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Volumn 60, Issue 7, 2008, Pages 795-804

TLR9 as a key receptor for the recognition of DNA

Author keywords

Autoimmunity; Cell signaling; CpG DNA; Innate immunity; Plasmacytoid dendritic cell; Type I interferon

Indexed keywords

IMMUNOLOGY; LIGANDS; PROTEINS; SIGNAL TRANSDUCTION;

EID: 41349106548     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2007.12.004     Document Type: Review
Times cited : (302)

References (105)
  • 1
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S., Uematsu S., and Takeuchi O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 2
    • 0021256125 scopus 로고
    • Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
    • Tokunaga T., Yamamoto H., Shimada S., Abe H., Fukuda T., Fujisawa Y., Furutani Y., Yano O., Kataoka T., Sudo T., et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J. Natl. Cancer Inst. 72 (1984) 955-962
    • (1984) J. Natl. Cancer Inst. , vol.72 , pp. 955-962
    • Tokunaga, T.1    Yamamoto, H.2    Shimada, S.3    Abe, H.4    Fukuda, T.5    Fujisawa, Y.6    Furutani, Y.7    Yano, O.8    Kataoka, T.9    Sudo, T.10
  • 4
    • 33749490571 scopus 로고    scopus 로고
    • Innate immune recognition of, and regulation by, DNA
    • Ishii K.J., and Akira S. Innate immune recognition of, and regulation by, DNA. Trends Immunol. 27 (2006) 525-532
    • (2006) Trends Immunol. , vol.27 , pp. 525-532
    • Ishii, K.J.1    Akira, S.2
  • 5
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre B., Nicolas E., Michaut L., Reichhart J.M., and Hoffmann J.A. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86 (1996) 973-983
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 7
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi O., Hoshino K., Kawai T., Sanjo H., Takada H., Ogawa T., Takeda K., and Akira S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 (1999) 443-451
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6    Takeda, K.7    Akira, S.8
  • 9
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    • Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K., and Akira S. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162 (1999) 3749-3752
    • (1999) J Immunol , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6    Takeda, K.7    Akira, S.8
  • 10
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou L., Holt A.C., Medzhitov R., and Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 (2001) 732-738
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 11
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold S.S., Kaisho T., Hemmi H., Akira S., and Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303 (2004) 1529-1531
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis e Sousa, C.5
  • 16
    • 0842328805 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 activates murine natural interferon-producing cells through Toll-like receptor 9
    • Krug A., Luker G.D., Barchet W., Leib D.A., Akira S., and Colonna M. Herpes simplex virus type 1 activates murine natural interferon-producing cells through Toll-like receptor 9. Blood 103 (2004) 1433-1437
    • (2004) Blood , vol.103 , pp. 1433-1437
    • Krug, A.1    Luker, G.D.2    Barchet, W.3    Leib, D.A.4    Akira, S.5    Colonna, M.6
  • 17
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund J., Sato A., Akira S., Medzhitov R., and Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198 (2003) 513-520
    • (2003) J. Exp. Med. , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 18
    • 31344461659 scopus 로고    scopus 로고
    • Innate immune recognition of viral infection
    • Kawai T., and Akira S. Innate immune recognition of viral infection. Nat. Immunol. 7 (2006) 131-137
