메뉴 건너뛰기




Volumn 111, Issue 9, 2003, Pages 1329-1338

Anti-inflammatory properties of the μ opioid receptor support its use in the treatment of colon inflammation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CD4 ANTIGEN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; NALOXONE; OPIATE ANTAGONIST; TRINITROBENZENESULFONIC ACID; TYROSYL DEXTRO ARGINYLPHENYLALANYLLYSINAMIDE;

EID: 0037651166     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200316750     Document Type: Article
Times cited : (172)

References (84)
  • 2
    • 0035854428 scopus 로고    scopus 로고
    • Regional mu opioid receptor regulation of sensory and affective dimensions of pain
    • Zubieta, J.K., et al. 2001. Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science. 293:311-315.
    • (2001) Science , vol.293 , pp. 311-315
    • Zubieta, J.K.1
  • 3
    • 0020965003 scopus 로고
    • Antisecretory activity of opiates in vitro and in vivo in man
    • Turnberg, L.A. 1983. Antisecretory activity of opiates in vitro and in vivo in man. Scand. J. Gastroenterol. Suppl. 84:79-83.
    • (1983) Scand. J. Gastroenterol. Suppl. , vol.84 , pp. 79-83
    • Turnberg, L.A.1
  • 4
    • 0034681364 scopus 로고    scopus 로고
    • Effects of mu-opioid receptor agonists on intestinal secretion and permeability during acute intestinal inflammation in mice
    • Valle, L., Puig, M.M., and Pol, O. 2000. Effects of mu-opioid receptor agonists on intestinal secretion and permeability during acute intestinal inflammation in mice. Eur. J. Pharmacol. 389:235-242.
    • (2000) Eur. J. Pharmacol. , vol.389 , pp. 235-242
    • Valle, L.1    Puig, M.M.2    Pol, O.3
  • 5
    • 0017135212 scopus 로고
    • Opiates and intestinal secretion
    • Boyd, C.A. 1976. Opiates and intestinal secretion. Lancet. 2:1085.
    • (1976) Lancet , vol.2 , pp. 1085
    • Boyd, C.A.1
  • 6
    • 0017081520 scopus 로고
    • Loperamide: A new antidiarrheal agent in the treatment of chronic diarrhea
    • Galambos, J.T., Hersh, T., Schroder, S., and Wenger, J. 1976. Loperamide: a new antidiarrheal agent in the treatment of chronic diarrhea. Gastroenterology. 70:1026-1029.
    • (1976) Gastroenterology , vol.70 , pp. 1026-1029
    • Galambos, J.T.1    Hersh, T.2    Schroder, S.3    Wenger, J.4
  • 7
    • 0031012416 scopus 로고    scopus 로고
    • Effects of loperamide oxide on gastrointestinal transit time and anorectal function in patients with chronic diarrhoea and faecal incontinence
    • Sun, W.M., Read, N.W., and Verlinden, M. 1997. Effects of loperamide oxide on gastrointestinal transit time and anorectal function in patients with chronic diarrhoea and faecal incontinence. Scand. J. Gastroenterol. 32:34-38.
    • (1997) Scand. J. Gastroenterol. , vol.32 , pp. 34-38
    • Sun, W.M.1    Read, N.W.2    Verlinden, M.3
  • 8
    • 0032042138 scopus 로고    scopus 로고
    • Beta-endorphin in immune cells
    • Blalock, J.E. 1998. Beta-endorphin in immune cells. Immunol. Today. 19:191-192.
    • (1998) Immunol. Today , vol.19 , pp. 191-192
    • Blalock, J.E.1
  • 9
    • 0030814120 scopus 로고    scopus 로고
    • Immune cell-derived beta-endorphin. Production, release, and control of inflammatory pain in rats
    • Cabot, P.J., et al. 1997. Immune cell-derived beta-endorphin. Production, release, and control of inflammatory pain in rats. J. Clin. Invest. 100:142-148.
    • (1997) J. Clin. Invest. , vol.100 , pp. 142-148
    • Cabot, P.J.1
  • 10
    • 0032520651 scopus 로고    scopus 로고
    • Opiate binding sites in the cellular immune system: Expression and regulation
    • Madden, J.J., Whaley, W.L., and Ketelsen, D. 1998. Opiate binding sites in the cellular immune system: expression and regulation. J. Neuroimmunol. 83:57-62.
    • (1998) J. Neuroimmunol. , vol.83 , pp. 57-62
    • Madden, J.J.1    Whaley, W.L.2    Ketelsen, D.3
  • 11
    • 0028840583 scopus 로고
    • Mu opioid receptor gene expression in immune cells
    • Chuang, T.K., et al. 1995. Mu opioid receptor gene expression in immune cells. Biochem. Biophys. Res. Commun. 216:922-930.
