Pharmacokinetics and cytokine production in heroin and morphine-treated mice

International Journal of Immunopharmacology

Volumn 22, Issue 8, 2000, Pages 603-614

  Pacifici, Roberta ^a   Di Carlo, Simonetta ^a   Bacosi, Antonella ^a   Pichini, Simona ^a   Zuccaro, Piergiorgio ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Cytokine; Heroin; Mice; Morphine; Pharmacokinetics

Indexed keywords

CYTOKINE; DIAMORPHINE; ENDORPHIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 ACETATE; OPIATE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALS; CYTOKINES; HEROIN; INTERFERON TYPE II; INTERLEUKIN-2; MALE; MICE; MICE, INBRED C57BL; MORPHINE; NARCOTICS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034256959     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(00)00023-0     Document Type: Article

References (38)

1. Louria D.B., Hensle T., Rose J. The major medical complications of heroin addiction. Ann. Intern. Med. 67:1967;1-22.
2. Donahoe R.M., Falek A. Neuroimmunomodulation by opiates and other drugs of abuse: relationship to HIV infection and AIDS. Peter B. Psychological, neuropsychiatric, and substance abuse aspects of AIDS. 1988;145-158 Raven Press, New York.
3. Brown S.M., Stimmel B., Taub R.N., Kochwa S., Rosenfeld R.E. Immunologic disfunction in heroin adddicts. Arch. Intern. Med. 143:1974;1001-1006.
4. Bryant H.U., Bernton E.W., Holaday J.W. Immunomodulatory effects of chronic morphine treatment: pharmacologic and mechanistic studies. NIDA Res. Monogr. 96:1991;131-149.
5. Tubaro E., Avico U., Santiangeli C., Zuccaro P., Cavallo G., Pacifici R., Croce C., Borelli G. Morphine and methadone impact of human phagocytic physiology. Int. J. Immunopharmacol. 9:1985;865-874.
6. Yeh S.Y., McQuinn R.L., Gorodetzky C.W. Urinary excretion of heroin and its metabolites in man. J. Pharmacol. Exp. Ther. 196:1976;249-256.
7. Way E.L., Kemp J.W., Young J.M., Grassetti D.R. The pharmacologic effects of heroin in relationship to its rate of biotransformation. J. Pharmacol. Exp. Ther. 129:1960;144-154.
8. Umans J.G., Inturrisi C.E. Pharmacodynamics of subcutaneously administered diacetylmorphine, 6-acetylmorphine and morphine in mice. J. Pharmacol. Exp. Ther. 218:1981;409-415.
9. Osborne R.J., Joel S.P., Trew D., Slevin M.L. Analgesic activity of morphine-6-glucuronide. Lancet. 1:1988;828.
10. Pacifici G.M., Sawe J., Kager L., Rane A. Morphine glucuronidation in human fetal and adult liver. Eur. J. Clin. Pharmacol. 22:1982;553-558.
11. Kuo C.K., Hanioka N., Hoshikawa Y., Oguri K., Yoshimura H. Species difference of site-selective glucuronidation of morphine. J. Pharmacobio-Dyn. 14:1991;187-193.
12. Pacifici R., Pichini S., Altieri I., Caronna A., Passa A.R., Zuccaro P. High-performance liquid chromatographic-electrospray mass spectrometric determination of morphine and its 3- and 6-glucuronides: application to pharmacokinetic studies. J. Chromatogr. B. 664:1995;329-334.
13. Pacifici R., Minetti M., Zuccaro P., Pietraforte D. Morphine affects cytostatic activity of macrophages by the modulation of nitric oxide release. Int. J. Immunopharmac. 17:1995;771-777.
14. Pacifici R., Di Carlo, S., Bacosi A., Zuccaro P. Macrophage functions in drugs of abuse-treated mice. Int. J. Immunopharmac. 15:1993;711-716.
15. Pacifici R., Patrini G., Venier I., Parolaro D., Zuccaro P., Gori E. Effect of morphine and methadone acute treatment on immunological activity in mice: pharmacokinetic and pharmacodynamic correlates. J. Pharmacol. Exp. Ther. 269:1994;1112-1116.
16. Chao C.C., Molitor T.W., Close K., Hu S., Peterson P.K. Morphine inhibits the release of tumor necrosis factor in human peripheral blood mononuclear cell cultures. Int. J. Immunopharmac. 15:1993;447-453.
17. Jessop J.J., Taplits M.S. Effect of high doses of morphine on ConA-induced lymphokine production in vitro. Immunopharmacol. 22:1991;175-184.