    • (2006) Nat. Immunol. , vol.7 , pp. 131-137
    • Kawai, T.1    Akira, S.2
  • 20
    • 1842631153 scopus 로고    scopus 로고
    • Immunotherapeutic uses of CpG oligodeoxynucleotides
    • Klinman D.M. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4 (2004) 249-258
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 249-258
    • Klinman, D.M.1
  • 21
    • 0037443644 scopus 로고    scopus 로고
    • The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
    • Hemmi H., Kaisho T., Takeda K., and Akira S. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J. Immunol. 170 (2003) 3059-3064
    • (2003) J. Immunol. , vol.170 , pp. 3059-3064
    • Hemmi, H.1    Kaisho, T.2    Takeda, K.3    Akira, S.4
  • 22
    • 29144434113 scopus 로고    scopus 로고
    • TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
    • Bafica A., Scanga C.A., Feng C.G., Leifer C., Cheever A., and Sher A. TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. J. Exp. Med. 202 (2005) 1715-1724
    • (2005) J. Exp. Med. , vol.202 , pp. 1715-1724
    • Bafica, A.1    Scanga, C.A.2    Feng, C.G.3    Leifer, C.4    Cheever, A.5    Sher, A.6
  • 23
    • 34247161891 scopus 로고    scopus 로고
    • MyD88-dependent activation of B220-CD11b+LY-6C+dendritic cells during Brucella melitensis infection
    • Copin R., De Baetselier P., Carlier Y., Letesson J.J., and Muraille E. MyD88-dependent activation of B220-CD11b+LY-6C+dendritic cells during Brucella melitensis infection. J. Immunol. 178 (2007) 5182-5191
    • (2007) J. Immunol. , vol.178 , pp. 5182-5191
    • Copin, R.1    De Baetselier, P.2    Carlier, Y.3    Letesson, J.J.4    Muraille, E.5
  • 24
    • 34250305202 scopus 로고    scopus 로고
    • TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae
    • Lee K.S., Scanga C.A., Bachelder E.M., Chen Q., and Snapper C.M. TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae. Cell Immunol. 245 (2007) 103-110
    • (2007) Cell Immunol. , vol.245 , pp. 103-110
    • Lee, K.S.1    Scanga, C.A.2    Bachelder, E.M.3    Chen, Q.4    Snapper, C.M.5
  • 25
    • 34250650116 scopus 로고    scopus 로고
    • TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: results from a genome-wide scan
    • Anderson A.E., Worku M.L., Khamri W., Bamford K.B., Walker M.M., and Thursz M.R. TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: results from a genome-wide scan. Eur. J. Immunol. 37 (2007) 1548-1561
    • (2007) Eur. J. Immunol. , vol.37 , pp. 1548-1561
    • Anderson, A.E.1    Worku, M.L.2    Khamri, W.3    Bamford, K.B.4    Walker, M.M.5    Thursz, M.R.6
  • 26
    • 33947396347 scopus 로고    scopus 로고
    • Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and-independent pathways
    • Zhu J., Huang X., and Yang Y. Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and-independent pathways. J. Virol. 81 (2007) 3170-3180
    • (2007) J. Virol. , vol.81 , pp. 3170-3180
    • Zhu, J.1    Huang, X.2    Yang, Y.3
  • 31
    • 11844290125 scopus 로고    scopus 로고
    • Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides
    • Roberts T.L., Sweet M.J., Hume D.A., and Stacey K.J. Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides. J. Immunol. 174 (2005) 605-608
    • (2005) J. Immunol. , vol.174 , pp. 605-608
    • Roberts, T.L.1    Sweet, M.J.2    Hume, D.A.3    Stacey, K.J.4
  • 34
    • 0034698739 scopus 로고    scopus 로고
    • Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6
    • Hacker H., Vabulas R.M., Takeuchi O., Hoshino K., Akira S., and Wagner H. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med. 192 (2000) 595-600
    • (2000) J. Exp. Med. , vol.192 , pp. 595-600
    • Hacker, H.1    Vabulas, R.M.2    Takeuchi, O.3    Hoshino, K.4    Akira, S.5    Wagner, H.6
  • 35
