-
1
-
-
0036926339
-
Plasmacytoid dendritic cells: The key to CpG
-
Rothenfusser, S., E. Tuma, S. Endres, and G. Hartmann. 2002. Plasmacytoid dendritic cells: the key to CpG. Hum. Immunol. 63: 1111-1119.
-
(2002)
Hum. Immunol.
, vol.63
, pp. 1111-1119
-
-
Rothenfusser, S.1
Tuma, E.2
Endres, S.3
Hartmann, G.4
-
2
-
-
1542343950
-
The induction of Toll-like receptor tolerance enhances rather than suppresses HIV-1 gene expression in transgenic mice
-
Bafica, A., C. A. Scanga, O. Equils, and A. Sher. 2004. The induction of Toll-like receptor tolerance enhances rather than suppresses HIV-1 gene expression in transgenic mice. J. Leukocyte Biol. 75: 460-466.
-
(2004)
J. Leukocyte Biol.
, vol.75
, pp. 460-466
-
-
Bafica, A.1
Scanga, C.A.2
Equils, O.3
Sher, A.4
-
3
-
-
2942530690
-
Influence of coinfecting pathogens on HIV expression: Evidence for a role of Toll-like receptors
-
Bafica, A., C. A. Scanga, M. Schito. D. Chaussabel, and A. Sher. 2004. Influence of coinfecting pathogens on HIV expression: evidence for a role of Toll-like receptors. J. Immunol. 172: 7229-7234.
-
(2004)
J. Immunol.
, vol.172
, pp. 7229-7234
-
-
Bafica, A.1
Scanga, C.A.2
Schito, M.3
Chaussabel, D.4
Sher, A.5
-
4
-
-
0037313578
-
Interleukin-12 and the regulation of innate resistance and adaptive immunity
-
Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3: 133-146.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 133-146
-
-
Trinchieri, G.1
-
5
-
-
12144286763
-
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
-
Tabeta, K., P. Georgel, E. Janssen, X. Du, K. Hoebe, K. Crozat, S. Mudd, L. Shamel, S. Sovath, J. Goode, et al. 2004. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. USA 101: 3516-3521.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 3516-3521
-
-
Tabeta, K.1
Georgel, P.2
Janssen, E.3
Du, X.4
Hoebe, K.5
Crozat, K.6
Mudd, S.7
Shamel, L.8
Sovath, S.9
Goode, J.10
-
6
-
-
3242798925
-
Forward genetic dissection of afferent immunity: The role of TIR adapter proteins in innate and adaptive immune responses
-
Beutler, B., K. Hoebe, and L. Shamel. 2004. Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses. C. R. Biol. 327: 571-580.
-
(2004)
C. R. Biol.
, vol.327
, pp. 571-580
-
-
Beutler, B.1
Hoebe, K.2
Shamel, L.3
-
7
-
-
20044368019
-
Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88
-
Hasan, U., C. Chaffois, C. Gaillard, V. Saulnier, E. Merck, S. Tancredi, C. Guiet, F. Briere, J. Vlach, S. Lebecque, et al. 2005. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J. Immunol. 174: 2942-2950.
-
(2005)
J. Immunol.
, vol.174
, pp. 2942-2950
-
-
Hasan, U.1
Chaffois, C.2
Gaillard, C.3
Saulnier, V.4
Merck, E.5
Tancredi, S.6
Guiet, C.7
Briere, F.8
Vlach, J.9
Lebecque, S.10
-
8
-
-
0035979192
-
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
-
Bauer, S., C. J. Kirschning, H. Hacker, V. Redecke, S. Hausmann, S. Akira, H. Wagner, and G. B. Lipford. 2001. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. USA 98: 9237-9242.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9237-9242
-
-
Bauer, S.1
Kirschning, C.J.2
Hacker, H.3
Redecke, V.4
Hausmann, S.5
Akira, S.6
Wagner, H.7
Lipford, G.B.8
-
9
-
-
0042123694
-
Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells
-
Lund, J., A. Sato, S. Akira, R. Medzhitov, and A. Iwasaki. 2003. Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198: 513-520.
-
(2003)
J. Exp. Med.
, vol.198
, pp. 513-520
-
-
Lund, J.1
Sato, A.2
Akira, S.3
Medzhitov, R.4
Iwasaki, A.5
-
10
-
-
3142683548
-
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
-
Krug, A., A. R. French, W. Barchet, J. A. Fischer, A. Dzionek, J. T. Pingel, M. M. Orihuela, S. Akira, W. M. Yokoyama, and M. Colonna. 2004. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21: 107-119.
