-
1
-
-
32944464648
-
Pathogen recognition and innate immunity
-
Akira S., Uematsu S., and Takeuchi O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
2
-
-
0021256125
-
Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
-
Tokunaga T., Yamamoto H., Shimada S., Abe H., Fukuda T., Fujisawa Y., Furutani Y., Yano O., Kataoka T., Sudo T., et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J. Natl. Cancer Inst. 72 (1984) 955-962
-
(1984)
J. Natl. Cancer Inst.
, vol.72
, pp. 955-962
-
-
Tokunaga, T.1
Yamamoto, H.2
Shimada, S.3
Abe, H.4
Fukuda, T.5
Fujisawa, Y.6
Furutani, Y.7
Yano, O.8
Kataoka, T.9
Sudo, T.10
-
3
-
-
0030897625
-
Bacterial DNA causes septic shock
-
Sparwasser T., Miethke T., Lipford G., Borschert K., Hacker H., Heeg K., and Wagner H. Bacterial DNA causes septic shock. Nature 386 (1997) 336-337
-
(1997)
Nature
, vol.386
, pp. 336-337
-
-
Sparwasser, T.1
Miethke, T.2
Lipford, G.3
Borschert, K.4
Hacker, H.5
Heeg, K.6
Wagner, H.7
-
4
-
-
33749490571
-
Innate immune recognition of, and regulation by, DNA
-
Ishii K.J., and Akira S. Innate immune recognition of, and regulation by, DNA. Trends Immunol. 27 (2006) 525-532
-
(2006)
Trends Immunol.
, vol.27
, pp. 525-532
-
-
Ishii, K.J.1
Akira, S.2
-
5
-
-
0030595339
-
The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
-
Lemaitre B., Nicolas E., Michaut L., Reichhart J.M., and Hoffmann J.A. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86 (1996) 973-983
-
(1996)
Cell
, vol.86
, pp. 973-983
-
-
Lemaitre, B.1
Nicolas, E.2
Michaut, L.3
Reichhart, J.M.4
Hoffmann, J.A.5
-
6
-
-
34748827433
-
Genetic analysis of resistance to viral infection
-
Beutler B., Eidenschenk C., Crozat K., Imler J.L., Takeuchi O., Hoffmann J.A., and Akira S. Genetic analysis of resistance to viral infection. Nat. Rev., Immunol. 7 (2007) 753-766
-
(2007)
Nat. Rev., Immunol.
, vol.7
, pp. 753-766
-
-
Beutler, B.1
Eidenschenk, C.2
Crozat, K.3
Imler, J.L.4
Takeuchi, O.5
Hoffmann, J.A.6
Akira, S.7
-
7
-
-
0033213590
-
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
-
Takeuchi O., Hoshino K., Kawai T., Sanjo H., Takada H., Ogawa T., Takeda K., and Akira S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 (1999) 443-451
-
(1999)
Immunity
, vol.11
, pp. 443-451
-
-
Takeuchi, O.1
Hoshino, K.2
Kawai, T.3
Sanjo, H.4
Takada, H.5
Ogawa, T.6
Takeda, K.7
Akira, S.8
-
8
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
-
Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., and Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 (1998) 2085-2088
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
He, X.2
Smirnova, I.3
Liu, M.Y.4
Van Huffel, C.5
Du, X.6
Birdwell, D.7
Alejos, E.8
Silva, M.9
Galanos, C.10
Freudenberg, M.11
Ricciardi-Castagnoli, P.12
Layton, B.13
Beutler, B.14
-
9
-
-
0033120081
-
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
-
Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K., and Akira S. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162 (1999) 3749-3752
-
(1999)
J Immunol
, vol.162
, pp. 3749-3752
-
-
Hoshino, K.1
Takeuchi, O.2
Kawai, T.3
Sanjo, H.4
Ogawa, T.5
Takeda, Y.6
Takeda, K.7
Akira, S.8
-
10
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
-
Alexopoulou L., Holt A.C., Medzhitov R., and Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 (2001) 732-738
-
(2001)
Nature
, vol.413
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
11
-
-
1542317550
-
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
-
Diebold S.S., Kaisho T., Hemmi H., Akira S., and Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303 (2004) 1529-1531
-
(2004)
Science
, vol.303
, pp. 1529-1531
-
-
Diebold, S.S.1
Kaisho, T.2
Hemmi, H.3
Akira, S.4
Reis e Sousa, C.5
-
12
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8
-
Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., Lipford G., Wagner H., and Bauer S. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303 (2004) 1526-1529
-
(2004)
Science
, vol.303
, pp. 1526-1529
-
-
Heil, F.1
Hemmi, H.2
Hochrein, H.3
Ampenberger, F.4
Kirschning, C.5
Akira, S.6
Lipford, G.7
Wagner, H.8
Bauer, S.9
-
13
-
-
0036008014
-
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
-
Hemmi H., Kaisho T., Takeuchi O., Sato S., Sanjo H., Hoshino K., Horiuchi T., Tomizawa H., Takeda K., and Akira S. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3 (2002) 196-200
-
(2002)
Nat. Immunol.
, vol.3
, pp. 196-200
-
-
Hemmi, H.1
Kaisho, T.2
Takeuchi, O.3
Sato, S.4
Sanjo, H.5
Hoshino, K.6
Horiuchi, T.7
Tomizawa, H.8
Takeda, K.9
Akira, S.10
-
14
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., and Akira S. A Toll-like receptor recognizes bacterial DNA. Nature 408 (2000) 740-745
-
(2000)
Nature
, vol.408
, pp. 740-745
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Kaisho, T.4
Sato, S.5
Sanjo, H.6
Matsumoto, M.7
Hoshino, K.8
Wagner, H.9
Takeda, K.10
Akira, S.11
-
15
-
-
3142683548
-
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
-
Krug A., French A.R., Barchet W., Fischer J.A., Dzionek A., Pingel J.T., Orihuela M.M., Akira S., Yokoyama W.M., and Colonna M. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21 (2004) 107-119
-
(2004)
Immunity
, vol.21
, pp. 107-119
-
-
Krug, A.1
French, A.R.2
Barchet, W.3
Fischer, J.A.4
Dzionek, A.5
Pingel, J.T.6
Orihuela, M.M.7
Akira, S.8
Yokoyama, W.M.9
Colonna, M.10
-
16
-
-
0842328805
-
Herpes simplex virus type 1 activates murine natural interferon-producing cells through Toll-like receptor 9
-
Krug A., Luker G.D., Barchet W., Leib D.A., Akira S., and Colonna M. Herpes simplex virus type 1 activates murine natural interferon-producing cells through Toll-like receptor 9. Blood 103 (2004) 1433-1437
-
(2004)
Blood
, vol.103
, pp. 1433-1437
-
-
Krug, A.1
Luker, G.D.2
Barchet, W.3
Leib, D.A.4
Akira, S.5
Colonna, M.6
-
17
-
-
0042123694
-
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
-
Lund J., Sato A., Akira S., Medzhitov R., and Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198 (2003) 513-520
-
(2003)
J. Exp. Med.
, vol.198
, pp. 513-520
-
-
Lund, J.1
Sato, A.2
Akira, S.3
Medzhitov, R.4
Iwasaki, A.5
-
18
-
-
31344461659
-
Innate immune recognition of viral infection
-
Kawai T., and Akira S. Innate immune recognition of viral infection. Nat. Immunol. 7 (2006) 131-137
-
(2006)
Nat. Immunol.