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    • O'Neill L.A., and Bowie A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7 (2007) 353-364
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 353-364
    • O'Neill, L.A.1    Bowie, A.G.2
  • 36
    • 34249095729 scopus 로고    scopus 로고
    • Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling
    • Kawagoe T., Sato S., Jung A., Yamamoto M., Matsui K., Kato H., Uematsu S., Takeuchi O., and Akira S. Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. J. Exp. Med. 204 (2007) 1013-1024
    • (2007) J. Exp. Med. , vol.204 , pp. 1013-1024
    • Kawagoe, T.1    Sato, S.2    Jung, A.3    Yamamoto, M.4    Matsui, K.5    Kato, H.6    Uematsu, S.7    Takeuchi, O.8    Akira, S.9
  • 37
    • 0034644474 scopus 로고    scopus 로고
    • Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
    • Deng L., Wang C., Spencer E., Yang L., Braun A., You J., Slaughter C., Pickart C., and Chen Z.J. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103 (2000) 351-361
    • (2000) Cell , vol.103 , pp. 351-361
    • Deng, L.1    Wang, C.2    Spencer, E.3    Yang, L.4    Braun, A.5    You, J.6    Slaughter, C.7    Pickart, C.8    Chen, Z.J.9
  • 42
    • 0037099629 scopus 로고    scopus 로고
    • Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation
    • Ishii K.J., Takeshita F., Gursel I., Gursel M., Conover J., Nussenzweig A., and Klinman D.M. Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. J. Exp. Med. 196 (2002) 269-274
    • (2002) J. Exp. Med. , vol.196 , pp. 269-274
    • Ishii, K.J.1    Takeshita, F.2    Gursel, I.3    Gursel, M.4    Conover, J.5    Nussenzweig, A.6    Klinman, D.M.7
  • 43
    • 33646473522 scopus 로고    scopus 로고
    • Class I and III phosphatidylinositol 3′-kinase play distinct roles in TLR signaling pathway
    • Kuo C.C., Lin W.T., Liang C.M., and Liang S.M. Class I and III phosphatidylinositol 3′-kinase play distinct roles in TLR signaling pathway. J. Immunol. 176 (2006) 5943-5949
    • (2006) J. Immunol. , vol.176 , pp. 5943-5949
    • Kuo, C.C.1    Lin, W.T.2    Liang, C.M.3    Liang, S.M.4
  • 44
    • 0037629646 scopus 로고    scopus 로고
    • PI3K and negative regulation of TLR signaling
    • Fukao T., and Koyasu S. PI3K and negative regulation of TLR signaling. Trends Immunol. 24 (2003) 358-363
    • (2003) Trends Immunol. , vol.24 , pp. 358-363
    • Fukao, T.1    Koyasu, S.2
  • 45
    • 0036318851 scopus 로고    scopus 로고
    • Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
    • Ahmad-Nejad P., Hacker H., Rutz M., Bauer S., Vabulas R.M., and Wagner H. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32 (2002) 1958-1968
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1958-1968
    • Ahmad-Nejad, P.1    Hacker, H.2    Rutz, M.3    Bauer, S.4    Vabulas, R.M.5    Wagner, H.6
  • 46
    • 0032525023 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
    • Yi A.K., Tuetken R., Redford T., Waldschmidt M., Kirsch J., and Krieg A.M. CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J. Immunol. 160 (1998) 4755-4761
    • (1998) J. Immunol. , vol.160 , pp. 4755-4761
    • Yi, A.K.1    Tuetken, R.2    Redford, T.3    Waldschmidt, M.4    Kirsch, J.5    Krieg, A.M.6
  • 47
    • 0032476602 scopus 로고    scopus 로고
    • CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
    • Hacker H., Mischak H., Miethke T., Liptay S., Schmid R., Sparwasser T., Heeg K., Lipford G.B., and Wagner H. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. Embo. J. 17 (1998) 6230-6240
    • (1998) Embo. J. , vol.17 , pp. 6230-6240
    • Hacker, H.1    Mischak, H.2    Miethke, T.3    Liptay, S.4    Schmid, R.5    Sparwasser, T.6    Heeg, K.7    Lipford, G.B.8    Wagner, H.9
  • 48
