Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests

Pain

Volumn 75, Issue 1, 1998, Pages 129-140

  Elmer, Gregory I ^a   Pieper, Jeanne O ^a   Stevens Negus, S ^b   Woods, James H ^c  

^a Intramural Res Prog Natl I   (United States)

^b MCLEAN HOSPITAL   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Analgesia; Behavior genetics; Inbred strain; Morphine; Nociception

Indexed keywords

MORPHINE;

ANALGESIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CHEMICAL INJURY; CONTROLLED STUDY; GENETIC VARIABILITY; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; THERMAL EXPOSURE;

ACETIC ACID; ANALGESICS, OPIOID; ANIMALS; FEMALE; HEAT; MALE; MICE; MICE, INBRED STRAINS; MORPHINE; NOCICEPTORS; OSMOLAR CONCENTRATION; PAIN THRESHOLD; STIMULATION, CHEMICAL; VARIATION (GENETICS);

EID: 0031748909     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(97)00215-7     Document Type: Article

References (50)

1. Akopian A.N., Abson N.C., Wood J.N. Molecular genetic approaches to nociceptor development and function. Trends Neurosci. 19:1996;240-246.
2. Bachiocco V., Scesi M., Morselli A., Carli G. Individual pain history and familial pain tolerance models: relationships to post-surgical pain. Clin. J. Pain. 9:1993;266-271.
3. Beaver, W.T. and Feise, G., Comparison of the analgesic effects of morphine, hydroxyzine, and their combination in patients with postoperative pain. In: J.J. Bonica and D. Albe-Fessard (Eds.), Advances in Pain Research and Therapy, Raven Press, New York, 1976, pp. 553-557.
4. Belknap, J.K. and O'Toole, L.A., Studies of genetic differences in response to opioid drugs. In: R.A. Harris and J.C. Crabbe (Eds.), The Genetic Basis of Alcohol and Drug Actions, Plenum Press, New York, 1992, pp. 225-252.
5. Belknap J., Haltli N., Goebel D., Lame M. Intercorrelations between levorphanol induced antinociception, hypothermia, activity and constipation in a genetically heterogeneous mouse population, and the results of selective breeding for antinociception. Proc. West Pharmacol. Soc. 25:1982;299-302.
6. Belknap J., Noordewier B., Lame M. Genetic dissociation of multiple morphine effects among C57BL/6J, DBA/2J and C3H/HeJ inbred mouse strains. Physiol. Behav. 46:1989;69-74.
7. Belknap J.K., Lame M., Danielson P.W. Inbred strain differences in morphine-induced analgesia with the hot plate assay: a reassessment. Behav. Genet. 20:1990;333-338.
8. Belknap J.K., Mogil J.S., Helms M.L., Richards S.P., O'Toole L.A., Bergeson S.E., Buck K.J. Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 strains. Life Sci. 57:1995;PL117-PL124.
9. Bonica, J.J., Anatomic and physiologic basis of nociception and pain. In: J.J. Bonica (Ed.), The Management of Pain, Lea and Febiger, Philadelphia, PA, 1990a, pp. 28-94.
10. Bonica, J.J., Definitions and taxonomy of pain. In: J.J. Bonica (Ed.), The Management of Pain, Lea and Febiger, Philadelphia, PA, 1990b, pp. 19-27.
11. Chapman, C.R. and Turner, J.A., Psychological and psychosocial aspects of acute pain. In: J.J. Bonica (Ed.), The Management of Pain, Lea and Febiger, Philadelphia, PA, 1990, pp. 122-132.
12. Cooper S.A., Beaver W.T. A model to evaluate mild analgesics in oral surgery outpatients. Clin. Pharmacol. Ther. 20:1976;241-250.
13. Crabbe J.C., Phillips T.J., Kosobud A., Belknap J.K. Estimation of genetic correlation: interpretation of experiments using selectively bred and inbred animals. Alcohol. Clin. Exp. Res. 14:1990;141-151.
14. Davis B., Albers K., Seroogy K., Katz D. Overexpression of nerve growth factor in transgenic mice induces novel sympathetic projections to primary sensory neurons. J. Comp. Neurol. 349:1994;464-474.
15. Dirig D., Yaksh T. Differential right shifts in the dose-response curve for intrathecal morphine and sufentanil as a function of stimulus intensity. Pain. 62:1995;321-328.
16. Dubner R., Kenshalo D.J., Maixner W., Bushnell M., Oliveras J. The correlation of monkey medullary dorsal horn neuronal activity and the perceived intensity of noxious heat stimuli. J. Neurophysiol. 62:1989;450-457.
17. Dudek B.C., Underwood K.A. Selective breeding, congenic strains, and other classical genetic approaches to the analysis of alcohol-related polygenic pleiotropisms. Behav. Genet. 23:1993;179-190.
18. Elmer G.I., Pieper J.O., Goldberg S.R., George F.R. Opioid operant self-administration, analgesia, stimulation and respiratory depression in mu-deficient mice. Psychopharmacology (Berl.). 117:1995;23-29.
19. Falconer, D.S., Introduction to Quantitative Genetics, Longman Scientific and Technical and Wiley, New York, 1989.
20. Fields H.L., Heinricher M.M., Mason P. Neurotransmitters in nociceptive modulatory circuits. Annu. Rev. Neurosci. 14:1991;219-245.
21. Fordyce, W.E., Learned pain: pain as behavior. In: J.J. Bonica (Ed.), The Management of Pain, Lea and Febiger, Philadelphia, PA, 1990, pp. 291-299.
22. Go V., Yaksh T. Release of substance P from the cat spinal cord. J. Physiol. (Lond.). 391:1987;141-167.