, vol.7
, pp. 131-137
-
-
Kawai, T.1
Akira, S.2
-
19
-
-
29244471275
-
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
-
Ishii K.J., Coban C., Kato H., Takahashi K., Torii Y., Takeshita F., Ludwig H., Sutter G., Suzuki K., Hemmi H., Sato S., Yamamoto M., Uematsu S., Kawai T., Takeuchi O., and Akira S. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat. Immunol. 7 (2006) 40-48
-
(2006)
Nat. Immunol.
, vol.7
, pp. 40-48
-
-
Ishii, K.J.1
Coban, C.2
Kato, H.3
Takahashi, K.4
Torii, Y.5
Takeshita, F.6
Ludwig, H.7
Sutter, G.8
Suzuki, K.9
Hemmi, H.10
Sato, S.11
Yamamoto, M.12
Uematsu, S.13
Kawai, T.14
Takeuchi, O.15
Akira, S.16
-
20
-
-
1842631153
-
Immunotherapeutic uses of CpG oligodeoxynucleotides
-
Klinman D.M. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4 (2004) 249-258
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 249-258
-
-
Klinman, D.M.1
-
21
-
-
0037443644
-
The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
-
Hemmi H., Kaisho T., Takeda K., and Akira S. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J. Immunol. 170 (2003) 3059-3064
-
(2003)
J. Immunol.
, vol.170
, pp. 3059-3064
-
-
Hemmi, H.1
Kaisho, T.2
Takeda, K.3
Akira, S.4
-
22
-
-
29144434113
-
TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
-
Bafica A., Scanga C.A., Feng C.G., Leifer C., Cheever A., and Sher A. TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. J. Exp. Med. 202 (2005) 1715-1724
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1715-1724
-
-
Bafica, A.1
Scanga, C.A.2
Feng, C.G.3
Leifer, C.4
Cheever, A.5
Sher, A.6
-
23
-
-
34247161891
-
MyD88-dependent activation of B220-CD11b+LY-6C+dendritic cells during Brucella melitensis infection
-
Copin R., De Baetselier P., Carlier Y., Letesson J.J., and Muraille E. MyD88-dependent activation of B220-CD11b+LY-6C+dendritic cells during Brucella melitensis infection. J. Immunol. 178 (2007) 5182-5191
-
(2007)
J. Immunol.
, vol.178
, pp. 5182-5191
-
-
Copin, R.1
De Baetselier, P.2
Carlier, Y.3
Letesson, J.J.4
Muraille, E.5
-
24
-
-
34250305202
-
TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae
-
Lee K.S., Scanga C.A., Bachelder E.M., Chen Q., and Snapper C.M. TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae. Cell Immunol. 245 (2007) 103-110
-
(2007)
Cell Immunol.
, vol.245
, pp. 103-110
-
-
Lee, K.S.1
Scanga, C.A.2
Bachelder, E.M.3
Chen, Q.4
Snapper, C.M.5
-
25
-
-
34250650116
-
TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: results from a genome-wide scan
-
Anderson A.E., Worku M.L., Khamri W., Bamford K.B., Walker M.M., and Thursz M.R. TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: results from a genome-wide scan. Eur. J. Immunol. 37 (2007) 1548-1561
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 1548-1561
-
-
Anderson, A.E.1
Worku, M.L.2
Khamri, W.3
Bamford, K.B.4
Walker, M.M.5
Thursz, M.R.6
-
26
-
-
33947396347
-
Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and-independent pathways
-
Zhu J., Huang X., and Yang Y. Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and-independent pathways. J. Virol. 81 (2007) 3170-3180
-
(2007)
J. Virol.
, vol.81
, pp. 3170-3180
-
-
Zhu, J.1
Huang, X.2
Yang, Y.3
-
27
-
-
19944430901
-
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
-
Coban C., Ishii K.J., Kawai T., Hemmi H., Sato S., Uematsu S., Yamamoto M., Takeuchi O., Itagaki S., Kumar N., Horii T., and Akira S. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J. Exp. Med. 201 (2005) 19-25
-
(2005)
J. Exp. Med.
, vol.201
, pp. 19-25
-
-
Coban, C.1
Ishii, K.J.2
Kawai, T.3
Hemmi, H.4
Sato, S.5
Uematsu, S.6
Yamamoto, M.7
Takeuchi, O.8
Itagaki, S.9
Kumar, N.10
Horii, T.11
Akira, S.12
-
28
-
-
33846911691
-
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9
-
Parroche P., Lauw F.N., Goutagny N., Latz E., Monks B.G., Visintin A., Halmen K.A., Lamphier M., Olivier M., Bartholomeu D.C., Gazzinelli R.T., and Golenbock D.T. Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 1919-1924
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 1919-1924
-
-
Parroche, P.1
Lauw, F.N.2
Goutagny, N.3
Latz, E.4
Monks, B.G.5
Visintin, A.6
Halmen, K.A.7
Lamphier, M.8
Olivier, M.9
Bartholomeu, D.C.10
Gazzinelli, R.T.11
Golenbock, D.T.12
-
29
-
-
33845868751
-
Pathological role of Toll-like receptor signaling in cerebral malaria
-
Coban C., Ishii K.J., Uematsu S., Arisue N., Sato S., Yamamoto M., Kawai T., Takeuchi O., Hisaeda H., Horii T., and Akira S. Pathological role of Toll-like receptor signaling in cerebral malaria. Int. Immunol. 19 (2007) 67-79
-
(2007)
Int. Immunol.
