-
1
-
-
0029842459
-
Oxygen sensing and molecular adaptation to hypoxia
-
Bunn HF, Poyton RO. Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 1996; 76:839-85.
-
(1996)
Physiol Rev
, vol.76
, pp. 839-885
-
-
Bunn, H.F.1
Poyton, R.O.2
-
2
-
-
0033233243
-
2 homeostasis by hypoxia-inducible factor 1
-
2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 1999; 15:551-78.
-
(1999)
Annu Rev Cell Dev Biol
, vol.15
, pp. 551-578
-
-
Semenza, G.L.1
-
3
-
-
0036320934
-
2- regulated gene expression
-
2- regulated gene expression. Faseb J 2002; 16:1151-62.
-
(2002)
Faseb J
, vol.16
, pp. 1151-1162
-
-
Wenger, R.H.1
-
4
-
-
0037490210
-
Hypoxia-inducible factor and its biomedical relevance
-
Huang LE, Bunn HF. Hypoxia-inducible factor and its biomedical relevance. J Biol Chem 2003; 278:19575-8.
-
(2003)
J Biol Chem
, vol.278
, pp. 19575-19578
-
-
Huang, L.E.1
Bunn, H.F.2
-
5
-
-
0038037735
-
Regulation of angiogenesis by hypoxia: Role of the HIF system
-
Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: Role of the HIF system. Nat Med 2003; 9:677-84.
-
(2003)
Nat Med
, vol.9
, pp. 677-684
-
-
Pugh, C.W.1
Ratcliffe, P.J.2
-
6
-
-
0842303171
-
HIF-1 and hypoxic response: The plot thickens
-
Poellinger L, Johnson RS. HIF-1 and hypoxic response: The plot thickens. Curr Opin Genet Dev 2004; 14:81-5.
-
(2004)
Curr Opin Genet Dev
, vol.14
, pp. 81-85
-
-
Poellinger, L.1
Johnson, R.S.2
-
7
-
-
22244440847
-
Proline hydroxylation and gene expression
-
Kaelin WG. Proline hydroxylation and gene expression. Annu Rev Biochem 2005; 74:115-28.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 115-128
-
-
Kaelin, W.G.1
-
8
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshet E. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998; 394:485-90.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
Koch, C.J.11
Ratcliffe, P.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshet, E.16
-
10
-
-
0037214282
-
Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia
-
Goda N, Ryan HE, Khadivi B, McNulty W, Rickert RC, Johnson RS. Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol 2003; 23:359-69.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 359-369
-
-
Goda, N.1
Ryan, H.E.2
Khadivi, B.3
McNulty, W.4
Rickert, R.C.5
Johnson, R.S.6
-
11
-
-
3142631736
-
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
-
Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J 2004; 23:1949-56.
-
(2004)
EMBO J
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
12
-
-
0026713875
-
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15
-
Gu Y, Rosenblatt J, Morgan DO. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J 1992; 11:3995-4005.
-
(1992)
EMBO J
, vol.11
, pp. 3995-4005
-
-
Gu, Y.1
Rosenblatt, J.2
Morgan, D.O.3
-
13
-
-
0028314952
-
Cdc25A is a novel phosphatase functioning early in the cell cycle
-
Jinno S, Suto K, Nagata A, Igarashi M, Kanaoka Y, Nojima H, Okayama H. Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J 1994; 13:1549-56.
-
(1994)
EMBO J
, vol.13
, pp. 1549-1556
-
-
Jinno, S.1
Suto, K.2
Nagata, A.3
Igarashi, M.4
Kanaoka, Y.5
Nojima, H.6
Okayama, H.7
-
14
-
-
0029779280
-
Cdc25 cell-cycle phosphatase as a target of c-myc
-
Galaktionov K, Chen X, Beach D. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 1996; 382:511-7.
-
(1996)
Nature
, vol.382
, pp. 511-517
-
-
Galaktionov, K.1
Chen, X.2
Beach, D.3
-
15
-
-
0344931628
-
CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase
-
Vigo E, Muller H, Prosperini E, Hateboer G, Cartwright P, Moroni MC, Helin K. CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase. Mol Cell Biol 1999; 19:6379-95.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 6379-6395
-
-
Vigo, E.1
Muller, H.2
Prosperini, E.3
Hateboer, G.4
Cartwright, P.5
Moroni, M.C.6
Helin, K.7
-
16
-
-
0033000779
-
Serum-induced expression of the cdc25A gene by relief of E2F-mediated repression
-
Chen X, Prywes R. Serum-induced expression of the cdc25A gene by relief of E2F-mediated repression. Mol Cell Biol 1999; 19:4695-702.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4695-4702
-
-
Chen, X.1
Prywes, R.2
-
17
-
-
0032933352
-
E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest
-
Iavarone A, Massague J. E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest. Mol Cell Biol 1999; 19:916-22.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 916-922
-
-
Iavarone, A.1
Massague, J.2
-
18
-
-
0034717309
-
Rapid destruction of human Cdc25A in response to DNA damage
-
Mailand N, Falck J, Lukas C, Syljuasen RG, Welcker M, Bartek J, Lukas J. Rapid destruction of human Cdc25A in response to DNA damage. Science 2000; 288:1425-9.
