메뉴 건너뛰기




Volumn 152, Issue 4, 2007, Pages 429-448

Function, structure and therapeutic potential of complement C5a receptors

Author keywords

Antagonist; C5a; Complement; G protein; Immunity; Inflammation; Receptor

Indexed keywords

3D53; AMINOQUINOLINE DERIVATIVE; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A RECEPTOR; CYCLOPEPTIDE; ECULIZUMAB; GUANIDINE DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDANTOIN; JPE 1375; JSM 7431; JSM 7717; L 156602; NDT 9520492; NGD 2000 1; PERTUSSIS TOXIN; PHENYLGUANIDINE DERIVATIVE; PMX 53; RPR 121154; SYNTHETIC PEPTIDE; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG; W 54011;

EID: 35348821843     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707332     Document Type: Review
Times cited : (315)

References (259)
  • 1
    • 0035887920 scopus 로고    scopus 로고
    • Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats
    • Abe M, Shibata K, Akatsu H, Shimizu N, Sakata N, Katsuragi T et al. (2001). Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats. J Immunol 167: 4651-4660.
    • (2001) J Immunol , vol.167 , pp. 4651-4660
    • Abe, M.1    Shibata, K.2    Akatsu, H.3    Shimizu, N.4    Sakata, N.5    Katsuragi, T.6
  • 2
    • 33751195311 scopus 로고    scopus 로고
    • Probing the existence of G protein-coupled receptor dimers by positive and negative ligand-dependent cooperative binding
    • Albizu L, Balestre MN, Breton C, Pin JP, Manning M, Mouillac B et al. (2006). Probing the existence of G protein-coupled receptor dimers by positive and negative ligand-dependent cooperative binding. Mol Pharmacol 70: 1783-1791.
    • (2006) Mol Pharmacol , vol.70 , pp. 1783-1791
    • Albizu, L.1    Balestre, M.N.2    Breton, C.3    Pin, J.P.4    Manning, M.5    Mouillac, B.6
  • 3
    • 0030611748 scopus 로고    scopus 로고
    • Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor
    • Ali H, Fisher I, Haribabu B, Richardson RM, Snyderman R (1997). Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor. J Biol Chem 272: 11706-11709.
    • (1997) J Biol Chem , vol.272 , pp. 11706-11709
    • Ali, H.1    Fisher, I.2    Haribabu, B.3    Richardson, R.M.4    Snyderman, R.5
  • 6
    • 0036351871 scopus 로고    scopus 로고
    • Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine
    • Arumugam TV, Shiels IA, Woodruff TM, Reid RC, Fairlie DP, Taylor SM (2002). Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine. J Surg Res 103: 260-267.
    • (2002) J Surg Res , vol.103 , pp. 260-267
    • Arumugam, T.V.1    Shiels, I.A.2    Woodruff, T.M.3    Reid, R.C.4    Fairlie, D.P.5    Taylor, S.M.6
  • 8
    • 4043128086 scopus 로고    scopus 로고
    • The use of membrane translocating peptides to identify sites of interaction between the C5a receptor and downstream effector proteins
    • Auger GA, Smith BM, Pease JE, Barker MD (2004). The use of membrane translocating peptides to identify sites of interaction between the C5a receptor and downstream effector proteins. Immunology 112: 590-596.
    • (2004) Immunology , vol.112 , pp. 590-596
    • Auger, G.A.1    Smith, B.M.2    Pease, J.E.3    Barker, M.D.4
  • 9
    • 19944428796 scopus 로고    scopus 로고
    • Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation
    • Baelder R, Fuchs B, Bautsch W, Zwirner J, Kohl J, Hoymann HG et al. (2005). Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation. J Immunol 174: 783-789.
    • (2005) J Immunol , vol.174 , pp. 783-789
    • Baelder, R.1    Fuchs, B.2    Bautsch, W.3    Zwirner, J.4    Kohl, J.5    Hoymann, H.G.6
  • 10
    • 0034801665 scopus 로고    scopus 로고
    • G protein-coupled receptor drug discovery: Implications from the crystal structure of rhodopsin
    • Ballesteros J, Palczewski K (2001). G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin. Curr Opin Drug Discov Devel 4: 561-574.
    • (2001) Curr Opin Drug Discov Devel , vol.4 , pp. 561-574
    • Ballesteros, J.1    Palczewski, K.2
  • 11
    • 23844457665 scopus 로고    scopus 로고
    • C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist
    • Bao L, Osawe I, Puri T, Lambris JD, Haas M, Quigg RJ (2005). C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist. Eur J Immunol 35: 2496-2506.
    • (2005) Eur J Immunol , vol.35 , pp. 2496-2506
    • Bao, L.1    Osawe, I.2    Puri, T.3    Lambris, J.D.4    Haas, M.5    Quigg, R.J.6
  • 12
    • 0033025734 scopus 로고    scopus 로고
    • C5a receptor activation. Genetic identification of critical residues in four transmembrane helices
    • Baranski TJ, Herzmark P, Lichtarge O, Gerber BO, Trueheart J, Meng EC et al. (1999). C5a receptor activation. Genetic identification of critical residues in four transmembrane helices. J Biol Chem 274: 15757-15765.
    • (1999) J Biol Chem , vol.274 , pp. 15757-15765
    • Baranski, T.J.1    Herzmark, P.2    Lichtarge, O.3    Gerber, B.O.4    Trueheart, J.5    Meng, E.C.6
  • 13
    • 2942576449 scopus 로고    scopus 로고
    • A novel promoter polymorphism in the gene encoding complement component 5 receptor 1 on chromosome 19q13.3 is not associated with asthma and atopy in three independent populations
    • Barnes KC, Caraballo L, Munoz M, Zambelli-Weiner A, Ehrlich E, Burki M et al. (2004). A novel promoter polymorphism in the gene encoding complement component 5 receptor 1 on chromosome 19q13.3 is not associated with asthma and atopy in three independent populations. Clin Exp Allergy 34: 736-744.
    • (2004) Clin Exp Allergy , vol.34 , pp. 736-744
    • Barnes, K.C.1    Caraballo, L.2    Munoz, M.3    Zambelli-Weiner, A.4    Ehrlich, E.5    Burki, M.6
  • 14
    • 0015289322 scopus 로고
    • The relationship of the chemotactic behavior of the complement-derived factors, C3a, C5a, and C567, and a bacterial chemotactic factor to their ability to activate the proesterase 1 of rabbit polymorphonuclear leukocytes
    • Becker EL (1972). The relationship of the chemotactic behavior of the complement-derived factors, C3a, C5a, and C567, and a bacterial chemotactic factor to their ability to activate the proesterase 1 of rabbit polymorphonuclear leukocytes. J Exp Med 135: 376-387.
    • (1972) J Exp Med , vol.135 , pp. 376-387
    • Becker, E.L.1
  • 15
    • 1142281437 scopus 로고    scopus 로고
    • Novel therapeutic targets for acute pancreatitis and associated multiple organ dysfunction syndrome
    • Bhatia M (2002). Novel therapeutic targets for acute pancreatitis and associated multiple organ dysfunction syndrome. Curr Drug Targets Inflamm Allergy 1: 343-351.
    • (2002) Curr Drug Targets Inflamm Allergy , vol.1 , pp. 343-351
    • Bhatia, M.1
  • 17
    • 0031008081 scopus 로고    scopus 로고
    • The C terminus of the human C5a receptor (CD88) is required for normal ligand-dependent receptor internalization
    • Bock D, Martin U, Gartner S, Rheinheimer C, Raffetseder U, Arseniev L et al. (1997). The C terminus of the human C5a receptor (CD88) is required for normal ligand-dependent receptor internalization. Eur J Immunol 27: 1522-1529.
    • (1997) Eur J Immunol , vol.27 , pp. 1522-1529
    • Bock, D.1    Martin, U.2    Gartner, S.3    Rheinheimer, C.4    Raffetseder, U.5    Arseniev, L.6
  • 18
    • 0014900566 scopus 로고
    • Anaphylatoxin inactivator of human plasma: Its isolation and characterization as a carboxypeptidase
    • Bokisch VA, Muller-Eberhard HJ (1970). Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase. J Clin Invest 49: 2427-2436.
    • (1970) J Clin Invest , vol.49 , pp. 2427-2436
    • Bokisch, V.A.1    Muller-Eberhard, H.J.2
  • 19
    • 0038554077 scopus 로고    scopus 로고
    • Biology of the p21-activated kinases
    • Bokoch GM (2003). Biology of the p21-activated kinases. Annu Rev Biochem 72: 743-781.
    • (2003) Annu Rev Biochem , vol.72 , pp. 743-781
    • Bokoch, G.M.1
  • 20
    • 23844444138 scopus 로고    scopus 로고
    • Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6′-dimycolate
    • Borders CW, Courtney A, Ronen K, Pilar Laborde-Lahoz M, Guidry TV, Hwang SA et al. (2005). Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6′-dimycolate. Scand J Immunol 62: 123-130.
    • (2005) Scand J Immunol , vol.62 , pp. 123-130
    • Borders, C.W.1    Courtney, A.2    Ronen, K.3    Pilar Laborde-Lahoz, M.4    Guidry, T.V.5    Hwang, S.A.6
  • 21
    • 0008628104 scopus 로고
    • Les leukocytes et les proprietes actives du serum chez les vaccines
    • Bordet J (1895). Les leukocytes et les proprietes actives du serum chez les vaccines. Ann Inst Pasteur 9: 462.
    • (1895) Ann Inst Pasteur , vol.9 , pp. 462
    • Bordet, J.1
  • 22
    • 0025890276 scopus 로고
    • Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells
    • Boulay F, Mery L, Tardif M, Brouchon L, Vignais P (1991). Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells. Biochemistry 30: 2993-2999.
    • (1991) Biochemistry , vol.30 , pp. 2993-2999
    • Boulay, F.1    Mery, L.2    Tardif, M.3    Brouchon, L.4    Vignais, P.5
  • 23
    • 0029816638 scopus 로고    scopus 로고
    • Neurogenic amplification of immune complex inflammation
    • Bozic CR, Lu B, Hopken UE, Gerard C, Gerard NP (1996). Neurogenic amplification of immune complex inflammation. Science 273: 1722-1725.
    • (1996) Science , vol.273 , pp. 1722-1725
    • Bozic, C.R.1    Lu, B.2    Hopken, U.E.3    Gerard, C.4    Gerard, N.P.5
  • 24
    • 0037423283 scopus 로고    scopus 로고
    • Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway
    • Braun L, Christophe T, Boulay F (2003). Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway. J Biol Chem 278: 4277-4285.
    • (2003) J Biol Chem , vol.278 , pp. 4277-4285
    • Braun, L.1    Christophe, T.2    Boulay, F.3
  • 25
    • 0031786533 scopus 로고    scopus 로고
    • Cultured human glomerular mesangial cells express the C5a receptor
    • Braun M, Davis III AE (1998). Cultured human glomerular mesangial cells express the C5a receptor. Kidney Int 54: 1542-1549.
    • (1998) Kidney Int , vol.54 , pp. 1542-1549
    • Braun, M.1    Davis III, A.E.2
  • 26
    • 0028155959 scopus 로고
    • Site-specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptor Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis
    • Bubeck P, Grotzinger J, Winkler M, Kohl J, Wollmer A, Klos A et al. (1994). Site-specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptor Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis. Eur J Biochem 219: 897-904.
    • (1994) Eur J Biochem , vol.219 , pp. 897-904
    • Bubeck, P.1    Grotzinger, J.2    Winkler, M.3    Kohl, J.4    Wollmer, A.5    Klos, A.6
  • 27
    • 0029053840 scopus 로고
    • Expression of functional receptors for human C5a anaphylatoxin (CD88) on the human hepatocellular carcinoma cell line HepG2. Stimulation of acute-phase protein-specific mRNA and protein synthesis by human C5a anaphylatoxin
    • Buchner RR, Hugli TE, Ember JA, Morgan EL (1995). Expression of functional receptors for human C5a anaphylatoxin (CD88) on the human hepatocellular carcinoma cell line HepG2. Stimulation of acute-phase protein-specific mRNA and protein synthesis by human C5a anaphylatoxin. J Immunol 155: 308-315.
    • (1995) J Immunol , vol.155 , pp. 308-315
    • Buchner, R.R.1    Hugli, T.E.2    Ember, J.A.3    Morgan, E.L.4
  • 28
    • 14544271929 scopus 로고    scopus 로고
    • Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor
    • Buck E, Wells JA (2005). Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proc Natl Acad Sci USA 102: 2719-2724.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2719-2724
    • Buck, E.1    Wells, J.A.2
  • 29
    • 14244265111 scopus 로고    scopus 로고
    • Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor
    • Buck E, Bourne H, Wells JA (2005). Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor. J Biol Chem 280: 4009-4012.
    • (2005) J Biol Chem , vol.280 , pp. 4009-4012
    • Buck, E.1    Bourne, H.2    Wells, J.A.3
  • 30
    • 0028564917 scopus 로고
    • Mapping of the C5a receptor signal transduction network in human neutrophils
    • Buhl AM, Avdi N, Worthen GS, Johnson GL (1994). Mapping of the C5a receptor signal transduction network in human neutrophils. Proc Natl Acad Sci USA 91: 9190-9194.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9190-9194
    • Buhl, A.M.1    Avdi, N.2    Worthen, G.S.3    Johnson, G.L.4
  • 31
    • 0030589373 scopus 로고    scopus 로고
    • Differential regulation of the C3a and C5a receptors (CD88) by IFN-gamma and PMA in U937 cells and related myeloblastic cell lines
    • Burg M, Martin U, Bock D, Rheinheimer C, Kohl J, Bautsch W et al. (1996). Differential regulation of the C3a and C5a receptors (CD88) by IFN-gamma and PMA in U937 cells and related myeloblastic cell lines. J Immunol 157: 5574-5581.
    • (1996) J Immunol , vol.157 , pp. 5574-5581
    • Burg, M.1    Martin, U.2    Bock, D.3    Rheinheimer, C.4    Kohl, J.5    Bautsch, W.6
  • 32
    • 0036510770 scopus 로고    scopus 로고
    • The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)
    • Cain SA, Monk PN (2002). The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). J Biol Chem 277: 7165-7169.
    • (2002) J Biol Chem , vol.277 , pp. 7165-7169
    • Cain, S.A.1    Monk, P.N.2
  • 33
    • 0035923408 scopus 로고    scopus 로고
    • Mapping the ligand-binding site on the C5a receptor: Arginine74 of C5a contacts aspartate282 of the C5a receptor
    • Cain SA, Coughlan T, Monk PN (2001). Mapping the ligand-binding site on the C5a receptor: arginine74 of C5a contacts aspartate282 of the C5a receptor. Biochemistry 40: 14047-14052.