, vol.19
, pp. 67-79
-
-
Coban, C.1
Ishii, K.J.2
Uematsu, S.3
Arisue, N.4
Sato, S.5
Yamamoto, M.6
Kawai, T.7
Takeuchi, O.8
Hisaeda, H.9
Horii, T.10
Akira, S.11
-
30
-
-
4744368053
-
Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation
-
Vollmer J., Weeratna R.D., Jurk M., Samulowitz U., McCluskie M.J., Payette P., Davis H.L., Schetter C., and Krieg A.M. Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation. Immunology 113 (2004) 212-223
-
(2004)
Immunology
, vol.113
, pp. 212-223
-
-
Vollmer, J.1
Weeratna, R.D.2
Jurk, M.3
Samulowitz, U.4
McCluskie, M.J.5
Payette, P.6
Davis, H.L.7
Schetter, C.8
Krieg, A.M.9
-
31
-
-
11844290125
-
Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides
-
Roberts T.L., Sweet M.J., Hume D.A., and Stacey K.J. Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides. J. Immunol. 174 (2005) 605-608
-
(2005)
J. Immunol.
, vol.174
, pp. 605-608
-
-
Roberts, T.L.1
Sweet, M.J.2
Hume, D.A.3
Stacey, K.J.4
-
32
-
-
21044444274
-
Immunomodulatory oligonucleotides containing a cytosine-phosphate-2′-deoxy-7-deazaguanosine motif as potent Toll-like receptor 9 agonists
-
Kandimalla E.R., Bhagat L., Li Y., Yu D., Wang D., Cong Y.P., Song S.S., Tang J.X., Sullivan T., and Agrawal S. Immunomodulatory oligonucleotides containing a cytosine-phosphate-2′-deoxy-7-deazaguanosine motif as potent Toll-like receptor 9 agonists. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 6925-6930
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 6925-6930
-
-
Kandimalla, E.R.1
Bhagat, L.2
Li, Y.3
Yu, D.4
Wang, D.5
Cong, Y.P.6
Song, S.S.7
Tang, J.X.8
Sullivan, T.9
Agrawal, S.10
-
33
-
-
10744219675
-
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
-
Latz E., Schoenemeyer A., Visintin A., Fitzgerald K.A., Monks B.G., Knetter C.F., Lien E., Nilsen N.J., Espevik T., and Golenbock D.T. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5 (2004) 190-198
-
(2004)
Nat. Immunol.
, vol.5
, pp. 190-198
-
-
Latz, E.1
Schoenemeyer, A.2
Visintin, A.3
Fitzgerald, K.A.4
Monks, B.G.5
Knetter, C.F.6
Lien, E.7
Nilsen, N.J.8
Espevik, T.9
Golenbock, D.T.10
-
34
-
-
0034698739
-
Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6
-
Hacker H., Vabulas R.M., Takeuchi O., Hoshino K., Akira S., and Wagner H. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med. 192 (2000) 595-600
-
(2000)
J. Exp. Med.
, vol.192
, pp. 595-600
-
-
Hacker, H.1
Vabulas, R.M.2
Takeuchi, O.3
Hoshino, K.4
Akira, S.5
Wagner, H.6
-
35
-
-
34247566510
-
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
-
O'Neill L.A., and Bowie A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7 (2007) 353-364
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 353-364
-
-
O'Neill, L.A.1
Bowie, A.G.2
-
36
-
-
34249095729
-
Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling
-
Kawagoe T., Sato S., Jung A., Yamamoto M., Matsui K., Kato H., Uematsu S., Takeuchi O., and Akira S. Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. J. Exp. Med. 204 (2007) 1013-1024
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1013-1024
-
-
Kawagoe, T.1
Sato, S.2
Jung, A.3
Yamamoto, M.4
Matsui, K.5
Kato, H.6
Uematsu, S.7
Takeuchi, O.8
Akira, S.9
-
37
-
-
0034644474
-
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
-
Deng L., Wang C., Spencer E., Yang L., Braun A., You J., Slaughter C., Pickart C., and Chen Z.J. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103 (2000) 351-361
-
(2000)
Cell
, vol.103
, pp. 351-361
-
-
Deng, L.1
Wang, C.2
Spencer, E.3
Yang, L.4
Braun, A.5
You, J.6
Slaughter, C.7
Pickart, C.8
Chen, Z.J.9
-
38
-
-
0035913278
-
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
-
Wang C., Deng L., Hong M., Akkaraju G.R., Inoue J., and Chen Z.J. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412 (2001) 346-351
-
(2001)
Nature
, vol.412
, pp. 346-351
-
-
Wang, C.1
Deng, L.2
Hong, M.3
Akkaraju, G.R.4
Inoue, J.5
Chen, Z.J.6
-
39
-
-
33747615237
-
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
-
Yamamoto M., Okamoto T., Takeda K., Sato S., Sanjo H., Uematsu S., Saitoh T., Yamamoto N., Sakurai H., Ishii K.J., Yamaoka S., Kawai T., Matsuura Y., Takeuchi O., and Akira S. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat. Immunol. 7 (2006) 962-970
-
(2006)
Nat. Immunol.
, vol.7
, pp. 962-970
-
-
Yamamoto, M.1
Okamoto, T.2
Takeda, K.3
Sato, S.4
Sanjo, H.5
Uematsu, S.6
Saitoh, T.7
Yamamoto, N.8
Sakurai, H.9
Ishii, K.J.10
Yamaoka, S.11
Kawai, T.12
Matsuura, Y.13
Takeuchi, O.14
Akira, S.15
-
40
-
-
27544434183
-
Essential function for the kinase TAK1 in innate and adaptive immune responses
-
Sato S., Sanjo H., Takeda K., Ninomiya-Tsuji J., Yamamoto M., Kawai T., Matsumoto K., Takeuchi O., and Akira S. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat. Immunol. 6 (2005) 1087-1095
-
(2005)
Nat. Immunol.
, vol.6
, pp. 1087-1095
-
-
Sato, S.1
Sanjo, H.2
Takeda, K.3
Ninomiya-Tsuji, J.4
Yamamoto, M.5
Kawai, T.6
Matsumoto, K.7
Takeuchi, O.8
Akira, S.9
-
41
-
-
15044345461
-
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
-
Takaoka A., Yanai H., Kondo S., Duncan G., Negishi H., Mizutani T., Kano S., Honda K., Ohba Y., Mak T.W., and Taniguchi T. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434 (2005) 243-249
-
(2005)
Nature
, vol.434
, pp. 243-249
-
-
Takaoka, A.1
Yanai, H.2
Kondo, S.3
Duncan, G.4
Negishi, H.5
Mizutani, T.6
Kano, S.7
Honda, K.8
Ohba, Y.9
Mak, T.W.10
Taniguchi, T.11
-
42
-
-
0037099629
-
Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation
-
Ishii K.J., Takeshita F., Gursel I., Gursel M., Conover J., Nussenzweig A., and Klinman D.M. Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. J. Exp. Med. 196 (2002) 269-274
-
(2002)
J. Exp. Med.
, vol.196
, pp. 269-274
-
-
Ishii, K.J.1
Takeshita, F.2
Gursel, I.3
Gursel, M.4
Conover, J.5
Nussenzweig, A.6
Klinman, D.M.7
-
43
-
-
33646473522
-
Class I and III phosphatidylinositol 3′-kinase play distinct roles in TLR signaling pathway
-
Kuo C.C., Lin W.T., Liang C.M., and Liang S.M. Class I and III phosphatidylinositol 3′-kinase play distinct roles in TLR signaling pathway. J. Immunol. 176 (2006) 5943-5949
-
(2006)
J. Immunol.
, vol.176
, pp. 5943-5949
-
-
Kuo, C.C.1
Lin, W.T.2
Liang, C.M.3
Liang, S.M.4
-
44
-
-
0037629646
-
PI3K and negative regulation of TLR signaling
-
Fukao T., and Koyasu S. PI3K and negative regulation of TLR signaling. Trends Immunol. 24 (2003) 358-363
-
(2003)
Trends Immunol.
