147 , pp. 78-81
    • Roy, S.1    Wang, J.2    Gupta, S.3    Charboneau, R.4    Loh, H.H.5    Barke, R.A.6
  • 190
    • 0037791749 scopus 로고    scopus 로고
    • Effects of in vitro and in vivo opioids on the production of IL-12 and IL-10 by murine macrophages
    • Sacerdote P (2003) Effects of in vitro and in vivo opioids on the production of IL-12 and IL-10 by murine macrophages. Ann N Y Acad Sci 992:129-140.
    • (2003) Ann N Y Acad Sci , vol.992 , pp. 129-140
    • Sacerdote, P.1
  • 191
    • 2542438557 scopus 로고    scopus 로고
    • Elevated prostaglandin EP2 receptor in endometrial adenocarcinoma cells promotes vascular endothelial growth factor expression via cyclic 3′,5′-adenosine monophosphate-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase 1/2 signaling pathways
    • Sales KJ, Maudsley S, and Jabbour HN (2004) Elevated prostaglandin EP2 receptor in endometrial adenocarcinoma cells promotes vascular endothelial growth factor expression via cyclic 3′,5′-adenosine monophosphate-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase 1/2 signaling pathways Mol Endocrinol 18:1533-1545.
    • (2004) Mol Endocrinol , vol.18 , pp. 1533-1545
    • Sales, K.J.1    Maudsley, S.2    Jabbour, H.N.3
  • 193
    • 0037177363 scopus 로고    scopus 로고
    • Morphine analgesia suppresses tumor growth and metastasis in a mouse model of cancer pain produced by orthotopic tumor inoculation
    • Sasamura T, Nakamura S, Iida Y, Fujii H, Murata J, Saiki I, Nojima H, and Kuraishi Y (2002) Morphine analgesia suppresses tumor growth and metastasis in a mouse model of cancer pain produced by orthotopic tumor inoculation. Eur J Pharmacol 441:185-191.
    • (2002) Eur J Pharmacol , vol.441 , pp. 185-191
    • Sasamura, T.1    Nakamura, S.2    Iida, Y.3    Fujii, H.4    Murata, J.5    Saiki, I.6    Nojima, H.7    Kuraishi, Y.8
  • 194
    • 1342322686 scopus 로고    scopus 로고
    • Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion
    • Schafer B, Gschwind A, and Ullrich A (2004) Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion. Oncogene 23:991-999.
    • (2004) Oncogene , vol.23 , pp. 991-999
    • Schafer, B.1    Gschwind, A.2    Ullrich, A.3
  • 195
    • 0028176173 scopus 로고
    • Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue
    • Schafer M, Carter L, and Stein C (1994) Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue. Proc Natl Acad Sci USA 91:4219-4223.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4219-4223
    • Schafer, M.1    Carter, L.2    Stein, C.3
  • 196
    • 0033962013 scopus 로고    scopus 로고
    • Involvement of mitogen-activated protein kinase in agonist-induced phosphorylation of the mu-opioid receptor in HEK 293 cells
    • Schmidt H, Schulz S, Klutzny M, Koch T, Handel M, and Hollt V (2000) Involvement of mitogen-activated protein kinase in agonist-induced phosphorylation of the mu-opioid receptor in HEK 293 cells. J Neurochem 74:414-422.
    • (2000) J Neurochem , vol.74 , pp. 414-422
    • Schmidt, H.1    Schulz, S.2    Klutzny, M.3    Koch, T.4    Handel, M.5    Hollt, V.6
  • 197
    • 0036154075 scopus 로고    scopus 로고
    • Opioid receptor types selectively cointernalize with G protein-coupled receptor kinases 2 and 3
    • Schulz R, Wehmeyer A, and Schulz K (2002) Opioid receptor types selectively cointernalize with G protein-coupled receptor kinases 2 and 3. J Pharmacol Exp Ther 300:376-384.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 376-384
    • Schulz, R.1    Wehmeyer, A.2    Schulz, K.3
  • 198
    • 0035952766 scopus 로고    scopus 로고
    • Heterotrimeric G-protein betagamma-dimers in growth and differentiation
    • Schwindinger WF and Robishaw JD (2001) Heterotrimeric G-protein betagamma-dimers in growth and differentiation. Oncogene 20:1653-1660.