    • (1995) Biochem. Biophys. Res. Commun. , vol.216 , pp. 922-930
    • Chuang, T.K.1
  • 12
    • 0034456973 scopus 로고    scopus 로고
    • Involvement of central mu- but not delta- or kappa-opioid receptors in immunomodulation
    • Nelson, C.J., Schneider, G.M., and Lysle, D.T. 2000. Involvement of central mu- but not delta- or kappa-opioid receptors in immunomodulation. Brain Behav. Immun. 14:170-184.
    • (2000) Brain Behav. Immun. , vol.14 , pp. 170-184
    • Nelson, C.J.1    Schneider, G.M.2    Lysle, D.T.3
  • 13
    • 9544233532 scopus 로고    scopus 로고
    • Opioid and opiate immunoregulatory processes
    • Stefano, G.B., et al. 1996. Opioid and opiate immunoregulatory processes. Crit. Rev. Immunol. 16:109-144
    • (1996) Crit. Rev. Immunol. , vol.16 , pp. 109-144
    • Stefano, G.B.1
  • 15
    • 0242456263 scopus 로고    scopus 로고
    • Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site
    • Kraus, J., et al. 2001. Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site. J. Biol. Chem. 276:43901-43908.
    • (2001) J. Biol. Chem. , vol.276 , pp. 43901-43908
    • Kraus, J.1
  • 16
    • 0031010973 scopus 로고    scopus 로고
    • Antinociceptive and immunosuppressive effects of opiate drugs: A structure-related activity study
    • Sacerdote, P., Manfredi, B., Mantegazza, P., and Panerai, A.E. 1997. Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study. Br. J. Pharmacol. 121:834-840.
    • (1997) Br. J. Pharmacol. , vol.121 , pp. 834-840
    • Sacerdote, P.1    Manfredi, B.2    Mantegazza, P.3    Panerai, A.E.4
  • 17
    • 0033675548 scopus 로고    scopus 로고
    • The opioid antagonist naloxone induces a shift from type 2 to type 1 cytokine pattern in normal and skin-grafted mice
    • Sacerdote, P., Gaspani, L., and Panerai, A.E. 2000. The opioid antagonist naloxone induces a shift from type 2 to type 1 cytokine pattern in normal and skin-grafted mice. Ann. N. Y. Acad. Sci. 917:755-763.
    • (2000) Ann. N. Y. Acad. Sci. , vol.917 , pp. 755-763
    • Sacerdote, P.1    Gaspani, L.2    Panerai, A.E.3
  • 18
    • 0029417155 scopus 로고
    • Recent advances in molecular recognition and signal transduction of active peptides: Receptors for opioid peptides
    • Kieffer, B.L. 1995. Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides. Cell. Mol. Neurobiol. 15:615-635.
    • (1995) Cell. Mol. Neurobiol. , vol.15 , pp. 615-635
    • Kieffer, B.L.1
  • 19
    • 0027999375 scopus 로고
    • Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study
    • Mansour, A., et al. 1994. Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study. J. Comp. Neurol. 350:412-438.
    • (1994) J. Comp. Neurol. , vol.350 , pp. 412-438
    • Mansour, A.1
  • 20
    • 0029058036 scopus 로고
    • Immunohistochemical localization of the cloned mu opioid receptor in the rat CNS
    • Mansour, A., Fox, C.A., Burke, S., Akil, H., and Watson, SJ. 1995. Immunohistochemical localization of the cloned mu opioid receptor in the rat CNS. J. Chem. Neuroanat. 8:283-305.
    • (1995) J. Chem. Neuroanat. , vol.8 , pp. 283-305
    • Mansour, A.1    Fox, C.A.2    Burke, S.3    Akil, H.4    Watson, S.J.5
  • 21
    • 0030821574 scopus 로고    scopus 로고
    • Opioid receptors on peripheral sensory axons
    • Coggeshall, R.E., Zhou, S., and Carlton, S.M. 1997. Opioid receptors on peripheral sensory axons. Brain Res. 764:126-132.
    • (1997) Brain Res. , vol.764 , pp. 126-132
    • Coggeshall, R.E.1    Zhou, S.2    Carlton, S.M.3
  • 22
    • 0034814691 scopus 로고    scopus 로고
    • Receptors and transmission in the brain-gut axis: Potential for novel therapies. III. Mu-opioid receptors in the enteric nervous system
    • Sternini, C. 2001. Receptors and transmission in the brain-gut axis: potential for novel therapies. III. Mu-opioid receptors in the enteric nervous system. Am. J. Physiol. Gastrointest. Liver Physiol. 281:G8-G15.