, vol.24
, pp. 358-363
-
-
Fukao, T.1
Koyasu, S.2
-
45
-
-
0036318851
-
Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
-
Ahmad-Nejad P., Hacker H., Rutz M., Bauer S., Vabulas R.M., and Wagner H. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32 (2002) 1958-1968
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 1958-1968
-
-
Ahmad-Nejad, P.1
Hacker, H.2
Rutz, M.3
Bauer, S.4
Vabulas, R.M.5
Wagner, H.6
-
46
-
-
0032525023
-
CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
-
Yi A.K., Tuetken R., Redford T., Waldschmidt M., Kirsch J., and Krieg A.M. CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J. Immunol. 160 (1998) 4755-4761
-
(1998)
J. Immunol.
, vol.160
, pp. 4755-4761
-
-
Yi, A.K.1
Tuetken, R.2
Redford, T.3
Waldschmidt, M.4
Kirsch, J.5
Krieg, A.M.6
-
47
-
-
0032476602
-
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
-
Hacker H., Mischak H., Miethke T., Liptay S., Schmid R., Sparwasser T., Heeg K., Lipford G.B., and Wagner H. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. Embo. J. 17 (1998) 6230-6240
-
(1998)
Embo. J.
, vol.17
, pp. 6230-6240
-
-
Hacker, H.1
Mischak, H.2
Miethke, T.3
Liptay, S.4
Schmid, R.5
Sparwasser, T.6
Heeg, K.7
Lipford, G.B.8
Wagner, H.9
-
48
-
-
29244450802
-
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
-
Barton G.M., Kagan J.C., and Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat. Immunol. 7 (2006) 49-56
-
(2006)
Nat. Immunol.
, vol.7
, pp. 49-56
-
-
Barton, G.M.1
Kagan, J.C.2
Medzhitov, R.3
-
49
-
-
31344466165
-
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
-
Tabeta K., Hoebe K., Janssen E.M., Du X., Georgel P., Crozat K., Mudd S., Mann N., Sovath S., Goode J., Shamel L., Herskovits A.A., Portnoy D.A., Cooke M., Tarantino L.M., Wiltshire T., Steinberg B.E., Grinstein S., and Beutler B. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat. Immunol. 7 (2006) 156-164
-
(2006)
Nat. Immunol.
, vol.7
, pp. 156-164
-
-
Tabeta, K.1
Hoebe, K.2
Janssen, E.M.3
Du, X.4
Georgel, P.5
Crozat, K.6
Mudd, S.7
Mann, N.8
Sovath, S.9
Goode, J.10
Shamel, L.11
Herskovits, A.A.12
Portnoy, D.A.13
Cooke, M.14
Tarantino, L.M.15
Wiltshire, T.16
Steinberg, B.E.17
Grinstein, S.18
Beutler, B.19
-
50
-
-
17644372733
-
IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
-
Liu Y.J. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 23 (2005) 275-306
-
(2005)
Annu. Rev. Immunol.
, vol.23
, pp. 275-306
-
-
Liu, Y.J.1
-
51
-
-
24344478196
-
Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
-
Kolumam G.A., Thomas S., Thompson L.J., Sprent J., and Murali-Krishna K. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J. Exp. Med. 202 (2005) 637-650
-
(2005)
J. Exp. Med.
, vol.202
, pp. 637-650
-
-
Kolumam, G.A.1
Thomas, S.2
Thompson, L.J.3
Sprent, J.4
Murali-Krishna, K.5
-
52
-
-
33644837684
-
Cutting edge: the direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection
-
Havenar-Daughton C., Kolumam G.A., and Murali-Krishna K. Cutting edge: the direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection. J. Immunol. 176 (2006) 3315-3319
-
(2006)
J. Immunol.
, vol.176
, pp. 3315-3319
-
-
Havenar-Daughton, C.1
Kolumam, G.A.2
Murali-Krishna, K.3
-
53
-
-
32244448339
-
Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity
-
Chan C.W., Crafton E., Fan H.N., Flook J., Yoshimura K., Skarica M., Brockstedt D., Dubensky T.W., Stins M.F., Lanier L.L., Pardoll D.M., and Housseau F. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat. Med. 12 (2006) 207-213
-
(2006)
Nat. Med.
, vol.12
, pp. 207-213
-
-
Chan, C.W.1
Crafton, E.2
Fan, H.N.3
Flook, J.4
Yoshimura, K.5
Skarica, M.6
Brockstedt, D.7
Dubensky, T.W.8
Stins, M.F.9
Lanier, L.L.10
Pardoll, D.M.11
Housseau, F.12
-
54
-
-
32244445715
-
A novel dendritic cell subset involved in tumor immunosurveillance
-
Taieb J., Chaput N., Menard C., Apetoh L., Ullrich E., Bonmort M., Pequignot M., Casares N., Terme M., Flament C., Opolon P., Lecluse Y., Metivier D., Tomasello E., Vivier E., Ghiringhelli F., Martin F., Klatzmann D., Poynard T., Tursz T., Raposo G., Yagita H., Ryffel B., Kroemer G., and Zitvogel L. A novel dendritic cell subset involved in tumor immunosurveillance. Nat. Med. 12 (2006) 214-219
-
(2006)
Nat. Med.
, vol.12
, pp. 214-219
-
-
Taieb, J.1
Chaput, N.2
Menard, C.3
Apetoh, L.4
Ullrich, E.5
Bonmort, M.6
Pequignot, M.7
Casares, N.8
Terme, M.9
Flament, C.10
Opolon, P.11
Lecluse, Y.12
Metivier, D.13
Tomasello, E.14
Vivier, E.15
Ghiringhelli, F.16
Martin, F.17
Klatzmann, D.18
Poynard, T.19
Tursz, T.20
Raposo, G.21
Yagita, H.22
Ryffel, B.23
Kroemer, G.24
Zitvogel, L.25
more..