    • (2001) Oncogene , vol.20 , pp. 1653-1660
    • Schwindinger, W.F.1    Robishaw, J.D.2
  • 199
    • 0027167859 scopus 로고
    • Morphine effect on proliferation of normal and tumor cells of immune origin
    • Sergeeva MG, Grishina ZV, and Varfolomeyev SD (1993) Morphine effect on proliferation of normal and tumor cells of immune origin. Immunol Lett 36:215-218.
    • (1993) Immunol Lett , vol.36 , pp. 215-218
    • Sergeeva, M.G.1    Grishina, Z.V.2    Varfolomeyev, S.D.3
  • 200
    • 0033081102 scopus 로고    scopus 로고
    • Delta opioid receptors expressed by stably transfected jurkat cells signal through the map kinase pathway in a ras-independent manner
    • Shahabi NA, Daaka Y, McAllen K, and Sharp BM (1999) Delta opioid receptors expressed by stably transfected jurkat cells signal through the map kinase pathway in a ras-independent manner. J Neuroimmunol 94:48-57.
    • (1999) J Neuroimmunol , vol.94 , pp. 48-57
    • Shahabi, N.A.1    Daaka, Y.2    McAllen, K.3    Sharp, B.M.4
  • 201
    • 0029980066 scopus 로고    scopus 로고
    • Beta-endorphin enhances Concanavalin-A-stimulated calcium mobilization by murine splenic T cells
    • Shahabi NA, Heagy W, and Sharp BM (1996) Beta-endorphin enhances Concanavalin-A-stimulated calcium mobilization by murine splenic T cells. Endocrinology 137:3386-3393.
    • (1996) Endocrinology , vol.137 , pp. 3386-3393
    • Shahabi, N.A.1    Heagy, W.2    Sharp, B.M.3
  • 202
    • 0034319144 scopus 로고    scopus 로고
    • Expression of delta opioid receptors by splenocytes from SEB-treated mice and effects on phosphorylation of MAP kinase
    • Shahabi NA, McAllen K, Matta SG, and Sharp BM (2000) Expression of delta opioid receptors by splenocytes from SEB-treated mice and effects on phosphorylation of MAP kinase. Cell Immunol 205:84-93.
    • (2000) Cell Immunol , vol.205 , pp. 84-93
    • Shahabi, N.A.1    McAllen, K.2    Matta, S.G.3    Sharp, B.M.4
  • 203
    • 0027438566 scopus 로고
    • Activation of protein kinase C rapidly down-regulates naloxone-resistant receptors for beta-endorphin on U937 cells
    • Shahabi NA and Sharp BM (1993) Activation of protein kinase C rapidly down-regulates naloxone-resistant receptors for beta-endorphin on U937 cells. J Pharmacol Exp Ther 264:276-281.
    • (1993) J Pharmacol Exp Ther , vol.264 , pp. 276-281
    • Shahabi, N.A.1    Sharp, B.M.2
  • 204
    • 0037449422 scopus 로고    scopus 로고
    • Long-term interactions between opioid and cannabinoid agonists at the cellular level: Cross-desensitization and downregulation
    • Shapira M, Gafni M, and Sarne Y (2003) Long-term interactions between opioid and cannabinoid agonists at the cellular level: cross-desensitization and downregulation. Brain Res 960:190-200.
    • (2003) Brain Res , vol.960 , pp. 190-200
    • Shapira, M.1    Gafni, M.2    Sarne, Y.3
  • 205
    • 0031659662 scopus 로고    scopus 로고
    • Delta-opioid suppression of human immunodeficiency virus-1 expression in T cells (Jurkat)
    • Sharp BM, Gekker G, Li MD, Chao CC, and Peterson PK (1998a) Delta-opioid suppression of human immunodeficiency virus-1 expression in T cells (Jurkat). Biochem Pharmacol 56:289-292.