-
(2000)
Science
, vol.288
, pp. 1425-1429
-
-
Mailand, N.1
Falck, J.2
Lukas, C.3
Syljuasen, R.G.4
Welcker, M.5
Bartek, J.6
Lukas, J.7
-
19
-
-
33646422508
-
Cell cycling through Cdc25A: Transducer of cytokine proliferative signals
-
Kittipatarin C, Li WQ, Bulavin DV, Durum SK, Khaled AR. Cell cycling through Cdc25A: Transducer of cytokine proliferative signals. Cell Cycle 2006; 5:907-12.
-
(2006)
Cell Cycle
, vol.5
, pp. 907-912
-
-
Kittipatarin, C.1
Li, W.Q.2
Bulavin, D.V.3
Durum, S.K.4
Khaled, A.R.5
-
20
-
-
0035545996
-
1- and S-phase checkpoints in response to DNA damage
-
1- and S-phase checkpoints in response to DNA damage. Curr Opin Cell Biol 2001; 13:738-47.
-
(2001)
Curr Opin Cell Biol
, vol.13
, pp. 738-747
-
-
Bartek, J.1
Lukas, J.2
-
21
-
-
13144275217
-
Dynamic balancing of the dual nature of HIF-1alpha for cell survival
-
Koshiji M, Huang LE. Dynamic balancing of the dual nature of HIF-1alpha for cell survival. Cell Cycle 2004; 3:853-4.
-
(2004)
Cell Cycle
, vol.3
, pp. 853-854
-
-
Koshiji, M.1
Huang, L.E.2
-
22
-
-
15244344206
-
HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression
-
Koshiji M, To KK, Hammer S, Kumamoto K, Harris AL, Modrich P, Huang LE. HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Mol Cell 2005; 17:793-803.
-
(2005)
Mol Cell
, vol.17
, pp. 793-803
-
-
Koshiji, M.1
To, K.K.2
Hammer, S.3
Kumamoto, K.4
Harris, A.L.5
Modrich, P.6
Huang, L.E.7
-
23
-
-
33750202279
-
The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression
-
To KK, Sedelnikova OA, Samons M, Bonner WM, Huang LE. The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. EMBO J 2006; 25:4784-94.
-
(2006)
EMBO J
, vol.25
, pp. 4784-4794
-
-
To, K.K.1
Sedelnikova, O.A.2
Samons, M.3
Bonner, W.M.4
Huang, L.E.5
-
24
-
-
4043086934
-
Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation
-
Kageyama Y, Koshiji M, To KK, Tian YM, Ratcliffe PJ, Huang LE. Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation. Faseb J 2004; 18:1028-30.
-
(2004)
Faseb J
, vol.18
, pp. 1028-1030
-
-
Kageyama, Y.1
Koshiji, M.2
To, K.K.3
Tian, Y.M.4
Ratcliffe, P.J.5
Huang, L.E.6
-
26
-
-
0036828845
-
Leu-574 of HIF-1alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway
-
Huang LE, Pete EA, Schau M, Milligan J, Gu J. Leu-574 of HIF-1alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway. J Biol Chem 2002; 277:41750-5.
-
(2002)
J Biol Chem
, vol.277
, pp. 41750-41755
-
-
Huang, L.E.1
Pete, E.A.2
Schau, M.3
Milligan, J.4
Gu, J.5
-
28
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3:721-32.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
29
-
-
0036179376
-
Hypoxia links ATR and p53 through replication arrest
-
Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. Hypoxia links ATR and p53 through replication arrest. Mol Cell Biol 2002; 22:1834-43.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1834-1843
-
-
Hammond, E.M.1
Denko, N.C.2
Dorie, M.J.3
Abraham, R.T.4
Giaccia, A.J.5
-
30
-
-
0038146962
-
-
Hammond EM, Dorie MJ, Giaccia AJ. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem 2003; 278:12207-13.