    • (2001) Biochemistry , vol.40 , pp. 14047-14052
    • Cain, S.A.1    Coughlan, T.2    Monk, P.N.3
  • 34
    • 0141922889 scopus 로고    scopus 로고
    • Characterisation of C5a receptor agonists from phage display libraries
    • Cain SA, Higginbottom A, Monk PN (2003). Characterisation of C5a receptor agonists from phage display libraries. Biochem Pharmacol 66: 1833-1840.
    • (2003) Biochem Pharmacol , vol.66 , pp. 1833-1840
    • Cain, S.A.1    Higginbottom, A.2    Monk, P.N.3
  • 35
    • 0000325130 scopus 로고
    • Pro-DNMe-amino acid and D-Pro-NMe-amino acid - simple, efficient reverse-turn constraints
    • Chalmers DK, Marshall GR (1995). Pro-DNMe-amino acid and D-Pro-NMe-amino acid - simple, efficient reverse-turn constraints. J Am Chem Soc 117: 5927-5937.
    • (1995) J Am Chem Soc , vol.117 , pp. 5927-5937
    • Chalmers, D.K.1    Marshall, G.R.2
  • 36
    • 33947110020 scopus 로고    scopus 로고
    • C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a
    • Chen NJ, Mirtsos C, Suh D, Lu YC, Lin WJ, Mckerlie C et al. (2007). C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature 446: 203-207.
    • (2007) Nature , vol.446 , pp. 203-207
    • Chen, N.J.1    Mirtsos, C.2    Suh, D.3    Lu, Y.C.4    Lin, W.J.5    Mckerlie, C.6
  • 37
    • 0032562684 scopus 로고    scopus 로고
    • Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin
    • Chen Z, Zhang X, Gonnella NC, Pellas TC, Boyar WC, Ni F (1998). Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin. J Biol Chem 273: 10411-10419.
    • (1998) J Biol Chem , vol.273 , pp. 10411-10419
    • Chen, Z.1    Zhang, X.2    Gonnella, N.C.3    Pellas, T.C.4    Boyar, W.C.5    Ni, F.6
  • 38
    • 0034695490 scopus 로고    scopus 로고
    • Human complement 5a (C5a) anaphylatoxin receptor (CD88) phosphorylation sites and their specific role in receptor phosphorylation and attenuation of G protein-mediated responses. Desensitization of C5a receptor controls superoxide production but not receptor sequestration in HL-60 cells
    • Christophe T, Rabiet MJ, Tardif M, Milcent MD, Boulay F (2000). Human complement 5a (C5a) anaphylatoxin receptor (CD88) phosphorylation sites and their specific role in receptor phosphorylation and attenuation of G protein-mediated responses. Desensitization of C5a receptor controls superoxide production but not receptor sequestration in HL-60 cells. J Biol Chem 275: 1656-1664.
    • (2000) J Biol Chem , vol.275 , pp. 1656-1664
    • Christophe, T.1    Rabiet, M.J.2    Tardif, M.3    Milcent, M.D.4    Boulay, F.5
  • 40
    • 33845908728 scopus 로고    scopus 로고
    • Mycobacteria-primed macrophages and dendritic cells induce an up-regulation of complement C5a anaphylatoxin receptor (CD88) in CD3+ murine T cells
    • Connelly MA, Moulton RA, Smith AK, Lindsey DR, Sinha M, Wetsel RA et al. (2006). Mycobacteria-primed macrophages and dendritic cells induce an up-regulation of complement C5a anaphylatoxin receptor (CD88) in CD3+ murine T cells. J Leukoc Biol 81: 212-220.
    • (2006) J Leukoc Biol , vol.81 , pp. 212-220
    • Connelly, M.A.1    Moulton, R.A.2    Smith, A.K.3    Lindsey, D.R.4    Sinha, M.5    Wetsel, R.A.6
  • 42
    • 0033609445 scopus 로고    scopus 로고
    • Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand
    • Crass T, Bautsch W, Cain SA, Pease JE, Monk PN (1999b). Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand. Biochemistry 38: 9712-9717.
    • (1999) Biochemistry , vol.38 , pp. 9712-9717
    • Crass, T.1    Bautsch, W.2    Cain, S.A.3    Pease, J.E.4    Monk, P.N.5
  • 43
    • 4344686677 scopus 로고    scopus 로고
    • Expression of a functional C5a receptor in regenerating hepatocytes and its involvement in a proliferative signaling pathway in rat
    • Daveau M, Benard M, Scotte M, Schouft MT, Hiron M, Francois A et al. (2004). Expression of a functional C5a receptor in regenerating hepatocytes and its involvement in a proliferative signaling pathway in rat. J Immunol 173: 3418-3424.
    • (2004) J Immunol , vol.173 , pp. 3418-3424
    • Daveau, M.1    Benard, M.2    Scotte, M.3    Schouft, M.T.4    Hiron, M.5    Francois, A.6
  • 44
    • 0031033892 scopus 로고    scopus 로고
    • A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization
    • De Laszlo SE, Allen EE, Li B, Ondeyka D, Rivero R, Malkowitz L et al. (1997). A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization. Bioorg Med Chem Lett 7: 213-218.
    • (1997) Bioorg Med Chem Lett , vol.7 , pp. 213-218
    • De Laszlo, S.E.1    Allen, E.E.2    Li, B.3    Ondeyka, D.4    Rivero, R.5    Malkowitz, L.6
  • 45
    • 0028334663 scopus 로고
    • The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs
    • Demartino JA, Van Riper G, Siciliano SJ, Molineaux CJ, Konteatis ZD, Rosen H et al. (1994). The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs. J Biol Chem 269: 14446-14450.
    • (1994) J Biol Chem , vol.269 , pp. 14446-14450
    • Demartino, J.A.1    Van Riper, G.2    Siciliano, S.J.3    Molineaux, C.J.4    Konteatis, Z.D.5    Rosen, H.6
  • 46
    • 0033578840 scopus 로고    scopus 로고
    • RGS1 is expressed in monocytes and acts as a GTPase-activating protein for G-protein-coupled chemoattractant receptors
    • Denecke B, Meyerdierks A, Bottger EC (1999). RGS1 is expressed in monocytes and acts as a GTPase-activating protein for G-protein-coupled chemoattractant receptors. J Biol Chem 274: 26860-26868.
    • (1999) J Biol Chem , vol.274 , pp. 26860-26868
    • Denecke, B.1    Meyerdierks, A.2    Bottger, E.C.3
  • 47
    • 0027417058 scopus 로고
    • Synthetic C5a receptor agonists. Pharmacology, metabolism and in vivo cardiovascular and hematologic effects
    • Drapeau G, Brochu S, Godin D, Levesque L, Rioux F, Marceau F (1993). Synthetic C5a receptor agonists. Pharmacology, metabolism and in vivo cardiovascular and hematologic effects. Biochem Pharmacol 45: 1289-1299.
    • (1993) Biochem Pharmacol , vol.45 , pp. 1289-1299
    • Drapeau, G.1    Brochu, S.2    Godin, D.3    Levesque, L.4    Rioux, F.5    Marceau, F.6
  • 48
    • 0035253577 scopus 로고    scopus 로고
    • Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma
    • Drouin SM, Kildsgaard J, Haviland J, Zabner J, Jia HP, Mccray Jr PB et al. (2001). Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. J Immunol 166: 2025-2032.
    • (2001) J Immunol , vol.166 , pp. 2025-2032
    • Drouin, S.M.1    Kildsgaard, J.2    Haviland, J.3    Zabner, J.4    Jia, H.P.5    Mccray Jr, P.B.6
  • 49
    • 0019186486 scopus 로고
    • Human-B and T-lymphocyte locomotion in response to casein, C5a, and f-met-leu-phe
    • El-Naggar AK, Van Epps DE, Williams Jr RC (1980). Human-B and T-lymphocyte locomotion in response to casein, C5a, and f-met-leu-phe. Cell Immunol 56: 365-373.
    • (1980) Cell Immunol , vol.56 , pp. 365-373
    • El-Naggar, A.K.1    Van Epps, D.E.2    Williams Jr, R.C.3
  • 50
    • 0029084673 scopus 로고
    • Macrocyclic peptidomimetics - forcing peptides into bioactive conformations
    • Fairlie DP, Abbenante G, March DR (1995). Macrocyclic peptidomimetics - forcing peptides into bioactive conformations. Curr Med Chem 2: 654-686.
    • (1995) Curr Med Chem , vol.2 , pp. 654-686
    • Fairlie, D.P.1    Abbenante, G.2    March, D.R.3
  • 51
    • 0018926516 scopus 로고
    • Human monocyte chemotaxis: Migrating cells are a subpopulation with multiple chemotaxin specificities on each cell
    • Falk W, Leonard EJ (1980). Human monocyte chemotaxis: migrating cells are a subpopulation with multiple chemotaxin specificities on each cell. Infect Immun 29: 953-959.
    • (1980) Infect Immun , vol.29 , pp. 953-959
    • Falk, W.1    Leonard, E.J.2
  • 52
    • 0035821247 scopus 로고    scopus 로고
    • Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor
    • Farzan M, Schnitzler CE, Vasilieva N, Leung D, Kuhn J, Gerard C et al. (2001). Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor. J Exp Med 193: 1059-1066.
    • (2001) J Exp Med , vol.193 , pp. 1059-1066
    • Farzan, M.1    Schnitzler, C.E.2    Vasilieva, N.3    Leung, D.4    Kuhn, J.5    Gerard, C.6
  • 53
    • 0032941136 scopus 로고    scopus 로고
    • C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells
    • Fayyazi A, Sandau R, Duong LQ, Gotze O, Radzun HJ, Schweyer S et al. (1999). C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells. Am J Pathol 154: 495-501.
    • (1999) Am J Pathol , vol.154 , pp. 495-501
    • Fayyazi, A.1    Sandau, R.2    Duong, L.Q.3    Gotze, O.4    Radzun, H.J.5    Schweyer, S.6
  • 54
    • 0033978132 scopus 로고    scopus 로고
    • The C5a receptor is expressed in normal renal proximal tubular but not in normal pulmonary or hepatic epithelial cells
    • Fayyazi A, Scheel O, Werfel T, Schweyer S, Oppermann M, Gotze O et al. (2000). The C5a receptor is expressed in normal renal proximal tubular but not in normal pulmonary or hepatic epithelial cells. Immunology 99: 38-45.
    • (2000) Immunology , vol.99 , pp. 38-45
    • Fayyazi, A.1    Scheel, O.2    Werfel, T.3    Schweyer, S.4    Oppermann, M.5    Gotze, O.6
  • 55
    • 0022979529 scopus 로고
    • Complement activation in cystic fibrosis respiratory fluids: In vivo and in vitro generation of C5a and chemotactic activity
    • Fick Jr RB, Robbins RA, Squier SU, Schoderbek WE, Russ WD (1986). Complement activation in cystic fibrosis respiratory fluids: in vivo and in vitro generation of C5a and chemotactic activity. Pediatr Res 20: 1258-1268.
    • (1986) Pediatr Res , vol.20 , pp. 1258-1268
    • Fick Jr, R.B.1    Robbins, R.A.2    Squier, S.U.3    Schoderbek, W.E.4    Russ, W.D.5
  • 56
    • 0030946317 scopus 로고    scopus 로고
    • Biologically active conformer of the effector region of human C5a and modulatory effects of N-terminal receptor binding determinants on activity
    • Finch AM, Vogen SM, Sherman SA, Kirnarsky L, Taylor SM, Sanderson SD (1997). Biologically active conformer of the effector region of human C5a and modulatory effects of N-terminal receptor binding determinants on activity. J Med Chem 40: 877-884.
    • (1997) J Med Chem , vol.40 , pp. 877-884
    • Finch, A.M.1    Vogen, S.M.2    Sherman, S.A.3    Kirnarsky, L.4    Taylor, S.M.5    Sanderson, S.D.6
  • 57
    • 0033519733 scopus 로고    scopus 로고
    • Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a
    • Finch AM, Wong AK, Paczkowski NJ, Wadi SK, Craik DJ, Fairlie DP et al. (1999). Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. J Med Chem 42: 1965-1974.
    • (1999) J Med Chem , vol.42 , pp. 1965-1974
    • Finch, A.M.1    Wong, A.K.2    Paczkowski, N.J.3    Wadi, S.K.4    Craik, D.J.5    Fairlie, D.P.6
  • 59
    • 0032525008 scopus 로고    scopus 로고
    • Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: Enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke
    • Floreani AA, Heires AJ, Welniak LA, Miller-Lindholm A, Clark-Pierce L, Rennard SI et al. (1998). Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke. J Immunol 160: 5073-5081.
    • (1998) J Immunol , vol.160 , pp. 5073-5081
    • Floreani, A.A.1    Heires, A.J.2    Welniak, L.A.3    Miller-Lindholm, A.4    Clark-Pierce, L.5    Rennard, S.I.6
  • 60
    • 0041315583 scopus 로고    scopus 로고
    • C5a receptor oligomerization. II. Fluorescence resonance energy transfer studies of a human G protein-coupled receptor expressed in yeast
    • Floyd DH, Geva A, Bruinsma SP, Overton MC, Blumer KJ, Baranski TJ (2003). C5a receptor oligomerization. II. Fluorescence resonance energy transfer studies of a human G protein-coupled receptor expressed in yeast. J Biol Chem 278: 35354-35361.
    • (2003) J Biol Chem , vol.278 , pp. 35354-35361
    • Floyd, D.H.1    Geva, A.2    Bruinsma, S.P.3    Overton, M.C.4    Blumer, K.J.5    Baranski, T.J.6
  • 61
  • 62
    • 0013604088 scopus 로고
    • Weitere untersuchungen uber Eisissanaphylaxie: IV. Mitteilung
    • Friedberger E (1910). Weitere untersuchungen uber Eisissanaphylaxie: IV. Mitteilung. Immunitaetaforsch Exp Ther 4: 636-690.
    • (1910) Immunitaetaforsch Exp Ther , vol.4 , pp. 636-690
    • Friedberger, E.1
  • 63
    • 0036203008 scopus 로고    scopus 로고
    • C5a receptor-mediated production of IL-8 by the human retinal pigment epithelial cell line, ARPE-19
    • Fukuoka Y, Medof EM (2001). C5a receptor-mediated production of IL-8 by the human retinal pigment epithelial cell line, ARPE-19. Curr Eye Res 23: 320-325.
    • (2001) Curr Eye Res , vol.23 , pp. 320-325
    • Fukuoka, Y.1    Medof, E.M.2
  • 64
    • 33745435225 scopus 로고    scopus 로고
    • Effect of an anti-C5a monoclonal antibody indicates a prominent role for anaphylatoxin in pulmonary xenograft dysfunction
    • Gaca JG, Appel III JZ, Lukes JG, Gonzalez-Stawinski GV, Lesher A, Palestrant D et al. (2006). Effect of an anti-C5a monoclonal antibody indicates a prominent role for anaphylatoxin in pulmonary xenograft dysfunction. Transplantation 81: 1686-1694.