    • 29244450802 scopus 로고    scopus 로고
    • Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    • Barton G.M., Kagan J.C., and Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat. Immunol. 7 (2006) 49-56
    • (2006) Nat. Immunol. , vol.7 , pp. 49-56
    • Barton, G.M.1    Kagan, J.C.2    Medzhitov, R.3
  • 50
    • 17644372733 scopus 로고    scopus 로고
    • IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    • Liu Y.J. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 23 (2005) 275-306
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 51
    • 24344478196 scopus 로고    scopus 로고
    • Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
    • Kolumam G.A., Thomas S., Thompson L.J., Sprent J., and Murali-Krishna K. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J. Exp. Med. 202 (2005) 637-650
    • (2005) J. Exp. Med. , vol.202 , pp. 637-650
    • Kolumam, G.A.1    Thomas, S.2    Thompson, L.J.3    Sprent, J.4    Murali-Krishna, K.5
  • 52
    • 33644837684 scopus 로고    scopus 로고
    • Cutting edge: the direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection
    • Havenar-Daughton C., Kolumam G.A., and Murali-Krishna K. Cutting edge: the direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection. J. Immunol. 176 (2006) 3315-3319
    • (2006) J. Immunol. , vol.176 , pp. 3315-3319
    • Havenar-Daughton, C.1    Kolumam, G.A.2    Murali-Krishna, K.3
  • 55
    • 33846861553 scopus 로고    scopus 로고
    • Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells
    • Vremec D., O'Keeffe M., Hochrein H., Fuchsberger M., Caminschi I., Lahoud M., and Shortman K. Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells. Blood 109 (2007) 1165-1173
    • (2007) Blood , vol.109 , pp. 1165-1173
    • Vremec, D.1    O'Keeffe, M.2    Hochrein, H.3    Fuchsberger, M.4    Caminschi, I.5    Lahoud, M.6    Shortman, K.7
  • 56
    • 34548028711 scopus 로고    scopus 로고
    • Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses
    • Kumagai Y., Takeuchi O., Kato H., Kumar H., Matsui K., Morii E., Aozasa K., Kawai T., and Akira S. Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. Immunity 27 (2007) 240-252
    • (2007) Immunity , vol.27 , pp. 240-252
    • Kumagai, Y.1    Takeuchi, O.2    Kato, H.3    Kumar, H.4    Matsui, K.5    Morii, E.6    Aozasa, K.7    Kawai, T.8    Akira, S.9
  • 57
    • 35748972077 scopus 로고    scopus 로고
    • Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells
    • Blasius A.L., Barchet W., Cella M., and Colonna M. Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells. J. Exp. Med. 204 (2007) 2561-2568
    • (2007) J. Exp. Med. , vol.204 , pp. 2561-2568
    • Blasius, A.L.1    Barchet, W.2    Cella, M.3    Colonna, M.4
  • 60
    • 33745214259 scopus 로고    scopus 로고
    • Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
    • Kuwajima S., Sato T., Ishida K., Tada H., Tezuka H., and Ohteki T. Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat. Immunol. 7 (2006) 740-746
    • (2006) Nat. Immunol. , vol.7 , pp. 740-746
    • Kuwajima, S.1    Sato, T.2    Ishida, K.3    Tada, H.4    Tezuka, H.5    Ohteki, T.6
  • 61
    • 34247100277 scopus 로고    scopus 로고
    • Dendritic cells prime natural killer cells by trans-presenting interleukin 15
    • Lucas M., Schachterle W., Oberle K., Aichele P., and Diefenbach A. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26 (2007) 503-517
    • (2007) Immunity , vol.26 , pp. 503-517
    • Lucas, M.1    Schachterle, W.2    Oberle, K.3    Aichele, P.4    Diefenbach, A.5
  • 63
    • 2942748202 scopus 로고    scopus 로고
    • CpG DNA redirects class-switching towards "Th1-like" Ig isotype production via TLR9 and MyD88