-
55
-
-
33846861553
-
Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells
-
Vremec D., O'Keeffe M., Hochrein H., Fuchsberger M., Caminschi I., Lahoud M., and Shortman K. Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells. Blood 109 (2007) 1165-1173
-
(2007)
Blood
, vol.109
, pp. 1165-1173
-
-
Vremec, D.1
O'Keeffe, M.2
Hochrein, H.3
Fuchsberger, M.4
Caminschi, I.5
Lahoud, M.6
Shortman, K.7
-
56
-
-
34548028711
-
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses
-
Kumagai Y., Takeuchi O., Kato H., Kumar H., Matsui K., Morii E., Aozasa K., Kawai T., and Akira S. Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. Immunity 27 (2007) 240-252
-
(2007)
Immunity
, vol.27
, pp. 240-252
-
-
Kumagai, Y.1
Takeuchi, O.2
Kato, H.3
Kumar, H.4
Matsui, K.5
Morii, E.6
Aozasa, K.7
Kawai, T.8
Akira, S.9
-
57
-
-
35748972077
-
Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells
-
Blasius A.L., Barchet W., Cella M., and Colonna M. Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells. J. Exp. Med. 204 (2007) 2561-2568
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2561-2568
-
-
Blasius, A.L.1
Barchet, W.2
Cella, M.3
Colonna, M.4
-
58
-
-
35748942920
-
Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells
-
Caminschi I., Ahmet F., Heger K., Brady J., Nutt S.L., Vremec D., Pietersz S., Lahoud M.H., Schofield L., Hansen D.S., O'Keeffe M., Smyth M.J., Bedoui S., Davey G.M., Villadangos J.A., Heath W.R., and Shortman K. Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells. J. Exp. Med. 204 (2007) 2579-2590
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2579-2590
-
-
Caminschi, I.1
Ahmet, F.2
Heger, K.3
Brady, J.4
Nutt, S.L.5
Vremec, D.6
Pietersz, S.7
Lahoud, M.H.8
Schofield, L.9
Hansen, D.S.10
O'Keeffe, M.11
Smyth, M.J.12
Bedoui, S.13
Davey, G.M.14
Villadangos, J.A.15
Heath, W.R.16
Shortman, K.17
-
59
-
-
35748943227
-
CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells
-
Vosshenrich C.A., Lesjean-Pottier S., Hasan M., Richard-Le Goff O., Corcuff E., Mandelboim O., and Di Santo J.P. CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells. J. Exp. Med. 204 (2007) 2569-2578
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2569-2578
-
-
Vosshenrich, C.A.1
Lesjean-Pottier, S.2
Hasan, M.3
Richard-Le Goff, O.4
Corcuff, E.5
Mandelboim, O.6
Di Santo, J.P.7
-
60
-
-
33745214259
-
Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
-
Kuwajima S., Sato T., Ishida K., Tada H., Tezuka H., and Ohteki T. Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat. Immunol. 7 (2006) 740-746
-
(2006)
Nat. Immunol.
, vol.7
, pp. 740-746
-
-
Kuwajima, S.1
Sato, T.2
Ishida, K.3
Tada, H.4
Tezuka, H.5
Ohteki, T.6
-
61
-
-
34247100277
-
Dendritic cells prime natural killer cells by trans-presenting interleukin 15
-
Lucas M., Schachterle W., Oberle K., Aichele P., and Diefenbach A. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26 (2007) 503-517
-
(2007)
Immunity
, vol.26
, pp. 503-517
-
-
Lucas, M.1
Schachterle, W.2
Oberle, K.3
Aichele, P.4
Diefenbach, A.5
-
62
-
-
0028931102
-
CpG motifs in bacterial DNA trigger direct B-cell activation
-
Krieg A.M., Yi A.K., Matson S., Waldschmidt T.J., Bishop G.A., Teasdale R., Koretzky G.A., and Klinman D.M. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374 (1995) 546-549
-
(1995)
Nature
, vol.374
, pp. 546-549
-
-
Krieg, A.M.1
Yi, A.K.2
Matson, S.3
Waldschmidt, T.J.4
Bishop, G.A.5
Teasdale, R.6
Koretzky, G.A.7
Klinman, D.M.8
-
63
-
-
2942748202
-
CpG DNA redirects class-switching towards "Th1-like" Ig isotype production via TLR9 and MyD88
-
Lin L., Gerth A.J., and Peng S.L. CpG DNA redirects class-switching towards "Th1-like" Ig isotype production via TLR9 and MyD88. Eur. J. Immunol. 34 (2004) 1483-1487
-
(2004)
Eur. J. Immunol.
, vol.34
, pp. 1483-1487
-
-
Lin, L.1
Gerth, A.J.2
Peng, S.L.3
-
64
-
-
0038639600
-
CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells
-
Liu N., Ohnishi N., Ni L., Akira S., and Bacon K.B. CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat. Immunol. 4 (2003) 687-693
-
(2003)
Nat. Immunol.
, vol.4
, pp. 687-693
-
-
Liu, N.1
Ohnishi, N.2
Ni, L.3
Akira, S.4
Bacon, K.B.5
-
65
-
-
27844541797
-
Control of B-cell responses by Toll-like receptors
-
Pasare C., and Medzhitov R. Control of B-cell responses by Toll-like receptors. Nature 438 (2005) 364-368
-
(2005)
Nature
, vol.438
, pp. 364-368
-
-
Pasare, C.1
Medzhitov, R.2
-
66
-
-
33845905223
-
Adjuvant-enhanced antibody responses in the absence of Toll-like receptor signaling
-
Gavin A.L., Hoebe K., Duong B., Ota T., Martin C., Beutler B., and Nemazee D. Adjuvant-enhanced antibody responses in the absence of Toll-like receptor signaling. Science 314 (2006) 1936-1938
-
(2006)
Science
, vol.314
, pp. 1936-1938
-
-
Gavin, A.L.1
Hoebe, K.2
Duong, B.3
Ota, T.4
Martin, C.5
Beutler, B.6
Nemazee, D.7
-
67
-
-
33748455338
-
Type I interferons in host defense
-
Stetson D.B., and Medzhitov R. Type I interferons in host defense. Immunity 25 (2006) 373-381
-
(2006)
Immunity
, vol.25
, pp. 373-381
-
-
Stetson, D.B.1
Medzhitov, R.2
-
68
-
-
17144404177
-
IRF-7 is the master regulator of type-I interferon-dependent immune responses
-
Honda K., Yanai H., Negishi H., Asagiri M., Sato M., Mizutani T., Shimada N., Ohba Y., Takaoka A., Yoshida N., and Taniguchi T. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434 (2005) 772-777
-
(2005)
Nature
, vol.434
, pp. 772-777
-
-
Honda, K.1
Yanai, H.2
Negishi, H.3
Asagiri, M.4
Sato, M.5
Mizutani, T.6
Shimada, N.7
Ohba, Y.8
Takaoka, A.9
Yoshida, N.10
Taniguchi, T.11
-
69
-
-
5444274514
-
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
-
Kawai T., Sato S., Ishii K.J., Coban C., Hemmi H., Yamamoto M., Terai K., Matsuda M., Inoue J., Uematsu S., Takeuchi O., and Akira S. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5 (2004) 1061-1068
-
(2004)
Nat. Immunol.