    • (2001) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.281
    • Sternini, C.1
  • 23
  • 24
    • 0031559923 scopus 로고    scopus 로고
    • Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract
    • Bagnol, D., Mansour, A., Akil, H., and Watson, S.J. 1997. Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract. Neuroscience. 81:579-591.
    • (1997) Neuroscience , vol.81 , pp. 579-591
    • Bagnol, D.1    Mansour, A.2    Akil, H.3    Watson, S.J.4
  • 25
    • 0032520733 scopus 로고    scopus 로고
    • Opioid modulation of immune responses: Effects on phagocyte and lymphoid cell populations
    • Eisenstein, T.K., and Hilburger, M.E. 1998. Opioid modulation of immune responses: effects on phagocyte and lymphoid cell populations. J. Neuroimmunol. 83:36-44.
    • (1998) J. Neuroimmunol. , vol.83 , pp. 36-44
    • Eisenstein, T.K.1    Hilburger, M.E.2
  • 26
    • 0025756935 scopus 로고
    • N-acetyl-beta-endorphinl-31 antagonizes the suppressive effect of beta-endorphin1-31 on murine splenocyte proliferation via a naloxone-resistant receptor
    • Shahabi, N.A., Burtness, M.Z., and Sharp, B.M. 1991. N-acetyl-beta-endorphinl-31 antagonizes the suppressive effect of beta-endorphin1-31 on murine splenocyte proliferation via a naloxone-resistant receptor. Biochem. Biophys. Res. Commun. 175:936-942.
    • (1991) Biochem. Biophys. Res. Commun. , vol.175 , pp. 936-942
    • Shahabi, N.A.1    Burtness, M.Z.2    Sharp, B.M.3
  • 27
    • 0028987312 scopus 로고
    • The beta-endorphin inhibition of mitogen-induced splenocytes proliferation is mediated by central and peripheral paracrine/autocrine effects of the opioid
    • Panerai, A.E., Manfredi, B., Granucci, F., and Sacerdote, P. 1995. The beta-endorphin inhibition of mitogen-induced splenocytes proliferation is mediated by central and peripheral paracrine/autocrine effects of the opioid. J. Neuroimmunol. 58:71-76.
    • (1995) J. Neuroimmunol. , vol.58 , pp. 71-76
    • Panerai, A.E.1    Manfredi, B.2    Granucci, F.3    Sacerdote, P.4
  • 28
    • 0021342185 scopus 로고
    • Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity
    • Shavit, Y., Lewis, J.W., Terman, G.W., Gale, R.P., and Liebeskind, J.C. 1984. Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity. Science. 223:188-190.
    • (1984) Science , vol.223 , pp. 188-190
    • Shavit, Y.1    Lewis, J.W.2    Terman, G.W.3    Gale, R.P.4    Liebeskind, J.C.5
  • 29
    • 0025272151 scopus 로고
    • Corticotropin-releasing hormone augments natural killer cell activity through a naloxone-sensitive pathway
    • Carr, D.J., DeCosta, B.R., Jacobson, A.E., Rice, K.C., and Blalock, J.E. 1990. Corticotropin-releasing hormone augments natural killer cell activity through a naloxone-sensitive pathway. J. Neuroimmunol. 28:53-61.
    • (1990) J. Neuroimmunol. , vol.28 , pp. 53-61
    • Carr, D.J.1    DeCosta, B.R.2    Jacobson, A.E.3    Rice, K.C.4    Blalock, J.E.5
  • 30
    • 0031058917 scopus 로고    scopus 로고
    • Effect of morphine on lipopolysaccharide-induced tumor necrosis factor-alpha production in vivo: Involvement of the sympathetic nervous system
    • Bencsics, A., Elenkov, I.J., and Vizi, E.S. 1997. Effect of morphine on lipopolysaccharide-induced tumor necrosis factor-alpha production in vivo: involvement of the sympathetic nervous system. J. Neuroimmunol. 73:1-6.
    • (1997) J. Neuroimmunol. , vol.73 , pp. 1-6
    • Bencsics, A.1    Elenkov, I.J.2    Vizi, E.S.3
  • 31
    • 0031668176 scopus 로고    scopus 로고
    • The opiate sufentanil alters the inflammatory, endocrine, and metabolic responses to endotoxin in dogs
    • Moenitalam, H.S., et al. 1998. The opiate sufentanil alters the inflammatory, endocrine, and metabolic responses to endotoxin in dogs. Am. J. Physiol. 275:E440-E447.