    • (1998) Biochem Pharmacol , vol.56 , pp. 289-292
    • Sharp, B.M.1    Gekker, G.2    Li, M.D.3    Chao, C.C.4    Peterson, P.K.5
  • 206
    • 0035879358 scopus 로고    scopus 로고
    • Immunofluorescence detection of delta opioid receptors (DOR) on human peripheral blood CD4+ T cells and DOR-dependent suppression of HIV-1 expression
    • Sharp BM, McAllen K, Gekker G, Shahabi NA, and Peterson PK (2001) Immunofluorescence detection of delta opioid receptors (DOR) on human peripheral blood CD4+ T cells and DOR-dependent suppression of HIV-1 expression. J Immunol 167:1097-1102.
    • (2001) J Immunol , vol.167 , pp. 1097-1102
    • Sharp, B.M.1    McAllen, K.2    Gekker, G.3    Shahabi, N.A.4    Peterson, P.K.5
  • 207
    • 0032078291 scopus 로고    scopus 로고
    • Signaling through delta opioid receptors on murine splenic T cells and stably transfected Jurkat cells
    • Sharp BM, McKean DJ, McAllen K, and Shahabi NA (1998b) Signaling through delta opioid receptors on murine splenic T cells and stably transfected Jurkat cells. Ann N Y Acad Sci 840:420-424.
    • (1998) Ann N Y Acad Sci , vol.840 , pp. 420-424
    • Sharp, B.M.1    McKean, D.J.2    McAllen, K.3    Shahabi, N.A.4
  • 208
    • 0030945699 scopus 로고    scopus 로고
    • Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice
    • Shen KF and Grain SM (1997) Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice. Brain Res 757:176-190.
    • (1997) Brain Res , vol.757 , pp. 176-190
    • Shen, K.F.1    Grain, S.M.2
  • 209
    • 0037212376 scopus 로고    scopus 로고
    • U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant protein-1 (CCL2) production by human astrocytes
    • Sheng WS, Hu S, Lokensgard JR, and Peterson PK (2003) U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant protein-1 (CCL2) production by human astrocytes. Biochem Pharmacol 65:9-14.
    • (2003) Biochem Pharmacol , vol.65 , pp. 9-14
    • Sheng, W.S.1    Hu, S.2    Lokensgard, J.R.3    Peterson, P.K.4
  • 210
    • 0035834428 scopus 로고    scopus 로고
    • Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin
    • Shenoy SK, McDonald PH, Kohout TA, and Lefkowitz RJ (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science (Wash DC) 294:1307-1313.
    • (2001) Science (Wash DC) , vol.294 , pp. 1307-1313
    • Shenoy, S.K.1    McDonald, P.H.2    Kohout, T.A.3    Lefkowitz, R.J.4
  • 211
    • 0034791123 scopus 로고    scopus 로고
    • Activation of mu-opioid receptor induces expression of c-fos and junB via mitogen-activated protein kinase cascade
    • Shoda T, Fukuda K, Uga H, Mima H, and Morikawa H (2001) Activation of mu-opioid receptor induces expression of c-fos and junB via mitogen-activated protein kinase cascade. Anesthesiology 95:983-989.
    • (2001) Anesthesiology , vol.95 , pp. 983-989
    • Shoda, T.1    Fukuda, K.2    Uga, H.3    Mima, H.4    Morikawa, H.5
  • 212
    • 0022887158 scopus 로고
    • Morphine increases metastatic tumor growth
    • Simon RH and Arbo TE (1986) Morphine increases metastatic tumor growth. Brain Res Bull 16:363-367.
    • (1986) Brain Res Bull , vol.16 , pp. 363-367
    • Simon, R.H.1    Arbo, T.E.2
  • 214
    • 0035676919 scopus 로고    scopus 로고
    • Opiates promote T cell apoptosis through JNK and caspase pathway
    • Singhal P, Kapasi A, Reddy K, and Franki N (2001) Opiates promote T cell apoptosis through JNK and caspase pathway. Adv Exp Med Biol 493:127-135.