-
(2004)
Immunity
, vol.21
, pp. 107-119
-
-
Krug, A.1
French, A.R.2
Barchet, W.3
Fischer, J.A.4
Dzionek, A.5
Pingel, J.T.6
Orihuela, M.M.7
Akira, S.8
Yokoyama, W.M.9
Colonna, M.10
-
11
-
-
0032476602
-
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
-
Hacker, H., H. Mischak, T. Miethke, S. Liptay, R. Schmid, T. Sparwasser, K. Heeg, G. B. Lipford, and H. Wagner. 1998. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17: 6230-6240.
-
(1998)
EMBO J.
, vol.17
, pp. 6230-6240
-
-
Hacker, H.1
Mischak, H.2
Miethke, T.3
Liptay, S.4
Schmid, R.5
Sparwasser, T.6
Heeg, K.7
Lipford, G.B.8
Wagner, H.9
-
12
-
-
0034698739
-
Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6
-
Hacker, H., R. M. Vabulas, O. Takeuchi, K. Hoshino, S. Akira, and H. Wagner. 2000. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med. 192: 595-600.
-
(2000)
J. Exp. Med.
, vol.192
, pp. 595-600
-
-
Hacker, H.1
Vabulas, R.M.2
Takeuchi, O.3
Hoshino, K.4
Akira, S.5
Wagner, H.6
-
13
-
-
0037460116
-
Recognition of pathogen-associated molecular patterns by TLR family
-
Akira, S., and H. Hemmi. 2003. Recognition of pathogen-associated molecular patterns by TLR family. Immunol. Lett. 85: 85-95.
-
(2003)
Immunol. Lett.
, vol.85
, pp. 85-95
-
-
Akira, S.1
Hemmi, H.2
-
14
-
-
9144220961
-
The role of TRAF6 in signal transduction and the immune response
-
Kobayashi, T., M. C. Walsh, and Y. Choi. 2004. The role of TRAF6 in signal transduction and the immune response. Microbes Infect. 6: 1333-1338.
-
(2004)
Microbes Infect.
, vol.6
, pp. 1333-1338
-
-
Kobayashi, T.1
Walsh, M.C.2
Choi, Y.3
-
15
-
-
0037192829
-
PTEN blocks tumor necrosis factor-induced NF-κB-dependent transcription by inhibiting the transactivation potential of the p65 subunit
-
Mayo, M. W., L. V. Madrid, S. D. Westerheide, D. R. Jones, X. J. Yuan, A. S. Baldwin, Jr., and Y. E. Whang. 2002. PTEN blocks tumor necrosis factor-induced NF-κB-dependent transcription by inhibiting the transactivation potential of the p65 subunit. J. Biol Chem. 277: 11116-11125.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 11116-11125
-
-
Mayo, M.W.1
Madrid, L.V.2
Westerheide, S.D.3
Jones, D.R.4
Yuan, X.J.5
Baldwin Jr., A.S.6
Whang, Y.E.7
-
16
-
-
0036219195
-
CpG motifs in bacterial DNA and their immune effects
-
Krieg, A. M. 2002. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20: 709-760.
-
(2002)
Annu. Rev. Immunol.
, vol.20
, pp. 709-760
-
-
Krieg, A.M.1
-
17
-
-
0033637315
-
DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA
-
Chu, W., X. Gong, Z. Li, K. Takabayashi, H. Ouyang, Y. Chen, A. Lois, D. J. Chen, G. C. Li, M. Karin, and E. Raz. 2000. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell 103: 909-918.
-
(2000)
Cell
, vol.103
, pp. 909-918
-
-
Chu, W.1
Gong, X.2
Li, Z.3
Takabayashi, K.4
Ouyang, H.5
Chen, Y.6
Lois, A.7
Chen, D.J.8
Li, G.C.9
Karin, M.10
Raz, E.11
-
19
-
-
2342430991
-
Molecular mechanisms of endotoxin tolerance
-
Fan, H., and J. A. Cook. 2004. Molecular mechanisms of endotoxin tolerance. J. Endotoxin Res. 10: 71-84.
-
(2004)
J. Endotoxin Res.
, vol.10
, pp. 71-84
-
-
Fan, H.1
Cook, J.A.2
-
20
-
-
2142652249
-
Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils
-
Strassheim, D., K. Asehnoune, J. S. Park, J. Y. Kim, Q. He, D. Richter, K. Kuhn, S. Mitra, and E. Abraham. 2004. Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils. J. Immunol. 172: 5727-5733.