    • (2006) Transplantation , vol.81 , pp. 1686-1694
    • Gaca, J.G.1    Appel III, J.Z.2    Lukes, J.G.3    Gonzalez-Stawinski, G.V.4    Lesher, A.5    Palestrant, D.6
  • 65
    • 20444460795 scopus 로고    scopus 로고
    • Evidence for a functional role of the second C5a receptor C5L2
    • Gao H, Neff TA, Guo RF, Speyer CL, Sarma JV, Tomlins S et al. (2005). Evidence for a functional role of the second C5a receptor C5L2. FASEB J 19: 1003-1005.
    • (2005) FASEB J , vol.19 , pp. 1003-1005
    • Gao, H.1    Neff, T.A.2    Guo, R.F.3    Speyer, C.L.4    Sarma, J.V.5    Tomlins, S.6
  • 66
    • 0031031213 scopus 로고    scopus 로고
    • Expression of the receptor for complement C5a (CD88) is upregulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system
    • Gasque P, Singhrao SK, Neal JW, Gotze O, Morgan BP (1997). Expression of the receptor for complement C5a (CD88) is upregulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system. Am J Pathol 150: 31-41.
    • (1997) Am J Pathol , vol.150 , pp. 31-41
    • Gasque, P.1    Singhrao, S.K.2    Neal, J.W.3    Gotze, O.4    Morgan, B.P.5
  • 67
    • 0032055221 scopus 로고    scopus 로고
    • The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system: Analysis in multiple sclerosis and bacterial meningitis
    • Gasque P, Singhrao SK, Neal JW, Wang P, Sayah S, Fontaine M et al. (1998). The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system: analysis in multiple sclerosis and bacterial meningitis. J Immunol 160: 3543-3554.
    • (1998) J Immunol , vol.160 , pp. 3543-3554
    • Gasque, P.1    Singhrao, S.K.2    Neal, J.W.3    Wang, P.4    Sayah, S.5    Fontaine, M.6
  • 68
    • 14844314806 scopus 로고    scopus 로고
    • Identification of complement 5a-like receptor (C5L2) from astrocytes: Characterization of anti-inflammatory properties
    • Gavrilyuk V, Kalinin S, Hilbush BS, Middlecamp A, Mcguire S, Pelligrino D et al. (2005). Identification of complement 5a-like receptor (C5L2) from astrocytes: characterization of anti-inflammatory properties. J Neurochem 92: 1140-1149.
    • (2005) J Neurochem , vol.92 , pp. 1140-1149
    • Gavrilyuk, V.1    Kalinin, S.2    Hilbush, B.S.3    Middlecamp, A.4    Mcguire, S.5    Pelligrino, D.6
  • 69
    • 0027410996 scopus 로고
    • Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene
    • Gerard NP, Bao L, Xiao-Ping H, Eddy Jr RL, Shows TB, Gerard C (1993). Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene. Biochemistry 32: 1243-1250.
    • (1993) Biochemistry , vol.32 , pp. 1243-1250
    • Gerard, N.P.1    Bao, L.2    Xiao-Ping, H.3    Eddy Jr, R.L.4    Shows, T.B.5    Gerard, C.6
  • 70
    • 0026078539 scopus 로고
    • The chemotactic receptor for human C5a anaphylatoxin
    • Gerard NP, Gerard C (1991). The chemotactic receptor for human C5a anaphylatoxin. Nature 349: 614-617.
    • (1991) Nature , vol.349 , pp. 614-617
    • Gerard, N.P.1    Gerard, C.2
  • 71
    • 0036888590 scopus 로고    scopus 로고
    • Complement in allergy and asthma
    • Gerard NP, Gerard C (2002). Complement in allergy and asthma. Curr Opin Immunol 14: 705-708.
    • (2002) Curr Opin Immunol , vol.14 , pp. 705-708
    • Gerard, N.P.1    Gerard, C.2
  • 72
    • 28844434626 scopus 로고    scopus 로고
    • An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2
    • Gerard NP, Lu B, Liu P, Craig S, Fujiwara Y, Okinaga S et al. (2005). An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. J Biol Chem 280: 39677-39680.
    • (2005) J Biol Chem , vol.280 , pp. 39677-39680
    • Gerard, N.P.1    Lu, B.2    Liu, P.3    Craig, S.4    Fujiwara, Y.5    Okinaga, S.6
  • 73
    • 0035793604 scopus 로고    scopus 로고
    • An activation switch in the ligand binding pocket of the C5a receptor
    • Gerber BO, Meng EC, Dotsch V, Baranski TJ, Bourne HR (2001a). An activation switch in the ligand binding pocket of the C5a receptor. J Biol Chem 276: 3394-3400.
    • (2001) J Biol Chem , vol.276 , pp. 3394-3400
    • Gerber, B.O.1    Meng, E.C.2    Dotsch, V.3    Baranski, T.J.4    Bourne, H.R.5
  • 74
    • 0035793604 scopus 로고    scopus 로고
    • An activation switch in the ligand binding pocket of the C5a receptor
    • Gerber BO, Meng EC, Dotsch V, Baranski TJ, Bourne HR (2001b). An activation switch in the ligand binding pocket of the C5a receptor. J Biol Chem 276: 3394-3400.
    • (2001) J Biol Chem , vol.276 , pp. 3394-3400
    • Gerber, B.O.1    Meng, E.C.2    Dotsch, V.3    Baranski, T.J.4    Bourne, H.R.5
  • 75
    • 0034634690 scopus 로고    scopus 로고
    • Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function
    • Geva A, Lassere TB, Lichtarge O, Pollitt SK, Baranski TJ (2000). Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function. J Biol Chem 275: 35393-35401.
    • (2000) J Biol Chem , vol.275 , pp. 35393-35401
    • Geva, A.1    Lassere, T.B.2    Lichtarge, O.3    Pollitt, S.K.4    Baranski, T.J.5
  • 76
    • 0029021188 scopus 로고
    • Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo
    • Giannini E, Brouchon L, Boulay F (1995). Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo. J Biol Chem 270: 19166-19172.
    • (1995) J Biol Chem , vol.270 , pp. 19166-19172
    • Giannini, E.1    Brouchon, L.2    Boulay, F.3
  • 77
    • 0346969977 scopus 로고    scopus 로고
    • Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
    • Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D et al. (2003). Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest 112: 1644-1654.
    • (2003) J Clin Invest , vol.112 , pp. 1644-1654
    • Girardi, G.1    Berman, J.2    Redecha, P.3    Spruce, L.4    Thurman, J.M.5    Kraus, D.6
  • 78
    • 33748450585 scopus 로고    scopus 로고
    • Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction
    • Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE (2006). Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J Exp Med 203: 2165-2175.
    • (2006) J Exp Med , vol.203 , pp. 2165-2175
    • Girardi, G.1    Yarilin, D.2    Thurman, J.M.3    Holers, V.M.4    Salmon, J.E.5
  • 79
    • 4344600286 scopus 로고    scopus 로고
    • C5a initiates the inflammatory cascade in immune complex peritonitis
    • Godau J, Heller T, Hawlisch H, Trappe M, Howells E, Best J et al. (2004). C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol 173: 3437-3445.
    • (2004) J Immunol , vol.173 , pp. 3437-3445
    • Godau, J.1    Heller, T.2    Hawlisch, H.3    Trappe, M.4    Howells, E.5    Best, J.6
  • 80
    • 0030882264 scopus 로고    scopus 로고
    • Local therapy with soluble complement receptor 1 (sCR1) suppresses inflammation in rat mono-articular arthritis
    • Goodfellow RM, Williams AS, Levin JL, Williams BD, Morgan BP (1997). Local therapy with soluble complement receptor 1 (sCR1) suppresses inflammation in rat mono-articular arthritis. Clin Exp Immunol 110: 45-52.
    • (1997) Clin Exp Immunol , vol.110 , pp. 45-52
    • Goodfellow, R.M.1    Williams, A.S.2    Levin, J.L.3    Williams, B.D.4    Morgan, B.P.5
  • 81
    • 24744445789 scopus 로고    scopus 로고
    • Variability of biological effects of silicas: Different degrees of activation of the fifth component of complement by amorphous silicas
    • Governa M, Amati M, Fenoglio I, Valentino M, Coloccini S, Bolognini L et al. (2005). Variability of biological effects of silicas: different degrees of activation of the fifth component of complement by amorphous silicas. Toxicol Appl Pharmacol 208: 68-77.
    • (2005) Toxicol Appl Pharmacol , vol.208 , pp. 68-77
    • Governa, M.1    Amati, M.2    Fenoglio, I.3    Valentino, M.4    Coloccini, S.5    Bolognini, L.6
  • 82
    • 0034646813 scopus 로고    scopus 로고
    • In vitro cleavage by asbestos fibers of the fifth component of human complement through free-radical generation and kallikrein activation
    • Governa M, Amati M, Valentino M, Visona I, Fubini B, Botta GC et al. (2000). In vitro cleavage by asbestos fibers of the fifth component of human complement through free-radical generation and kallikrein activation. J Toxicol Environ Health A 59: 539-552.
    • (2000) J Toxicol Environ Health A , vol.59 , pp. 539-552
    • Governa, M.1    Amati, M.2    Valentino, M.3    Visona, I.4    Fubini, B.5    Botta, G.C.6
  • 83
    • 0037011022 scopus 로고    scopus 로고
    • Essential role for the C5a receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis
    • Grant EP, Picarella D, Burwell T, Delaney T, Croci A, Avitahl N et al. (2002). Essential role for the C5a receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis. J Exp Med 196: 1461-1471.
    • (2002) J Exp Med , vol.196 , pp. 1461-1471
    • Grant, E.P.1    Picarella, D.2    Burwell, T.3    Delaney, T.4    Croci, A.5    Avitahl, N.6
  • 84
    • 33646414189 scopus 로고    scopus 로고
    • The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
    • Gurevich VV, Gurevich EV (2006). The structural basis of arrestin-mediated regulation of G-protein-coupled receptors. Pharmacol Ther 110: 465-502.
    • (2006) Pharmacol Ther , vol.110 , pp. 465-502
    • Gurevich, V.V.1    Gurevich, E.V.2
  • 85
    • 35348922464 scopus 로고    scopus 로고
    • Human Plasmacytoid Dendritic Cells Express Receptors for Anaphylatoxins C3a and C5a and Are Chemoattracted to C3a and C5a
    • Gutzmer R, Kother B, Zwirner J, Dijkstra D, Purwar R, Wittmann M et al. (2006). Human Plasmacytoid Dendritic Cells Express Receptors for Anaphylatoxins C3a and C5a and Are Chemoattracted to C3a and C5a. J Invest Dermatol 111: 435-443.
    • (2006) J Invest Dermatol , vol.111 , pp. 435-443
    • Gutzmer, R.1    Kother, B.2    Zwirner, J.3    Dijkstra, D.4    Purwar, R.5    Wittmann, M.6
  • 86
    • 33846011082 scopus 로고    scopus 로고
    • Random mutagenesis of the C5A receptor amino terminus provides a structural constraint for C5A docking
    • Hagemann IS, Narzinski KD, Floyd DH, Baranski TJ (2006). Random mutagenesis of the C5A receptor amino terminus provides a structural constraint for C5A docking. J Biol Chem 281: 36783-36792.
    • (2006) J Biol Chem , vol.281 , pp. 36783-36792
    • Hagemann, I.S.1    Narzinski, K.D.2    Floyd, D.H.3    Baranski, T.J.4
  • 87
    • 0018828611 scopus 로고
    • Granulocyte aggregometry: A sensitive technique for the detection of C5a and complement activation
    • Hammerschmidt DE, Bowers TK, Lammi-Keefe CJ, Jacob HS, Craddock PR (1980a). Granulocyte aggregometry: a sensitive technique for the detection of C5a and complement activation. Blood 55: 898-902.
    • (1980) Blood , vol.55 , pp. 898-902
    • Hammerschmidt, D.E.1    Bowers, T.K.2    Lammi-Keefe, C.J.3    Jacob, H.S.4    Craddock, P.R.5
  • 88
    • 0019512097 scopus 로고
    • Cholesterol and atheroma lipids activate complement and stimulate granulocytes. A possible mechanism for amplification of ischemic injury in atherosclerotic states
    • Hammerschmidt DE, Greenberg CS, Yamada O, Craddock PR, Jacob HS (1981). Cholesterol and atheroma lipids activate complement and stimulate granulocytes. A possible mechanism for amplification of ischemic injury in atherosclerotic states. J Lab Clin Med 98: 68-77.
    • (1981) J Lab Clin Med , vol.98 , pp. 68-77
    • Hammerschmidt, D.E.1    Greenberg, C.S.2    Yamada, O.3    Craddock, P.R.4    Jacob, H.S.5
  • 89
    • 0018857939 scopus 로고
    • Association of complement activation and elevated plasma-C5a with adult respiratory distress syndrome. Pathophysiological relevance and possible prognostic value
    • Hammerschmidt DE, Weaver LJ, Hudson LD, Craddock PR, Jacob HS (1980b). Association of complement activation and elevated plasma-C5a with adult respiratory distress syndrome. Pathophysiological relevance and possible prognostic value. Lancet 1: 947-949.
    • (1980) Lancet , vol.1 , pp. 947-949
    • Hammerschmidt, D.E.1    Weaver, L.J.2    Hudson, L.D.3    Craddock, P.R.4    Jacob, H.S.5
  • 90
    • 0347595295 scopus 로고    scopus 로고
    • Complement C5a receptor antagonist attenuates multiple organ injury in a model of ruptured abdominal aortic aneurysm
    • Harkin DW, Romaschin A, Taylor SM, Rubin BB, Lindsay TF (2004). Complement C5a receptor antagonist attenuates multiple organ injury in a model of ruptured abdominal aortic aneurysm. J Vasc Surg 39: 196-206.
    • (2004) J Vasc Surg , vol.39 , pp. 196-206
    • Harkin, D.W.1    Romaschin, A.2    Taylor, S.M.3    Rubin, B.B.4    Lindsay, T.F.5
  • 91
    • 0028850938 scopus 로고
    • Cellular expression of the C5a anaphylatoxin receptor (C5aR): Demonstration of C5aR on nonmyeloid cells of the liver and lung
    • Haviland DL, Mccoy RL, Whitehead WT, Akama H, Molmenti EP, Brown A et al. (1995). Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung. J Immunol 154: 1861-1869.
    • (1995) J Immunol , vol.154 , pp. 1861-1869
    • Haviland, D.L.1    Mccoy, R.L.2    Whitehead, W.T.3    Akama, H.4    Molmenti, E.P.5    Brown, A.6
  • 93
    • 0034285071 scopus 로고    scopus 로고
    • Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production in vitro by a new C5a receptor antagonist
    • Haynes DR, Harkin DG, Bignold LP, Hutchens MJ, Taylor SM, Fairlie DP (2000). Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production in vitro by a new C5a receptor antagonist. Biochem Pharmacol 60: 729-733.
