Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: An in vitro and in vivo study

European Journal of Neuroscience

Volumn 14, Issue 7, 2001, Pages 1091-1104

  Ma, Weiya ^a,d   Zheng, Wen Hua ^a,b,d   Powell, Kelly ^c,d   Jhamandas, Khem ^c,d   Quirion, Remi ^a,b,d  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c QUEEN S UNIVERSITY   (Canada)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Calcitonin gene related peptide; Cell culture; Naloxone; Opiates; Substance P; Tolerance

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MORPHINE; NALOXONE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONCENTRATION RESPONSE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MALE; MORPHINE TOLERANCE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SPINAL CORD NERVE CELL; SPINAL GANGLION;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CELL COUNT; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DRUG ADMINISTRATION SCHEDULE; DRUG TOLERANCE; ENZYME INHIBITORS; FLAVONOIDS; FLUORESCENT ANTIBODY TECHNIQUE; GANGLIA, SPINAL; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHINE; NARCOTIC ANTAGONISTS; NEURONS, AFFERENT; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PAIN; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SUBSTANCE P;

EID: 0035783434     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01731.x     Document Type: Article

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