    • (2001) Adv Exp Med Biol , vol.493 , pp. 127-135
    • Singhal, P.1    Kapasi, A.2    Reddy, K.3    Franki, N.4
  • 215
    • 0037090092 scopus 로고    scopus 로고
    • Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis
    • Singhal PC, Bhaskaran M, Patel J, Patel K, Kasinath BS, Duraisamy S, Franki N, Reddy K, and Kapasi AA (2002) Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis. J Immunol 168:4025-4033.
    • (2002) J Immunol , vol.168 , pp. 4025-4033
    • Singhal, P.C.1    Bhaskaran, M.2    Patel, J.3    Patel, K.4    Kasinath, B.S.5    Duraisamy, S.6    Franki, N.7    Reddy, K.8    Kapasi, A.A.9
  • 216
    • 0034054677 scopus 로고    scopus 로고
    • Morphine-induced macrophage apoptosis: The role of transforming growth factor-beta
    • Singhal PC, Kapasi AA, Franki N, and Reddy K (2000) Morphine-induced macrophage apoptosis: the role of transforming growth factor-beta. Immunology 100:57-62.
    • (2000) Immunology , vol.100 , pp. 57-62
    • Singhal, P.C.1    Kapasi, A.A.2    Franki, N.3    Reddy, K.4
  • 219
    • 0029417334 scopus 로고
    • Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation
    • Stefano GB, Hartman A, Bilfinger TV, Magazine HI, Liu Y, Casares F, and Goligorsky MS (1995) Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation. J Biol Chem 270:30290-30293.
    • (1995) J Biol Chem , vol.270 , pp. 30290-30293
    • Stefano, G.B.1    Hartman, A.2    Bilfinger, T.V.3    Magazine, H.I.4    Liu, Y.5    Casares, F.6    Goligorsky, M.S.7
  • 220
    • 0025362849 scopus 로고
    • Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation
    • Stein C, Hassan AH, Przewlocki R, Gramsch C, Peter K, and Herz A (1990) Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation. Proc Natl Acad Sci USA 87:5935-5939.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 5935-5939
    • Stein, C.1    Hassan, A.H.2    Przewlocki, R.3    Gramsch, C.4    Peter, K.5    Herz, A.6
  • 221
    • 0025877383 scopus 로고
    • Morphine alters astrocyte growth in primary cultures of mouse glial cells: Evidence for a direct effect of opiates on neural maturation
    • Stiene-Martin A, Gurwell JA, and Hauser KF (1991) Morphine alters astrocyte growth in primary cultures of mouse glial cells: evidence for a direct effect of opiates on neural maturation. Brain Res Dev Brain Res 60:1-7.
    • (1991) Brain Res Dev Brain Res , vol.60 , pp. 1-7
    • Stiene-Martin, A.1    Gurwell, J.A.2    Hauser, K.F.3
  • 222
    • 0027219839 scopus 로고
    • Morphine suppresses DNA synthesis in cultured murine astrocytes from cortex, hippocampus and striatum
    • Stiene-Martin A and Hauser KF (1993) Morphine suppresses DNA synthesis in cultured murine astrocytes from cortex, hippocampus and striatum. Neurosci Lett 157:1-3.
    • (1993) Neurosci Lett , vol.157 , pp. 1-3
    • Stiene-Martin, A.1    Hauser, K.F.2
  • 224
    • 0032573361 scopus 로고    scopus 로고
    • Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-kappaB activation
    • Sueoka E, Sueoka N, Kai Y, Okabe S, Suganuma M, Kanematsu K, Yamamoto T, and Fujiki H (1998) Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-kappaB activation. Biochem Biophys Res Commun 252:566-570.
    • (1998) Biochem Biophys Res Commun , vol.252 , pp. 566-570
    • Sueoka, E.1    Sueoka, N.2    Kai, Y.3    Okabe, S.4    Suganuma, M.5    Kanematsu, K.6    Yamamoto, T.7    Fujiki, H.8
  • 225
    • 0029830205 scopus 로고    scopus 로고
    • Anti-cancer effects of morphine through inhibition of tumour necrosis factor-alpha release and mRNA expression
    • Sueoka N, Sueoka E, Okabe S, and Fujiki H (1996) Anti-cancer effects of morphine through inhibition of tumour necrosis factor-alpha release and mRNA expression. Carcinogenesis 17:2337-2341.