    • Lin L., Gerth A.J., and Peng S.L. CpG DNA redirects class-switching towards "Th1-like" Ig isotype production via TLR9 and MyD88. Eur. J. Immunol. 34 (2004) 1483-1487
    • (2004) Eur. J. Immunol. , vol.34 , pp. 1483-1487
    • Lin, L.1    Gerth, A.J.2    Peng, S.L.3
  • 64
    • 0038639600 scopus 로고    scopus 로고
    • CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells
    • Liu N., Ohnishi N., Ni L., Akira S., and Bacon K.B. CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat. Immunol. 4 (2003) 687-693
    • (2003) Nat. Immunol. , vol.4 , pp. 687-693
    • Liu, N.1    Ohnishi, N.2    Ni, L.3    Akira, S.4    Bacon, K.B.5
  • 65
    • 27844541797 scopus 로고    scopus 로고
    • Control of B-cell responses by Toll-like receptors
    • Pasare C., and Medzhitov R. Control of B-cell responses by Toll-like receptors. Nature 438 (2005) 364-368
    • (2005) Nature , vol.438 , pp. 364-368
    • Pasare, C.1    Medzhitov, R.2
  • 66
    • 33845905223 scopus 로고    scopus 로고
    • Adjuvant-enhanced antibody responses in the absence of Toll-like receptor signaling
    • Gavin A.L., Hoebe K., Duong B., Ota T., Martin C., Beutler B., and Nemazee D. Adjuvant-enhanced antibody responses in the absence of Toll-like receptor signaling. Science 314 (2006) 1936-1938
    • (2006) Science , vol.314 , pp. 1936-1938
    • Gavin, A.L.1    Hoebe, K.2    Duong, B.3    Ota, T.4    Martin, C.5    Beutler, B.6    Nemazee, D.7
  • 67
    • 33748455338 scopus 로고    scopus 로고
    • Type I interferons in host defense
    • Stetson D.B., and Medzhitov R. Type I interferons in host defense. Immunity 25 (2006) 373-381
    • (2006) Immunity , vol.25 , pp. 373-381
    • Stetson, D.B.1    Medzhitov, R.2
  • 71
    • 33645841633 scopus 로고    scopus 로고
    • IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9
    • Hoshino K., Sugiyama T., Matsumoto M., Tanaka T., Saito M., Hemmi H., Ohara O., Akira S., and Kaisho T. IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature 440 (2006) 949-953
    • (2006) Nature , vol.440 , pp. 949-953
    • Hoshino, K.1    Sugiyama, T.2    Matsumoto, M.3    Tanaka, T.4    Saito, M.5    Hemmi, H.6    Ohara, O.7    Akira, S.8    Kaisho, T.9
  • 72
    • 33645963170 scopus 로고    scopus 로고
    • Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells
    • Shinohara M.L., Lu L., Bu J., Werneck M.B., Kobayashi K.S., Glimcher L.H., and Cantor H. Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol 7 (2006) 498-506
    • (2006) Nat Immunol , vol.7 , pp. 498-506
    • Shinohara, M.L.1    Lu, L.2    Bu, J.3    Werneck, M.B.4    Kobayashi, K.S.5    Glimcher, L.H.6    Cantor, H.7
  • 74
    • 30544447047 scopus 로고    scopus 로고
    • Critical role of TRAF3 in the Toll-like receptor-dependent and-independent antiviral response
    • Oganesyan G., Saha S.K., Guo B., He J.Q., Shahangian A., Zarnegar B., Perry A., and Cheng G. Critical role of TRAF3 in the Toll-like receptor-dependent and-independent antiviral response. Nature 439 (2006) 208-211
    • (2006) Nature , vol.439 , pp. 208-211
    • Oganesyan, G.1    Saha, S.K.2    Guo, B.3    He, J.Q.4    Shahangian, A.5    Zarnegar, B.6    Perry, A.7    Cheng, G.8
  • 75
    • 33947134377 scopus 로고    scopus 로고
    • Autophagy-dependent viral recognition by plasmacytoid dendritic cells
    • Lee H.K., Lund J.M., Ramanathan B., Mizushima N., and Iwasaki A. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315 (2007) 1398-1401
    • (2007) Science , vol.315 , pp. 1398-1401
    • Lee, H.K.1    Lund, J.M.2    Ramanathan, B.3    Mizushima, N.4    Iwasaki, A.5
  • 77
    • 21444443078 scopus 로고    scopus 로고
    • Tissue-specific positive feedback requirements for production of type I interferon following virus infection