18. Peterson P.K., Sharp B., Gekker G., Brummitt C., Keane W.F. Opioid-mediated suppression of interferon-γ production by cultured peripheral blood mononuclear cells. J. Clin. Invest. 80:1987;824-831.
19. Zuccaro P., Ricciarello R., Pichini S., Pacifici R., Altieri I., Pellegrini M., D’Ascenzo G. Simoultaneous determination of heroin, 6-monoacetylmorphine, morphine and its glucuronides by liquid chromatography-atmospheric pressure ionspray-mass spectrometry. J. Anal. Toxicol. 21:1997;268-277.
20. Thomas P.T., House R.V., Bhargava H.N. Direct cellular immunomodulation produced by diacetylmorphine (heroin) or methadone. Gen. Pharmacol. 26:1995;123-130.
21. Umans J.G., Inturrisi C.E. Heroin: analgesia, toxicity and disposition in the mouse. Eur. J. Pharmacol. 85:1982;317-323.
22. Schreurs J. Cytokines in infections disease: the battle between host and pathogene. Curr. Opinion Biotechnology. 4:1993;727-733.
23. Whiteside T.L. Cytokine measurements and interpretation of cytokine assays in human disease. J. Clin. Immunol. 14:1994;327-339.
24. Chuang L.F., Killam K.F., Chuang R.Y. Opioid defendency and T-helper cell functions in rhesus monkey. In. Vivo. 7:1993;159-166.
25. Coussons-Read M.E., Dykstra L.A., Lysle D.T. Pavlovion conditioning of morphine-induced alterations of immune status: evidence for opioid receptor involvment. J. Neuroimmunology. 55:1994;135-142.
26. Lysle D.T., Coussons M.E., Watts V.J., Bennett E.H., Dykstra L.A. Morphine-induced alterations of immune status: dose dependency, comportment specificity and antagonism by naltrexone. J. Pharmacol. Exp. Ther. 265:1993;1071-1078.
27. Fecho K., Maslonek K.A., Dykstra L.A., Lysle D.T. Assessment of the involvement of central nervous system and peripheral opioid receptors in the immunomodulatory effects of acute morphine treatment in rats. J. Pharmacol. Exp. Ther. 276:1996;626-636.
28. Chao C.C., Hu S., Molitor T.W., Zhou Y., Murtaugh M.P., Tsang M., Peterson P.K. Morphine potentiates transforming growth factor-β release from human peripheral blood mononuclear cell cultures. J. Pharmacol. Exp. Ther. 262:1992;19-24.
29. Sosroseno W., Herminajeng E. The immunoregulatory roles of transforming growth factor beta. British J. Biom. Sci. 52:1995;142-148.
30. Kut J.L., Young M.R., Crayton J.W., Wright M.A., Young M.E. Regulation of murine T-lymphocyte function by spleen cell-derived and exogenous serotonin. Immunopharmac. Immunotox. 14:1992;783-796.
31. Young M.R.I., Kut J.L., Coogan M.P., Wright M.A., Young M.E., Matthews J. Stimulation of splenic T-lymphocyte function by endogenous serotonine and by low-dose exogenous serotonine. Immunology. 80:1993;395-400.
32. Rowland R.R.R., Chukwuocha R., Tokuda S. Modulation of the in vitro murine immune response by met-enkephalin. Brain Behav. Immun. 1:1987;342-348.
33. Brown S.L., Van Epps, D.E. Opioid peptides modulate production of interferon γ by human mononuclear cells. Cell Immun. 103:1986;19-26.
34. Van den Bergh, P., Dobber R., Ramlaz S., Rozing J., Nagelkerken L. Role of opioid peptides in the regulation of cytokine production by murine CD4+ T cells. Cell. Immunol. 154:1994;109-122.
35. Roda L.G., Bongiorno L., Trani E., Urbani A., Marini M. Review paper. Positive and negative immunomodulation by opioid peptides. Int. J. Immunopharmac. 18:1996;1-16.
36. Patrini G., Massi P., Ricevuti G., Mazzone A., Fossati G., Mazzucchelli I., Gori E., Parolaro D. Changes in opioid receptor density on murine splenocytes induced by in vivo treatment with morphine and methadone. J. Pharmacol. Exp. Ther. 279:1996;172-176.
37. Carr D.J.J. Neuroendocrine peptide receptors on cells of the immune system. Chem. Immun. 52:1992;84-105.
38. Oswald I.P., Gazzinelli R.T., Sher A., James S.L. IL-10 synergizes with IL-4 and transforming growth factor beta to inhibit macrophage cytotoxic activity. J. Immunol. 148:1992;3578-3582.