    • (1996) Carcinogenesis , vol.17 , pp. 2337-2341
    • Sueoka, N.1    Sueoka, E.2    Okabe, S.3    Fujiki, H.4
  • 227
    • 0037097645 scopus 로고    scopus 로고
    • Morphine promotes simian acquired immunodeficiency syndrome virus replication in monkey peripheral mononuclear cells: Induction of CC chemokine receptor 5 expression for virus entry
    • Suzuki S, Chuang AJ, Chuang LF, Doi RH, and Chuang RY (2002a) Morphine promotes simian acquired immunodeficiency syndrome virus replication in monkey peripheral mononuclear cells: induction of CC chemokine receptor 5 expression for virus entry. J Infect Dis 185:1826-1829.
    • (2002) J Infect Dis , vol.185 , pp. 1826-1829
    • Suzuki, S.1    Chuang, A.J.2    Chuang, L.F.3    Doi, R.H.4    Chuang, R.Y.5
  • 228
    • 0036430682 scopus 로고    scopus 로고
    • Interactions of opioid and chemokine receptors: Oligomerization of mu, kappa, and delta with CCR5 on immune cells
    • Suzuki S, Chuang LF, Yau P, Doi RH, and Chuang RY (2002b) Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells. Exp Cell Res 280:192-200.
    • (2002) Exp Cell Res , vol.280 , pp. 192-200
    • Suzuki, S.1    Chuang, L.F.2    Yau, P.3    Doi, R.H.4    Chuang, R.Y.5
  • 229
    • 0036679172 scopus 로고    scopus 로고
    • Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain
    • Szabo I, Chen XH, Xin L, Adler MW, Howard OM, Oppenheim JJ, and Rogers TJ (2002) Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain. Proc Natl Acad Sci USA 99: 10276-10281.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10276-10281
    • Szabo, I.1    Chen, X.H.2    Xin, L.3    Adler, M.W.4    Howard, O.M.5    Oppenheim, J.J.6    Rogers, T.J.7
  • 231
    • 0041833766 scopus 로고    scopus 로고
    • Phosphatidic acid has a potential to promote hair growth in vitro and in vivo and activates mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in hair epithelial cells
    • Takahashi T, Kamimura A, Hamazono-Matsuoka T, and Honda S (2003) Phosphatidic acid has a potential to promote hair growth in vitro and in vivo and activates mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in hair epithelial cells. J Investig Dermatol 121:448-456.
    • (2003) J Investig Dermatol , vol.121 , pp. 448-456
    • Takahashi, T.1    Kamimura, A.2    Hamazono-Matsuoka, T.3    Honda, S.4
  • 232
    • 0034785197 scopus 로고    scopus 로고
    • Endorphin and enkephalin ameliorate excessive synovial cell functions in patients with rheumatoid arthritis
    • Takeba Y, Suzuki N, Kaneko A, Asai T, and Sakane T (2001) Endorphin and enkephalin ameliorate excessive synovial cell functions in patients with rheumatoid arthritis. J Rheumatol 28:2176-2183.
    • (2001) J Rheumatol , vol.28 , pp. 2176-2183
    • Takeba, Y.1    Suzuki, N.2    Kaneko, A.3    Asai, T.4    Sakane, T.5
  • 233
    • 0036597808 scopus 로고    scopus 로고
    • The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activities
    • Takuwa Y, Takuwa N, and Sugimoto N (2002) The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities. J Biochem 131:767-771.
    • (2002) J Biochem , vol.131 , pp. 767-771
    • Takuwa, Y.1    Takuwa, N.2    Sugimoto, N.3
  • 234
    • 2342587454 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate transactivates the platelet-derived growth actor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells
    • Tanimoto T, Lungu AO, and Berk BC (2004) Sphingosine 1-phosphate transactivates the platelet-derived growth actor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. Circ Res 94:1050-1058.