, vol.5
, pp. 1061-1068
-
-
Kawai, T.1
Sato, S.2
Ishii, K.J.3
Coban, C.4
Hemmi, H.5
Yamamoto, M.6
Terai, K.7
Matsuda, M.8
Inoue, J.9
Uematsu, S.10
Takeuchi, O.11
Akira, S.12
-
70
-
-
20244388983
-
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7-and TLR9-mediated interferon-{alpha} induction
-
Uematsu S., Sato S., Yamamoto M., Hirotani T., Kato H., Takeshita F., Matsuda M., Coban C., Ishii K.J., Kawai T., Takeuchi O., and Akira S. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7-and TLR9-mediated interferon-{alpha} induction. J. Exp. Med. 201 (2005) 915-923
-
(2005)
J. Exp. Med.
, vol.201
, pp. 915-923
-
-
Uematsu, S.1
Sato, S.2
Yamamoto, M.3
Hirotani, T.4
Kato, H.5
Takeshita, F.6
Matsuda, M.7
Coban, C.8
Ishii, K.J.9
Kawai, T.10
Takeuchi, O.11
Akira, S.12
-
71
-
-
33645841633
-
IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9
-
Hoshino K., Sugiyama T., Matsumoto M., Tanaka T., Saito M., Hemmi H., Ohara O., Akira S., and Kaisho T. IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature 440 (2006) 949-953
-
(2006)
Nature
, vol.440
, pp. 949-953
-
-
Hoshino, K.1
Sugiyama, T.2
Matsumoto, M.3
Tanaka, T.4
Saito, M.5
Hemmi, H.6
Ohara, O.7
Akira, S.8
Kaisho, T.9
-
72
-
-
33645963170
-
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells
-
Shinohara M.L., Lu L., Bu J., Werneck M.B., Kobayashi K.S., Glimcher L.H., and Cantor H. Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol 7 (2006) 498-506
-
(2006)
Nat Immunol
, vol.7
, pp. 498-506
-
-
Shinohara, M.L.1
Lu, L.2
Bu, J.3
Werneck, M.B.4
Kobayashi, K.S.5
Glimcher, L.H.6
Cantor, H.7
-
73
-
-
30544451546
-
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
-
Hacker H., Redecke V., Blagoev B., Kratchmarova I., Hsu L.C., Wang G.G., Kamps M.P., Raz E., Wagner H., Hacker G., Mann M., and Karin M. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439 (2006) 204-207
-
(2006)
Nature
, vol.439
, pp. 204-207
-
-
Hacker, H.1
Redecke, V.2
Blagoev, B.3
Kratchmarova, I.4
Hsu, L.C.5
Wang, G.G.6
Kamps, M.P.7
Raz, E.8
Wagner, H.9
Hacker, G.10
Mann, M.11
Karin, M.12
-
74
-
-
30544447047
-
Critical role of TRAF3 in the Toll-like receptor-dependent and-independent antiviral response
-
Oganesyan G., Saha S.K., Guo B., He J.Q., Shahangian A., Zarnegar B., Perry A., and Cheng G. Critical role of TRAF3 in the Toll-like receptor-dependent and-independent antiviral response. Nature 439 (2006) 208-211
-
(2006)
Nature
, vol.439
, pp. 208-211
-
-
Oganesyan, G.1
Saha, S.K.2
Guo, B.3
He, J.Q.4
Shahangian, A.5
Zarnegar, B.6
Perry, A.7
Cheng, G.8
-
75
-
-
33947134377
-
Autophagy-dependent viral recognition by plasmacytoid dendritic cells
-
Lee H.K., Lund J.M., Ramanathan B., Mizushima N., and Iwasaki A. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315 (2007) 1398-1401
-
(2007)
Science
, vol.315
, pp. 1398-1401
-
-
Lee, H.K.1
Lund, J.M.2
Ramanathan, B.3
Mizushima, N.4
Iwasaki, A.5
-
76
-
-
33750064259
-
Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program
-
Negishi H., Fujita Y., Yanai H., Sakaguchi S., Ouyang X., Shinohara M., Takayanagi H., Ohba Y., Taniguchi T., and Honda K. Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 15136-15141
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 15136-15141
-
-
Negishi, H.1
Fujita, Y.2
Yanai, H.3
Sakaguchi, S.4
Ouyang, X.5
Shinohara, M.6
Takayanagi, H.7
Ohba, Y.8
Taniguchi, T.9
Honda, K.10
-
77
-
-
21444443078
-
Tissue-specific positive feedback requirements for production of type I interferon following virus infection
-
Prakash A., Smith E., Lee C.K., and Levy D.E. Tissue-specific positive feedback requirements for production of type I interferon following virus infection. J. Biol. Chem. 280 (2005) 18651-18657
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 18651-18657
-
-
Prakash, A.1
Smith, E.2
Lee, C.K.3
Levy, D.E.4
-
78
-
-
17844380477
-
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
-
Honda K., Ohba Y., Yanai H., Negishi H., Mizutani T., Takaoka A., Taya C., and Taniguchi T. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434 (2005) 1035-1040
-
(2005)
Nature
, vol.434
, pp. 1035-1040
-
-
Honda, K.1
Ohba, Y.2
Yanai, H.3
Negishi, H.4
Mizutani, T.5
Takaoka, A.6
Taya, C.7
Taniguchi, T.8
-
79
-
-
33746884630
-
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
-
Guiducci C., Ott G., Chan J.H., Damon E., Calacsan C., Matray T., Lee K.D., Coffman R.L., and Barrat F.J. Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J. Exp. Med. 203 (2006) 1999-2008
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1999-2008
-
-
Guiducci, C.1
Ott, G.2
Chan, J.H.3
Damon, E.4
Calacsan, C.5
Matray, T.6
Lee, K.D.7
Coffman, R.L.8
Barrat, F.J.9
-
80
-
-
3843103508
-
Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and-independent pathways
-
