C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a

Nature

Volumn 446, Issue 7132, 2007, Pages 203-207

  Chen, Nien Jung ^a   Mirtsos, Christine ^a   Suh, Daniel ^a   Lu, Yong Chen ^a   Lin, Wen Jye ^a   McKerlie, Colin ^b   Lee, Taeweon ^c   Baribault, Helene ^c   Tian, Hui ^c   Yeh, Wen Chen ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHYLATOXIN; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 77; UNCLASSIFIED DRUG;

GENETIC ANALYSIS; IMMUNE RESPONSE; PROTEIN; SIGNAL; TOXIC SUBSTANCE; TOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRONCHUS HYPERREACTIVITY; CELL INFILTRATION; COMPLEMENT ACTIVATION; CONTROLLED STUDY; FIBROBLAST; GAMMA IRRADIATION; GENE TARGETING; IN VITRO STUDY; INFLAMMATORY INFILTRATE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; SEPTIC SHOCK; SIGNAL TRANSDUCTION;

MUS;

EID: 33947110020     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05559     Document Type: Article

References (24)

1. Shin, H. S., Snyderman, R., Friedman, E., Mellors, A. & Mayer, M. M. Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement. Science 162, 361-363 (1968).
2. Bokisch, V. A., Muller-Eberhard, H. J. & Cochrane, C. G. Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and description of an anaphylatoxin inactivator of human serum. J. Exp. Med. 129, 1109-1130 (1969).
3. Höpken, U. E., Lu, B., Gerard, N. P. & Gerard, C. The C5a chemoattractant receptor mediates mucosal defence to infection. Nature 383, 86-89 (1996).
4. Humbles, A. A. et al. A role for the C3a anaphylatoxin receptor in the effector phase of asthma. Nature 406, 998-1001 (2000).
5. Ohno, M. et al. A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. Mol. Immunol. 37, 407-412 (2000).
6. 74. J. Biol. Chem. 277, 7165-7169 (2002).
7. Gerard, N. P. et al. An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. J. Biol. Chem. 280, 39677-39680 (2005).
8. Kildsgaard, J. et al. Cutting edge: targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock. J. Immunol. 165, 5406-5409 (2000).
9. Ratajczak, M. Z. et al. Transplantation studies in C3-deficient animals reveal a novel role of the third complement component (C3) in engraftment of bone marrow cells. Leukemia 18, 1482-1490 (2004).
10. Hsu, M. H. et al. Cloning and functional characterization of the mouse C3a anaphylatoxin receptor gene. Immunogenetics 47, 64-72 (1997).
11. Perret, J. J., Raspe, E., Vassart, G. & Parmentier, M. Cloning and functional expression of the canine anaphylatoxin C5a receptor. Evidence for high interspecies variability. Biochem. J. 288, 911-917 (1992).
12. 77/acylation-stimulating protein. J. Biol. Chem. 278, 11123-11129 (2003).
13. Okinaga, S. et al. C5L2, a nonsignaling C5A binding protein. Biochemistry 42, 9406-9415 (2003).
14. Kalant, D. et al. C5L2 is a functional receptor for acylation stimulating protein. J. Biol. Chem. 280, 23936-23944 (2005).
15. Riedemann, N. C. et al. Regulation by C5a of neutrophil activation during sepsis. Immunity 19, 193-202 (2003).
16. Riedemann, N. C. et al. Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. FASEB J. 18, 370-372 (2004).
17. Perianayagam, M. C., Balakrishnan, V. S., King, A. J., Pereira, B. J. & Jaber, B. L. C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway. Kidney Int. 61, 456-463 (2002).
18. Hawlisch, H. et al. C5a negatively regulates Toll-like receptor 4-induced immune responses. Immunity 22, 415-426 (2005).
19. Guo, R. F., Riedemann, N. C. & Ward, P. A. Role of C5a-C5aR interaction in sepsis. Shock 21, 1-7 (2004).
20. Gavrilyuk, V. et al. Identification of complement 5a-like receptor (C5L2) from astrocytes: characterization of anti-inflammatory properties. J. Neurochem. 92, 1140-1149 (2005).
21. Gao, H. et al. Evidence for a functional role of the second C5a receptor C5L2. FASEB J. 19, 1003-1005 (2005).
22. B receptor. Nature 396, 679-682 (1998).
23. Sasaki, T. et al. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration. Science 287, 1040-1046 (2000).
24. Duncan, G. S. et al. Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J. Immunol. 162, 3022-3030 (1999).