β-Endorphin stimulates cytokeratin 16 expression and downregulates μ- opiate receptor expression in human epidermis

Journal of Investigative Dermatology

Volumn 114, Issue 3, 2000, Pages 527-532

  Bigliardi Qi, Mei ^a   Bigliardi, Paul L ^a   Eberle, Alex N ^a   Büchner, Stanislaus ^a   Rufli, Theo ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Psoriasis; Skin differentiation

Indexed keywords

BETA ENDORPHIN; CYTOKERATIN; CYTOKERATIN 16; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; NALTREXONE; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL TRIAL; EPIDERMIS CELL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS;

EID: 0034044916     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00801.x     Document Type: Article

References (23)

1. Bigliardi PL, Herron MJ, Nelson RD, Dahl MV: Effects of detergents on proliferation and metabolism of human keratinocytes. Exp Dermatol 3:89-94, 1994
2. Bigliardi PL, Bigliardi-Qi M, Büchner S, Rufli T: Expression of μ-opiate receptor in human epidermis and keratinocytes. J Invest Dermatol 111:101-105, 1998
3. Bos JD, De Rie ME: The pathogenesis of psoriasis: immunological facts and speculations. Immunol Today 20:40-46, 1999
4. Dewing SB: Remission of psoriasis associated with cutaneous nerve section. Arch Dermatol 104:220-221, 1971
5. Eberle AN: The Melanotropins; Chemistry, Physiology and Mechanisms of Action. Basel: Karger, 1988, pp. 33-47
6. Farber EM, Raychaudhuri SP: Is psoriasis a neuroimmunologic disease? Int J Dermatol 38:12-15, 1999
7. Farber EM, Nickoloff BJ, Recht B, Fraki JE: Stress, symmetry, and psoriasis: Possible role of neuropeptides. J Am Acad Dermatol 14:305-311, 1986
8. Gerritsen MJ: Recruitment of cycling epidermal cells and expression of filaggrin, involucrin and tenascin in the margin of the active psoriatic plaque, in the uninvolved skin of psoriatic patients and in the normal healthy skin. J Dermatol Sci 14:179-188, 1997
9. Glinski W, Brodecka H, Glinska-Ferenz M, Kowalski D: Neuropeptides in psoriasis: possible role of beta-endorphin in the pathomechanism of the disease. Int J Dermatol 33:356-360, 1994
10. Glinski W, Brodecka H, Glinska-Ferenz M, Kowalski D: Increased concentration of β-endorphin in the sera of patients with severe atopic dermatitis. Acta Derm Venereol 75:9-11, 1995
11. Köck A, Schauer E, Schwarz T, Luger TA: Neuropeptides such as α-MSH and ACTH are produced by human keratinocytes. J Invest Dermatol 95:476, 1990
12. Leigh IM, Navsaria H, Purkis PE, McKay IA, Bowden PE, Riddle PN: Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro. Br J Dermatol 133:501-511, 1995
13. Misery L: Skin, immunity and the nervous system. Br J Dermatol 137:843-850, 1997
14. Mozzanica N, Villa ML, Foppa S, Vignati G, Cattaneo A, Diotti R, Finzi AF: Plasma α-melanocyte-stimulating hormone, β-endorphin, met-enkephalin, and natural killer cell actiity in vitiligo. J Am Acad Dermatol 26:693-700, 1992
15. Nissen JB: Enkephalins modulate differentiation of normal human keratinocytes in vitro. Exp Dermatol 6:222-229, 1997
16. Olson GA, Olson RD, Kastin AJ: Endogenous opiates. Peptides 7:907-933, 1986
17. Paus R, Lüftl M, Czarnetzki BM: Nerve growth factor modulates keratinocyte proliferation in murine skin organ culture. Br J Dermatol 130:174-180, 1994
18. Pincelli C: Psoriasis and the nervous system. Acta Derm Venereol (Stockh) 186 (Suppl.):60-61, 1994
19. Seville RH: Stress and psoriasis: The importance of insight and empathy in prognosis. J Am Acad Dermatol 20:97-100, 1989
20. Slominski A, Wortsman J, Mazurkiewicz JE, et al: Detection of proopiomelanocortin-derived antigens in normal and pathologic human skin. J Lab Clin Med 122:658-666, 1993
21. Wintzen M, Gilchrest BA: Proopiomelanocortin, its derived peptides, and the skin. J Invest Dermatol 106:3-10, 1996
22. Wintzen M, Yaar M, Avila E, Vermeer BJ, Gilchrest BA: Keratinocytes produce β-endorphin and β-lipotropic hormone after stimulation by UV, IL-1α or phorbol esters. J Invest Dermatol 104:641, 1995
23. Wintzen M, Yaar M, Burbach JP, Gilchrest BA: Proopiomelanocortin gene product regulation in keratinocytes. J Invest Dermatol 106:673-678, 1996