Immune cell-derived β-endorphin: Production, release, and control of inflammatory pain in rats

Journal of Clinical Investigation

Volumn 100, Issue 1, 1997, Pages 142-148

  Cabot, Peter J ^a,b,d   Carter, Laurenda ^a,b   Gaiddon, Christian ^c   Zhang, Qin ^a,b   Schäfer, Michael ^a,b   Loeffler, Jean Philippe ^c   Stein, Christoph ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d NIDA Addiction Research Center   (United States)

Author keywords

Analgesia; Corticotropin releasing factor; IL 1; Lymphocytes; Opioid

Indexed keywords

BETA ENDORPHIN; INTERLEUKIN 1BETA;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; HINDLIMB; IMMUNOFLUORESCENCE TEST; IMMUNOREGULATION; INFLAMMATION; MALE; MEMORY CELL; NONHUMAN; PAIN; PAW EDEMA; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; T LYMPHOCYTE ACTIVATION;

EID: 0030814120     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119506     Document Type: Article

References (25)

1. Stein, C., A.H.S. Hassan, R. Przewlocki, C. Gramsch, K. Peter, and A. Herz. 1990. Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation. Proc. Natl. Acad. Sci. USA. 87: 5935-5939.
2. Przewlocki, R., A.H.S. Hassan, W. Lason, C. Epplen, A. Herz, and C. Stein. 1992. Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception. Neuroscience. 48: 491-500.
3. Czlonkowski, A., C. Stein, and A. Herz. 1993. Peripheral mechanisms of opioid antinociception in inflammation: involvement of cytokines. Eur. J. Pharmacol. 242:229-235.
4. Schäfer, M., L. Carter, and C. Stein. 1994. Interleukin 1‡ and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue. Proc. Natl. Acad. Sci. USA. 91:4219-4223.
5. Mousa, S.A., M. Schäfer, W.M. Mitchell, A.H.S. Hassan, and C. Stein. 1996. Local upregulation of CRH and IL-1 receptors in inflamed tissue and local CRH- and IL-1β-induced antinociception. Eur. J. Pharmacol. 311:221-231.
6. Carr, D.J. 1991. The role of endogenous opioids and their receptors in the immune system. Proc. Soc. Exp. Biol. Med. 198:710-720.
7. Stein, C., M. Pflüger, A. Yassouridis, J. Hoelzl, K. Lehrberger, C. Welte, and A.H.S. Hassan. 1996. No tolerance to peripheral morphine analgesia in presence of opioid expression in inflamed synovia. J. Clin. Invest. 98:793-799.
8. Yaksh, T.L. 1988. Substance P release from knee joint afferent terminals: modulation by opioids. Brain Res. 458:319-324.
9. Stein, C. 1995. The control of pain in peripheral tissue by opioids. N. Engl. J. Med. 332:1685-1690.
10. Stein, C., C. Gramsch, and A. Herz. 1990. Intrinsic mechanisms of antinociception in inflammation: local opioid receptors and beta-endorphin. J. Neurosci. 10:1292-1298.
11. Westly, H.J., A.J. Kleiss, K.W. Kelley, P.K. Wong, and P.H. Yuen. 1986. Newcastle disease virus-infected splenocytes express the proopiomelanocortin gene. J. Exp. Med. 163:1589-1594.
12. Heijnen, C.J., A. Kavelaars, and R.E. Ballieux. 1991. β-endorphin: cytokine and neuropeptide. Immunol. Rev. 119:41-63.
13. Sharp, B., and K. Linner. 1993. What do we know about the expression of proopiomelanocortin transcripts and related peptides in lymphoid tissue? Endocrinology. 133:1921A-1921B.
14. Mackay, C.R. 1993. Homing of naive, memory and effector lymphocytes. Curr. Opin. Immunol. 5:423-427.
15. Davis, T.P., and P.N.M. Konings. 1993. Peptidases in the CNS: formation of biologically active, receptor-specific peptide fragments. Crit. Rev. Neurobiol. 7:163-174.
16. Miller, B.C., D.L. Theile, D. Rodd, L.B. Hersh, and G.L. Cottam. 1995. Active β-endorphin metabolites generated by T-cell ectopeptidases. In The Brain Immune Axis and Substance Abuse. B. Sharp, T.K. Eisenstein, J.J. Madden, and H. Friedman, editors. Plenum Publishing Corp., New York. 49-56.
17. Stein, C., M.J. Millan, and A. Herz. 1988. Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: alterations in behavior and nociceptive thresholds. Pharmacol. Biochem. Behav. 31:455-451.
18. Bell, E.B., S.M. Sparshott, and A. Ager. 1995. Migration pathways of CD4 T cell subsets in vivo: the CD45RC-subset enters the thymus via alpha 4 integrin-VCAM-1 interaction. Int. Immunol. 7:1861-1871.
19. Shimizu, Y., and S. Shaw. 1991. Lymphocyte interactions with extracellular matrix. FASEB. (Fed. Am. Soc. Exp. Biol.) J. 5:2292-2299.
20. Mackay, C.R., W. Marston, and L. Dudler. 1992. Altered patterns of T cell migration through lymph nodes and skin following antigen challenge. Eur. J. Immunol. 22:2205-2210.
21. Westermann, J., S. Persin, J. Matyas, P. van der Meide, and R. Pabst. 1994. Migration of so-called naive and memory T lymphocytes from blood to lymph in the rat. The influence of IFN-gamma on the circulation pattern. J. Immunol. 152:1744-1750.
22. Schäfer, M., S.A. Mousa, Q. Zhang, L. Carter, and C. Stein. 1996. Expression of corticotropin-releasing factor in inflamed tissue is required for intrinsic peripheral opioid analgesia. Proc. Natl. Acad. Sci. USA. 93:6090-6100.
23. Miller, R.J. 1987. Calcium channels in neurones. In Receptor Biochemistry and Methodology. Volume 9: Structure and Physiology of the Slow Inward Calcium Channel. J.C. Venter and D. Triggle, editors. Alan R. Liss, New York. 161-246.
24. + T cells to effector interleukin-4-producing T helper cells. Immunol. Res. 14:176-188.
25. Simon, E.J. 1991. Opioid receptors and endogenous opioid peptides. Med. Res. Rev. 11:357-374.