Hochrein H., Schlatter B., O'Keeffe M., Wagner C., Schmitz F., Schiemann M., Bauer S., Suter M., and Wagner H. Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and-independent pathways. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 11416-11421
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 11416-11421
-
-
Hochrein, H.1
Schlatter, B.2
O'Keeffe, M.3
Wagner, C.4
Schmitz, F.5
Schiemann, M.6
Bauer, S.7
Suter, M.8
Wagner, H.9
-
81
-
-
37049010982
-
Type I IFN production during herpes simplex virus infection is controlled by cell-type specific viral recognition through TLR9, the MAVS pathway, and novel recognition systems
-
Rasmussen S.B., Sorensen L.N., Malmgaard L., Ank N., Baines J.D., Chen Z.J., and Paludan S.R. Type I IFN production during herpes simplex virus infection is controlled by cell-type specific viral recognition through TLR9, the MAVS pathway, and novel recognition systems. J Virol 81 (2007) 13315-13324
-
(2007)
J Virol
, vol.81
, pp. 13315-13324
-
-
Rasmussen, S.B.1
Sorensen, L.N.2
Malmgaard, L.3
Ank, N.4
Baines, J.D.5
Chen, Z.J.6
Paludan, S.R.7
-
82
-
-
33748447541
-
Type I interferon in systemic lupus erythematosus and other autoimmune diseases
-
Banchereau J., and Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 25 (2006) 383-392
-
(2006)
Immunity
, vol.25
, pp. 383-392
-
-
Banchereau, J.1
Pascual, V.2
-
83
-
-
0037061453
-
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
-
Leadbetter E.A., Rifkin I.R., Hohlbaum A.M., Beaudette B.C., Shlomchik M.J., and Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416 (2002) 603-607
-
(2002)
Nature
, vol.416
, pp. 603-607
-
-
Leadbetter, E.A.1
Rifkin, I.R.2
Hohlbaum, A.M.3
Beaudette, B.C.4
Shlomchik, M.J.5
Marshak-Rothstein, A.6
-
84
-
-
27744444832
-
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
-
Lau C.M., Broughton C., Tabor A.S., Akira S., Flavell R.A., Mamula M.J., Christensen S.R., Shlomchik M.J., Viglianti G.A., Rifkin I.R., and Marshak-Rothstein A. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J. Exp. Med. 202 (2005) 1171-1177
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1171-1177
-
-
Lau, C.M.1
Broughton, C.2
Tabor, A.S.3
Akira, S.4
Flavell, R.A.5
Mamula, M.J.6
Christensen, S.R.7
Shlomchik, M.J.8
Viglianti, G.A.9
Rifkin, I.R.10
Marshak-Rothstein, A.11
-
85
-
-
28544449709
-
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
-
Vollmer J., Tluk S., Schmitz C., Hamm S., Jurk M., Forsbach A., Akira S., Kelly K.M., Reeves W.H., Bauer S., and Krieg A.M. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J. Exp. Med. 202 (2005) 1575-1585
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1575-1585
-
-
Vollmer, J.1
Tluk, S.2
Schmitz, C.3
Hamm, S.4
Jurk, M.5
Forsbach, A.6
Akira, S.7
Kelly, K.M.8
Reeves, W.H.9
Bauer, S.10
Krieg, A.M.11
-
86
-
-
0034939627
-
Mutation of DNASE1 in people with systemic lupus erythematosus
-
Yasutomo K., Horiuchi T., Kagami S., Tsukamoto H., Hashimura C., Urushihara M., and Kuroda Y. Mutation of DNASE1 in people with systemic lupus erythematosus. Nat. Genet. 28 (2001) 313-314
-
(2001)
Nat. Genet.
, vol.28
, pp. 313-314
-
-
Yasutomo, K.1
Horiuchi, T.2
Kagami, S.3
Tsukamoto, H.4
Hashimura, C.5
Urushihara, M.6
Kuroda, Y.7
-
87
-
-
17844370012
-
DNase II polymorphisms associated with risk of renal disorder among systemic lupus erythematosus patients
-
Shin H.D., Park B.L., Cheong H.S., Lee H.S., Jun J.B., and Bae S.C. DNase II polymorphisms associated with risk of renal disorder among systemic lupus erythematosus patients. J. Hum. Genet. 50 (2005) 107-111
-
(2005)
J. Hum. Genet.
, vol.50
, pp. 107-111
-
-
Shin, H.D.1
Park, B.L.2
Cheong, H.S.3
Lee, H.S.4
Jun, J.B.5
Bae, S.C.6
-
88
-
-
34548327158
-
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus
-
Lee-Kirsch M.A., Gong M., Chowdhury D., Senenko L., Engel K., Lee Y.A., de Silva U., Bailey S.L., Witte T., Vyse T.J., Kere J., Pfeiffer C., Harvey S., Wong A., Koskenmies S., Hummel O., Rohde K., Schmidt R.E., Dominiczak A.F., Gahr M., Hollis T., Perrino F.W., Lieberman J., and Hubner N. Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat. Genet. 39 (2007) 1065-1067
-
(2007)
Nat. Genet.
, vol.39
, pp. 1065-1067
-
-
Lee-Kirsch, M.A.1
Gong, M.2
Chowdhury, D.3
Senenko, L.4
Engel, K.5
Lee, Y.A.6
de Silva, U.7
Bailey, S.L.8
Witte, T.9
Vyse, T.J.10
Kere, J.11
Pfeiffer, C.12
Harvey, S.13
Wong, A.14
Koskenmies, S.15
Hummel, O.16
Rohde, K.17
Schmidt, R.E.18
Dominiczak, A.F.19
Gahr, M.20
Hollis, T.21
Perrino, F.W.22
Lieberman, J.23
Hubner, N.24
more..
-
89
-
-
3042548183
-
Toll-like receptor 9-dependent and-independent dendritic cell activation by chromatin-immunoglobulin G complexes
-
Boule M.W., Broughton C., Mackay F., Akira S., Marshak-Rothstein A., and Rifkin I.R. Toll-like receptor 9-dependent and-independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med. 199 (2004) 1631-1640
-
(2004)
