μ and δ-opioid receptor agonists induce mitogen-activated protein kinase (MAPK) activation in the absence of receptor internalization

Neuropharmacology

Volumn 39, Issue 10, 2000, Pages 1707-1719

  Kramer, H Kenneth ^a   Simon, Eric J ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Concanavalin A; MAP kinase; Opioids; Phosphorylation; Receptor internalization

Indexed keywords

CONCANAVALIN A; DELTA OPIATE RECEPTOR; DELTAKEPHALIN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MITOGEN ACTIVATED PROTEIN KINASE; MORPHINE; MU OPIATE RECEPTOR; OPIATE; RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; INTERNALIZATION; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CONCANAVALIN A; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCYTOSIS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENZYME ACTIVATION; HYPERTONIC SOLUTIONS; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHINE; OLIGOPEPTIDES; PHOSPHORYLATION; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; SUCROSE; TIME FACTORS;

EID: 0034126705     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00243-9     Document Type: Article

References (54)

1. Ahn S., Maudsley S., Luttrell L.M., Lefkowitz R.J., Daaka Y. Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. Journal of Biological Chemistry. 274:1999;1185-1188.
2. 35S]thio)triphosphate binding by endogenous opioids acting at the cloned mu receptor. Journal of Pharmacological and Experimental Therapeutics. 286:1998;282-288.
3. Arden J.R., Segredo V., Wang Z., Lameh J., Sadee W. Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cells. Journal of Neurochemistry. 65:1995;1636-1645.
4. Belcheva M.M., Vogel Z., Ignatova E., Avidor-Reiss T., Zippel R., Levy R., Young E.C., Barg J., Coscia C.J. Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves G-beta/gamma subunits. Journal of Neurochemistry. 70:1998;635-645.
5. Blake A.D., Bot G., Freeman J.C., Reisine T. Differential opioid agonist regulation of the mouse mu opioid receptor. Journal of Biological Chemistry. 272:1997;782-790.
6. Blumer J.K., Johnson G.L. Diversity in function and regulation of MAP kinase pathways. Trends in Biochemical Sciences. 19:1994;236-240.
7. Budd D.C., Rae A., Tobin A.B. Activation of the mitogen-activated protein kinase pathway by a Gq/11-coupled muscarinic receptor is independent of receptor internalization. Journal of Biological Chemistry. 274:1999;12355-12360.
8. Burford N.T., Tolbert L.M., Sadee W. Specific G-protein activation and μ-opioid receptor internalization caused by morphine, DAMGO and endomorphin I. European Journal of Pharmacology. 342:1998;123-126.
9. Capeyrou R., Riond J., Corbani M., Lepage J.F., Bertin B., Emorine L.J. Agonist-induced signaling and trafficking of the μ-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain. Federation of European Biochemical Societies Letters. 415:1997;200-205.
10. 50) of an enzymatic reaction. Biochemical Pharmacology. 22:1973;3099-3108.
11. Chu P., Murray S., Lissin D., von Zastrow M. δ and κ-opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated when activated by the same alkaloid agonist. Journal of Biological Chemistry. 272:1997;27124-27130.
12. Clark M.J., Emmerson P.J., Mansour A., Akil H., Woods J.H., Portoghese P.S., Remmers A.E., Medzihradsky F. Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor. Journal of Pharmacological and Experimental Therapeutics. 283:1997;501-510.
13. Crespo P., Cachero T.G., Xu N., Gutkind J.S. Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition. Journal of Biological Chemistry. 270:1995;25259-25265.
14. Cvejic S., Trapaidze N., Cyr C., Devi L.A. Thr353, located within the COOH-terminal tail of the delta opiate receptor, is involved in receptor down-regulation. Journal of Biological Chemistry. 271:1996;4073-4076.
