Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice

European Journal of Pharmacology

Volumn 366, Issue 2-3, 1999, Pages 261-269

  Wu, Wei Ran ^a   Zheng, Ji Wang ^b   Li, Na ^a   Bai, Hui Qing ^c   Zhang, Ke Ren ^c   Li, Ying ^c  

^a XI'AN MEDICAL UNIVERSITY   (China)

^b National Institute on Drug Dependence   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Dependence; Dihydroetorphine; Immunosuppression

Indexed keywords

DIHYDROETORPHINE; MORPHINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DEPENDENCE; FEMALE; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE PROLIFERATION; MOUSE; NARCOTIC DEPENDENCE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; SPLEEN CELL; SUBCUTANEOUS DRUG ADMINISTRATION;

ANALGESICS, OPIOID; ANIMALS; ANTIBODY-PRODUCING CELLS; BODY WEIGHT; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; ETORPHINE; FEMALE; HYPERSENSITIVITY, DELAYED; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; LYMPHOCYTES; LYMPHOKINES; MICE; MICE, INBRED C57BL; NALOXONE; OPIOID-RELATED DISORDERS; ORGAN SIZE; SPLEEN; SUBSTANCE WITHDRAWAL SYNDROME; THYMUS GLAND;

EID: 0033066830     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00915-7     Document Type: Article

References (42)