J. Exp. Med.
, vol.199
, pp. 1631-1640
-
-
Boule, M.W.1
Broughton, C.2
Mackay, F.3
Akira, S.4
Marshak-Rothstein, A.5
Rifkin, I.R.6
-
90
-
-
85047693371
-
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
-
Means T.K., Latz E., Hayashi F., Murali M.R., Golenbock D.T., and Luster A.D. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J. Clin. Invest. 115 (2005) 407-417
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 407-417
-
-
Means, T.K.1
Latz, E.2
Hayashi, F.3
Murali, M.R.4
Golenbock, D.T.5
Luster, A.D.6
-
91
-
-
34948862264
-
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
-
Lande R., Gregorio J., Facchinetti V., Chatterjee B., Wang Y.H., Homey B., Cao W., Wang Y.H., Su B., Nestle F.O., Zal T., Mellman I., Schroder J.M., Liu Y.J., and Gilliet M. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449 (2007) 564-569
-
(2007)
Nature
, vol.449
, pp. 564-569
-
-
Lande, R.1
Gregorio, J.2
Facchinetti, V.3
Chatterjee, B.4
Wang, Y.H.5
Homey, B.6
Cao, W.7
Wang, Y.H.8
Su, B.9
Nestle, F.O.10
Zal, T.11
Mellman, I.12
Schroder, J.M.13
Liu, Y.J.14
Gilliet, M.15
-
92
-
-
33745030751
-
Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen-and Sjogren's syndrome autoantigen-associated RNA
-
Lovgren T., Eloranta M.L., Kastner B., Wahren-Herlenius M., Alm G.V., and Ronnblom L. Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen-and Sjogren's syndrome autoantigen-associated RNA. Arthritis Rheum. 54 (2006) 1917-1927
-
(2006)
Arthritis Rheum.
, vol.54
, pp. 1917-1927
-
-
Lovgren, T.1
Eloranta, M.L.2
Kastner, B.3
Wahren-Herlenius, M.4
Alm, G.V.5
Ronnblom, L.6
-
93
-
-
33748472865
-
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
-
Christensen S.R., Shupe J., Nickerson K., Kashgarian M., Flavell R.A., and Shlomchik M.J. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25 (2006) 417-428
-
(2006)
Immunity
, vol.25
, pp. 417-428
-
-
Christensen, S.R.1
Shupe, J.2
Nickerson, K.3
Kashgarian, M.4
Flavell, R.A.5
Shlomchik, M.J.6
-
94
-
-
33745864016
-
Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus
-
Lartigue A., Courville P., Auquit I., Francois A., Arnoult C., Tron F., Gilbert D., and Musette P. Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus. J Immunol 177 (2006) 1349-1354
-
(2006)
J Immunol
, vol.177
, pp. 1349-1354
-
-
Lartigue, A.1
Courville, P.2
Auquit, I.3
Francois, A.4
Arnoult, C.5
Tron, F.6
Gilbert, D.7
Musette, P.8
-
95
-
-
33748465308
-
Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE
-
Yu P., Wellmann U., Kunder S., Quintanilla-Martinez L., Jennen L., Dear N., Amann K., Bauer S., Winkler T.H., and Wagner H. Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE. Int. Immunol. 18 (2006) 1211-1219
-
(2006)
Int. Immunol.
, vol.18
, pp. 1211-1219
-
-
Yu, P.1
Wellmann, U.2
Kunder, S.3
Quintanilla-Martinez, L.4
Jennen, L.5
Dear, N.6
Amann, K.7
Bauer, S.8
Winkler, T.H.9
Wagner, H.10
-
96
-
-
27944453599
-
Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
-
Okabe Y., Kawane K., Akira S., Taniguchi T., and Nagata S. Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J Exp. Med. 202 (2005) 1333-1339
-
(2005)
J Exp. Med.
, vol.202
, pp. 1333-1339
-
-
Okabe, Y.1
Kawane, K.2
Akira, S.3
Taniguchi, T.4
Nagata, S.5
-
97
-
-
33750465224
-
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
-
Kawane K., Ohtani M., Miwa K., Kizawa T., Kanbara Y., Yoshioka Y., Yoshikawa H., and Nagata S. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 443 (2006) 998-1002
-
(2006)
Nature
, vol.443
, pp. 998-1002
-
-
Kawane, K.1
Ohtani, M.2
Miwa, K.3
Kizawa, T.4
Kanbara, Y.5
Yoshioka, Y.6
Yoshikawa, H.7
Nagata, S.8
-
98
-
-
30444450839
-
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
-
Stetson D.B., and Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24 (2006) 93-103
-
(2006)
Immunity
, vol.24
, pp. 93-103
-
-
Stetson, D.B.1
Medzhitov, R.2
-
99
-
-
34547143110
-
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
-
Takaoka A., Wang Z., Choi M.K., Yanai H., Negishi H., Ban T., Lu Y., Miyagishi M., Kodama T., Honda K., Ohba Y., and Taniguchi T. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448 (2007) 501-505
-
(2007)
Nature
, vol.448
, pp. 501-505
-
-
Takaoka, A.1
Wang, Z.2
Choi, M.K.3
Yanai, H.4
Negishi, H.5
Ban, T.6
Lu, Y.7
Miyagishi, M.8
Kodama, T.9
Honda, K.10
Ohba, Y.11
Taniguchi, T.12
-
100
-
-
33747772707
-
Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection
-
Louten J., van Rooijen N., and Biron C.A. Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection. J. Immunol. 177 (2006) 3266-3272
-
(2006)
J. Immunol.
, vol.177
, pp. 3266-3272
-
-
Louten, J.1
van Rooijen, N.2
Biron, C.A.3
-
101
-
-
36248952699
-
Seeing is believing: a focus on the contribution of microscopic imaging to our understanding of immune system function
-
Bajenoff M., and Germain R.N. Seeing is believing: a focus on the contribution of microscopic imaging to our understanding of immune system function. Eur. J. Immunol. 37 (2007) 18-33
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 18-33
-
-
Bajenoff, M.1
Germain, R.N.2
-
102
-
-
35348955182
-
Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus
-
Kwissa M., Amara R.R., Robinson H.L., Moss B., Alkan S., Jabbar A., Villinger F., and Pulendran B. Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus. J. Exp. Med. 204 (2007) 2733-2746
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2733-2746
-
-
Kwissa, M.1
Amara, R.R.2
Robinson, H.L.3
Moss, B.4
Alkan, S.5
Jabbar, A.6
Villinger, F.7
Pulendran, B.8
-
103
-
-
3042548161
-
Use of CpG oligodeoxynucleotides as immunoprotective agents
-
Klinman D.M. Use of CpG oligodeoxynucleotides as immunoprotective agents. Expert. Opin. Biol. Ther. 4 (2004) 937-946
-
(2004)
Expert. Opin. Biol. Ther.
, vol.4
, pp. 937-946
-
-
Klinman, D.M.1
-
104
-
-
34248169629
-
Development of TLR9 agonists for cancer therapy
-
Krieg A.M. Development of TLR9 agonists for cancer therapy. J. Clin. Invest. 117 (2007) 1184-1194
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1184-1194
-
-
Krieg, A.M.1
-
105
-
-
33745946911
-
Therapeutic potential of Toll-like receptor 9 activation
-
Krieg A.M. Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov 5 (2006) 471-484
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 471-484
-
-
Krieg, A.M.1
|