15. Daaka Y., Luttrell L.M., Ahn S., Della Rocca G.J., Ferguson S.S., Caron M.G., Lefkowitz R.J. Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. Journal of Biological Chemistry. 273:1998;685-688.
16. DeGraff J.L., Gagnon A.W., Benovic J.L., Orsini M.J. Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes. Journal of Biological Chemistry. 274:1999;11253-11259.
17. Della Rocca G.J., van Biesen T., Daaka Y., Luttrell D.K., Luttrell L.M., Lefkowitz R.J. Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. Journal of Biological Chemistry. 272:1997;19125-19132.
18. Fukuda K., Kato S., Morikawa H., Shoda T., Mori K. Functional coupling of the delta-, mu-, and kappa-opioid receptors to mitogen-activated protein kinase and arachidonate release in Chinese hamster ovary cells. Journal of Neurochemistry. 67:1996;1309-1316.
19. Gutkind J.S. The pathway connecting G-protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. Journal of Biological Chemistry. 273:1998;1839-1842.
20. Hausdorff W.P., Caron M.G., Lefkowitz R.J. Turning off the signal: desensitization of β-adrenergic receptor function. Federation of the American Societies of Experimental Biology Journal. 4:1990;2881-2889.
21. Hawes B.E., Fried S., Yao X., Weig B., Graziano M.P. Nociceptin (ORL-1) and mu-opioid receptors mediate mitogen-activated protein kinase activation in CHO cells through a Gi-coupled signaling pathway: evidence for distinct mechanisms of agonist-mediated desensitization. Journal of Neurochemistry. 71:1998;1024-1033.
22. Hordijk P.L., Verlaan I., van Corven E.J., Moolenaar W.H. Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway. Journal of Biological Chemistry. 269:1994;645-651.
23. Ignatova E.G., Belcheva M.M., Bohn L.M., Neuman M.C., Coscia C.J. Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: biochemical and immunofluorescence confocal microscopic evidence. Journal of Neuroscience. 19:1999;56-63.
24. Keith D.E., Anton B., Murray S.R., Zaki P.A., Chu P.C., Lissin D.V., Monteillet-Agius G., Stewart P.L., Evans C.J., von Zastrow M. Mu-opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain. Molecular Pharmacology. 53:1998;377-384.
25. Keith D.E., Murray S.R., Zaki P.A., Chu P.C., Lissin D.V., Kang L., Evans C.J., von Zastrow M. Morphine activates opioid receptors without causing their rapid internalization. Journal of Biological Chemistry. 271:1996;19021-19024.
26. Koenig J.A., Edwardson J.M. Endocytosis and recycling of G-protein-coupled receptors. Trends in Pharmacological Sciences. 18:1997;276-287.
27. Kramer H.K., Simon E.J. The role of protein kinase C (PKC) in agonist-induced μ-opioid receptor down-regulation: II. Activation and involvement of the α, ε, and ζ isoforms of PKC. Journal of Neurochemistry. 72:1999;594-604.
28. Law P.Y., Hom D.S., Loh H.H. Opiate receptor downregulation and desensitization in neuroblastoma x glioma NG108-15 hybrid cells are two cellular adaptation processes. Molecular Pharmacology. 24:1983;413-424.
29. Lefkowitz R.J. G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. Journal of Biological Chemistry. 273:1998;18677-18680.
30. Li J.G., Luo L.Y., Krupnick J.G., Benovic J.L., Liu-Chen L.Y. U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activation. Journal of Biological Chemistry. 274:1999;12087-12094.
31. Li L.Y., Chang K.J. The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors. Molecular Pharmacology. 50:1996;599-602.
32. Lopez-Ilasaca M., Crespo P., Pellici P.G., Gutkind J.S., Wetzker R. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science. 275:1997;394-397.
33. Luttrell L.M., Ferguson S.S., Daaka Y., Miller W.E., Maudsley S., Della Rocca G.J., Lin F., Kawakatsu H., Owada K., Luttrell D.K., Caron M.G., Lefkowitz R.J. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes [see comments]. Science. 283:1999;655-661.