-
Hammond EM, Dorie MJ, Giaccia AJ. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem 2003; 278:12207-13.
-
-
-
-
31
-
-
0032493368
-
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2- dependent degradation domain via the ubiquitin-proteasome pathway
-
Huang LE, Gu J, Schau M, Bunn HF. Regulation of hypoxia-inducible factor 1alpha is mediated by an O2- dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 1998; 95:7987-92.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
32
-
-
0035793584
-
Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction: A leucine-rich interface regulated by a single cysteine
-
Gu J, Milligan J, Huang LE. Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction: A leucine-rich interface regulated by a single cysteine. J Biol Chem 2001; 276:3550-4.
-
(2001)
J Biol Chem
, vol.276
, pp. 3550-3554
-
-
Gu, J.1
Milligan, J.2
Huang, L.E.3
-
33
-
-
0029753008
-
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
-
Huang LE, Arany Z, Livingston DM, Bunn HF. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 1996; 271:32253-9.
-
(1996)
J Biol Chem
, vol.271
, pp. 32253-32259
-
-
Huang, L.E.1
Arany, Z.2
Livingston, D.M.3
Bunn, H.F.4
-
34
-
-
18944376218
-
Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27
-
Mack FA, Patel JH, Biju MP, Haase VH, Simon MC. Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. Mol Cell Biol 2005; 25:4565-78.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4565-4578
-
-
Mack, F.A.1
Patel, J.H.2
Biju, M.P.3
Haase, V.H.4
Simon, M.C.5
-
35
-
-
33845939121
-
The cell cycle inhibitor p21waf1 binds to the myc and cdc25A promoters upon DNA damage and induces transcriptional repression
-
Vigneron A, Cherier J, Barre B, Gamelin E, Coqueret O. The cell cycle inhibitor p21waf1 binds to the myc and cdc25A promoters upon DNA damage and induces transcriptional repression. J Biol Chem 2006; 281:34742-50.
-
(2006)
J Biol Chem
, vol.281
, pp. 34742-34750
-
-
Vigneron, A.1
Cherier, J.2
Barre, B.3
Gamelin, E.4
Coqueret, O.5
-
37
-
-
25444432052
-
Genetic instability: The dark side of the hypoxic response
-
To KK, Koshiji M, Hammer S, Huang LE. Genetic instability: The dark side of the hypoxic response. Cell Cycle 2005; 4:881-2.
-
(2005)
Cell Cycle
, vol.4
, pp. 881-882
-
-
To, K.K.1
Koshiji, M.2
Hammer, S.3
Huang, L.E.4
-
38
-
-
18144388986
-
The STAT3 transcription factor is a target for the Myc and riboblastoma proteins on the Cdc25A promoter
-
Barre B, Vigneron A, Coqueret O. The STAT3 transcription factor is a target for the Myc and riboblastoma proteins on the Cdc25A promoter. J Biol Chem 2005; 280:15673-81.
-
(2005)
J Biol Chem
, vol.280
, pp. 15673-15681
-
-
Barre, B.1
Vigneron, A.2
Coqueret, O.3
-
39
-
-
20144384882
-
-
Gartel AL, Radhakrishnan SK. Lost in transcription: p21 repression, mechanisms, and consequences. Cancer Res 2005; 65:3980-5.
-
Gartel AL, Radhakrishnan SK. Lost in transcription: p21 repression, mechanisms, and consequences. Cancer Res 2005; 65:3980-5.
-
-
-
-
40
-
-
17144416530
-
Differential gene upregulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells
-
Wang V, Davis DA, Haque M, Huang LE, Yarchoan R. Differential gene upregulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells. Cancer Res 2005; 65:3299-306.
-
(2005)
Cancer Res
, vol.65
, pp. 3299-3306
-
-
Wang, V.1
Davis, D.A.2
Haque, M.3
Huang, L.E.4
Yarchoan, R.5
-
41
-
-
27544473311
-
The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation
-
Adhikary S, Marinoni F, Hock A, Hulleman E, Popov N, Beier R, Bernard S, Quarto M, Capra M, Goettig S, Kogel U, Scheffner M, Helin K, Eilers M. The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell 2005; 123:409-21.
-
(2005)
Cell
, vol.123
, pp. 409-421
-
-
Adhikary, S.1
Marinoni, F.2
Hock, A.3
Hulleman, E.4
Popov, N.5
Beier, R.6
Bernard, S.7
Quarto, M.8
Capra, M.9
Goettig, S.10
Kogel, U.11
Scheffner, M.12
Helin, K.13
Eilers, M.14
|