23. Hamann S.R., Martin W.R. Thermally evoked tail avoidance reflex: input-output relationships and their modulation. Brain Res. Bull. 29:1992;507-509.
24. Hardy, J.D., Wolff, H.G. and Goodell, H., Pain Sensations and Reactions, Williams and Wilkins, Baltimore, MD, 1952.
25. Honkasalo M., Kaprio J., Winter T., Heikkila K., Sillanpaa M., Koskenvuo M. Migraine and concomitant symptoms among 8167 adult twin pairs. Headache. 35:1995;70-78.
26. Indo Y., Tsuruta M., Hayashida Y., Karim M., Ohta K., Kawano T., Mitsubuchi H., Tonoki H., Awaya Y., Matsuda I. Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Nat. Genet. 13:1996;485-488.
27. Kampov-Polevoy A., Kasheffskaya O., Overstreet D., Rezvani A., Viglinskaya I., Badistov B., Seredenin S., Halikas J., Sinclair J. Pain sensitivity and saccharin intake in alcohol-preferring and non-preferring rat strains. Physiol. Behav. 59:1996;683-688.
28. Kenakin, T.P., Pharmacologic Analysis of Drug-Receptor Interaction, Raven Press, New York, 1993.
29. LaMotte R.J., Campbell J.N. Comparison of responses of warm and nociceptive C-fiber afferents in monkey with human judgements of thermal pain. J. Neurophysiol. 41:1978;509-517.
30. Laursen S., Belknap J. Intracerebroventricular injections in mice. Some methodological refinements. J. Pharmacol. Methods. 16:1986;355-357.
31. Lester N., Lefebvre J., Keefe F. Pain in young adults: I. Relationship to gender and family pain history. Clin. J. Pain. 10:1994;282-289.
32. Marek P., Panocka I., Sadowski B. Selective breeding of mice for high and low swim analgesia: differential effect on discrete forms of footshock analgesia. Pain. 29:1987;393-398.
33. Marek P., Yirmiya R., Liebeskind J. Strain differences in the magnitude of swimming-induced analgesia in mice correlate with brain opiate receptor concentration. Brain Res. 447:1988;188-194.
34. Marek P., Yirmiya R., Liebeskind J. Genetic influences on brain stimulation-produced analgesia in mice: II. Correlation with brain opiate receptor concentration. Brain Res. 507:1990;155-161.
35. Mogil, J.S., Flodman, P., Spence, M., Sternberg, W., Kest, B., Sadowski, B., Liebeskind, J. and Belknap, J., Oligogenic determination of morphine analgesic magnitude: a genetic analysis of selectively bred mouse lines, Behav. Genet., 25 (1995a) 397-406.
36. Mogil, J.S., Marek, P., Flodman, P., Spence, M., Sternberg, W., Kest, B., Sadowski, B. and Liebeskind, J., One or two genetic loci mediate high opiate analgesia in selectively bred mice, Pain, 60 (1995b) 125-135.
37. Mogil, J.S., Kest, B., Sadowski, B. and Belknap, J., Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay, J. Pharmacol. Exp. Ther., 276 (1996a) 532-544.
38. Mogil, J.S., Sternberg, W., Marek, P., Sadowski, B., Belknap, J. and Liebeskind, J., The genetics of pain and pain inhibition, Proc. Natl. Acad. Sci. USA, 93 (1996b) 3048-3055.
39. Mogil J.S., Richards S.P., O'Toole L.A., Helms M.L., Mitchell S.R., Belknap J.K. Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by delta2-opioid receptors. Pain. 70:1997;267-277.
40. Mountcastle, V.B., Pain and temperature sensibilities. In: V.B. Mountcastle (Ed.), Medical Physiology, CV Mosby, St. Louis, MO, 1980, pp. 391-425.
41. Oliveras, J., Maixner, W., Dubner, R., Bushnell, M., Duncan, G., Thomas, D. and Bates, R., Dorsal horn opiate administration attenuates the perceived intensity of noxious heat stimulation in behaving monkey, Brain Res., 371 (1986a) 368-371.
42. Oliveras, J., Maixner, W., Dubner, R., Bushnell, M., Kenshalo, D.J., Duncan, G., Thomas, D. and Bates, R., The medullary dorsal horn: a target for the expression of opiate effects on the perceived intensity of noxious heat, J. Neurosci., 6 (1986b) 3086-3093.
43. Pieper, J.O., Kramer, B. and Elmer, G.I., Stability of analgesic phenotypes in recombinant inbred mice over multiple generations in an in-house breeding colony, Presented at the AALAS Meeting, Anaheim CA, 1997.
44. Ramabadran K., Michaud G., Jacob J. Genetic influences on the control of nociceptive responses and precipitated abstinence in mice. Indian J. Exp. Biol. 20:1982;74-76.
45. Saeki S., Yaksh T. Suppression by spinal alpha-2 agonists of motor and autonomic responses evoked by low- and high-intensity thermal stimuli. J. Pharmacol. Exp. Ther. 260:1992;795-802.
46. Saeki S., Yaksh T. Suppression of nociceptive responses by spinal mu opioid agonists: effects of stimulus intensity and agonist efficacy. Anesth. Analg. 77:1993;265-274.
47. Vaught J., Mathiasen J., Raffa R. Examination of the involvement of supraspinal and spinal mu and delta opioid receptors in analgesia using the mu receptor deficient CXBK mouse. J. Pharmacol. Exp. Ther. 245:1988;13-20.
48. Von Korff M., Dworkin S., Le R.L. Graded chronic pain status: an epidemiologic evaluation. Pain. 40:1990;279-291.
49. Yamada K., Nabeshima T. Stress-induced behavioral responses and multiple opioid systems in the brain. Behav. Brain Res. 67:1995;133-145.
50. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals (editorial). Pain. 16:1983;109-110.