34. Luttrell L.M., Hawes B.E., van Biesen T., Luttrell D.K., Lansing T.J., Lefkowitz R.J. Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. Journal of Biological Chemistry. 271:1996;19443-19450.
35. Mundell S.J., Kelly E. The effect of inhibitors of receptor internalization on the desensitization and resensitization of three Gs-coupled receptor responses. British Journal of Pharmacology. 125:1999;594-600.
36. Munson P.J., Rodbard D. LIGAND: a versatile computerized approach for characterization of ligand binding systems. Analytical Biochemistry. 107:1980;220-239.
37. Polakiewicz R.D., Schieferl S.M., Dorner L.F., Kansra V., Comb M.J. A mitogen-activated protein kinase pathway is required for mu-opioid receptor desensitization. Journal of Biological Chemistry. 273:1998;12402-12406.
38. Ptasznik A., Traynor-Kaplan A., Bokoch G.M. G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase Shc adapter protein signaling complexes. Journal of Biological Chemistry. 270:1995;19969-19973.
39. Schramm N.L., Limbird L.E. Stimulation of mitogen-activated protein kinase by G protein-coupled 2-adrenergic receptors does not require agonist-elicited endocytosis. Journal of Biological Chemistry. 274:1999;24935-24940.
40. Segal R.A., Greenberg M.E. Intracellular signaling pathways activated by neurotrophic factors. Annual Reviews in Neuroscience. 19:1996;463-489.
41. Seger R., Krebs E.G. The MAPK signaling cascade. Federation of the American Societies of Experimental Biology Journal. 9:1995;726-735.
42. Segredo V., Burford N.T., Lameh J., Sadee W. A constitutively internalizing and recycling mutant of the mu-opioid receptor. Journal of Neurochemistry. 68:1997;2395-2404.
43. Shahabi N.A., Daaka Y., McAllen K., Sharp B.M. Delta opioid receptors expressed by stably transfected jurkat cells signal through the map kinase pathway in a ras-independent manner. Journal of Neuroimmunology. 94:1999;48-57.
44. Slowiejko D.M., Fisher S.K. Radioligand binding measurement of receptor sequestration in intact and permeabilized cells. Challiss R.A.J. Receptor Signal Transduction Protocols. vol. 83:1997;243-251 Humana Press, Totowa, New Jersey.
45. 2+ from intracellular stores, in undifferentiated Ng108-15 cells. Journal of Neurochemistry. 66:1996;1462-1467.
46. 2A cells by activation of multiple opioid receptor subtypes. Biochemical Pharmacology. 54:1997;809-818.
47. Standifer K.M., Pasternak G.W. G proteins and opioid receptor-mediated signalling. Cellular Signalling. 9:1997;237-248.
48. Trapaidze N., Keith D.E., Cvejic S., Evans C.J., Devi L.A. Sequestration of the delta opioid receptor. Role of the C terminus in agonist-mediated internalization. Journal of Biological Chemistry. 271:1996;29279-29285.
49. Ueda H. Opioid receptor signal transduction in narcotic tolerance and dependence. NIDA Research Monographs. 162:1996;64-66.
50. van Biesen T., Hawes B.E., Luttrell D.K., Krueger K.M., Touhara K., Porfiri E., Sakaue M., Luttrell L.M., Lefkowitz R.J. Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway [see comments]. Nature. 376:1995;781-784.
51. Whistler J.L., von Zastrow M. Morphine-activated opioid receptors elude desensitization by β-arrestin. Journal of Biological Chemistry. 95:1998;9914-9919.
52. Whistler J.L., von Zastrow M. Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction. Journal of Biological Chemistry. 274:1999;24575-24578.
53. Zhang J., Ferguson S.S.G., Barak L.S., Bodduluri S.R., Laporte S.A., Law P.-Y., Caron M.G. Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness. Proceedings of the National Academy of Sciences, USA. 95:1998;7157-7162.
54. Zhang L., Yu Y., Mackin S., Weight F.F., Uhl G.R., Wang J.B. Differential mu opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters. Journal of Biological Chemistry. 271:1996;11449-11454.