    • Prakash A., Smith E., Lee C.K., and Levy D.E. Tissue-specific positive feedback requirements for production of type I interferon following virus infection. J. Biol. Chem. 280 (2005) 18651-18657
    • (2005) J. Biol. Chem. , vol.280 , pp. 18651-18657
    • Prakash, A.1    Smith, E.2    Lee, C.K.3    Levy, D.E.4
  • 78
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    • Honda K., Ohba Y., Yanai H., Negishi H., Mizutani T., Takaoka A., Taya C., and Taniguchi T. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434 (2005) 1035-1040
    • (2005) Nature , vol.434 , pp. 1035-1040
    • Honda, K.1    Ohba, Y.2    Yanai, H.3    Negishi, H.4    Mizutani, T.5    Takaoka, A.6    Taya, C.7    Taniguchi, T.8
  • 79
  • 81
    • 37049010982 scopus 로고    scopus 로고
    • Type I IFN production during herpes simplex virus infection is controlled by cell-type specific viral recognition through TLR9, the MAVS pathway, and novel recognition systems
    • Rasmussen S.B., Sorensen L.N., Malmgaard L., Ank N., Baines J.D., Chen Z.J., and Paludan S.R. Type I IFN production during herpes simplex virus infection is controlled by cell-type specific viral recognition through TLR9, the MAVS pathway, and novel recognition systems. J Virol 81 (2007) 13315-13324
    • (2007) J Virol , vol.81 , pp. 13315-13324
    • Rasmussen, S.B.1    Sorensen, L.N.2    Malmgaard, L.3    Ank, N.4    Baines, J.D.5    Chen, Z.J.6    Paludan, S.R.7
  • 82
    • 33748447541 scopus 로고    scopus 로고
    • Type I interferon in systemic lupus erythematosus and other autoimmune diseases
    • Banchereau J., and Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 25 (2006) 383-392
    • (2006) Immunity , vol.25 , pp. 383-392
    • Banchereau, J.1    Pascual, V.2
  • 87
    • 17844370012 scopus 로고    scopus 로고
    • DNase II polymorphisms associated with risk of renal disorder among systemic lupus erythematosus patients
    • Shin H.D., Park B.L., Cheong H.S., Lee H.S., Jun J.B., and Bae S.C. DNase II polymorphisms associated with risk of renal disorder among systemic lupus erythematosus patients. J. Hum. Genet. 50 (2005) 107-111
    • (2005) J. Hum. Genet. , vol.50 , pp. 107-111
    • Shin, H.D.1    Park, B.L.2    Cheong, H.S.3    Lee, H.S.4    Jun, J.B.5    Bae, S.C.6
  • 89
    • 3042548183 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent and-independent dendritic cell activation by chromatin-immunoglobulin G complexes
    • Boule M.W., Broughton C., Mackay F., Akira S., Marshak-Rothstein A., and Rifkin I.R. Toll-like receptor 9-dependent and-independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med. 199 (2004) 1631-1640
    • (2004) J. Exp. Med. , vol.199 , pp. 1631-1640
    • Boule, M.W.1    Broughton, C.2    Mackay, F.3    Akira, S.4    Marshak-Rothstein, A.5    Rifkin, I.R.6
  • 90
    • 85047693371 scopus 로고    scopus 로고
    • Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
    • Means T.K., Latz E., Hayashi F., Murali M.R., Golenbock D.T., and Luster A.D. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J. Clin. Invest. 115 (2005) 407-417
    • (2005) J. Clin. Invest. , vol.115 , pp. 407-417
    • Means, T.K.1    Latz, E.2    Hayashi, F.3    Murali, M.R.4    Golenbock, D.T.5    Luster, A.D.6
  • 92
    • 33745030751 scopus 로고    scopus 로고
    • Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen-and Sjogren's syndrome autoantigen-associated RNA
    • Lovgren T., Eloranta M.L., Kastner B., Wahren-Herlenius M., Alm G.V., and Ronnblom L. Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen-and Sjogren's syndrome autoantigen-associated RNA. Arthritis Rheum. 54 (2006) 1917-1927
    • (2006) Arthritis Rheum. , vol.54 , pp. 1917-1927
    • Lovgren, T.1    Eloranta, M.L.2    Kastner, B.3    Wahren-Herlenius, M.4    Alm, G.V.5    Ronnblom, L.6
  • 93