    • (2000) Biochem Pharmacol , vol.60 , pp. 729-733
    • Haynes, D.R.1    Harkin, D.G.2    Bignold, L.P.3    Hutchens, M.J.4    Taylor, S.M.5    Fairlie, D.P.6
  • 94
    • 24044468702 scopus 로고    scopus 로고
    • Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site
    • Higginbottom A, Cain SA, Woodruff TM, Proctor LM, Madala PK, Tyndall JD et al. (2005). Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. J Biol Chem 280: 17831-17840.
    • (2005) J Biol Chem , vol.280 , pp. 17831-17840
    • Higginbottom, A.1    Cain, S.A.2    Woodruff, T.M.3    Proctor, L.M.4    Madala, P.K.5    Tyndall, J.D.6
  • 95
    • 23044477984 scopus 로고    scopus 로고
    • Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans
    • Hillebrandt S, Wasmuth HE, Weiskirchen R, Hellerbrand C, Keppeler H, Werth A et al. (2005). Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet 37: 835-843.
    • (2005) Nat Genet , vol.37 , pp. 835-843
    • Hillebrandt, S.1    Wasmuth, H.E.2    Weiskirchen, R.3    Hellerbrand, C.4    Keppeler, H.5    Werth, A.6
  • 96
    • 0016734659 scopus 로고
    • Complement-induced histamine release from human basophils. I. Generation of activity in human serum
    • Hook WA, Siraganian RP, Wahl SM (1975). Complement-induced histamine release from human basophils. I. Generation of activity in human serum. J Immunol 114: 1185-1190.
    • (1975) J Immunol , vol.114 , pp. 1185-1190
    • Hook, W.A.1    Siraganian, R.P.2    Wahl, S.M.3
  • 97
    • 0029795542 scopus 로고    scopus 로고
    • The C5a chemoattractant receptor mediates mucosal defence to infection
    • Hopken UE, Lu B, Gerard NP, Gerard C (1996). The C5a chemoattractant receptor mediates mucosal defence to infection. Nature 383: 86-89.
    • (1996) Nature , vol.383 , pp. 86-89
    • Hopken, U.E.1    Lu, B.2    Gerard, N.P.3    Gerard, C.4
  • 98
    • 1842333302 scopus 로고    scopus 로고
    • Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor
    • Hopken UE, Lu B, Gerard NP, Gerard C (1997). Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. J Exp Med 186: 749-756.
    • (1997) J Exp Med , vol.186 , pp. 749-756
    • Hopken, U.E.1    Lu, B.2    Gerard, N.P.3    Gerard, C.4
  • 100
    • 0031724925 scopus 로고    scopus 로고
    • Neutrophils stimulated with a variety of chemoattractants exhibit rapid activation of p21-activated kinases (Paks): Separate signals are required for activation and inactivation of paks
    • Huang R, Lian JP, Robinson D, Badwey JA (1998). Neutrophils stimulated with a variety of chemoattractants exhibit rapid activation of p21-activated kinases (Paks): separate signals are required for activation and inactivation of paks. Mol Cell Biol 18: 7130-7138.
    • (1998) Mol Cell Biol , vol.18 , pp. 7130-7138
    • Huang, R.1    Lian, J.P.2    Robinson, D.3    Badwey, J.A.4
  • 102
    • 19944428475 scopus 로고    scopus 로고
    • Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans
    • Huber-Lang M, Sarma JV, Rittirsch D, Schreiber H, Weiss M, Flierl M et al. (2005). Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans. J Immunol 174: 1104-1110.
    • (2005) J Immunol , vol.174 , pp. 1104-1110
    • Huber-Lang, M.1    Sarma, J.V.2    Rittirsch, D.3    Schreiber, H.4    Weiss, M.5    Flierl, M.6
  • 103
    • 0022379596 scopus 로고
    • Characterization of a C5a receptor on human polymorphonuclear leukocytes (PMN)
    • Huey R, Hugli TE (1985). Characterization of a C5a receptor on human polymorphonuclear leukocytes (PMN). J Immunol 135: 2063-2068.
    • (1985) J Immunol , vol.135 , pp. 2063-2068
    • Huey, R.1    Hugli, T.E.2
  • 104
    • 20444420144 scopus 로고    scopus 로고
    • Transcriptional regulation of the murine C5a receptor gene: NF-Y is required for basal and LPS induced expression in macrophages and endothelial cells
    • Hunt JR, Martin CB, Martin BK (2005). Transcriptional regulation of the murine C5a receptor gene: NF-Y is required for basal and LPS induced expression in macrophages and endothelial cells. Mol Immunol 42: 1405-1415.
    • (2005) Mol Immunol , vol.42 , pp. 1405-1415
    • Hunt, J.R.1    Martin, C.B.2    Martin, B.K.3
  • 105
    • 27844541754 scopus 로고    scopus 로고
    • G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers
    • Huttenrauch F, Pollok-Kopp B, Oppermann M (2005). G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers. J Biol Chem 280: 37503-37515.
    • (2005) J Biol Chem , vol.280 , pp. 37503-37515
    • Huttenrauch, F.1    Pollok-Kopp, B.2    Oppermann, M.3
  • 106
    • 22144446756 scopus 로고    scopus 로고
    • Silencing the expression of multiple Gbeta-subunits eliminates signaling mediated by all four families of G proteins
    • Hwang JI, Choi S, Fraser ID, Chang MS, Simon MI (2005). Silencing the expression of multiple Gbeta-subunits eliminates signaling mediated by all four families of G proteins. Proc Natl Acad Sci USA 102: 9493-9498.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9493-9498
    • Hwang, J.I.1    Choi, S.2    Fraser, I.D.3    Chang, M.S.4    Simon, M.I.5
  • 107
    • 0345743710 scopus 로고    scopus 로고
    • Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA
    • Hwang JI, Fraser ID, Choi S, Qin XF, Simon MI (2004). Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA. Proc Natl Acad Sci USA 101: 488-493.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 488-493
    • Hwang, J.I.1    Fraser, I.D.2    Choi, S.3    Qin, X.F.4    Simon, M.I.5
  • 109
    • 0029885318 scopus 로고    scopus 로고
    • Pertussis toxin-sensitive activation of phospholipase C by the C5a and fMet-Leu-Phe receptors
    • Jiang H, Kuang Y, Wu Y, Smrcka A, Simon MI, Wu D (1996). Pertussis toxin-sensitive activation of phospholipase C by the C5a and fMet-Leu-Phe receptors. J Biol Chem 271: 13430-13434.
    • (1996) J Biol Chem , vol.271 , pp. 13430-13434
    • Jiang, H.1    Kuang, Y.2    Wu, Y.3    Smrcka, A.4    Simon, M.I.5    Wu, D.6
  • 110
    • 33846027130 scopus 로고    scopus 로고
    • Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell-lines
    • Johswich K, Martin M, Thalmann J, Rheinheimer C, Monk PN, Klos A (2006). Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell-lines. J Biol Chem 281: 39088-39095.
    • (2006) J Biol Chem , vol.281 , pp. 39088-39095
    • Johswich, K.1    Martin, M.2    Thalmann, J.3    Rheinheimer, C.4    Monk, P.N.5    Klos, A.6
  • 112
    • 0037126208 scopus 로고    scopus 로고
    • Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands
    • research0063.1-research0063.16
    • Joost P, Methner A (2002). Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands. Genome Biol 3: research0063.1-research0063.16.
    • (2002) Genome Biol , vol.3
    • Joost, P.1    Methner, A.2
  • 113
    • 0038662716 scopus 로고    scopus 로고
    • The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein
    • Kalant D, Cain SA, Maslowska M, Sniderman AD, Cianflone K, Monk PN (2003). The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein. J Biol Chem 278: 11123-11129.
    • (2003) J Biol Chem , vol.278 , pp. 11123-11129
    • Kalant, D.1    Cain, S.A.2    Maslowska, M.3    Sniderman, A.D.4    Cianflone, K.5    Monk, P.N.6
  • 114
    • 0021973760 scopus 로고
    • Involvement of complement in atopic dermatitis
    • Kapp A, Schopf E (1985). Involvement of complement in atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 114: 152-154.
    • (1985) Acta Derm Venereol Suppl (Stockh) , vol.114 , pp. 152-154
    • Kapp, A.1    Schopf, E.2
  • 115
    • 0025915252 scopus 로고
    • Identification and synthesis of a receptor binding site of human anaphylatoxin C5a
    • Kawai M, Quincy DA, Lane B, Mollison KW, Luly JR, Carter GW (1991). Identification and synthesis of a receptor binding site of human anaphylatoxin C5a. J Med Chem 34: 2068-2071.
    • (1991) J Med Chem , vol.34 , pp. 2068-2071
    • Kawai, M.1    Quincy, D.A.2    Lane, B.3    Mollison, K.W.4    Luly, J.R.5    Carter, G.W.6
  • 116
    • 35348825108 scopus 로고
    • New hexa - and heptapeptides are anaphylatoxin antagonists and agonists - for treating inflammatory and immunodeficiency diseases, cancers and severe infections
    • Kawai M, Wiedeman PE, Luly JR, Or YS (1992). New hexa - and heptapeptides are anaphylatoxin antagonists and agonists - for treating inflammatory and immunodeficiency diseases, cancers and severe infections. World Intellectual Property Organisation W092/12168-A1.
    • (1992) World Intellectual Property Organisation W092/12168-A1
    • Kawai, M.1    Wiedeman, P.E.2    Luly, J.R.3    Or, Y.S.4
  • 117
    • 0015784855 scopus 로고
    • Selective attraction of eosinophils and synergism between eosinophil chemotactic factor of anaphylaxis (ECF-A) and a fragment cleaved from the fifth component of complement (C5a)
    • Kay AB, Shin HS, Austen KF (1973). Selective attraction of eosinophils and synergism between eosinophil chemotactic factor of anaphylaxis (ECF-A) and a fragment cleaved from the fifth component of complement (C5a). Immunology 24: 969-976.
    • (1973) Immunology , vol.24 , pp. 969-976
    • Kay, A.B.1    Shin, H.S.2    Austen, K.F.3
  • 119
    • 17844409078 scopus 로고    scopus 로고
    • Immunological factors in the pathogenesis and treatment of age-related macular degeneration
    • Kijlstra A, La Heij E, Hendrikse F (2005). Immunological factors in the pathogenesis and treatment of age-related macular degeneration. Ocul Immunol Inflamm 13: 3-11.
    • (2005) Ocul Immunol Inflamm , vol.13 , pp. 3-11
    • Kijlstra, A.1    La Heij, E.2    Hendrikse, F.3
  • 120
    • 4043077003 scopus 로고    scopus 로고
    • Complement C5a receptor is essential for the optimal generation of antiviral CD8+ T cell responses
    • Kim AH, Dimitriou ID, Holland MC, Mastellos D, Mueller YM, Altman JD et al. (2004). Complement C5a receptor is essential for the optimal generation of antiviral CD8+ T cell responses. J Immunol 173: 2524-2529.
    • (2004) J Immunol , vol.173 , pp. 2524-2529
    • Kim, A.H.1    Dimitriou, I.D.2    Holland, M.C.3    Mastellos, D.4    Mueller, Y.M.5    Altman, J.D.6
  • 121
    • 0041315589 scopus 로고    scopus 로고
    • C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor
    • Klco JM, Lassere TB, Baranski TJ (2003). C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor. J Biol Chem 278: 35345-35353.
    • (2003) J Biol Chem , vol.278 , pp. 35345-35353
    • Klco, J.M.1    Lassere, T.B.2    Baranski, T.J.3
  • 122
    • 33744959047 scopus 로고    scopus 로고
    • Genetic analysis of the first and third extracellular loops of the C5a receptor reveals an essential WXFG motif in the first loop
    • Klco JM, Nikiforovich GV, Baranski TJ (2006). Genetic analysis of the first and third extracellular loops of the C5a receptor reveals an essential WXFG motif in the first loop. J Biol Chem 281: 12010-12019.
    • (2006) J Biol Chem , vol.281 , pp. 12010-12019
    • Klco, J.M.1    Nikiforovich, G.V.2    Baranski, T.J.3
  • 123
    • 18744402177 scopus 로고    scopus 로고
    • Essential role for the second extracellular loop in C5a receptor activation
    • Klco JM, Wiegand CB, Narzinski K, Baranski TJ (2005). Essential role for the second extracellular loop in C5a receptor activation. Nat Struct Mol Biol 12: 320-326.
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 320-326
    • Klco, J.M.1    Wiegand, C.B.2    Narzinski, K.3    Baranski, T.J.4
  • 124
    • 33845514506 scopus 로고    scopus 로고
    • Drug evaluation: The C5a receptor antagonist PMX-53
    • Kohl J (2006). Drug evaluation: the C5a receptor antagonist PMX-53. Curr Opin Mol Ther 8: 529-538.
    • (2006) Curr Opin Mol Ther , vol.8 , pp. 529-538
    • Kohl, J.1
  • 125
    • 33750488768 scopus 로고    scopus 로고
    • Complement regulates inhalation tolerance at the dendritic cell/T cell interface
    • Kohl J, Wills-Karp M (2007). Complement regulates inhalation tolerance at the dendritic cell/T cell interface. Mol Immunol 44: 44-56.
    • (2007) Mol Immunol , vol.44 , pp. 44-56
    • Kohl, J.1    Wills-Karp, M.2
  • 127
    • 0029046606 scopus 로고
    • Probing the 'message:address' sites for chemoattractant binding to the C5a receptor. Mutagenesis of hydrophilic and proline residues within the transmembrane segments
    • Kolakowski Jr LF, Lu B, Gerard C, Gerard NP (1995). Probing the 'message:address' sites for chemoattractant binding to the C5a receptor. Mutagenesis of hydrophilic and proline residues within the transmembrane segments. J Biol Chem 270: 18077-18082.
    • (1995) J Biol Chem , vol.270 , pp. 18077-18082
    • Kolakowski Jr, L.F.1    Lu, B.2    Gerard, C.3    Gerard, N.P.4
  • 128
    • 0036180753 scopus 로고    scopus 로고
    • Induction of anaphylatoxin C5a receptors in rat hepatocytes by lipopolysaccharide in vivo: Mediation by interleukin-6 from Kupffer cells
    • Koleva M, Schlaf G, Landmann R, Gotze O, Jungermann K, Schieferdecker HL (2002). Induction of anaphylatoxin C5a receptors in rat hepatocytes by lipopolysaccharide in vivo: mediation by interleukin-6 from Kupffer cells. Gastroenterology 122: 697-708.
    • (2002) Gastroenterology , vol.122 , pp. 697-708
    • Koleva, M.1    Schlaf, G.2    Landmann, R.3    Gotze, O.4    Jungermann, K.5    Schieferdecker, H.L.6
  • 131
    • 0025989361 scopus 로고
    • Chemotaxis of germinal center B cells in response to C5a
    • Kupp LI, Kosco MH, Schenkein HA, Tew JG (1991). Chemotaxis of germinal center B cells in response to C5a. Eur J Immunol 21: 2697-2701.
