Opioid receptor types selectively cointernalize with G protein-coupled receptor kinases 2 and 3

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 2, 2002, Pages 376-384

  Schulz, Rüdiger ^a   Wehmeyer, Andrea ^a   Schulz, Karin ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DELTA OPIATE RECEPTOR; G PROTEIN COULPED RECEPTOR KINASE 3; G PROTEIN COUPLED RECEPTOR KINASE 2; GREEN FLUORESCENT PROTEIN; MU OPIATE RECEPTOR; OPIATE RECEPTOR; PHOSDUCIN; PHOSPHOTRANSFERASE; RED FLUORESCENT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; INTERNALIZATION; LASER MICROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TRANSPORT; RECEPTOR BINDING;

ANALGESICS, OPIOID; BETA-ADRENERGIC RECEPTOR KINASE; BLOTTING, WESTERN; CELL LINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA; FLUORESCENT DYES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; GTP-BINDING PROTEINS; HUMANS; LUMINESCENT PROTEINS; MICROSCOPY, CONFOCAL; MORPHINE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; TRANSFECTION;

EID: 0036154075     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.2.376     Document Type: Article

References (36)

1. Coupling of prostaglandin E1 receptors to the stimulatory GTP-binding protein Gs is enhanced in neuroblastoma x glioma (NG108-15) hybrid cells chronically exposed to an opioid
2. Enhanced stimulatory adenylyl cyclase signaling during opioid dependence is associated with a reduction in palmitoylated Gs alpha
3. G-protein-coupled receptors: Turn-ons and turn-offs
4. Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist
5. Opioid receptor-G protein interactions: Acute and chronic effects of opioids
6. Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases
7. Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
8. Opiate tolerance and dependence: Receptors, G-proteins, and antiopiates
9. Improved green fluorescence
10. Changes in the expression of G protein-coupled receptor kinases and beta-arrestin 2 in rat brain during opioid tolerance and supersensitivity
11. Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy
12. The role of receptor kinases and arrestins in G protein-coupled receptor regulation
13. Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor
14. G protein-coupled receptor kinases
15. G protein-coupled receptor kinase 2 mediates mu-opioid receptor desensitization in GABAergic neurons of the nucleus raphe magnus
16. Protein measurement with the folin phenol reagent
17. The human delta opioid receptor activates Gilalpha more efficiently than Go1alpha
18. The role of G-protein beta gamma subunits in signal transduction
19. Selectivity of beta-adrenergic receptor kinase 2 for G protein betagamma subunits
20. Regulation of G protein-coupled receptor kinase 2 in brains of opiate-treated rats and human opiate addicts
21. G protein-coupled receptor kinases
22. Kinase-inactive g-protein-coupled receptor kinases are able to attenuate follicle-stimulating hormone-induced signaling
23. Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor
24. Beta adrenergic receptor kinase (GRK2) colocalizes with beta-adrenergic receptors during agonist-induced receptor internalization
25. Rat beta-adrenergic receptor kinases 1 and 2 in mouse neuroblastoma X rat glioma NG 108-15 hybrid cells
26. The pharmacology of phosducin
27. Translocation of phosducin in living neuroblastoma x glioma hybrid cells (NG 108-15) monitored by red-shifted green fluorescent protein
28. Phosducin, beta-arrestin and opioid receptor migration
29. Effect of phosducin on opioid receptor function
30. Regulation of G protein-coupled receptors by receptor kinases and arrestins
31. Chronic morphine administration increases beta-adrenergic receptor kinase (beta ARK) levels in the rat locus coeruleus
32. Opioid receptor desensitization in NG 108-15 cells. Differential effects of a full and a partial agonist on the opioid-dependent GTPase
33. The structural basis for red fluorescence in the tetrameric GFP homolog DsRed
34. Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein coupling
35. Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness
36. Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin