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Volumn 37, Issue 8, 2005, Pages 835-843

Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C5A RECEPTOR; DNA; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA;

EID: 23044477984     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1599     Document Type: Article
Times cited : (232)

References (50)
  • 2
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis - From bench to bedside
    • Friedman, S.L. Liver fibrosis - from bench to bedside. J. Hepatol. 38, S38-S53 (2003).
    • (2003) J. Hepatol. , vol.38
    • Friedman, S.L.1
  • 3
    • 0030933395 scopus 로고    scopus 로고
    • Natural history of liver fibrosis progression in patients with chronic hepatitis C
    • Poynard, T., Bedossa, P. & Opolon, P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet 349, 825-832 (1997).
    • (1997) Lancet , vol.349 , pp. 825-832
    • Poynard, T.1    Bedossa, P.2    Opolon, P.3
  • 4
    • 85035392112 scopus 로고    scopus 로고
    • Liver fibrosis. J. Clin
    • Bataller, R. & Brenner, D.A. Liver fibrosis. J. Clin. Invest. 115, 209-218 (2005).
    • (2005) Invest. , vol.115 , pp. 209-218
    • Bataller, R.1    Brenner, D.A.2
  • 5
    • 0036892365 scopus 로고    scopus 로고
    • Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15
    • Hillebrandt, S., Goos, C., Matern, S. & Lammert, F. Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15. Gastroenterology 123, 2041-2051 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 2041-2051
    • Hillebrandt, S.1    Goos, C.2    Matern, S.3    Lammert, F.4
  • 6
    • 0030885185 scopus 로고    scopus 로고
    • Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses
    • Shi, Z., Wakil, A.E. & Rockey, D.C. Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Proc. Natl. Acad. Sci. USA 94, 10663-10668 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10663-10668
    • Shi, Z.1    Wakil, A.E.2    Rockey, D.C.3
  • 7
    • 0242291131 scopus 로고    scopus 로고
    • The nature and identification of quantitative trait loci: A community's view
    • Complex Trait Consortium. The nature and identification of quantitative trait loci: a community's view. Nat. Rev. Genet. 4, 911-916 (2003).
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 911-916
  • 8
    • 20044394908 scopus 로고    scopus 로고
    • Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse
    • Pletcher, M.T. et al. Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol. 2, e393 (2004).
    • (2004) PLoS Biol. , vol.2
    • Pletcher, M.T.1
  • 9
    • 0025347074 scopus 로고
    • Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5′-exon
    • Wetsel, R.A., Fleischer, D.T. & Haviland, D.L. Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5′-exon. J. Biol. Chem. 265, 2435-2440 (1990).
    • (1990) J. Biol. Chem. , vol.265 , pp. 2435-2440
    • Wetsel, R.A.1    Fleischer, D.T.2    Haviland, D.L.3
  • 10
    • 0028151261 scopus 로고
    • Empirical threshold values for quantitative trait mapping
    • Churchill, G.A. & Doerge, R.W. Empirical threshold values for quantitative trait mapping. Genetics 138, 963-971 (1994).
    • (1994) Genetics , vol.138 , pp. 963-971
    • Churchill, G.A.1    Doerge, R.W.2
  • 11
    • 0742288585 scopus 로고    scopus 로고
    • The complex interplay among factors that influence allelic association
    • Zondervan, K.T. & Cardon, L.R. The complex interplay among factors that influence allelic association. Nat. Rev. Genet. 5, 89-100 (2004).
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 89-100
    • Zondervan, K.T.1    Cardon, L.R.2
  • 12
    • 0031664853 scopus 로고    scopus 로고
    • A new logic for DNA engineering using recombination in Escherichia coli
    • Zhang, Y., Buchholz, F., Muyrers, J.P. & Stewart, A.F. A new logic for DNA engineering using recombination in Escherichia coli. Nat. Genet. 20, 123-128 (1998).
    • (1998) Nat. Genet. , vol.20 , pp. 123-128
    • Zhang, Y.1    Buchholz, F.2    Muyrers, J.P.3    Stewart, A.F.4
  • 13
    • 0034861323 scopus 로고    scopus 로고
    • Anaphylatoxins and infectious and non-infectious inflammatory diseases
    • Köhl, J. Anaphylatoxins and infectious and non-infectious inflammatory diseases. Mol. Immunol. 38, 175-187 (2001).
    • (2001) Mol. Immunol. , vol.38 , pp. 175-187
    • Köhl, J.1
  • 14
    • 0037214907 scopus 로고    scopus 로고
    • Expression and induction of anaphylatoxin C5a receptors in the rat liver
    • Schlaf, G. et al. Expression and induction of anaphylatoxin C5a receptors in the rat liver. Histol. Histopathol. 18, 299-308 (2003).
    • (2003) Histol. Histopathol. , vol.18 , pp. 299-308
    • Schlaf, G.1
  • 15
    • 15244356690 scopus 로고    scopus 로고
    • Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications
    • Friedman, S.L. Mechanisms of disease: mechanisms of hepatic fibrosis and therapeutic implications. Nat. Clin. Pract. Gastroenterol. Hepatol. 1, 98-105 (2004).