    • (1991) Eur J Immunol , vol.21 , pp. 2697-2701
    • Kupp, L.I.1    Kosco, M.H.2    Schenkein, H.A.3    Tew, J.G.4
  • 132
    • 0033178827 scopus 로고    scopus 로고
    • Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines
    • Kuroki M, O'Flaherty JT (1999). Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines. Biochem J 341 (Part 3): 691-696.
    • (1999) Biochem J , vol.341 , Issue.PART 3 , pp. 691-696
    • Kuroki, M.1    O'Flaherty, J.T.2
  • 133
    • 23844434887 scopus 로고    scopus 로고
    • G(i)-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK
    • La Sala A, Gadina M, Kelsall BL (2005). G(i)-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK. J Immunol 175: 2994-2999.
    • (2005) J Immunol , vol.175 , pp. 2994-2999
    • La Sala, A.1    Gadina, M.2    Kelsall, B.L.3
  • 134
    • 33644637509 scopus 로고    scopus 로고
    • An unexpected role for the anaphylatoxin C5a receptor in allergic sensitization
    • Lambrecht BN (2006). An unexpected role for the anaphylatoxin C5a receptor in allergic sensitization. J Clin Invest 116: 628-632.
    • (2006) J Clin Invest , vol.116 , pp. 628-632
    • Lambrecht, B.N.1
  • 135
    • 0033381145 scopus 로고    scopus 로고
    • Ligand-induced phosphorylation of anaphylatoxin receptors C3aR and C5aR is mediated by 'G protein-coupled receptor kinases
    • Langkabel P, Zwirner J, Oppermann M (1999). Ligand-induced phosphorylation of anaphylatoxin receptors C3aR and C5aR is mediated by 'G protein-coupled receptor kinases. Eur J Immunol 29: 3035-3046.
    • (1999) Eur J Immunol , vol.29 , pp. 3035-3046
    • Langkabel, P.1    Zwirner, J.2    Oppermann, M.3
  • 137
    • 0023037216 scopus 로고
    • Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver
    • Laskin DL, Pilaro AM (1986). Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver. Toxicol Appl Pharmacol 86: 204-215.
    • (1986) Toxicol Appl Pharmacol , vol.86 , pp. 204-215
    • Laskin, D.L.1    Pilaro, A.M.2
  • 138
    • 0037111535 scopus 로고    scopus 로고
    • Expression and function of C5a receptor in mouse microvascular endothelial cells
    • Laudes IJ, Chu JC, Huber-Lang M, Guo RF, Riedemann NC, Sarma JV et al. (2002). Expression and function of C5a receptor in mouse microvascular endothelial cells. J Immunol 169: 5962-5970.
    • (2002) J Immunol , vol.169 , pp. 5962-5970
    • Laudes, I.J.1    Chu, J.C.2    Huber-Lang, M.3    Guo, R.F.4    Riedemann, N.C.5    Sarma, J.V.6
  • 140
    • 0035977698 scopus 로고    scopus 로고
    • Identification of four novel human G protein-coupled receptors expressed in the brain
    • Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M et al. (2001). Identification of four novel human G protein-coupled receptors expressed in the brain. Brain Res Mol Brain Res 86: 13-22.
    • (2001) Brain Res Mol Brain Res , vol.86 , pp. 13-22
    • Lee, D.K.1    George, S.R.2    Cheng, R.3    Nguyen, T.4    Liu, Y.5    Brown, M.6
  • 141
    • 33749840453 scopus 로고    scopus 로고
    • Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies
    • Lee H, Zahra D, Vogelzang A, Newton R, Thatcher J, Quan A et al. (2006). Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies. Nat Biotechnol 24: 1279-1284.
    • (2006) Nat Biotechnol , vol.24 , pp. 1279-1284
    • Lee, H.1    Zahra, D.2    Vogelzang, A.3    Newton, R.4    Thatcher, J.5    Quan, A.6
  • 142
    • 0041352963 scopus 로고    scopus 로고
    • Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42
    • Li Z, Hannigan M, Mo Z, Liu B, Lu W, Wu Y et al. (2003). Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell 114: 215-227.
    • (2003) Cell , vol.114 , pp. 215-227
    • Li, Z.1    Hannigan, M.2    Mo, Z.3    Liu, B.4    Lu, W.5    Wu, Y.6
  • 143
    • 0346101797 scopus 로고    scopus 로고
    • Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism
    • Lo RK, Cheung H, Wong YH (2003). Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism. J Biol Chem 278: 52154-52165.
    • (2003) J Biol Chem , vol.278 , pp. 52154-52165
    • RK, L.1    Cheung, H.2    Wong, Y.H.3
  • 145
    • 12144290258 scopus 로고    scopus 로고
    • Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity
    • March DR, Proctor LM, Stoermer MJ, Sbaglia R, Abbenante G, Reid RC et al. (2004). Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity. Mol Pharmacol 65: 868-879.
    • (2004) Mol Pharmacol , vol.65 , pp. 868-879
    • March, D.R.1    Proctor, L.M.2    Stoermer, M.J.3    Sbaglia, R.4    Abbenante, G.5    Reid, R.C.6
  • 146
    • 33748794781 scopus 로고    scopus 로고
    • Regulation of the C5a receptor promoter in glial cells: Minimal dependence upon the CCAAT element in astrocytes
    • Martin CB, Ingersoll SA, Martin BK (2006). Regulation of the C5a receptor promoter in glial cells: Minimal dependence upon the CCAAT element in astrocytes. Mol Immunol 44: 713-721.
    • (2006) Mol Immunol , vol.44 , pp. 713-721
    • Martin, C.B.1    Ingersoll, S.A.2    Martin, B.K.3
  • 147
    • 0023789213 scopus 로고
    • C5a decreases regional coronary blood flow and myocardial function in pigs: Implications for a granulocyte mechanism
    • Martin SE, Chenoweth DE, Engler RL, Roth DM, Longhurst JC (1988). C5a decreases regional coronary blood flow and myocardial function in pigs: implications for a granulocyte mechanism. Circ Res 63: 483-491.
    • (1988) Circ Res , vol.63 , pp. 483-491
    • Martin, S.E.1    Chenoweth, D.E.2    Engler, R.L.3    Roth, D.M.4    Longhurst, J.C.5
  • 148
    • 0030793679 scopus 로고    scopus 로고
    • Generation of anaphylatoxins through proteolytic processing of C3 and C5 by house dust mite protease
    • Maruo K, Akaike T, Ono T, Okamoto T, Maeda H (1997). Generation of anaphylatoxins through proteolytic processing of C3 and C5 by house dust mite protease. J Allergy Clin Immunol 100: 253-260.
    • (1997) J Allergy Clin Immunol , vol.100 , pp. 253-260
    • Maruo, K.1    Akaike, T.2    Ono, T.3    Okamoto, T.4    Maeda, H.5
  • 149
    • 0035865055 scopus 로고    scopus 로고
    • A novel role of complement: Mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration
    • Mastellos D, Papadimitriou JC, Franchini S, Tsonis PA, Lambris JD (2001). A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration. J Immunol 166: 2479-2486.
    • (2001) J Immunol , vol.166 , pp. 2479-2486
    • Mastellos, D.1    Papadimitriou, J.C.2    Franchini, S.3    Tsonis, P.A.4    Lambris, J.D.5
  • 150
    • 34047246323 scopus 로고    scopus 로고
    • A comprehensive structure-function map of the intracellular surface of the human C5a receptor: I. Identification of critical residues
    • Matsumoto ML, Narzinski K, Kiser PD, Nikiforovich GV, Baranski TJ (2007a). A comprehensive structure-function map of the intracellular surface of the human C5a receptor: I. Identification of critical residues. J Biol Chem 282: 3105-3121.
    • (2007) J Biol Chem , vol.282 , pp. 3105-3121
    • Matsumoto, M.L.1    Narzinski, K.2    Kiser, P.D.3    Nikiforovich, G.V.4    Baranski, T.J.5
  • 151
    • 34047274266 scopus 로고    scopus 로고
    • A comprehensive structure-function map of the intracellular surface of the human C5a receptor: II. Elucidation of G protein specificity determinants
    • Matsumoto ML, Narzinski K, Nikiforovich GV, Baranski TJ (2007b). A comprehensive structure-function map of the intracellular surface of the human C5a receptor: II. Elucidation of G protein specificity determinants. J Biol Chem 282: 3122-3133.
    • (2007) J Biol Chem , vol.282 , pp. 3122-3133
    • Matsumoto, M.L.1    Narzinski, K.2    Nikiforovich, G.V.3    Baranski, T.J.4
  • 152
    • 33745216502 scopus 로고    scopus 로고
    • Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2
    • Mazaki Y, Hashimoto S, Tsujimura T, Morishige M, Hashimoto A, Aritake K et al. (2006). Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2. Nat Immunol 7: 724-731.
    • (2006) Nat Immunol , vol.7 , pp. 724-731
    • Mazaki, Y.1    Hashimoto, S.2    Tsujimura, T.3    Morishige, M.4    Hashimoto, A.5    Aritake, K.6
  • 153
    • 0018613207 scopus 로고
    • Induction of lysosomal enzyme secretion by alveolar macrophages in response to the purified complement fragments C5a and C5a des-arg
    • McCarthy K, Henson PM (1979). Induction of lysosomal enzyme secretion by alveolar macrophages in response to the purified complement fragments C5a and C5a des-arg. J Immunol 123: 2511-2517.
    • (1979) J Immunol , vol.123 , pp. 2511-2517
    • McCarthy, K.1    Henson, P.M.2
  • 154
    • 0029033888 scopus 로고
    • N-formylpeptide and complement C5a receptors are expressed in liver cells and mediate hepatic acute phase gene regulation
    • McCoy R, Haviland DL, Molmenti EP, Ziambaras T, Wetsel RA, Perlmutter DH (1995). N-formylpeptide and complement C5a receptors are expressed in liver cells and mediate hepatic acute phase gene regulation. J Exp Med 182: 207-217.
    • (1995) J Exp Med , vol.182 , pp. 207-217
    • McCoy, R.1    Haviland, D.L.2    Molmenti, E.P.3    Ziambaras, T.4    Wetsel, R.A.5    Perlmutter, D.H.6
  • 155
    • 0027724659 scopus 로고
    • Evidence that the extracellular N-terminal domain of C5aR contains amino-acid residues crucial for C5a binding
    • Mery L, Boulay F (1993). Evidence that the extracellular N-terminal domain of C5aR contains amino-acid residues crucial for C5a binding. Eur J Haematol 51: 282-287.
    • (1993) Eur J Haematol , vol.51 , pp. 282-287
    • Mery, L.1    Boulay, F.2
  • 156
    • 0028169697 scopus 로고
    • The NH2-terminal region of C5aR but not that of FPR is critical for both protein transport and ligand binding
    • Mery L, Boulay F (1994). The NH2-terminal region of C5aR but not that of FPR is critical for both protein transport and ligand binding. J Biol Chem 269: 3457-3463.
    • (1994) J Biol Chem , vol.269 , pp. 3457-3463
    • Mery, L.1    Boulay, F.2
  • 157
    • 0033609360 scopus 로고    scopus 로고
    • Overexpression of wild-type and catalytically inactive forms of GRK2 and GRK6 fails to alter the agonist-induced phosphorylation of the C5a receptor (CD88): Evidence that GRK6 is autophosphorylated in COS-7 cells
    • Milcent MD, Christophe T, Rabiet MJ, Tardif M, Boulay F (1999). Overexpression of wild-type and catalytically inactive forms of GRK2 and GRK6 fails to alter the agonist-induced phosphorylation of the C5a receptor (CD88): evidence that GRK6 is autophosphorylated in COS-7 cells. Biochem Biophys Res Commun 259: 224-229.
    • (1999) Biochem Biophys Res Commun , vol.259 , pp. 224-229
    • Milcent, M.D.1    Christophe, T.2    Rabiet, M.J.3    Tardif, M.4    Boulay, F.5
  • 160
    • 0031982250 scopus 로고    scopus 로고
    • Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis
    • Mohr M, Hopken U, Oppermann M, Mathes C, Goldmann K, Siever S et al. (1998). Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis. Eur J Clin Invest 28: 227-234.
    • (1998) Eur J Clin Invest , vol.28 , pp. 227-234
    • Mohr, M.1    Hopken, U.2    Oppermann, M.3    Mathes, C.4    Goldmann, K.5    Siever, S.6
  • 161
    • 0027367783 scopus 로고
    • Characterization of a complement-fragment- C5a-stimulated calcium-influx mechanism in U937 monocytic cells
    • Monk PN, Partridge LJ (1993). Characterization of a complement-fragment- C5a-stimulated calcium-influx mechanism in U937 monocytic cells. Biochem J 295 (Part 3): 679-684.
    • (1993) Biochem J , vol.295 , Issue.PART 3 , pp. 679-684
    • Monk, P.N.1    Partridge, L.J.2
  • 162
    • 0029016905 scopus 로고
    • Mutation of glutamate 199 of the human C5a receptor defines a binding site for ligand distinct from the receptor N terminus
    • Monk PN, Barker MD, Partridge LJ, Pease JE (1995). Mutation of glutamate 199 of the human C5a receptor defines a binding site for ligand distinct from the receptor N terminus. J Biol Chem 270: 16625-16629.
    • (1995) J Biol Chem , vol.270 , pp. 16625-16629
    • Monk, P.N.1    Barker, M.D.2    Partridge, L.J.3    Pease, J.E.4
  • 163
    • 0028278594 scopus 로고
    • C5a stimulus-secretion coupling in rat basophilic leukaemia (RBL-2H3) cells transfected with the human C5a receptor is mediated by pertussis and cholera toxin-sensitive G proteins
    • Monk PN, Pease JE, Barker MD (1994a). C5a stimulus-secretion coupling in rat basophilic leukaemia (RBL-2H3) cells transfected with the human C5a receptor is mediated by pertussis and cholera toxin-sensitive G proteins. Biochem Mol Biol Int 32: 13-20.
    • (1994) Biochem Mol Biol Int , vol.32 , pp. 13-20
    • Monk, P.N.1    Pease, J.E.2    Barker, M.D.3
  • 164
    • 0028089716 scopus 로고
    • Mutation of aspartate 82 of the human C5a receptor abolishes the secretory response to human C5a in transfected rat basophilic leukemia cells
    • Monk PN, Pease JE, Marland G, Barker MD (1994b). Mutation of aspartate 82 of the human C5a receptor abolishes the secretory response to human C5a in transfected rat basophilic leukemia cells. Eur J Immunol 24: 2922-2925.
    • (1994) Eur J Immunol , vol.24 , pp. 2922-2925
    • Monk, P.N.1    Pease, J.E.2    Marland, G.3    Barker, M.D.4
  • 165
    • 0041589205 scopus 로고    scopus 로고
    • The biology and enzymology of protein tyrosine O-sulfation
    • Moore KL (2003). The biology and enzymology of protein tyrosine O-sulfation. J Biol Chem 278: 24243-24246.