    • (1998) Am. J. Physiol. , vol.275
    • Moenitalam, H.S.1
  • 32
    • 0033103748 scopus 로고    scopus 로고
    • Morphine synergizes with lipopolysaccharide in a chronic endotoxemia model
    • Roy, S., Charboneau, R.G., and Barke, R.A. 1999. Morphine synergizes with lipopolysaccharide in a chronic endotoxemia model. J. Neuroimmunol. 95:107-114.
    • (1999) J. Neuroimmunol. , vol.95 , pp. 107-114
    • Roy, S.1    Charboneau, R.G.2    Barke, R.A.3
  • 33
    • 0023039386 scopus 로고
    • Opioid peptides modulate production of interferon gamma by human mononuclear cells
    • Brown, S.L., and Van Epps, D.E. 1986. Opioid peptides modulate production of interferon gamma by human mononuclear cells. Cell. Immunol. 103:19-26.
    • (1986) Cell. Immunol. , vol.103 , pp. 19-26
    • Brown, S.L.1    Van Epps, D.E.2
  • 34
    • 0034654402 scopus 로고    scopus 로고
    • The opioid antagonist naloxone induces a shift from type 2 to type 1 cytokine pattern in BALB/cJ mice
    • Sacerdote, P., Manfredi, B., Gaspani, L., and Panerai, A.E. 2000. The opioid antagonist naloxone induces a shift from type 2 to type 1 cytokine pattern in BALB/cJ mice. Blood. 95:2031-2036.
    • (2000) Blood , vol.95 , pp. 2031-2036
    • Sacerdote, P.1    Manfredi, B.2    Gaspani, L.3    Panerai, A.E.4
  • 36
    • 0032811903 scopus 로고    scopus 로고
    • Hypothalamic beta-endorphin concentrations are decreased in animal models of autoimmune disease
    • Sacerdote, P., Lechner, O., Sidman, C., Wick, G., and Panerai, A.E. 1999. Hypothalamic beta-endorphin concentrations are decreased in animal models of autoimmune disease. Ann. N. Y. Acad. Sci. 876:305-308.
    • (1999) Ann. N. Y. Acad. Sci. , vol.876 , pp. 305-308
    • Sacerdote, P.1    Lechner, O.2    Sidman, C.3    Wick, G.4    Panerai, A.E.5
  • 37
    • 0032915101 scopus 로고    scopus 로고
    • Hypothalamic beta-endorphin concentrations are decreased in animals models of autoimmune disease
    • Sacerdote, P., Lechner, O., Sidman, C., Wick, G., and Panerai, A.E. 1999. Hypothalamic beta-endorphin concentrations are decreased in animals models of autoimmune disease. J. Neuroimmunol. 97:129-133.
    • (1999) J. Neuroimmunol. , vol.97 , pp. 129-133
    • Sacerdote, P.1    Lechner, O.2    Sidman, C.3    Wick, G.4    Panerai, A.E.5
  • 38
    • 0035795077 scopus 로고    scopus 로고
    • beta-endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue
    • Mousa, S.A., Zhang, Q., Sitte, N., Ji, R., and Stein, C. 2001. beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue. J. Neuroimmunol. 115:71-78.
    • (2001) J. Neuroimmunol. , vol.115 , pp. 71-78
    • Mousa, S.A.1    Zhang, Q.2    Sitte, N.3    Ji, R.4    Stein, C.5
  • 39
    • 0024153212 scopus 로고
    • Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: Alterations in behavior and nociceptive thresholds
    • Stein, C., Millan, M.J., and Herz, A. 1988. Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: alterations in behavior and nociceptive thresholds. Pharmacol. Biochem. Behav. 31:451-455.
    • (1988) Pharmacol. Biochem. Behav. , vol.31 , pp. 451-455
    • Stein, C.1    Millan, M.J.2    Herz, A.3
  • 40
    • 0023550490 scopus 로고
    • Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat
    • Stein, C., Millan, M.J., Shippenberg, T.S., and Herz, A. 1988. Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat. Neurosci. Lett. 84:225-228.
    • (1988) Neurosci. Lett. , vol.84 , pp. 225-228
    • Stein, C.1    Millan, M.J.2    Shippenberg, T.S.3    Herz, A.4
  • 41
    • 0035794293 scopus 로고    scopus 로고
    • Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies
    • Desreumaux, P., et al. 2001. Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies. J. Exp. Med. 193:827-838.