    • (2004) Nat. Clin. Pract. Gastroenterol. Hepatol. , vol.1 , pp. 98-105
    • Friedman, S.L.1
  • 16
    • 0028072084 scopus 로고
    • Development of C5a receptor antagonists. Differential loss of functional responses
    • Konteatis, Z.D. et al. Development of C5a receptor antagonists. Differential loss of functional responses. J. Immunol. 153, 4200-4205 (1994).
    • (1994) J. Immunol. , vol.153 , pp. 4200-4205
    • Konteatis, Z.D.1
  • 17
    • 0141449968 scopus 로고    scopus 로고
    • The proinflammatory mediators C3a and C5a are essential for liver regeneration
    • Strey, C.W. et al. The proinflammatory mediators C3a and C5a are essential for liver regeneration. J. Exp. Med. 198, 913-923 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 913-923
    • Strey, C.W.1
  • 18
    • 0035849176 scopus 로고    scopus 로고
    • Complement. Second of two parts
    • Walport, M.J. Complement. Second of two parts. N. Engl. J. Med. 344, 1140-1144 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1140-1144
    • Walport, M.J.1
  • 19
    • 0030679662 scopus 로고    scopus 로고
    • Complement and complement deficiencies
    • Whaley, K. & Schwaeble, W. Complement and complement deficiencies. Semin. Liver Dis. 17, 297-310 (1997).
    • (1997) Semin. Liver Dis. , vol.17 , pp. 297-310
    • Whaley, K.1    Schwaeble, W.2
  • 20
    • 0025181831 scopus 로고
    • Complement levels in patients with hepatic dysfunction
    • Ellison, R.T., Horsburgh, C.R. & Curd, J. Complement levels in patients with hepatic dysfunction. Dig. Dis. Sci. 35, 231-235 (1990).
    • (1990) Dig. Dis. Sci. , vol.35 , pp. 231-235
    • Ellison, R.T.1    Horsburgh, C.R.2    Curd, J.3
  • 21
    • 15944376562 scopus 로고    scopus 로고
    • Strategies for mapping and cloning quantitative trait genes in rodents
    • Flint, J., Valdar, W., Shifman, S. & Mott, R. Strategies for mapping and cloning quantitative trait genes in rodents. Nat. Rev. Genet. 6, 271-284 (2005).
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 271-284
    • Flint, J.1    Valdar, W.2    Shifman, S.3    Mott, R.4
  • 22
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Project
    • The International HapMap Consortium. The International HapMap Project. Nature 426, 789-796 (2003).
    • (2003) Nature , vol.426 , pp. 789-796
  • 23
    • 1542515172 scopus 로고    scopus 로고
    • From genotypes to haplotypes in hepatobiliary diseases: One plus one equals (sometimes) more than two
    • Wasmuth, H.E., Matern, S. & Lammert, F. From genotypes to haplotypes in hepatobiliary diseases: one plus one equals (sometimes) more than two. Hepatology 39, 604-607 (2004).
    • (2004) Hepatology , vol.39 , pp. 604-607
    • Wasmuth, H.E.1    Matern, S.2    Lammert, F.3
  • 24
    • 17744376024 scopus 로고    scopus 로고
    • Many little things: One geneticist's view of complex diseases
    • Smithies, O. Many little things: one geneticist's view of complex diseases. Nat. Rev. Genet. 6, 419-425 (2005).
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 419-425
    • Smithies, O.1
  • 25
    • 7244247475 scopus 로고    scopus 로고
    • Fibrosis progression after liver transplantation in patients with recurrent hepatitis C
    • Neumann, U.P. et al. Fibrosis progression after liver transplantation in patients with recurrent hepatitis C. J. Hepatol. 41, 830-836 (2004).
    • (2004) J. Hepatol. , vol.41 , pp. 830-836
    • Neumann, U.P.1
  • 26
    • 0031745733 scopus 로고    scopus 로고
    • Role of complement in in vitro and in vivo lung inflammatory reactions
    • Czermak, B.J. et al. Role of complement in in vitro and in vivo lung inflammatory reactions. J. Leukoc. Biol. 64, 40-48 (1998).
    • (1998) J. Leukoc. Biol. , vol.64 , pp. 40-48
    • Czermak, B.J.1
  • 27
    • 0020039359 scopus 로고
    • Inhibition of bleomycin-induced pulmonary fibrosis by cobra venom factor
    • Phan, S.H. & Thrall, R.S. Inhibition of bleomycin-induced pulmonary fibrosis by cobra venom factor. Am. J. Pathol. 107, 25-28 (1982).
    • (1982) Am. J. Pathol. , vol.107 , pp. 25-28
    • Phan, S.H.1    Thrall, R.S.2
  • 28
    • 0036378407 scopus 로고    scopus 로고
    • Leaked protein and interstitial damage in the kidney: Is complement the missing link?