    • (2003) J Biol Chem , vol.278 , pp. 24243-24246
    • Moore, K.L.1
  • 166
    • 0027201170 scopus 로고
    • Anti-C5a receptor antibodies. Characterization of neutralizing antibodies specific for a peptide, C5aR-(9-29), derived from the predicted amino-terminal sequence of the human C5a receptor
    • Morgan EL, Ember JA, Sanderson SD, Scholz W, Buchner R, Ye RD et al. (1993). Anti-C5a receptor antibodies. Characterization of neutralizing antibodies specific for a peptide, C5aR-(9-29), derived from the predicted amino-terminal sequence of the human C5a receptor. J Immunol 151: 377-388.
    • (1993) J Immunol , vol.151 , pp. 377-388
    • Morgan, E.L.1    Ember, J.A.2    Sanderson, S.D.3    Scholz, W.4    Buchner, R.5    Ye, R.D.6
  • 167
    • 0020701621 scopus 로고
    • Anaphylatoxin-mediated regulation of the immune response. II. C5a-mediated enhancement of human humoral and T cell-mediated immune responses
    • Morgan EL, Thoman ML, Weigle WO, Hugli TE (1983). Anaphylatoxin-mediated regulation of the immune response. II. C5a-mediated enhancement of human humoral and T cell-mediated immune responses. J Immunol 130: 1257-1261.
    • (1983) J Immunol , vol.130 , pp. 1257-1261
    • Morgan, E.L.1    Thoman, M.L.2    Weigle, W.O.3    Hugli, T.E.4
  • 168
    • 33846395782 scopus 로고    scopus 로고
    • Mast cell-expressed complement receptor, not TLR2, is the main detector of zymosan in peritonitis
    • Mullaly SC, Kubes P (2007). Mast cell-expressed complement receptor, not TLR2, is the main detector of zymosan in peritonitis. Eur J Immunol 37: 224-234.
    • (2007) Eur J Immunol , vol.37 , pp. 224-234
    • Mullaly, S.C.1    Kubes, P.2
  • 170
    • 0000693801 scopus 로고    scopus 로고
    • Internalization and recycling of the C5a anaphylatoxin receptor: Evidence that the agonist-mediated internalization is modulated by phosphorylation of the C-terminal domain
    • Naik N, Giannini E, Brouchon L, Boulay F (1997). Internalization and recycling of the C5a anaphylatoxin receptor: evidence that the agonist-mediated internalization is modulated by phosphorylation of the C-terminal domain. J Cell Sci 110 (Part 19): 2381-2390.
    • (1997) J Cell Sci , vol.110 , Issue.PART 19 , pp. 2381-2390
    • Naik, N.1    Giannini, E.2    Brouchon, L.3    Boulay, F.4
  • 171
    • 27744600835 scopus 로고    scopus 로고
    • Blockade of p38 map kinase inhibits complement-induced acute lung injury in a murine model
    • Nash SP, Heuertz RM (2005). Blockade of p38 map kinase inhibits complement-induced acute lung injury in a murine model. Int Immunopharmacol 5: 1870-1880.
    • (2005) Int Immunopharmacol , vol.5 , pp. 1870-1880
    • Nash, S.P.1    Heuertz, R.M.2
  • 172
    • 0033120587 scopus 로고    scopus 로고
    • Human T cells express the C5a receptor and are chemoattracted to C5a
    • Nataf S, Davoust N, Ames RS, Barnum SR (1999). Human T cells express the C5a receptor and are chemoattracted to C5a. J Immunol 162: 4018-4023.
    • (1999) J Immunol , vol.162 , pp. 4018-4023
    • Nataf, S.1    Davoust, N.2    Ames, R.S.3    Barnum, S.R.4
  • 173
    • 0035896427 scopus 로고    scopus 로고
    • Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage
    • Nataf S, Levison SW, Barnum SR (2001). Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage. Brain Res 894: 321-326.
    • (2001) Brain Res , vol.894 , pp. 321-326
    • Nataf, S.1    Levison, S.W.2    Barnum, S.R.3
  • 174
  • 175
    • 0030023396 scopus 로고    scopus 로고
    • Monocyte chemotactic factor in rheumatoid arthritis synovial tissue. Probably a cross-linked derivative of S19 ribosomal protein
    • Nishiura H, Shibuya Y, Matsubara S, Tanase S, Kambara T, Yamamoto T (1996). Monocyte chemotactic factor in rheumatoid arthritis synovial tissue. Probably a cross-linked derivative of S19 ribosomal protein. J Biol Chem 271: 878-882.
    • (1996) J Biol Chem , vol.271 , pp. 878-882
    • Nishiura, H.1    Shibuya, Y.2    Matsubara, S.3    Tanase, S.4    Kambara, T.5    Yamamoto, T.6
  • 176
    • 0035869453 scopus 로고    scopus 로고
    • Neuronal expression of a functional receptor for the C5a complement activation fragment
    • O'barr SA, Caguioa J, Gruol D, Perkins G, Ember JA, Hugli T et al. (2001). Neuronal expression of a functional receptor for the C5a complement activation fragment. J Immunol 166: 4154-4162.
    • (2001) J Immunol , vol.166 , pp. 4154-4162
    • O'barr, S.A.1    Caguioa, J.2    Gruol, D.3    Perkins, G.4    Ember, J.A.5    Hugli, T.6
  • 177
    • 23044433925 scopus 로고    scopus 로고
    • Structure and function of the Wiskott-Aldrich syndrome protein
    • Ochs HD, Notarangelo LD (2005). Structure and function of the Wiskott-Aldrich syndrome protein. Curr Opin Hematol 12: 284-291.
    • (2005) Curr Opin Hematol , vol.12 , pp. 284-291
    • Ochs, H.D.1    Notarangelo, L.D.2
  • 178
    • 0033709969 scopus 로고    scopus 로고
    • A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells
    • Ohno M, Hirata T, Enomoto M, Araki T, Ishimaru H, Takahashi TA (2000). A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. Mol Immunol 37: 407-412.
    • (2000) Mol Immunol , vol.37 , pp. 407-412
    • Ohno, M.1    Hirata, T.2    Enomoto, M.3    Araki, T.4    Ishimaru, H.5    Takahashi, T.A.6
  • 179
    • 0018297767 scopus 로고
    • Chemotactic activity in periodontal disease. I. The role of complement in monocyte chemotaxis
    • Okada H, Silverman MS (1979). Chemotactic activity in periodontal disease. I. The role of complement in monocyte chemotaxis. J Periodontal Res 14: 20-25.
    • (1979) J Periodontal Res , vol.14 , pp. 20-25
    • Okada, H.1    Silverman, M.S.2
  • 181
    • 0344739377 scopus 로고
    • Complement C5a receptor antagonism by protamine and poly-L-Arg on human leukocytes
    • Olsen UB, Selmer J, Kahl JU (1988). Complement C5a receptor antagonism by protamine and poly-L-Arg on human leukocytes. Complement 5: 153-162.
    • (1988) Complement , vol.5 , pp. 153-162
    • Olsen, U.B.1    Selmer, J.2    Kahl, J.U.3
  • 182
    • 0035985370 scopus 로고    scopus 로고
    • Expression of the anaphylatoxin receptor C5aR (CD88) by human articular chondrocytes
    • Onuma H, Masuko-Hongo K, Yuan G, Sakata M, Nakamura H, Kato T et al. (2002). Expression of the anaphylatoxin receptor C5aR (CD88) by human articular chondrocytes. Rheumatol Int 22: 52-55.
    • (2002) Rheumatol Int , vol.22 , pp. 52-55
    • Onuma, H.1    Masuko-Hongo, K.2    Yuan, G.3    Sakata, M.4    Nakamura, H.5    Kato, T.6
  • 183
    • 0027932151 scopus 로고
    • Plasma clearance of the human C5a anaphylatoxin by binding to leucocyte C5a receptors
    • Oppermann M, Gotze O (1994). Plasma clearance of the human C5a anaphylatoxin by binding to leucocyte C5a receptors. Immunology 82: 516-521.
    • (1994) Immunology , vol.82 , pp. 516-521
    • Oppermann, M.1    Gotze, O.2
  • 184
    • 0027282775 scopus 로고
    • Probing the human receptor for C5a anaphylatoxin with site-directed antibodies. Identification of a potential ligand binding site on the NH2-terminal domain
    • Oppermann M, Raedt U, Hebell T, Schmidt B, Zimmermann B, Gotze O (1993). Probing the human receptor for C5a anaphylatoxin with site-directed antibodies. Identification of a potential ligand binding site on the NH2-terminal domain. J Immunol 151: 3785-3794.
    • (1993) J Immunol , vol.151 , pp. 3785-3794
    • Oppermann, M.1    Raedt, U.2    Hebell, T.3    Schmidt, B.4    Zimmermann, B.5    Gotze, O.6
  • 185
    • 20444477046 scopus 로고    scopus 로고
    • Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell
    • Oskeritzian CA, Zhao W, Min HK, Xia HZ, Pozez A, Kiev J et al. (2005). Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell. J Allergy Clin Immunol 115: 1162-1168.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 1162-1168
    • Oskeritzian, C.A.1    Zhao, W.2    Min, H.K.3    Xia, H.Z.4    Pozez, A.5    Kiev, J.6
  • 186
    • 0347052898 scopus 로고    scopus 로고
    • C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: Position 69 is the locus that determines agonism or antagonism
    • Otto M, Hawlisch H, Monk PN, Muller M, Klos A, Karp CL et al. (2004). C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism. J Biol Chem 279: 142-151.
    • (2004) J Biol Chem , vol.279 , pp. 142-151
    • Otto, M.1    Hawlisch, H.2    Monk, P.N.3    Muller, M.4    Klos, A.5    Karp, C.L.6
  • 187
    • 0033152775 scopus 로고    scopus 로고
    • rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: Implications for B cell trafficking in secondary lymphoid tissues
    • Ottonello L, Corcione A, Tortolina G, Airoldi I, Albesiano E, Favre A et al. (1999). rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues. J Immunol 162: 6510-6517.
    • (1999) J Immunol , vol.162 , pp. 6510-6517
    • Ottonello, L.1    Corcione, A.2    Tortolina, G.3    Airoldi, I.4    Albesiano, E.5    Favre, A.6
  • 188
    • 0027955272 scopus 로고
    • Generation of chimeric C5a/ formyl peptide receptors: Towards the identification of the human C5a receptor binding site
    • Pease JE, Burton DR, Barker MD (1994). Generation of chimeric C5a/ formyl peptide receptors: towards the identification of the human C5a receptor binding site. Eur J Immunol 24: 211-215.
    • (1994) Eur J Immunol , vol.24 , pp. 211-215
    • Pease, J.E.1    Burton, D.R.2    Barker, M.D.3
  • 189
    • 0036151650 scopus 로고    scopus 로고
    • C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway
    • Perianayagam MC, Balakrishnan VS, King AJ, Pereira BJ, Jaber BL (2002). C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway. Kidney Int 61: 456-463.
    • (2002) Kidney Int , vol.61 , pp. 456-463
    • Perianayagam, M.C.1    Balakrishnan, V.S.2    King, A.J.3    Pereira, B.J.4    Jaber, B.L.5
  • 190
    • 1242292337 scopus 로고    scopus 로고
    • C5a delays apoptosis of human neutrophils via an extracellular signal-regulated kinase and Bad-mediated signalling pathway
    • Perianayagam MC, Balakrishnan VS, Pereira BJ, Jaber BL (2004). C5a delays apoptosis of human neutrophils via an extracellular signal-regulated kinase and Bad-mediated signalling pathway. Eur J Clin Invest 34: 50-56.
    • (2004) Eur J Clin Invest , vol.34 , pp. 50-56
    • Perianayagam, M.C.1    Balakrishnan, V.S.2    Pereira, B.J.3    Jaber, B.L.4
  • 191
    • 33645888404 scopus 로고    scopus 로고
    • CREB transcription factor modulates Bcl2 transcription in response to C5a in HL-60-derived neutrophils
    • Perianayagam MC, Madias NE, Pereira BJ, Jaber BL (2006). CREB transcription factor modulates Bcl2 transcription in response to C5a in HL-60-derived neutrophils. Eur J Clin Invest 36: 353-361.
    • (2006) Eur J Clin Invest , vol.36 , pp. 353-361
    • Perianayagam, M.C.1    Madias, N.E.2    Pereira, B.J.3    Jaber, B.L.4
  • 193
    • 3242776043 scopus 로고    scopus 로고
    • Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury
    • Proctor LM, Arumugam TV, Shiels I, Reid RC, Fairlie DP, Taylor SM (2004). Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. Br J Pharmacol 142: 756-764.
    • (2004) Br J Pharmacol , vol.142 , pp. 756-764
    • Proctor, L.M.1    Arumugam, T.V.2    Shiels, I.3    Reid, R.C.4    Fairlie, D.P.5    Taylor, S.M.6
  • 195
    • 33645742906 scopus 로고    scopus 로고
    • Complement inhibitors finally find orphan niches
    • Ratner M (2006). Complement inhibitors finally find orphan niches. Nat Biotechnol 24: 371-372.
    • (2006) Nat Biotechnol , vol.24 , pp. 371-372
    • Ratner, M.1
  • 196
    • 0021018884 scopus 로고
    • Effects of C5a on guinea pig lung: Histamine release and mechanism of contraction
    • Regal JF, Hardy TM, Casey FB, Chakrin LW (1983). Effects of C5a on guinea pig lung: histamine release and mechanism of contraction. Immunopharmacology 5: 315-327.
    • (1983) Immunopharmacology , vol.5 , pp. 315-327
    • Regal, J.F.1    Hardy, T.M.2    Casey, F.B.3    Chakrin, L.W.4
  • 197
    • 0036232710 scopus 로고    scopus 로고
    • Disruption of the C5a receptor gene fails to protect against experimental allergic encephalomyelitis
    • Reiman R, Gerard C, Campbell IL, Barnum SR (2002). Disruption of the C5a receptor gene fails to protect against experimental allergic encephalomyelitis. Eur J Immunol 32: 1157-1163.
    • (2002) Eur J Immunol , vol.32 , pp. 1157-1163
    • Reiman, R.1    Gerard, C.2    Campbell, I.L.3    Barnum, S.R.4
  • 198
    • 33947424008 scopus 로고    scopus 로고
    • The G protein-coupled receptor kinase (GRK) interactome: Role of GRKs in GPCR regulation and signaling
    • Ribas C, Penela P, Murga C, Salcedo A, Garcia-Hoz C, Jurado-Pueyo M et al. (2007). The G protein-coupled receptor kinase (GRK) interactome: Role of GRKs in GPCR regulation and signaling. Biochim Biophys Acta 1768: 913-942.