    • (2001) J. Exp. Med. , vol.193 , pp. 827-838
    • Desreumaux, P.1
  • 42
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux, H., et al. 1997. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 389:737-742.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1
  • 43
    • 0030818051 scopus 로고    scopus 로고
    • Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice
    • Neurath, M.F., et al. 1997. Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice. Eur J. Immunol. 27:1743-1750.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1743-1750
    • Neurath, M.F.1
  • 44
    • 0028519015 scopus 로고
    • Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
    • Powrie, F., et al. 1994. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity. 1:553-562.
    • (1994) Immunity , vol.1 , pp. 553-562
    • Powrie, F.1
  • 45
    • 0034005581 scopus 로고    scopus 로고
    • Role of cytokines in the pathogenesis of inflammatory bowel disease
    • Papadakis, K.A., and Targan, S.R. 2000. Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu. Rev. Med. 51:289-298.
    • (2000) Annu. Rev. Med. , vol.51 , pp. 289-298
    • Papadakis, K.A.1    Targan, S.R.2
  • 46
    • 0030267661 scopus 로고    scopus 로고
    • Persistent clonal expansions of peripheral blood CD4+ lymphocytes in chronic inflammatory bowel disease
    • Probert, C.S., et al. 1996. Persistent clonal expansions of peripheral blood CD4+ lymphocytes in chronic inflammatory bowel disease. J. Immunol. 157:3183-3191.
    • (1996) J. Immunol. , vol.157 , pp. 3183-3191
    • Probert, C.S.1
  • 47
    • 0029979529 scopus 로고    scopus 로고
    • Increased frequency of abnormal gamma delta T cells in blood of patients with inflammatory bowel diseases
    • Soderstrom, K., et al. 1996. Increased frequency of abnormal gamma delta T cells in blood of patients with inflammatory bowel diseases. J. Immunol. 156:2331-2339.
    • (1996) J. Immunol. , vol.156 , pp. 2331-2339
    • Soderstrom, K.1
  • 48
    • 0028149834 scopus 로고
    • Increase of circulating gamma/delta T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease
    • Giacomelli, R., et al. 1994. Increase of circulating gamma/delta T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease. Clin. Exp. Immunol. 98:83-88.
    • (1994) Clin. Exp. Immunol. , vol.98 , pp. 83-88
    • Giacomelli, R.1
  • 49
    • 0024508329 scopus 로고
    • Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely high mu opioid receptor selectivity
    • Schiller, P.W., Nguyen, T.M., Chung, N.N., and Lemieux, C. 1989. Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely high mu opioid receptor selectivity. J. Med. Chem. 32:698-703.
    • (1989) J. Med. Chem. , vol.32 , pp. 698-703
    • Schiller, P.W.1    Nguyen, T.M.2    Chung, N.N.3    Lemieux, C.4
  • 50
    • 0019395141 scopus 로고
    • Analogues of beta-LPH61-64 possessing selective agonist activity at mu-opiate receptors
    • Handa, B.K., et al. 1981. Analogues of beta-LPH61-64 possessing selective agonist activity at mu-opiate receptors. Eur. J. Pharmacol. 70:531-540.
    • (1981) Eur. J. Pharmacol. , vol.70 , pp. 531-540
    • Handa, B.K.1
  • 51
    • 17744416149 scopus 로고
    • TyPD-Ala-Gly-MePhe-Gly-ol is a selective ligand for the μ-opiate binding site
    • Abstr.
    • Kosterlitz, H.W., and Paterson, S.J. 1981. TyPD-Ala-Gly-MePhe-Gly-ol is a selective ligand for the μ-opiate binding site. Br. J. Pharmacol. 73:299P. (Abstr.)
    • (1981) Br. J. Pharmacol. , vol.73
    • Kosterlitz, H.W.1    Paterson, S.J.2
  • 52
    • 0027950804 scopus 로고
    • Blood-brain barrier transport of neuropeptides: Analysis with a metabolically stable dermorphin analogue
    • Samii, A., Bickel, U., Stroth, U., and Patdridge, W.M. 1994. Blood-brain barrier transport of neuropeptides: analysis with a metabolically stable dermorphin analogue. Am. J. Physiol. 267:E124-E131.
    • (1994) Am. J. Physiol. , vol.267
    • Samii, A.1    Bickel, U.2    Stroth, U.3    Patdridge, W.M.4
  • 53
    • 0026671412 scopus 로고
    • Effect of brain lesions on [3H]ohmefentanyl binding site densities in the rat striatum and substantia nigra
    • Masuo, Y., Wang, H., Pelaprat, D., Chi, Z.Q., and Rostene, W. 1992. Effect of brain lesions on [3H]ohmefentanyl binding site densities in the rat striatum and substantia nigra. Chem. Pharm. Bull. (Tokyo). 40:2520-2524.