-
(2004)
J. Immunol.
, vol.172
, pp. 5727-5733
-
-
Strassheim, D.1
Asehnoune, K.2
Park, J.S.3
Kim, J.Y.4
He, Q.5
Richter, D.6
Kuhn, K.7
Mitra, S.8
Abraham, E.9
-
21
-
-
0037099629
-
Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation
-
Ishii, K. J., F. Takeshita, I. Gursel, M. Gursel, J. Conover, A. Nussenzweig, and D. M. Klinman. 2002. Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. J. Exp. Med. 196: 269-274.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 269-274
-
-
Ishii, K.J.1
Takeshita, F.2
Gursel, I.3
Gursel, M.4
Conover, J.5
Nussenzweig, A.6
Klinman, D.M.7
-
23
-
-
0032407241
-
Phosphoinositide lipids as signaling molecules: Common themes for signal transduction, cytoskeletal regulation, and membrane trafficking
-
Martin, T. F. 1998. Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking. Annu. Rev. Cell Dev. Biol. 14: 231-264.
-
(1998)
Annu. Rev. Cell Dev. Biol.
, vol.14
, pp. 231-264
-
-
Martin, T.F.1
-
24
-
-
0038549067
-
PI3K in lymphocyte development, differentiation and activation
-
Okkenhaug, K., and B. Vanhaesebroeck. 2003. PI3K in lymphocyte development, differentiation and activation. Nat. Rev. Immunol. 3: 317-330.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 317-330
-
-
Okkenhaug, K.1
Vanhaesebroeck, B.2
-
25
-
-
0036199607
-
Phosphoinositide 3-kinase in immunological systems
-
Fruman, D. A., and L. C. Cantley. 2002. Phosphoinositide 3-kinase in immunological systems. Semin. Immunol. 14: 7-18.
-
(2002)
Semin. Immunol.
, vol.14
, pp. 7-18
-
-
Fruman, D.A.1
Cantley, L.C.2
-
26
-
-
0037374815
-
The role of PI3K in immune cells
-
Koyasu, S. 2003. The role of PI3K in immune cells. Nat. Immunol. 4: 313-319.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 313-319
-
-
Koyasu, S.1
-
27
-
-
0032517624
-
Distinct roles for the p110α and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis
-
Siddhanta, U., J. McIlroy, A. Shah, Y. Zhang, and J. M. Backer. 1998. Distinct roles for the p110α and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis. J. Cell Biol. 143: 1647-1659.
-
(1998)
J. Cell Biol.
, vol.143
, pp. 1647-1659
-
-
Siddhanta, U.1
McIlroy, J.2
Shah, A.3
Zhang, Y.4
Backer, J.M.5
-
28
-
-
0033978633
-
Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
-
Petiot, A., E. Ogier-Denis, E. F. Blommaart, A. J. Meijer, and P. Codogno. 2000. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol. Chem. 275: 992-998.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 992-998
-
-
Petiot, A.1
Ogier-Denis, E.2
Blommaart, E.F.3
Meijer, A.J.4
Codogno, P.5
-
29
-
-
0037352702
-
Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages
-
Ojaniemi, M., V. Glumoff, K. Harju, M. Liljeroos, K. Vuori, and M. Hallman. 2003. Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur. J. Immunol. 33: 597-605.
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 597-605
-
-
Ojaniemi, M.1
Glumoff, V.2
Harju, K.3
Liljeroos, M.4
Vuori, K.5
Hallman, M.6
-
30
-
-
0033812537
-
Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide- stimulated nitric oxide production in macrophages via interferon-β
-
Weinstein, S. L., A. I. Finn, S. H. Dave, F. Meng, C. A. Lowell, J. S. Sanghera, and A. L. DeFranco. 2000. Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-β. J. Leukocyte Biol. 67: 405-414.
-
(2000)
J. Leukocyte Biol.
, vol.67
, pp. 405-414
-
-
Weinstein, S.L.1
Finn, A.I.2
Dave, S.H.3
Meng, F.4
Lowell, C.A.5
Sanghera, J.S.6
Defranco, A.L.7
-
31
-
-
0031587403
-
Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages
-
Park, Y. C., C. H. Lee, H. S. Kang, H. T. Chung, and H. D. Kim. 1997. Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages. Biochem. Biophys. Res. Commun. 240: 692-696.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.240
, pp. 692-696
-
-
Park, Y.C.1
Lee, C.H.2
Kang, H.S.3
Chung, H.T.4
Kim, H.D.5
-
32
-
-
0037629646
-
PI3K and negative regulation of TLR signaling
-
Fukao, T., and S. Koyasu. 2003. PI3K and negative regulation of TLR signaling. Trends Immunol. 24: 358-363.
-
(2003)
Trends Immunol.