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 913-942
    • Ribas, C.1    Penela, P.2    Murga, C.3    Salcedo, A.4    Garcia-Hoz, C.5    Jurado-Pueyo, M.6
  • 202
    • 33749257848 scopus 로고    scopus 로고
    • CXCL12 and C5a trigger cell migration via a PAK1/ 2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway
    • Rousseau S, Dolado I, Beardmore V, Shpiro N, Marquez R, Nebreda AR et al. (2006). CXCL12 and C5a trigger cell migration via a PAK1/ 2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway. Cell Signal 18: 1897-1905.
    • (2006) Cell Signal , vol.18 , pp. 1897-1905
    • Rousseau, S.1    Dolado, I.2    Beardmore, V.3    Shpiro, N.4    Marquez, R.5    Nebreda, A.R.6
  • 203
    • 0026069842 scopus 로고
    • Regulation of complement 5a receptor expression in U937 cells by phorbol ester
    • Rubin J, Titus L, Nanes MS (1991). Regulation of complement 5a receptor expression in U937 cells by phorbol ester. J Leukoc Biol 50: 502-508.
    • (1991) J Leukoc Biol , vol.50 , pp. 502-508
    • Rubin, J.1    Titus, L.2    Nanes, M.S.3
  • 204
    • 0029880746 scopus 로고    scopus 로고
    • Ultrafiltration after cardiopulmonary bypass in children: Effects on hemodynamics, cytokines and complement
    • Saatvedt K, Lindberg H, Geiran OR, Michelsen S, Pedersen T, Seem E et al. (1996). Ultrafiltration after cardiopulmonary bypass in children: effects on hemodynamics, cytokines and complement. Cardiovasc Res 31: 596-602.
    • (1996) Cardiovasc Res , vol.31 , pp. 596-602
    • Saatvedt, K.1    Lindberg, H.2    Geiran, O.R.3    Michelsen, S.4    Pedersen, T.5    Seem, E.6
  • 205
    • 0034657253 scopus 로고    scopus 로고
    • Induction of functional anaphylatoxin C5a receptors on hepatocytes by in vivo treatment of rats with IL-6
    • Schieferdecker HL, Schlaf G, Koleva M, Gotze O, Jungermann K (2000). Induction of functional anaphylatoxin C5a receptors on hepatocytes by in vivo treatment of rats with IL-6. J Immunol 164: 5453-5458.
    • (2000) J Immunol , vol.164 , pp. 5453-5458
    • Schieferdecker, H.L.1    Schlaf, G.2    Koleva, M.3    Gotze, O.4    Jungermann, K.5
  • 206
    • 6344294224 scopus 로고    scopus 로고
    • Upregulation of fibronectin but not of entactin, collagen IV and smooth muscle actin by anaphylatoxin C5a in rat hepatic stellate cells
    • Schlaf G, Schmitz M, Heine I, Demberg T, Schieferdecker HL, Gotze O (2004). Upregulation of fibronectin but not of entactin, collagen IV and smooth muscle actin by anaphylatoxin C5a in rat hepatic stellate cells. Histol Histopathol 19: 1165-1174.
    • (2004) Histol Histopathol , vol.19 , pp. 1165-1174
    • Schlaf, G.1    Schmitz, M.2    Heine, I.3    Demberg, T.4    Schieferdecker, H.L.5    Gotze, O.6
  • 208
    • 33747368498 scopus 로고    scopus 로고
    • Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: Increased receptor specificity and in vivo activity
    • Schnatbaum K, Locardi E, Scharn D, Richter U, Hawlisch H, Knolle J et al. (2006). Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett 16: 5088-5092.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 5088-5092
    • Schnatbaum, K.1    Locardi, E.2    Scharn, D.3    Richter, U.4    Hawlisch, H.5    Knolle, J.6
  • 209
    • 0037103283 scopus 로고    scopus 로고
    • Complement c3a and c5a induce different signal transduction cascades in endothelial cells
    • Schraufstatter IU, Trieu K, Sikora L, Sriramarao P, Discipio R (2002). Complement c3a and c5a induce different signal transduction cascades in endothelial cells. J Immunol 169: 2102-2110.
    • (2002) J Immunol , vol.169 , pp. 2102-2110
    • Schraufstatter, I.U.1    Trieu, K.2    Sikora, L.3    Sriramarao, P.4    Discipio, R.5
  • 210
    • 33947530321 scopus 로고    scopus 로고
    • The role of the n-terminal domain of the complement fragment receptor, C5l2, in ligand binding
    • Scola A-M, Higginbottom A, Partridge LJ, Reid C, Woodruff TM, Taylor SM et al. (2007). The role of the n-terminal domain of the complement fragment receptor, C5l2, in ligand binding. J Biol Chem 282: 3664-3671.
    • (2007) J Biol Chem , vol.282 , pp. 3664-3671
    • Scola, A.-M.1    Higginbottom, A.2    Partridge, L.J.3    Reid, C.4    Woodruff, T.M.5    Taylor, S.M.6
  • 211
    • 4444242782 scopus 로고    scopus 로고
    • Complement C3 and C5 play critical roles in traumatic brain cryoinjury: Blocking effects on neutrophil extravasation by C5a receptor antagonist
    • Sewell DL, Nacewicz B, Liu F, Macvilay S, Erdei A, Lambris JD et al. (2004). Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist. J Neuroimmunol 155: 55-63.
    • (2004) J Neuroimmunol , vol.155 , pp. 55-63
    • Sewell, D.L.1    Nacewicz, B.2    Liu, F.3    Macvilay, S.4    Erdei, A.5    Lambris, J.D.6
  • 212
    • 0025731025 scopus 로고
    • The regulation of actin polymerization in differentiating U937 cells correlates with increased membrane levels of the pertussis-toxin-sensitive G-protein Gi2
    • Sheth B, Banks P, Burton DR, Monk PN (1991). The regulation of actin polymerization in differentiating U937 cells correlates with increased membrane levels of the pertussis-toxin-sensitive G-protein Gi2. Biochem J 275 (Part 3): 809-811.
    • (1991) Biochem J , vol.275 , Issue.PART 3 , pp. 809-811
    • Sheth, B.1    Banks, P.2    Burton, D.R.3    Monk, P.N.4
  • 213
    • 0033029306 scopus 로고    scopus 로고
    • Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat
    • Short A, Wong AK, Finch AM, Haaima G, Shiels IA, Fairlie DP et al. (1999). Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. Br J Pharmacol 126: 551-554.
    • (1999) Br J Pharmacol , vol.126 , pp. 551-554
    • Short, A.1    Wong, A.K.2    Finch, A.M.3    Haaima, G.4    Shiels, I.A.5    Fairlie, D.P.6
  • 214
    • 1242338872 scopus 로고    scopus 로고
    • Bacterial chaperone protein, Skp, induces leukocyte chemotaxis via C5a receptor
    • Shrestha A, Shi L, Tanase S, Tsukamoto M, Nishino N, Tokita K et al. (2004). Bacterial chaperone protein, Skp, induces leukocyte chemotaxis via C5a receptor. Am J Pathol 164: 763-772.
    • (2004) Am J Pathol , vol.164 , pp. 763-772
    • Shrestha, A.1    Shi, L.2    Tanase, S.3    Tsukamoto, M.4    Nishino, N.5    Tokita, K.6
  • 215
    • 0036945832 scopus 로고    scopus 로고
    • C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease
    • Shushakova N, Skokowa J, Schulman J, Baumann U, Zwirner J, Schmidt RE et al. (2002). C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease. J Clin Invest 110: 1823-1830.
    • (2002) J Clin Invest , vol.110 , pp. 1823-1830
    • Shushakova, N.1    Skokowa, J.2    Schulman, J.3    Baumann, U.4    Zwirner, J.5    Schmidt, R.E.6
  • 216
    • 20044381682 scopus 로고    scopus 로고
    • Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation
    • Skokowa J, Ali SR, Felda O, Kumar V, Konrad S, Shushakova N et al. (2005). Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. J Immunol 174: 3041-3050.
    • (2005) J Immunol , vol.174 , pp. 3041-3050
    • Skokowa, J.1    Ali, S.R.2    Felda, O.3    Kumar, V.4    Konrad, S.5    Shushakova, N.6
  • 217
    • 0000379225 scopus 로고
    • Polymorphonuclear Leukocyte Chemotactic Activity in Rabbit Serum and Guinea Pig Serum Treated with Immune Complexes: Evidence for C5a as the Major Chemotactic Factor
    • Snyderman R, Phillips J, Mergenhagen SE (1970). Polymorphonuclear Leukocyte Chemotactic Activity in Rabbit Serum and Guinea Pig Serum Treated with Immune Complexes: Evidence for C5a as the Major Chemotactic Factor. Infect Immun 1: 521-525.
    • (1970) Infect Immun , vol.1 , pp. 521-525
    • Snyderman, R.1    Phillips, J.2    Mergenhagen, S.E.3
  • 218
    • 0016697436 scopus 로고
    • Quantification of mouse macrophage chemotaxis in vitro: Role of C5 for the production of chemotactic activity
    • Snyderman R, Pike MC, Mccarley D, Lang L (1975). Quantification of mouse macrophage chemotaxis in vitro: role of C5 for the production of chemotactic activity. Infect Immun 11: 488-492.
    • (1975) Infect Immun , vol.11 , pp. 488-492
    • Snyderman, R.1    Pike, M.C.2    Mccarley, D.3    Lang, L.4
  • 219
    • 0037443560 scopus 로고    scopus 로고
    • IL-4 down-regulates anaphylatoxin receptors in monocytes and dendritic cells and impairs anaphylatoxin-induced migration in vivo
    • Soruri A, Kiafard Z, Dettmer C, Riggert J, Kohl J, Zwirner J (2003a). IL-4 down-regulates anaphylatoxin receptors in monocytes and dendritic cells and impairs anaphylatoxin-induced migration in vivo. J Immunol 170: 3306-3314.
    • (2003) J Immunol , vol.170 , pp. 3306-3314
    • Soruri, A.1    Kiafard, Z.2    Dettmer, C.3    Riggert, J.4    Kohl, J.5    Zwirner, J.6
  • 220
    • 0037824636 scopus 로고    scopus 로고
    • Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody
    • Soruri A, Kim S, Kiafard Z, Zwirner J (2003b). Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody. Immunol Lett 88: 47-52.
    • (2003) Immunol Lett , vol.88 , pp. 47-52
    • Soruri, A.1    Kim, S.2    Kiafard, Z.3    Zwirner, J.4
  • 221
    • 0031570894 scopus 로고    scopus 로고
    • TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis
    • Stahel PF, Frei K, Eugster HP, Fontana A, Hummel KM, Wetsel RA et al. (1997). TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis. J Immunol 159: 861-869.
    • (1997) J Immunol , vol.159 , pp. 861-869
    • Stahel, P.F.1    Frei, K.2    Eugster, H.P.3    Fontana, A.4    Hummel, K.M.5    Wetsel, R.A.6
  • 222
    • 0034703412 scopus 로고    scopus 로고
    • Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-alpha following closed head injury in mice
    • Stahel PF, Kariya K, Shohami E, Barnum SR, Eugster H, Trentz O et al. (2000). Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-alpha following closed head injury in mice. J Neuroimmunol 109: 164-172.
    • (2000) J Neuroimmunol , vol.109 , pp. 164-172
    • Stahel, P.F.1    Kariya, K.2    Shohami, E.3    Barnum, S.R.4    Eugster, H.5    Trentz, O.6
  • 223
    • 0035675932 scopus 로고    scopus 로고
    • Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist
    • Strachan AJ, Shiels IA, Reid RC, Fairlie DP, Taylor SM (2001). Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist. Br J Pharmacol 134: 1778-1786.
    • (2001) Br J Pharmacol , vol.134 , pp. 1778-1786
    • Strachan, A.J.1    Shiels, I.A.2    Reid, R.C.3    Fairlie, D.P.4    Taylor, S.M.5
  • 224
    • 0034659827 scopus 로고    scopus 로고
    • A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats
    • Strachan AJ, Woodruff TM, Haaima G, Fairlie DP, Taylor SM (2000). A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats. J Immunol 164: 6560-6565.
    • (2000) J Immunol , vol.164 , pp. 6560-6565
    • Strachan, A.J.1    Woodruff, T.M.2    Haaima, G.3    Fairlie, D.P.4    Taylor, S.M.5
  • 226
    • 0037147332 scopus 로고    scopus 로고
    • Identification of a potent and orally active nonpeptide C5a receptor antagonist
    • Sumichika H, Sakata K, Sato N, Takeshita S, Ishibuchi S, Nakamura M et al. (2002). Identification of a potent and orally active nonpeptide C5a receptor antagonist. J Biol Chem 277: 49403-49407.
    • (2002) J Biol Chem , vol.277 , pp. 49403-49407
    • Sumichika, H.1    Sakata, K.2    Sato, N.3    Takeshita, S.4    Ishibuchi, S.5    Nakamura, M.6
  • 227
    • 0032698758 scopus 로고    scopus 로고
    • Identification of ligand effector binding sites in transmembrane regions of the human G protein-coupled C3a receptor
    • Sun J, Ember JA, Chao TH, Fukuoka Y, Ye RD, Hugli TE (1999). Identification of ligand effector binding sites in transmembrane regions of the human G protein-coupled C3a receptor. Protein Sci 8: 2304-2311.
    • (1999) Protein Sci , vol.8 , pp. 2304-2311
    • Sun, J.1    Ember, J.A.2    Chao, T.H.3    Fukuoka, Y.4    Ye, R.D.5    Hugli, T.E.6
  • 228
    • 30144441512 scopus 로고    scopus 로고
    • A chemogenomic analysis of the transmembrane binding cavity of human G-protein-coupled receptors
    • Surgand JS, Rodrigo J, Kellenberger E, Rognan D (2006). A chemogenomic analysis of the transmembrane binding cavity of human G-protein-coupled receptors. Proteins 62: 509-538.
    • (2006) Proteins , vol.62 , pp. 509-538
    • Surgand, J.S.1    Rodrigo, J.2    Kellenberger, E.3    Rognan, D.4
  • 229
    • 0038000556 scopus 로고    scopus 로고
    • Direct binding of a fragment of the Wiskott-Aldrich syndrome protein to the C-terminal end of the anaphylatoxin C5a receptor
    • Tardif M, Brouchon L, Rabiet MJ, Boulay F (2003). Direct binding of a fragment of the Wiskott-Aldrich syndrome protein to the C-terminal end of the anaphylatoxin C5a receptor. Biochem J 372: 453-463.
    • (2003) Biochem J , vol.372 , pp. 453-463
    • Tardif, M.1    Brouchon, L.2    Rabiet, M.J.3    Boulay, F.4
  • 230
    • 33444471507 scopus 로고    scopus 로고
    • Discovery of potent cyclic antagonists of human C5a receptors
    • Morikis D and Lambris JD eds, CRC Press: New York, pp
    • Taylor SM, Fairlie DP (2005). Discovery of potent cyclic antagonists of human C5a receptors. In: Morikis D and Lambris JD (eds). Structural Biology of the Complement System. CRC Press: New York, pp 341-362.