    • (1992) Chem. Pharm. Bull. (Tokyo) , vol.40 , pp. 2520-2524
    • Masuo, Y.1    Wang, H.2    Pelaprat, D.3    Chi, Z.Q.4    Rostene, W.5
  • 54
    • 0025289189 scopus 로고
    • Quaternary naloxone blocks morphine analgesia in spinal but not intact rats
    • Milne, R.J., Coddington, J.M., and Gamble, G.D. 1990. Quaternary naloxone blocks morphine analgesia in spinal but not intact rats. Neurosci. Lett. 114:259-264.
    • (1990) Neurosci. Lett. , vol.114 , pp. 259-264
    • Milne, R.J.1    Coddington, J.M.2    Gamble, G.D.3
  • 55
    • 0028930240 scopus 로고
    • Peripheral opioid modulation of pain and inflammation in the formalin test
    • Hong, Y., and Abbott, F.V. 1995. Peripheral opioid modulation of pain and inflammation in the formalin test. Eur. J. Pharmacol. 277:21-28.
    • (1995) Eur. J. Pharmacol. , vol.277 , pp. 21-28
    • Hong, Y.1    Abbott, F.V.2
  • 56
    • 0029852678 scopus 로고    scopus 로고
    • Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene
    • Matthes, H.W., et al. 1996. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature. 383:819-823.
    • (1996) Nature , vol.383 , pp. 819-823
    • Matthes, H.W.1
  • 57
    • 0024584951 scopus 로고
    • Inhibition of leukocriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease
    • Wallace, J.L., MacNaughton, W.K., Morris, G.P., and Beck, P.L. 1989. Inhibition of leukocriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease. Gastroenterology. 96:29-36.
    • (1989) Gastroenterology , vol.96 , pp. 29-36
    • Wallace, J.L.1    MacNaughton, W.K.2    Morris, G.P.3    Beck, P.L.4
  • 58
    • 9844228499 scopus 로고    scopus 로고
    • Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor alpha production in trinitrobenzene sulphonic acid induced colitis
    • Ameho, C.K, et al. 1997. Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor alpha production in trinitrobenzene sulphonic acid induced colitis. Gut. 41:487-493.
    • (1997) Gut , vol.41 , pp. 487-493
    • Ameho, C.K.1
  • 59
    • 0030835678 scopus 로고    scopus 로고
    • The organization, promoter analysis, and expression of the human PPARγ gene
    • Fajas, L., et al. 1997. The organization, promoter analysis, and expression of the human PPARγ gene. J. Biol. Chem. 272:18779-18789.
    • (1997) J. Biol. Chem , vol.272 , pp. 18779-18789
    • Fajas, L.1
  • 60
    • 0028179230 scopus 로고
    • Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity
    • Powrie, F., Correa-Oliveira, R., Mauze, S., and Coffman, R.L. 1994. Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp Med. 179:589-600.
    • (1994) J. Exp Med. , vol.179 , pp. 589-600
    • Powrie, F.1    Correa-Oliveira, R.2    Mauze, S.3    Coffman, R.L.4
  • 61
    • 0027517545 scopus 로고
    • Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
    • Powrie, F., Leach, M.W., Mauze, S., Caddle, L.B., and Coffman, R.L. 1993. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 5:1461-1471.
    • (1993) Int. Immunol. , vol.5 , pp. 1461-1471
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Caddle, L.B.4    Coffman, R.L.5
  • 62
    • 0034193039 scopus 로고    scopus 로고
    • IL-6 is required for the development of Th1 cell-mediated murine colitis
    • Yamamoto, M., Yoshizaki, K., Kishimoto, T., and Ito, H. 2000. IL-6 is required for the development of Th1 cell-mediated murine colitis. J. Immunol. 164:4878-4882.
    • (2000) J. Immunol. , vol.164 , pp. 4878-4882
    • Yamamoto, M.1    Yoshizaki, K.2    Kishimoto, T.3    Ito, H.4
  • 63
    • 0031760741 scopus 로고    scopus 로고
    • Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis
    • Mackay, F., et al. 1998. Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis. Gastroenterology. 115:1464-1475.
    • (1998) Gastroenterology , vol.115 , pp. 1464-1475
    • Mackay, F.1
  • 64
    • 0034931947 scopus 로고    scopus 로고
    • CD28+ intraepithelial lymphocytes with long telomeres are recruited within the inflamed ileal mucosa in Crohn disease
    • Meresse, B., et al. 2001. CD28+ intraepithelial lymphocytes with long telomeres are recruited within the inflamed ileal mucosa in Crohn disease. Hum. Immunol. 62:694-700.