1. Bayer B.M., Daussin S., Hernadez M., Irvin L. Morphine inhibition of lymphocyte activity is mediated by an opioid dependent mechanism. Neuropharmacol. 29:1990;369-374.
2. Bentley K.W., Hardy D.G. Novel analgesics and molecular rearrangements in the morphine-thebaine group: III. Alcohols of the 6,14-endo-ethanotetrahydrooripavine series and derived analogues of N-allylnormorphine and -norcodeine. J. Am. Chem. Soc. 89:1967;3281-3292.
3. Blane G.F., Boura A.L.A., Fitzgerald A.E., Lister R.E. Actions of etorphine hydrochloride (M99): a potent morphine-like agent. Br. J. Pharmacol. Chemother. 30:1967;11-12.
4. Bryant H.U., Bernton E.W., Holaday J.W. Immunosuppressive effects of chronic morphine treatment in mice. Life Sci. 41:1987;1731-1738.
5. Bryant H.U., Bernton E.W., Holaday J.W. Morphine pellet-induced immunomodulation in mice: temporal relationships. J. Pharmacol. Exp. Ther. 245:1988;913-920.
6. Bryant H.U., Bernton E.W., Kenner J.R., Holaday J.W. Role of adrenal cortical activation in the immunosuppressive effects of chronic morphine treatment. Endocrinology. 128:1991;3253-3258.
7. Bunjes D., Hardt C., Rollinghoff M., Wagner H. Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2. Eur. J. Immunol. 11:1981;657-661.
8. Cao Y.-X., Sun Y.-L., Xing F., Wang N.-Y., Gao W.-X. A survey of 185 dihydroetorphine hydrochloride abusers. Chin. Bull. Drug Depend. 4:1995;21-23.
9. Carr D.J.J., France C.P. Immune alteration in morphine-treated rhesus monkeys. J. Pharmacol. Exp. Ther. 267:1993;9-15.
10. Chen J., Li X., Zheng J.-W. The discrimination effect of three opiate analgesics. Chin. Pharmacol. Bull. 11:1995;32-35.
11. Cowan A., Lewis J.W., MacFarlane I.R. Analgesic and dependence studies with oripavine partial agonists. Br. J. Pharmacol. 43:1971;461-462.
12. Deneau, G.A., Seevers, M.H., 1964. Drug dependence. In: Laurence, D.R., Bacharach, A.L. (Eds.), Evaluation of Drug Activities: Pharmacometrics. Academic Press, London, pp. 167-179.
13. Freier D.O., Fuchs B.A. Morphine-induced alteration in thymocyte subpopulations of B6C3F1 mice. J. Pharmacol. Exp. Ther. 265:1993;81-88.
14. Freier D.O., Fuchs B.A. A mechanism of action of morphine-induced immunosuppression: corticosterone mediates morphine-induced suppression of natural killer cell activity. J. Pharmacol. Exp. Ther. 270:1994;1127-1133.
15. Fuchs B.A., Pruett S.B. Morphine induces apoptosis in murine thymocytes in vivo but not in vitro: Involvement of both opiate receptors and glucocorticoid receptors. J. Pharmacol. Exp. Ther. 266:1993;417-423.
16. Huang M., Qin B.-Y. Analgesic and other CNS depressive effects of dihydroetorphine. Acta. Pharmacol. Sin. 3:1982;9-13.
17. Huang M., Qin B.-Y. Physical dependence of dihydroetorphine in mice and monkeys. Acta. Pharmacol. Sin. 3:1982;81-84.
18. Jasinski D.R., Griffith J.D., Carr C.B. Etorphine in man: 1. Subjective effects and suppression of morphine abstinence. Clin. Pharmacol. Ther. 17:1975;267-272.
19. Kaneto H., Yamazaki A., Kihara T. Evidence for the dissociation of morphine analgesia, tolerance and dependence. J. Pharm. Pharmacol. 37:1985;507-508.
20. Langrange P.H., MacKaness G.B., Miller T.E. Influence of dose and route of antigen injection on the immunological function of T cells. J. Exp. Med. 139:1974;528-541.
21. Lepkowitz S.S., Chiang C.Y. Effects of certain abused drugs on hemolysin forming cells. Life Sci. 17:1975;1763-1769.
22. Li W.-M., Nie B., Zhu Z.-L., Pang Y.-T. Comparison of the characteristics of pathophysiology between the dihydroetorphine and heroin addicts. Chin. Bull. Drug Depend. 4:1995;114-116.
23. Ling G.S.F., MacLeod J.M., Lee S., Lockhart S.H., Pasternak G.W. Separation of morphine analgesia from physical dependence. Science. 226:1984;462-464.
24. Liu Z.-M., Cao J.-Q., Shi F., Cai Z.-J. An epidemiological study on dihydroetorphine abuse. Chin. Bull. Drug Depend. 4:1995;223-231.
25. Lysle D.J., Coussons M.E., Watts V.J., Bennett E.H., Dykstra L.A. Morphine-induced alterations of immune status: dose-dependency, compartment specificity and antagonism by naltrexone. J. Pharmacol. Exp. Ther. 265:1993;1071-1078.
26. Pruett S.B., Han Y.-C., Fuchs B.A. Morphine suppresses primary humoral immune responses by a predominantly indirect mechanism. J. Pharmacol. Exp. Ther. 262:1992;923-928.
27. Qian J., Zhang E.-X. Preliminary evaluation on the clinical application of dihydroetorphine. Bull. Acad. Mil. Med. Sci. 5:1983;527-529.
28. Qin B.-Y. Advances in dihydroetorphine: from analgesia to detoxification. Drug Dev. Res. 39:1996;131-134.
29. Ren B.-S., Gao Y.-M., Xu Z.-W., Liang X.-C. Clinical use of dihydroetorphine in pain. New Drugs Clin. Remed. 12:1993;299-300.
30. Sha L.-J., Zhu H., Liu Z.-Y., Wang L., Zhang Z.-X. Dihydroetorphine on heroinism withdrawal. New Drugs Clin. Remed. 12:1993;27-30.
31. Shen K.-F., Crain S.M. Antagonists at excitatory opioid receptors in sensory neurons in culture increase potency and specificity of opiate analgesics and attenuate development of tolerance/dependence. Brain Res. 636:1994;286-287.
32. Su M.-J., Deng B.-M., He Z.-Q., Wang J., Sha L. A clinical study on the treatment of heroin addicts by dihydroetorphine hydrochloride combined with methadone. Chin. Bull. Drug Depend. 3:1994;99-102.
33. Su M.-J., Liu Y., Deng B.-M., He Z.-Q., Wang A.-L., Huang H. Combining usage of dihydroetorphine hydrochloride and buprenorphine hydrochloride in detoxification of heroin addicts: analysis of clinical curative effect in 57 cases. Chin. Bull. Drug Depend. 3:1994;12-16.
34. Wang D.-X., Huang M., Qin B.-Y. Binding characteristics of dihydroetorphine to opioid receptors in rat brain. Chin. J. Pharmacol. Toxicol. 5:1991;161-163.
35. Wang D.-X., Liu Y.-S., Qin B.-Y. Experimental therapeutic effects of dihydroetorphine in morphine-dependent rats and monkeys. Clin. J. Pharmacol. Toxicol. 6:1992;36-40.
36. Wang Z.-G., Zhao Z.-L., Zhang X.-W., Zhang Y.-Y. Analysis of mortal cases caused by dihydroetorphine hydrochloride abuse. Chin. Bull. Drug Depend. 3:1994;176-177.
37. Wu G.-Q., Sun Y. Dihydroetorphine hydrochloride for moderate and severe cancer pain. Chin. J. Oncol. 13:1991;64-67.
38. Wu W.-R., Li Y., Zhang K.-R., Wang G.-L., Xie L., Bai H.-Q. Effects of dihydroetorphine on immune functions in rats treated by 72-h automatical intravenous injection. Chin. J. Drug Depend. 7:1998;85-88.
39. Wu W.-R., Zheng J.-W., Li F.-Y., Li Y. Immunosuppressive effects of intravenous self-administration of dihydroetorphine on lymphocyte functions in rats. Acta. Pharmacol. Sin. 19:1998;387-390.
40. Wu W.-R., Zheng J.-W., Li F.-Y., Li Y., Zhang K.-R., Bai H.-Q. Involvement of μ-opioid and α-adrenergic receptors in the immunomodulatory effects of dihydroetorphine. Eur. J. Pharmacol. 353:1998;79-85.
41. 3H ]dihydroetorphine in rat brain observed by in vitro quantitative autoradiography Chin. J. Pharmacol. Toxicol. 9:1995;61-64.
42. Zheng J.-W., Zhang K.-G. Abuse liability of dihydroetorphine. Chin. Bull. Drug Depend. 4:1995;65-69.