    • (2005) Structural Biology of the Complement System , pp. 341-362
    • Taylor, S.M.1    Fairlie, D.P.2
  • 231
    • 31144460785 scopus 로고    scopus 로고
    • The central role of the alternative complement pathway in human disease
    • Thurman JM, Holers VM (2006). The central role of the alternative complement pathway in human disease. J Immunol 176: 1305-1310.
    • (2006) J Immunol , vol.176 , pp. 1305-1310
    • Thurman, J.M.1    Holers, V.M.2
  • 232
    • 0031757369 scopus 로고    scopus 로고
    • Anti-C5a monoclonal antibody reduces cardiopulmonary bypass and cardioplegia-induced coronary endothelial dysfunction
    • Tofukuji M, Stahl GL, Agah A, Metais C, Simons M, Sellke FW (1998). Anti-C5a monoclonal antibody reduces cardiopulmonary bypass and cardioplegia-induced coronary endothelial dysfunction. J Thorac Cardiovasc Surg 116: 1060-1068.
    • (1998) J Thorac Cardiovasc Surg , vol.116 , pp. 1060-1068
    • Tofukuji, M.1    Stahl, G.L.2    Agah, A.3    Metais, C.4    Simons, M.5    Sellke, F.W.6
  • 233
    • 0034254650 scopus 로고    scopus 로고
    • Early local generation of C5a initiates the elicitation of contact sensitivity by leading to early T cell recruitment
    • Tsuji RF, Kawikova I, Ramabhadran R, Akahira-Azuma M, Taub D, Hugli TE et al. (2000). Early local generation of C5a initiates the elicitation of contact sensitivity by leading to early T cell recruitment. J Immunol 165: 1588-1598.
    • (2000) J Immunol , vol.165 , pp. 1588-1598
    • Tsuji, R.F.1    Kawikova, I.2    Ramabhadran, R.3    Akahira-Azuma, M.4    Taub, D.5    Hugli, T.E.6
  • 234
    • 0028876829 scopus 로고
    • Anti-inflammatory effects and specificity of L-156,602: Comparison of effects on concanavalin A and zymosan-induced footpad edema, and contact sensitivity response
    • Tsuji RF, Yamakoshi J, Uramoto M, Koshino H, Saito M, Kikuchi M et al. (1995). Anti-inflammatory effects and specificity of L-156,602: comparison of effects on concanavalin A and zymosan-induced footpad edema, and contact sensitivity response. Immunopharmacology 29: 79-87.
    • (1995) Immunopharmacology , vol.29 , pp. 79-87
    • Tsuji, R.F.1    Yamakoshi, J.2    Uramoto, M.3    Koshino, H.4    Saito, M.5    Kikuchi, M.6
  • 235
    • 0037791771 scopus 로고    scopus 로고
    • Activation of complement in the central nervous system: Roles in neurodegeneration and neuroprotection
    • Van Beek J, Elward K, Gasque P (2003). Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection. Ann N Y Acad Sci 992: 56-71.
    • (2003) Ann N Y Acad Sci , vol.992 , pp. 56-71
    • Van Beek, J.1    Elward, K.2    Gasque, P.3
  • 236
    • 0021279149 scopus 로고
    • Analysis of the binding of fluorescent C5a and C3a to human peripheral blood leukocytes
    • Van Epps DE, Chenoweth DE (1984). Analysis of the binding of fluorescent C5a and C3a to human peripheral blood leukocytes. J Immunol 132: 2862-2867.
    • (1984) J Immunol , vol.132 , pp. 2862-2867
    • Van Epps, D.E.1    Chenoweth, D.E.2
  • 237
    • 0025174372 scopus 로고
    • Regulation of C5a and formyl peptide receptor expression on human polymorphonuclear leukocytes
    • Van Epps DE, Simpson S, Bender JG, Chenoweth DE (1990). Regulation of C5a and formyl peptide receptor expression on human polymorphonuclear leukocytes. J Immunol 144: 1062-1068.
    • (1990) J Immunol , vol.144 , pp. 1062-1068
    • Van Epps, D.E.1    Simpson, S.2    Bender, J.G.3    Chenoweth, D.E.4
  • 238
    • 33747352549 scopus 로고    scopus 로고
    • Natural IgM antibodies: The orphaned molecules in immune surveillance
    • Vollmers HP, Brandlein S (2006). Natural IgM antibodies: the orphaned molecules in immune surveillance. Adv Drug Deliv Rev 58: 755-765.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 755-765
    • Vollmers, H.P.1    Brandlein, S.2
  • 239
    • 28844441553 scopus 로고    scopus 로고
    • Molecular characterization of the gerbil c5a receptor and identification of a transmembrane domain v amino Acid that is crucial for small molecule antagonist interaction
    • Waters SM, Brodbeck RM, Steflik J, Yu J, Baltazar C, Peck AE et al. (2005). Molecular characterization of the gerbil c5a receptor and identification of a transmembrane domain v amino Acid that is crucial for small molecule antagonist interaction. J Biol Chem 280: 40617-40623.
    • (2005) J Biol Chem , vol.280 , pp. 40617-40623
    • Waters, S.M.1    Brodbeck, R.M.2    Steflik, J.3    Yu, J.4    Baltazar, C.5    Peck, A.E.6
  • 240
    • 0346221279 scopus 로고    scopus 로고
    • Up-regulation of C5a receptor expression and function on human monocyte derived dendritic cells by prostaglandin E2
    • Weinmann O, Gutzmer R, Zwirner J, Wittmann M, Langer K, Lisewski M et al. (2003). Up-regulation of C5a receptor expression and function on human monocyte derived dendritic cells by prostaglandin E2. Immunology 110: 458-465.
    • (2003) Immunology , vol.110 , pp. 458-465
    • Weinmann, O.1    Gutzmer, R.2    Zwirner, J.3    Wittmann, M.4    Langer, K.5    Lisewski, M.6
  • 241
    • 0025529033 scopus 로고
    • Recombinant soluble CR1 suppressed complement activation, inflammation, and necrosis associated with reperfusion of ischemic myocardium
    • Weisman HF, Bartow T, Leppo MK, Boyle MP, Marsh Jr HC, Carson GR et al. (1990). Recombinant soluble CR1 suppressed complement activation, inflammation, and necrosis associated with reperfusion of ischemic myocardium. Trans Assoc Am Physicians 103: 64-72.
    • (1990) Trans Assoc Am Physicians , vol.103 , pp. 64-72
    • Weisman, H.F.1    Bartow, T.2    Leppo, M.K.3    Boyle, M.P.4    Marsh Jr, H.C.5    Carson, G.R.6
  • 242
    • 0036378385 scopus 로고    scopus 로고
    • C5a is important in the tubulointerstitial component of experimental immune complex glomerulonephritis
    • Welch TR, Frenzke M, Witte D, Davis AE (2002). C5a is important in the tubulointerstitial component of experimental immune complex glomerulonephritis. Clin Exp Immunol 130: 43-48.
    • (2002) Clin Exp Immunol , vol.130 , pp. 43-48
    • Welch, T.R.1    Frenzke, M.2    Witte, D.3    Davis, A.E.4
  • 243
    • 0032572818 scopus 로고    scopus 로고
    • Small molecular probes for G-protein-coupled C5a receptors: Conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a
    • Wong AK, Finch AM, Pierens GK, Craik DJ, Taylor SM, Fairlie DP (1998). Small molecular probes for G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a. J Med Chem 41: 3417-3425.
    • (1998) J Med Chem , vol.41 , pp. 3417-3425
    • Wong, A.K.1    Finch, A.M.2    Pierens, G.K.3    Craik, D.J.4    Taylor, S.M.5    Fairlie, D.P.6
  • 244
    • 35348927659 scopus 로고    scopus 로고
    • PhD Thesis, University of Queensland
    • Wong AK (1999b). PhD Thesis, University of Queensland.
    • (1999)
    • Wong, A.K.1
  • 245
    • 0033051688 scopus 로고    scopus 로고
    • Development of C5a receptor antagonists
    • Wong AK, Taylor SM, Fairlie DP (1999a). Development of C5a receptor antagonists. IDrugs 2: 686-693.
    • (1999) IDrugs , vol.2 , pp. 686-693
    • Wong, A.K.1    Taylor, S.M.2    Fairlie, D.P.3
  • 246
    • 0242494255 scopus 로고    scopus 로고
    • A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease
    • Woodruff TM, Arumugam TV, Shiels IA, Reid RC, Fairlie DP, Taylor SM (2003). A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. J Immunol 171: 5514-5520.
    • (2003) J Immunol , vol.171 , pp. 5514-5520
    • Woodruff, T.M.1    Arumugam, T.V.2    Shiels, I.A.3    Reid, R.C.4    Fairlie, D.P.5    Taylor, S.M.6
  • 247
    • 0345829310 scopus 로고    scopus 로고
    • Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats
    • Woodruff TM, Arumugam TV, Shiels IA, Reid RC, Fairlie DP, Taylor SM (2004). Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats. J Surg Res 116: 81-90.
    • (2004) J Surg Res , vol.116 , pp. 81-90
    • Woodruff, T.M.1    Arumugam, T.V.2    Shiels, I.A.3    Reid, R.C.4    Fairlie, D.P.5    Taylor, S.M.6
  • 248
    • 33746505701 scopus 로고    scopus 로고
    • Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration
    • Woodruff TM, Crane JW, Proctor LM, Buller KM, Shek AB, De Vos K et al. (2006). Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration. FASEB J 20: 1407-1417.
    • (2006) FASEB J , vol.20 , pp. 1407-1417
    • Woodruff, T.M.1    Crane, J.W.2    Proctor, L.M.3    Buller, K.M.4    Shek, A.B.5    De Vos, K.6
  • 249
    • 0036745078 scopus 로고    scopus 로고
    • Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat
    • Woodruff TM, Strachan AJ, Dryburgh N, Shiels IA, Reid RC, Fairlie DP et al. (2002). Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Arthritis Rheum 46: 2476-2485.
    • (2002) Arthritis Rheum , vol.46 , pp. 2476-2485
    • Woodruff, T.M.1    Strachan, A.J.2    Dryburgh, N.3    Shiels, I.A.4    Reid, R.C.5    Fairlie, D.P.6
  • 250
    • 0035007326 scopus 로고    scopus 로고
    • Species dependence for binding of small molecule agonist and antagonists to the C5a receptor on polymorphonuclear leukocytes
    • Woodruff TM, Strachan AJ, Sanderson SD, Monk PN, Wong AK, Fairlie DP et al. (2001). Species dependence for binding of small molecule agonist and antagonists to the C5a receptor on polymorphonuclear leukocytes. Inflammation 25: 171-177.
    • (2001) Inflammation , vol.25 , pp. 171-177
    • Woodruff, T.M.1    Strachan, A.J.2    Sanderson, S.D.3    Monk, P.N.4    Wong, A.K.5    Fairlie, D.P.6
  • 251
    • 33845593909 scopus 로고    scopus 로고
    • Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes
    • Yamamoto T (2007). Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes. Pathol Int 57: 1-11.
    • (2007) Pathol Int , vol.57 , pp. 1-11
    • Yamamoto, T.1
  • 253
    • 0141503303 scopus 로고    scopus 로고
    • Expression of C5aR (CD88) of synoviocytes isolated from patients with rheumatoid arthritis and osteoarthritis
    • Yuan G, Wei J, Zhou J, Hu H, Tang Z, Zhang G (2003). Expression of C5aR (CD88) of synoviocytes isolated from patients with rheumatoid arthritis and osteoarthritis. Chin Med J (England) 116: 1408-1412.
    • (2003) Chin Med J (England) , vol.116 , pp. 1408-1412
    • Yuan, G.1    Wei, J.2    Zhou, J.3    Hu, H.4    Tang, Z.5    Zhang, G.6
  • 254
    • 0030901002 scopus 로고    scopus 로고
    • Chemoattractant receptors for interleukin-8 and C5a: Expression on peripheral blood leukocytes and differential regulation on HL-60 and AML-193 cells by vitamin D3 and all-trans retinoic acid
    • Zahn S, Zwirner J, Spengler HP, Gotze O (1997). Chemoattractant receptors for interleukin-8 and C5a: expression on peripheral blood leukocytes and differential regulation on HL-60 and AML-193 cells by vitamin D3 and all-trans retinoic acid. Eur J Immunol 27: 935-940.
    • (1997) Eur J Immunol , vol.27 , pp. 935-940
    • Zahn, S.1    Zwirner, J.2    Spengler, H.P.3    Gotze, O.4
  • 255
    • 0030999525 scopus 로고    scopus 로고
    • Structural definition of the C5a C terminus by two-dimensional nuclear magnetic resonance spectroscopy
    • Zhang X, Boyar W, Toth MJ, Wennogle L, Gonnella NC (1997). Structural definition of the C5a C terminus by two-dimensional nuclear magnetic resonance spectroscopy. Proteins 28: 261-267.
    • (1997) Proteins , vol.28 , pp. 261-267
    • Zhang, X.1    Boyar, W.2    Toth, M.J.3    Wennogle, L.4    Gonnella, N.C.5
  • 256
    • 13444269022 scopus 로고    scopus 로고
    • The ancient origin of the complement system
    • Zhu Y, Thangamani S, Ho B, Ding JL (2005). The ancient origin of the complement system. EMBO J 24: 382-394.
    • (2005) EMBO J , vol.24 , pp. 382-394
    • Zhu, Y.1    Thangamani, S.2    Ho, B.3    Ding, J.L.4
  • 257
    • 0024595889 scopus 로고
    • Heteronuclear three-dimensional NMR spectroscopy of the inflammatory protein C5a
    • Zuiderweg ER, Fesik SW (1989). Heteronuclear three-dimensional NMR spectroscopy of the inflammatory protein C5a. Biochemistry 28: 2387-2391.
    • (1989) Biochemistry , vol.28 , pp. 2387-2391
    • Zuiderweg, E.R.1    Fesik, S.W.2
  • 258
    • 0024493978 scopus 로고
    • Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data
    • Zuiderweg ER, Nettesheim DG, Mollison KW, Carter GW (1989). Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data. Biochemistry 28: 172-185.
    • (1989) Biochemistry , vol.28 , pp. 172-185
    • Zuiderweg, E.R.1    Nettesheim, D.G.2    Mollison, K.W.3    Carter, G.W.4
  • 259
    • 0033370490 scopus 로고    scopus 로고
    • Expression of the anaphylatoxin C5a receptor in non-myeloid cells
    • Zwirner J, Fayyazi A, Gotze O (1999). Expression of the anaphylatoxin C5a receptor in non-myeloid cells. Mol Immunol 36: 877-884.
    • (1999) Mol Immunol , vol.36 , pp. 877-884
    • Zwirner, J.1    Fayyazi, A.2    Gotze, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.