    • (2001) Hum. Immunol. , vol.62 , pp. 694-700
    • Meresse, B.1
  • 65
    • 0033040282 scopus 로고    scopus 로고
    • Inflammatory alterations in mesenteric adipose tissue in Crohn's disease
    • Desreumaux, P., et al. 1999. Inflammatory alterations in mesenteric adipose tissue in Crohn's disease. Gastroenterology. 117:73-81.
    • (1999) Gastroenterology , vol.117 , pp. 73-81
    • Desreumaux, P.1
  • 66
    • 17044445736 scopus 로고    scopus 로고
    • Streptococcal pyrogenic exotoxin A (SPE A) superantigen induced production of hematopoietic cytokines, IL-12 and IL-13 by human peripheral blood mononuclear cells
    • Müller-Alouf, H., et al. 1997. Streptococcal pyrogenic exotoxin A (SPE A) superantigen induced production of hematopoietic cytokines, IL-12 and IL-13 by human peripheral blood mononuclear cells. Microb Pathog. 23:265-272.
    • (1997) Microb. Pathog. , vol.23 , pp. 265-272
    • Müller-Alouf, H.1
  • 67
    • 18744425752 scopus 로고    scopus 로고
    • Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease
    • Desreumaux, P., et al. 1997. Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease. Gastroenterology. 113:118-126.
    • (1997) Gastroenterology , vol.113 , pp. 118-126
    • Desreumaux, P.1
  • 68
    • 0034763961 scopus 로고    scopus 로고
    • Inflammation enhances μ-opioid receptor transcription and expression in mice intestine
    • Pol, O., Alameda, F., and Puig, M.M. 2001. Inflammation enhances μ-opioid receptor transcription and expression in mice intestine. Mol. Pharmacol. 60:894-899.
    • (2001) Mol. Pharmacol. , vol.60 , pp. 894-899
    • Pol, O.1    Alameda, F.2    Puig, M.M.3
  • 69
    • 0031836135 scopus 로고    scopus 로고
    • Urinary 8-hydroxydeoxyguanosine excretion as a non-invasive marker of neutrophil activation in animal models of inflammatory bowel disease
    • Dykens, J.A., and Baginski, T.J. 1998. Urinary 8-hydroxydeoxyguanosine excretion as a non-invasive marker of neutrophil activation in animal models of inflammatory bowel disease. Scand. J. Gastroenterol. 33:628-636.
    • (1998) Scand. J. Gastroenterol. , vol.33 , pp. 628-636
    • Dykens, J.A.1    Baginski, T.J.2
  • 70
    • 0033584928 scopus 로고    scopus 로고
    • Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBotzinger complex
    • Gray, P.A., Rekling, J C., Bocchiaro, C.M., and Feldman, J.L. 1999. Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBotzinger complex. Science. 286:1566-1568.
    • (1999) Science , vol.286 , pp. 1566-1568
    • Gray, P.A.1    Rekling, J.C.2    Bocchiaro, C.M.3    Feldman, J.L.4
  • 71
    • 0031555402 scopus 로고    scopus 로고
    • Actions ofopioids on respiratory, activity, via activation of brainstem mudelta- and kappa-receptors; an in vitro study
    • Takita, K., Herlenius, E.A., Lindahl, S.G., and Yamamoto, Y. 1997. Actions ofopioids on respiratory, activity, via activation of brainstem mudelta- and kappa-receptors; an in vitro study. Brain Res. 778:233-241.
    • (1997) Brain Res. , vol.778 , pp. 233-241
    • Takita, K.1    Herlenius, E.A.2    Lindahl, S.G.3    Yamamoto, Y.4
  • 72
    • 0031807504 scopus 로고    scopus 로고
    • Respiratory and cardiovascular effects of the mu-opioid receptor agonist [Lys7]dermorphin in awake rats
    • Negri, L., Lattanzi, R., Tabacco, F., and Melchiorri, P. 1998. Respiratory and cardiovascular effects of the mu-opioid receptor agonist [Lys7]dermorphin in awake rats. Br. J. Pharmacol. 124:345-355.
    • (1998) Br. J. Pharmacol. , vol.124 , pp. 345-355
    • Negri, L.1    Lattanzi, R.2    Tabacco, F.3    Melchiorri, P.4
  • 73
    • 16744364787 scopus 로고    scopus 로고
    • Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses
    • Filliol, D., et al. 2000. Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat. Genet. 25:195-200.
    • (2000) Nat. Genet. , vol.25 , pp. 195-200
    • Filliol, D.1
  • 74
    • 0031728019 scopus 로고    scopus 로고
    • Immunomodulatory action of class mu-, delta- and kappa-opioid receptor agonists in mice
    • Kowalski, J. 1998. Immunomodulatory action of class mu-, delta- and kappa-opioid receptor agonists in mice. Neuropeptides. 32:301-306.
