Immunomodulatory oligonucleotides containing a cytosine-phosphate-2′- deoxy-7-deazaguanosine motif as potent Toll-like receptor 9 agonists

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 19, 2005, Pages 6925-6930

  Kandimalla, Ekambar R ^a   Bhagat, Lakshmi ^a   Li, Yukui ^a   Yu, Dong ^a   Wang, Daqing ^a   Cong, Yan Ping ^a   Song, Sam S ^a   Tang, Jimmy X ^a   Sullivan, Tim ^a   Agrawal, Sudhir ^a  

^a HYBRIDON INC   (United States)

Author keywords

CpG DNA; Cytokines; Immune stimulation; Immunotherapy; Innate immunity

Indexed keywords

ALPHA INTERFERON; BACTERIAL DNA; CD69 ANTIGEN; CD86 ANTIGEN; CHEMOKINE; CYTOKINE; CYTOSINE DERIVATIVE; CYTOSINE PHOSPHATE 2' DEOXY 7 DEAZAGUANOSINE; IMMUNOMODULATING AGENT; IMMUNOMODULATORY OLIGONUCLEOTIDE; OLIGOMER; OLIGONUCLEOTIDE; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL STRAIN HEK293; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; EMBRYO; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; IMMUNOSTIMULATION; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; MONKEY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; TERMINAL OLIGOPYRIMIDINE TRACT;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD86; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; B-LYMPHOCYTES; BASE SEQUENCE; CELL LINE; CELL PROLIFERATION; CHEMOKINES; CPG ISLANDS; CYTOKINES; DENDRITIC CELLS; DEOXYGUANOSINE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HAPLORHINI; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NUCLEOTIDES; OLIGONUCLEOTIDES; PROTEIN BINDING; RECEPTORS, CELL SURFACE; RNA, MESSENGER; TIME FACTORS; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 9; TOLL-LIKE RECEPTORS; UP-REGULATION;

BACTERIA (MICROORGANISMS);

EID: 21044444274     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0501729102     Document Type: Article

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