, vol.24
, pp. 358-363
-
-
Fukao, T.1
Koyasu, S.2
-
33
-
-
0029943605
-
Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
-
Klippel, A., C. Reinhard, W. M. Kavanaugh, G. Apell, M. A. Escobedo, and L. T. Williams. 1996. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol. Cell. Biol. 16: 4117-4127.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4117-4127
-
-
Klippel, A.1
Reinhard, C.2
Kavanaugh, W.M.3
Apell, G.4
Escobedo, M.A.5
Williams, L.T.6
-
34
-
-
20844438509
-
PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase
-
Leenders, F., K. Mopert, A. Schmiedeknecht, A. Santel, F. Czauderna, M. Aleku, S. Penschuck, S. Dames, M. Sternberger, T. Rohl, et al. 2004. PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase. EMBO J. 23: 3303-3313.
-
(2004)
EMBO J.
, vol.23
, pp. 3303-3313
-
-
Leenders, F.1
Mopert, K.2
Schmiedeknecht, A.3
Santel, A.4
Czauderna, F.5
Aleku, M.6
Penschuck, S.7
Dames, S.8
Sternberger, M.9
Rohl, T.10
-
35
-
-
0242268528
-
Human VPS34 and pI50 are Rab7 interacting partners
-
Stein, M. P., Y. Feng, K. L. Cooper, A. M. Welford, and A. Wandinger-Ness. 2003. Human VPS34 and pI50 are Rab7 interacting partners. Traffic 4: 754-771.
-
(2003)
Traffic
, vol.4
, pp. 754-771
-
-
Stein, M.P.1
Feng, Y.2
Cooper, K.L.3
Welford, A.M.4
Wandinger-Ness, A.5
-
36
-
-
0034577944
-
Toll-like receptor 2-mediated NF-κB activation requires a Rac1-dependent pathway
-
Arbibe, L., J. P. Mira, N. Teusch, L. Kline, M. Guha, N. Mackman, P. J. Godowski, R. J. Ulevitch, and U. G. Knaus. 2000. Toll-like receptor 2-mediated NF-κB activation requires a Rac1-dependent pathway. Nat. Immunol. 1: 533-540.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 533-540
-
-
Arbibe, L.1
Mira, J.P.2
Teusch, N.3
Kline, L.4
Guha, M.5
Mackman, N.6
Godowski, P.J.7
Ulevitch, R.J.8
Knaus, U.G.9
-
37
-
-
0036707521
-
PI3K-mediated negative feedback regulation of IL-12 production in DCs
-
Fukao, T., M. Tanabe, Y. Terauchi, T. Ota, S. Matsuda, T. Asano, T. Kadowaki, T. Takeuchi, and S. Koyasu. 2002. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat. Immunol. 3: 875-881.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 875-881
-
-
Fukao, T.1
Tanabe, M.2
Terauchi, Y.3
Ota, T.4
Matsuda, S.5
Asano, T.6
Kadowaki, T.7
Takeuchi, T.8
Koyasu, S.9
-
38
-
-
10744219675
-
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
-
Latz, E., A. Schoenemeyer, A. Visintin, K. A. Fitzgerald, B. G. Monks, C. F. Knetter, E. Lien, N. J. Nilsen, T. Espevik, and D. T. Golenbock. 2004. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5: 190-198.
-
(2004)
Nat. Immunol.
, vol.5
, pp. 190-198
-
-
Latz, E.1
Schoenemeyer, A.2
Visintin, A.3
Fitzgerald, K.A.4
Monks, B.G.5
Knetter, C.F.6
Lien, E.7
Nilsen, N.J.8
Espevik, T.9
Golenbock, D.T.10
-
39
-
-
0742289969
-
Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9
-
Takeshita, F., I. Gursel, K. J. Ishii, K. Suzuki, M. Gursel, and D. M. Klinman. 2004. Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9. Semin. Immunol. 16: 17-22.
-
(2004)
Semin. Immunol.
, vol.16
, pp. 17-22
-
-
Takeshita, F.1
Gursel, I.2
Ishii, K.J.3
Suzuki, K.4
Gursel, M.5
Klinman, D.M.6
-
40
-
-
0035904227
-
Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells
-
Tuma, P. L., L. K. Nyasae, J. M. Backer, and A. L. Hubbard. 2001. Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells. J. Cell Biol. 154; 1197-1208.
-
(2001)
J. Cell Biol.
, vol.154
, pp. 1197-1208
-
-
Tuma, P.L.1
Nyasae, L.K.2
Backer, J.M.3
Hubbard, A.L.4
-
41
-
-
0036318851
-
Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
-
Ahmad-Nejad, P., H. Hacker, M. Rutz, S. Bauer, R. M. Vabulas, and H. Wagner. 2002. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32: 1958-1968.
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 1958-1968
-
-
Ahmad-Nejad, P.1
Hacker, H.2
Rutz, M.3
Bauer, S.4
Vabulas, R.M.5
Wagner, H.6
|