    • (1998) Neuropeptides , vol.32 , pp. 301-306
    • Kowalski, J.1
  • 75
    • 0023895450 scopus 로고
    • Modulation of binding at opioid receptors by mono- and divalent cations and by cholinergic compounds
    • Kosterlitz, H.W., Paterson, S.J., and Robson, L.E. 1988. Modulation of binding at opioid receptors by mono- and divalent cations and by cholinergic compounds. J. Recept. Res. 8:363-373.
    • (1988) J. Recept. Res. , vol.8 , pp. 363-373
    • Kosterlitz, H.W.1    Paterson, S.J.2    Robson, L.E.3
  • 76
    • 0025190418 scopus 로고
    • Central nervous system action of peptides to influence gastrointestinal motor function
    • Tache, Y., Garrick, T., and Raybould, H. 1990. Central nervous system action of peptides to influence gastrointestinal motor function. Gastroenterology. 98:517-528.
    • (1990) Gastroenterology , vol.98 , pp. 517-528
    • Tache, Y.1    Garrick, T.2    Raybould, H.3
  • 77
    • 0021994984 scopus 로고
    • Central and peripheral control of gastrointestinal and colonic motility by endogenous opiates in conscious dogs
    • Bueno, L., Fioramonti, J., Honde, C., Fargeas, M.J., and Primi, M.P. 1985. Central and peripheral control of gastrointestinal and colonic motility by endogenous opiates in conscious dogs. Gastroenterology. 88:549-556.
    • (1985) Gastroenterology , vol.88 , pp. 549-556
    • Bueno, L.1    Fioramonti, J.2    Honde, C.3    Fargeas, M.J.4    Primi, M.P.5
  • 78
    • 0029809721 scopus 로고    scopus 로고
    • Agonist-selective endocytosis of mu opioid receptor by neurons in vivo
    • Sternini, C., et al. 1996. Agonist-selective endocytosis of mu opioid receptor by neurons in vivo. Proc. Natl. Acad. Sci. U. S. A. 93:9241-9246.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 9241-9246
    • Sternini, C.1
  • 79
    • 0035796803 scopus 로고    scopus 로고
    • Identification of delta- and mu-type opioid receptors on human and murine dendritic cells
    • Makarenkova, V.P., et al. 2001. Identification of delta- and mu-type opioid receptors on human and murine dendritic cells. J. Neuroimmunol. 117:68-77.
    • (2001) J. Neuroimmunol. , vol.117 , pp. 68-77
    • Makarenkova, V.P.1
  • 80
    • 0029857664 scopus 로고    scopus 로고
    • Opioid receptors on guinea-pig intestinal crypt epithelial cells
    • Lang, M.E., Davison, J.S., Bates, S.L., and Meddings, J.B. 1996. Opioid receptors on guinea-pig intestinal crypt epithelial cells. J. Physiol. 497:161-174.
    • (1996) J. Physiol. , vol.497 , pp. 161-174
    • Lang, M.E.1    Davison, J.S.2    Bates, S.L.3    Meddings, J.B.4
  • 81
    • 0034905665 scopus 로고    scopus 로고
    • Morphine directs T cells toward T(H2) differentiation
    • Roy, S., et al. 2001. Morphine directs T cells toward T(H2) differentiation. Surgery. 130:304-309.
    • (2001) Surgery , vol.130 , pp. 304-309
    • Roy, S.1
  • 82
    • 0034162570 scopus 로고    scopus 로고
    • Systemic activation and antigen-driven oligoclonal expansion of T cells in a mouse model of colitis
    • Matsuda, J.L., et al. 2000. Systemic activation and antigen-driven oligoclonal expansion of T cells in a mouse model of colitis. J. Immunol. 164:2797-2806.
    • (2000) J. Immunol. , vol.164 , pp. 2797-2806
    • Matsuda, J.L.1
  • 83
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
    • Atreya, R., et al. 2000. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat. Med. 6:583-588.
    • (2000) Nat. Med. , vol.6 , pp. 583-588
    • Atreya, R.1
  • 84
    • 0033022768 scopus 로고    scopus 로고
    • Subjective, psychomotor, and physiological effects of cumulative doses of opioid mu agonists in healthy volunteers
    • Walker, D.J., and Zacny, J.P. 1999. Subjective, psychomotor, and physiological effects of cumulative doses of opioid mu agonists in healthy volunteers. J. Pharmacol. Exp. Ther. 289:1454-1464.
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 1454-1464
    • Walker, D.J.1    Zacny, J.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.