    • (2004) Circ Res , vol.94 , pp. 1050-1058
    • Tanimoto, T.1    Lungu, A.O.2    Berk, B.C.3
  • 235
    • 0037446984 scopus 로고    scopus 로고
    • G protein-independent G(1) cell cycle block and apoptosis with morphine in adenocarcinoma cells: Involvement of p53 phosphorylation
    • Tegeder I, Grosch S, Schmidtko A, Haussler A, Schmidt H, Niederberger E, Scholich K, and Geisslinger G (2003) G protein-independent G(1) cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation. Cancer Res 63:1846-1852.
    • (2003) Cancer Res , vol.63 , pp. 1846-1852
    • Tegeder, I.1    Grosch, S.2    Schmidtko, A.3    Haussler, A.4    Schmidt, H.5    Niederberger, E.6    Scholich, K.7    Geisslinger, G.8
  • 237
    • 0034333221 scopus 로고    scopus 로고
    • Effects of morphine on immune response in rats with sciatic constriction injury
    • Tsai YC, Won SJ, and Lin MT (2000) Effects of morphine on immune response in rats with sciatic constriction injury. Pain 88:155-160.
    • (2000) Pain , vol.88 , pp. 155-160
    • Tsai, Y.C.1    Won, S.J.2    Lin, M.T.3
  • 238
    • 0035341402 scopus 로고    scopus 로고
    • Protein kinase C-mediated inhibition of mu-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral mu-agonist analgesia
    • Ueda H, Inoue M, and Matsumoto T (2001) Protein kinase C-mediated inhibition of mu-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral mu-agonist analgesia. J Neurosci 21:2967-2973.
    • (2001) J Neurosci , vol.21 , pp. 2967-2973
    • Ueda, H.1    Inoue, M.2    Matsumoto, T.3
  • 239
    • 0025765161 scopus 로고
    • Two opposing modes of action of beta-endorphin on lymphocyte function
    • van den Bergh P, Rozing J, and Nagelkerken L (1991) Two opposing modes of action of beta-endorphin on lymphocyte function. Immunology 72:537-543.
    • (1991) Immunology , vol.72 , pp. 537-543
    • Van Den Bergh, P.1    Rozing, J.2    Nagelkerken, L.3
  • 240
    • 0028173803 scopus 로고
    • Activated mutant of G alpha 13 induces Egr-1, c-fos, and transformation in NIH 3T3 cells
    • Vara Prasad MV, Shore SK, and Dhanasekaran N (1994) Activated mutant of G alpha 13 induces Egr-1, c-fos, and transformation in NIH 3T3 cells. Oncogene 9:2425-2429.
    • (1994) Oncogene , vol.9 , pp. 2425-2429
    • Vara Prasad, M.V.1    Shore, S.K.2    Dhanasekaran, N.3
  • 241
    • 0028100892 scopus 로고
    • Mutant alpha subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts
    • Voyno-Yasenetskaya TA, Pace AM, and Bourne HR (1994) Mutant alpha subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts. Oncogene 9:2559-2565.
    • (1994) Oncogene , vol.9 , pp. 2559-2565
    • Voyno-Yasenetskaya, T.A.1    Pace, A.M.2    Bourne, H.R.3
  • 242
    • 0033622109 scopus 로고    scopus 로고
    • Nuclear Ca2+/calmodulin translocation activated by mu-opioid (OP3) receptor
    • Wang D, Tolbert LM, Carlson KW, and Sadee W (2000) Nuclear Ca2+/calmodulin translocation activated by mu-opioid (OP3) receptor. J Neurochem 74:1418-1425.
    • (2000) J Neurochem , vol.74 , pp. 1418-1425
    • Wang, D.1    Tolbert, L.M.2    Carlson, K.W.3    Sadee, W.4
  • 243
    • 0034548719 scopus 로고    scopus 로고
    • Mu-opioid induction of monocyte chemoattractant protein-1, RANTES, and IFN-gamma-inducible protein-10 expression in human peripheral blood mononuclear cells
    • Wetzel MA, Steele AD, Eisenstein TK, Adler MW, Henderson EE, and Rogers TJ (2000) Mu-opioid induction of monocyte chemoattractant protein-1, RANTES, and IFN-gamma-inducible protein-10 expression in human peripheral blood mononuclear cells. J Immunol 165:6519-6524.
