Internalization and recycling of the C5a anaphylatoxin receptor: Evidence that the agonist-mediated internalization is modulated by phosphorylation of the C-terminal domain

Journal of Cell Science

Volumn 110, Issue 19, 1997, Pages 2381-2390

  Naik, Nishigandha ^a,b   Giannini, Eric ^a   Brouchon, Laurence ^a   Boulay, François ^a  

^a CEA GRENOBLE   (France)

^b TATA MEMORIAL HOSPITAL   (India)

Author keywords

C5a receptor; Chemoattractant; Endocytosis; Phosphorylation; Recycling

Indexed keywords

EID: 0000693801     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Ali, H., Richardson, R. M., Tomhave, E. D., Didsbury, J. R. and Snyderman, R. (1993). Differences in phosphorylation of formylpeptide and C5a chemoatlractant receptors correlate with differences in desensitization. J. Biol. Chem. 268, 24247-24254.
2. Ashworth, R., Yu, R., Nelson, E. J., Dermer, S., Gershengorn, M. C. and Hinkle, P. M. (1995). Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling. Proc. Nat. Acad. Sci. USA 92, 512-516.
3. Barak, L. S., Tiberi, M., Freedman, N. J., Kwatra, M. M., Lefkowitz, R. J. and Caron, M. G. (1994). A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated β2-adrenergic receptor sequestration. J. Biol. Chem. 269, 2790-2795.
4. Boulay, F., Mery, L., Tardif, M., Brouchon, L. and Vignais, P. (1991). Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells. Biochemistry 30, 2993-2999.
5. Dohlman, H. G., Thorner, J., Caron, M. and Lefkowitz, R. J. (1991). Model systems for the study of seven-transmembrane-segment receptors. Annu. Rev. Biochem. 60, 653-688.
6. 2-adrenergic receptor sequestration. J. Biol. Chem. 270, 24782-24789.
7. Ferguson, S. S. G., Downey III, W. E., Colapietro, A.-M., Barak, L. S., Ménard, L. and Caron, M. G. (1996). Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science 271, 363-366.
8. Franci, C., Gosling, J., Tsou, C.-L., Coughlin, S. R. and Charo, I. F. (1996). Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. J. Immunol. 157, 5606-5612.
9. Füreder, W., Agis, H., Willheim, M., Bankl, H. C., Maier, U., Kishi, K., Müller, M. R., Czerwenka, K., Radaszkiewicz, T., Butterfield, J. H., Klappacher, G., Sperr, W. R., Oppermann, M., Lechner, K. and Valent, P. (1995). Differential expression of complement receptors on human basophils and mast cells. J. Immunol. 155, 3152-3160.
10. Gerard, C. and Gerard, N. P. (1994). C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 12, 775-808.
11. Gerard, N. P. and Gerard, C. (1991). The chemotactic receptor for human C5a anaphylatoxin. Nature 349, 614-617.
12. Ghinea, N., Hai, M. T. V., GroyePicard, M.-T., Houlier, A., Schoëvaërt, D. and Milgrom, E. (1992). Pathways of internalization of the hCG/LH receptor: immunoelectron microscopic studies in Leydig cells and transfected L-cells. J. Cell Biol. 118, 1347-1358.
13. Giannini, E. and Boulay, F. (1995). Phosphorylation, dephosphorylation, and recycling of the C5a receptor in differentiated HL60 cells. J. Immunol. 154, 4055-4064.
14. Giannini, E., Brouchon, L. and Boulay, F. (1995). Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo. J. Biol. Chem. 270, 19166-19172.
15. Goodman, O. B., Krupnick, J. G. J., Santini, F., Gurevich, V. V., Penn, R. B., Gagnon, A. W., Keen, J. H. and Benovic, J. L. (1996). β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor. Nature 383, 447-450.
16. Grady, E. F., Garland, A. M., Gamp, P. D., Lovett, M., Payan, D. G. and Bunnet, N. W. (1995a). Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol. Biol. Cell 6, 509-524.
17. Grady, E. F., Slice, L. W., Bran, W. O., Walsh, J. H., Payan, D. G. and Bunnet, N. W. (1995b). Direct observation of endocytosis of gastrin releasing peptide and its receptor. J. Biol. Chem. 270, 4603-4611.
18. Hausdorff, W. P., Caron, M. G. and Lefkowitz, R. J. (1990). Turning off the signal: desensitization of β-adrenergic receptor function. FASEB J. 4, 2881-2889.
19. Hein, L., Ishii, K., Coughlin, S. R. and Kolbika, B. K. (1994). Intracellular targeting and trafficking of thrombin receptors. J. Biol. Chem. 269, 27719-27726.
20. Hicke, L. and Riezman, H. (1996). Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell 84, 277-287.
21. Holtmann, M. H., Roettger, B. F., Pinon, D. I. and Miller, L. J. (1996). Role of receptor phosphorylation in desensitization and internalization of the secretin receptor. J. Biol. Chem. 271, 23566-23571.
22. Höpken, U. E., Lu, B., Gerard, N. P. and Gerard, C. (1996). The C5a chemoattractant receptor mediates mucosal defence to infection. Nature 383, 86-89.
23. Hoxie, J. A., Ahuja, M., Belmonte, E., Pizarro, S., Parton, R. and Brass, L. F. (1993). Internalization and recycling of activated thrombin receptors. J. Biol. Chem. 268, 13756-13763.
24. Hunyady, L., Bor, M., Baukal, A. J., Balla, T. and Catt, K. J. (1995). A conserved NPLFY sequence contributes to agonist binding and signal transduction but is not an internalization signal for the type 1 angiotensin II receptor. J. Biol. Chem. 270, 16602-16609.
25. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
26. Lang, J., Boulay, F., Li, G. and Wollheim, C. B. (1993). Conserved transducer coupling but different effector linkage upon expression of the myeloid fMet-Leu-Phe receptor in insulin secreting cells. EMBO J. 12, 2671-2679.
27. Liggett, S. B., Freedman, N. J., Schwinn, D. A. and Lefkowitz, R. J. (1993). Structural basis for receptor subtype-specific regulation revealed by chimeric β3/β2-adrenergic receptor. Proc. Nat. Acad. Sci. USA 90, 3665-3669.
28. Lutz, M. P., Pinon, D. I., Gates, L. K., Shenolikar, S. and Miller, L. J. (1993). Control of cholecystokinin receptor dephosphorylation in pancreatic acinar cells. J. Biol. Chem. 268, 12136-12142.