    • 33748472865 scopus 로고    scopus 로고
    • Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    • Christensen S.R., Shupe J., Nickerson K., Kashgarian M., Flavell R.A., and Shlomchik M.J. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25 (2006) 417-428
    • (2006) Immunity , vol.25 , pp. 417-428
    • Christensen, S.R.1    Shupe, J.2    Nickerson, K.3    Kashgarian, M.4    Flavell, R.A.5    Shlomchik, M.J.6
  • 94
    • 33745864016 scopus 로고    scopus 로고
    • Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus
    • Lartigue A., Courville P., Auquit I., Francois A., Arnoult C., Tron F., Gilbert D., and Musette P. Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus. J Immunol 177 (2006) 1349-1354
    • (2006) J Immunol , vol.177 , pp. 1349-1354
    • Lartigue, A.1    Courville, P.2    Auquit, I.3    Francois, A.4    Arnoult, C.5    Tron, F.6    Gilbert, D.7    Musette, P.8
  • 96
    • 27944453599 scopus 로고    scopus 로고
    • Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
    • Okabe Y., Kawane K., Akira S., Taniguchi T., and Nagata S. Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J Exp. Med. 202 (2005) 1333-1339
    • (2005) J Exp. Med. , vol.202 , pp. 1333-1339
    • Okabe, Y.1    Kawane, K.2    Akira, S.3    Taniguchi, T.4    Nagata, S.5
  • 97
  • 98
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson D.B., and Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24 (2006) 93-103
    • (2006) Immunity , vol.24 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 100
    • 33747772707 scopus 로고    scopus 로고
    • Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection
    • Louten J., van Rooijen N., and Biron C.A. Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection. J. Immunol. 177 (2006) 3266-3272
    • (2006) J. Immunol. , vol.177 , pp. 3266-3272
    • Louten, J.1    van Rooijen, N.2    Biron, C.A.3
  • 101
    • 36248952699 scopus 로고    scopus 로고
    • Seeing is believing: a focus on the contribution of microscopic imaging to our understanding of immune system function
    • Bajenoff M., and Germain R.N. Seeing is believing: a focus on the contribution of microscopic imaging to our understanding of immune system function. Eur. J. Immunol. 37 (2007) 18-33
    • (2007) Eur. J. Immunol. , vol.37 , pp. 18-33
    • Bajenoff, M.1    Germain, R.N.2
  • 102
    • 35348955182 scopus 로고    scopus 로고
    • Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus
    • Kwissa M., Amara R.R., Robinson H.L., Moss B., Alkan S., Jabbar A., Villinger F., and Pulendran B. Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus. J. Exp. Med. 204 (2007) 2733-2746
    • (2007) J. Exp. Med. , vol.204 , pp. 2733-2746
    • Kwissa, M.1    Amara, R.R.2    Robinson, H.L.3    Moss, B.4    Alkan, S.5    Jabbar, A.6    Villinger, F.7    Pulendran, B.8
  • 103
    • 3042548161 scopus 로고    scopus 로고
    • Use of CpG oligodeoxynucleotides as immunoprotective agents
    • Klinman D.M. Use of CpG oligodeoxynucleotides as immunoprotective agents. Expert. Opin. Biol. Ther. 4 (2004) 937-946
    • (2004) Expert. Opin. Biol. Ther. , vol.4 , pp. 937-946
    • Klinman, D.M.1
  • 104
    • 34248169629 scopus 로고    scopus 로고
    • Development of TLR9 agonists for cancer therapy
    • Krieg A.M. Development of TLR9 agonists for cancer therapy. J. Clin. Invest. 117 (2007) 1184-1194
    • (2007) J. Clin. Invest. , vol.117 , pp. 1184-1194
    • Krieg, A.M.1
  • 105
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of Toll-like receptor 9 activation
    • Krieg A.M. Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov 5 (2006) 471-484
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 471-484
    • Krieg, A.M.1


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