    • (2000) J Immunol , vol.165 , pp. 6519-6524
    • Wetzel, M.A.1    Steele, A.D.2    Eisenstein, T.K.3    Adler, M.W.4    Henderson, E.E.5    Rogers, T.J.6
  • 244
    • 0032544061 scopus 로고    scopus 로고
    • Morphine-activated opioid receptors elude desensitization by beta-arrestin
    • Whistler JL and von Zastrow M (1998) Morphine-activated opioid receptors elude desensitization by beta-arrestin. Proc Natl Acad Sci USA 95:9914-9919.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9914-9919
    • Whistler, J.L.1    Von Zastrow, M.2
  • 246
    • 0011204773 scopus 로고
    • Classification of multiple morphine and enkephalin binding sites in the central nervous system
    • Wolozin BL and Pasternak GW (1981) Classification of multiple morphine and enkephalin binding sites in the central nervous system. Proc Natl Acad Sci USA 78:6181-6185.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 6181-6185
    • Wolozin, B.L.1    Pasternak, G.W.2
  • 247
    • 0028998475 scopus 로고
    • Mutant alpha subunit of Gz transforms Swiss 3T3 cells
    • Wong YH, Chan JS, Yung LY, and Bourne HR (1995) Mutant alpha subunit of Gz transforms Swiss 3T3 cells. Oncogene 10:1927-1933.
    • (1995) Oncogene , vol.10 , pp. 1927-1933
    • Wong, Y.H.1    Chan, J.S.2    Yung, L.Y.3    Bourne, H.R.4
  • 248
    • 0033066830 scopus 로고    scopus 로고
    • Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice
    • Wu WR, Zheng JW, Li N, Bai HQ, Zhang KR, and Li Y (1999) Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice. Eur J Pharmacol 366:61-69.
    • (1999) Eur J Pharmacol , vol.366 , pp. 61-69
    • Wu, W.R.1    Zheng, J.W.2    Li, N.3    Bai, H.Q.4    Zhang, K.R.5    Li, Y.6
  • 249
    • 0035896001 scopus 로고    scopus 로고
    • Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization
    • Xiang B, Yu GH, Guo J, Chen L, Hu W, Pel G, and Ma L (2001) Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization. J Biol Chem 276:4709-4716.
    • (2001) J Biol Chem , vol.276 , pp. 4709-4716
    • Xiang, B.1    Yu, G.H.2    Guo, J.3    Chen, L.4    Hu, W.5    Pel, G.6    Ma, L.7
  • 250
    • 0028338743 scopus 로고
    • Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes
    • Xu N, Voyno-Yasenetskaya T, and Gutkind JS (1994) Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes. Biochem Biophys Res Commun 201:603-609.
    • (1994) Biochem Biophys Res Commun , vol.201 , pp. 603-609
    • Xu, N.1    Voyno-Yasenetskaya, T.2    Gutkind, J.S.3
  • 251
    • 0025730229 scopus 로고
    • Effect of morphine on growth of metastatic colon cancer in vivo
    • Yeager MP and Colacchio TA (1991) Effect of morphine on growth of metastatic colon cancer in vivo. Arch Surg 126:454-456.
    • (1991) Arch Surg , vol.126 , pp. 454-456
    • Yeager, M.P.1    Colacchio, T.A.2
  • 252
    • 0036138715 scopus 로고    scopus 로고
    • Intravenous fentanyl increases natural killer cell cytotoxicity and circulating CD16(+) lymphocytes in humans
    • Yeager MP, Procopio MA, DeLeo JA, Arruda JL, Hildebrandt L, and Howell AL (2002) Intravenous fentanyl increases natural killer cell cytotoxicity and circulating CD16(+) lymphocytes in humans. Anesth Analg 94:94-99.
    • (2002) Anesth Analg , vol.94 , pp. 94-99
    • Yeager, M.P.1    Procopio, M.A.2    DeLeo, J.A.3    Arruda, J.L.4    Hildebrandt, L.5    Howell, A.L.6
  • 253
    • 0033590446 scopus 로고    scopus 로고
    • Fas-mediated cell death promoted by opioids
    • Yin D, Mufson RA, Wang R, and Shi Y (1999) Fas-mediated cell death promoted by opioids. Nature (Lond) 397:218.
