Systemic Morphine Administration Suppresses Genes Involved in Antigen Presentation

Molecular Pharmacology

Volumn 65, Issue 2, 2004, Pages 437-442

  Beagles, Karen ^a   Wellstein, Anton ^b   Bayer, Barbara ^b  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; BACTERIAL INFECTION; CELL SURFACE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE TIME EFFECT RELATION; DRUG ABUSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; IMMUNE SYSTEM; LEUKOCYTE; LEUKOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; METABOLISM; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT; RAT STRAIN; REGULATORY MECHANISM; STATISTICAL SIGNIFICANCE; SUPPRESSOR GENE; VIRUS INFECTION;

ANIMALS; ANTIGEN PRESENTATION; GENE EXPRESSION REGULATION; GENE SILENCING; LEUKOCYTES; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MORPHINE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 1642579498     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.2.437     Document Type: Article

References (30)

1. Abbas AK, Lichtman AH, and Pober JS (2002) Cellular and Molecular Immunology, 4th ed, p 187-196, WB Saunders, Philadelphia.
2. Bayer BM, Daussin S, Hernandez M, and Irvin L (1990) Morphine inhibition of lymphocyte activity is mediated by an opioid dependent mechanism. Neuropharmacology 29:369-374.
3. Benacerraf B and Germain RN (1981) A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression. Scand J Immunol 13:1-10.
4. Bhaskaran M, Reddy K, Sharma S, Singh J, Radhakrishnan N, Kapasi A, and Singhal PC (2001) Morphine-induced degradation of the host defense barrier: role of macrophage injury. J Infect Dis 184:1524-1531.
5. Bryant HU and Roudebush RE (1990) Suppressive effects of morphine pellet implants on in vivo parameters of immune function. J Pharmacol Exp Ther 255:410-414.
6. Chomczynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
7. Dadgostar H, Zarnegar B, Hoffmann A, Qin XF, Truong U, Rao G, Baltimore D, and Cheng G (2002) Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proc Natl Acad Sci USA 99:1497-1502.
8. Eisenstein TK and Hilburger ME (1998) Opioid modulation of immune responses: effects on phagocyte and lymphoid cell populations. J Neuroimmunol 83:36-44.
9. Eisenstein TK, Rogers TJ, Meissler JJ Jr, Adler MW, and Hilburger ME (1998) Morphine depresses macrophage numbers and function in mouse spleens. Adv Exp Med Biol 437:33-41.
10. Fecho K and Lysle DT (2002) Morphine-induced enhancement in the granulocyte response to thioglycollate administration in the rat. Inflammation 26:259-271.
11. Fecho K, Nelson CJ, and Lysle DT (2000) Phenotypic and functional assessments of immune status in the rat spleen following acute heroin treatment. Immunopharmacology 46:193-207.
12. Flores LR, Wahl SM, and Bayer BM (1995) Mechanism of morphine-induced immunosuppression: effect of acute morphine administration on lymphocyte trafficking. J Pharmacol Exp Ther 272:1246-1251.
13. Gosselin EJ, Wardwell K, Rigby WF, and Guyre PM (1993) Induction of MHC class II on human polymorphonuclear neutrophils by granulocyte/macrophage colony-stimulating factor, IFN-gamma and IL-3. J Immunol 151:1482-1490.
14. Grimm M, Spiecker M, De Caterina R, Shin WS, and Liao JK (2002) Inhibition of major histocompatibility complex class II gene transcription by nitric oxide and antioxidants. J Biol Chem 277:26460-26467.
15. Guan L, Eisenstein TK, Adler MW, and Rogers TJ (1997) Inhibition of T cell superantigen responses following treatment with the kappa-opioid agonist U50,488H. J Neuroimmunol 75:163-168.
16. Guo CJ, Li Y, Tian S, Wang X, Douglas SD, and Ho WZ (2002) Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptor. J Investig Med 50:435-442.
17. Houghtling RA and Bayer BM (2002) Rapid elevation of plasma interleukin-6 by morphine is dependent on autonomic stimulation of adrenal gland. J Pharmacol Exp Ther 300:213-219.
18. Kimura I, Makino M, Honda R, Ma J, and Kimura M (1995) Expression of major histocompatibility complex in mouse peritoneal macrophages increasingly depends on plasma corticosterone levels: stimulation by aconitine. Biol Pharm Bull 18:1504-1508.
19. Li G, Harton JA, Zhu X, and Ting JP (2001) Downregulation of CIITA function by protein kinase a (PKA)-mediated phosphorylation: mechanism of prostaglandin E, cyclic AMP and PKA inhibition of class II major histocompatibility complex expression in monocytic lines. Mol Cell Biol 21:4626-4635.
20. Lockwood LL, Silbert LH, Fleshner MR, McNeal C, Watkins LR, Laudenslager ML, Rice KC, Weber RJ, and Maier SF (1996) Morphine-induced alterations in antibody levels: receptor and immune mechanisms. J Pharmacol Exp Ther 278:689-696.
21. Lord JD, McIntosh BC, Greenberg PD, and Nelson BH (2000) The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2 and bcl-x genes through the trans-activation domain of Stat5. J Immunol 164:2533-2541.
22. Lu ZW, Dai WJ, Wang GL, and Lin ZB (1996) Subchronic in vivo treatments of morphine inhibit T-cell proliferation by acting on macrophages. Brain Behav Immun 10:351-363.
23. Luder CG, Lang T, Beuerle B, and Gross U (1998) Down-regulation of MHC class II molecules and inability to up-regulate class I molecules in murine macrophages after infection with Toxoplasma gondii. Clin Exp Immunol 112:308-316.
24. Mellon RD and Bayer BM (1999) The effects of morphine, nicotine and epibatidine on lymphocyte activity and hypothalamic-pituitary-adrenal axis responses. J Pharmacol Exp Ther 288:635-642.
25. Pan J, Ju D, Wang Q, Zhang M, Xia D, Zhang L, Yu H, and Cao X (2001) Dexamethasone inhibits the antigen presentation of dendritic cells in MHC class II pathway. Immunol Lett 76:153-161.
26. Roos A, Schilder-Tol EJ, Chand MA, Claessen N, Lakkis FG, Pascual DW, Weening JJ, and Aten J (1998) Differential regulation of expression of the MHC class II molecules RT1.B and RT1.D on rat B lymphocytes: effects of interleukin-4, interleukin-13 and interferon-gamma. Immunology 93:33-40.
27. Stefano GB, Neenan K, Cadet P, Magazine H, and Bilfinger TV (2001) Ischemic preconditioning-an opiate constitutive nitric oxide molecular hypothesis. Med Sci Monit 7:1357-1375.
28. Stumptner-Cuvelette P and Benaroch P (2002) Multiple roles of the invariant chain in MHC class II function. Biochim Biophys Acta 1542:1-13.
29. Sukwit S, Chuenchitra T, Samakoses R, Songprasom K, Aree C, Akapirat S, Panjapornsuk K, Ubol S, and Nitayaphan S (2001) Flow cytometric detection of intracellular cytokines in peripheral blood of HIV-1 infected Thai children. Asian Pac J Allergy Immunol 19:107-113.
30. Thomas JW, Schroer J, Yokomuro K, Blake JT, and Rosenthal AS (1979) Macrophage-lymphocyte interaction and genetic control of immune responsiveness. Adv Exp Med Biol 121B:165-179.