    • (1999) Nature (Lond) , vol.397 , pp. 218
    • Yin, D.1    Mufson, R.A.2    Wang, R.3    Shi, Y.4
  • 254
    • 0030773305 scopus 로고    scopus 로고
    • Etorphine inhibits cell growth and induces apoptosis in SK-N-SH cells: Involvement of pertussis toxin-sensitive G proteins
    • Yin DL, Ren XH, Zheng ZL, Pu L, Jiang LZ, Ma L, and Pei G (1997) Etorphine inhibits cell growth and induces apoptosis in SK-N-SH cells: involvement of pertussis toxin-sensitive G proteins. Neurosci Res 29:121-127.
    • (1997) Neurosci Res , vol.29 , pp. 121-127
    • Yin, D.L.1    Ren, X.H.2    Zheng, Z.L.3    Pu, L.4    Jiang, L.Z.5    Ma, L.6    Pei, G.7
  • 255
    • 0020565744 scopus 로고
    • Naltrexone modulates tumor response in mice with neuroblastoma
    • Zagon IS and McLaughlin PJ (1983) Naltrexone modulates tumor response in mice with neuroblastoma. Science (Wash DC) 221:671-673.
    • (1983) Science (Wash DC) , vol.221 , pp. 671-673
    • Zagon, I.S.1    McLaughlin, P.J.2
  • 257
    • 0034657746 scopus 로고    scopus 로고
    • Kappa-opioid regulation of thymocyte IL-7 receptor and C-C chemokine receptor 2 expression
    • Zhang L and Rogers TJ (2000) Kappa-opioid regulation of thymocyte IL-7 receptor and C-C chemokine receptor 2 expression. J Immunol 164:5088-5093.
    • (2000) J Immunol , vol.164 , pp. 5088-5093
    • Zhang, L.1    Rogers, T.J.2
  • 258
    • 0038645834 scopus 로고    scopus 로고
    • Ca2+-independent protein kinase Cs mediate heterologous desensitization of leukocyte chemokine receptors by opioid receptors
    • Zhang N, Hodge D, Rogers TJ, and Oppenheim JJ (2003a) Ca2+-independent protein kinase Cs mediate heterologous desensitization of leukocyte chemokine receptors by opioid receptors. J Biol Chem 278:12729-12736.
    • (2003) J Biol Chem , vol.278 , pp. 12729-12736
    • Zhang, N.1    Hodge, D.2    Rogers, T.J.3    Oppenheim, J.J.4
  • 259
    • 0042933866 scopus 로고    scopus 로고
    • A novel function of Goalpha: Mediation of extracellular signal-regulated kinase activation by opioid receptors in neural cells
    • Zhang WB, Zhang Z, Ni YX, Wu YL, and Pei G (2003b) A novel function of Goalpha: mediation of extracellular signal-regulated kinase activation by opioid receptors in neural cells. J Neurochem 86:1213-1222.
    • (2003) J Neurochem , vol.86 , pp. 1213-1222
    • Zhang, W.B.1    Zhang, Z.2    Ni, Y.X.3    Wu, Y.L.4    Pei, G.5
  • 260
    • 0031008458 scopus 로고    scopus 로고
    • Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis
    • Ziche M, Morbidelli L, Choudhuri R, Zhang HT, Donnini S, Granger HJ, and Bicknell R (1997) Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Investig 99:2625-2634.
    • (1997) J Clin Investig , vol.99 , pp. 2625-2634
    • Ziche, M.1    Morbidelli, L.2    Choudhuri, R.3    Zhang, H.T.4    Donnini, S.5    Granger, H.J.6    Bicknell, R.7
  • 261
    • 0033844780 scopus 로고    scopus 로고
    • Morphine antinociception is enhanced in mdr1a gene-deficient mice
    • Zong J and Pollack GM (2000) Morphine antinociception is enhanced in mdr1a gene-deficient mice. Pharm Res (NY) 17:749-753.
    • (2000) Pharm Res (NY) , vol.17 , pp. 749-753
    • Zong, J.1    Pollack, G.M.2


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