    • Sheerin, N.S. & Sacks, S.H. Leaked protein and interstitial damage in the kidney: is complement the missing link? Clin. Exp. Immunol. 130, 1-3 (2002).
    • (2002) Clin. Exp. Immunol. , vol.130 , pp. 1-3
    • Sheerin, N.S.1    Sacks, S.H.2
  • 29
    • 0033519733 scopus 로고    scopus 로고
    • Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a
    • Finch, A.M. et al. Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. J. Med. Chem. 42, 1965-1974 (1999).
    • (1999) J. Med. Chem. , vol.42 , pp. 1965-1974
    • Finch, A.M.1
  • 30
    • 0035865055 scopus 로고    scopus 로고
    • A novel role of complement: Mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration
    • Mastellos, D., Papadimitriou, J.C., Franchini, S., Tsonis, P.A. & Lambris, J.D. A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration. J. Immunol. 166, 2479-2486 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 2479-2486
    • Mastellos, D.1    Papadimitriou, J.C.2    Franchini, S.3    Tsonis, P.A.4    Lambris, J.D.5
  • 31
    • 0036793526 scopus 로고    scopus 로고
    • Protection of innate immunity by CSaR antagonist in septic mice
    • Huber-Lang, M.S. et al. Protection of innate immunity by CSaR antagonist in septic mice. FASEB J. 16, 1567-1574 (2002).
    • (2002) FASEB J. , vol.16 , pp. 1567-1574
    • Huber-Lang, M.S.1
  • 32
    • 10744228553 scopus 로고    scopus 로고
    • Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria
    • Hillmen, P. et al. Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria. N. Engl. J. Med. 350, 552-559 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 552-559
    • Hillmen, P.1
  • 33
    • 17444403917 scopus 로고    scopus 로고
    • C5a negatively regulates Toll-like receptor 4-induced immune responses
    • Hawlisch, H. et al. C5a negatively regulates Toll-like receptor 4-induced immune responses. Immunity 22, 415-426 (2005).
    • (2005) Immunity , vol.22 , pp. 415-426
    • Hawlisch, H.1
  • 35
    • 0036648981 scopus 로고    scopus 로고
    • From QTL to gene: The harvest begins
    • Korstanje, R. & Paigen, B. From QTL to gene: the harvest begins. Nat. Genet. 31, 235-236 (2002).
    • (2002) Nat. Genet. , vol.31 , pp. 235-236
    • Korstanje, R.1    Paigen, B.2
  • 36
    • 0000094145 scopus 로고    scopus 로고
    • Primary biliary cirrhosis
    • (eds. Zakim, D. & Boyer, TD.) (W.B. Saunders, Philadelphia)
    • Poupon, R. & Poupon, R.E. Primary biliary cirrhosis. In Hepatology: A Textbook of Liver Diseases vol. 2 (eds. Zakim, D. & Boyer, TD.) 1329-1365 (W.B. Saunders, Philadelphia, 1996).
    • (1996) Hepatology: A Textbook of Liver Diseases , vol.2 , pp. 1329-1365
    • Poupon, R.1    Poupon, R.E.2
  • 37
    • 0024398447 scopus 로고
    • Activation of the complement system in primary sclerosing cholangitis
    • Senaldi, G. et al. Activation of the complement system in primary sclerosing cholangitis. Gastroenterology 97, 1430-1434 (1989).
    • (1989) Gastroenterology , vol.97 , pp. 1430-1434
    • Senaldi, G.1
  • 38
    • 4444377059 scopus 로고    scopus 로고
    • Common heterozygous hemochromatosis gene mutations are risk factors for inflammation and fibrosis in chronic hepatitis C
    • Geier, A. et al. Common heterozygous hemochromatosis gene mutations are risk factors for inflammation and fibrosis in chronic hepatitis C. Liver Int. 24, 285-294 (2004).
    • (2004) Liver Int. , vol.24 , pp. 285-294
    • Geier, A.1
  • 39
    • 0037006383 scopus 로고    scopus 로고
    • Case-control studies: Research in reverse
    • Schulz, K.F. & Grimes, D.A. Case-control studies: research in reverse. Lancet 359, 431-434 (2002).
    • (2002) Lancet , vol.359 , pp. 431-434
    • Schulz, K.F.1    Grimes, D.A.2
  • 40
    • 10744232281 scopus 로고    scopus 로고
    • CC Chemokine Receptor 5 Δ32 polymorphism in two independent cohorts of HCV infected patients without hemophilia
    • Wasmuth, H.E. et al. CC Chemokine Receptor 5 Δ32 polymorphism in two independent cohorts of HCV infected patients without hemophilia. J. Mol. Med. 82, 64-69 (2004).
    • (2004) J. Mol. Med. , vol.82 , pp. 64-69
    • Wasmuth, H.E.1
  • 41
    • 0032805974 scopus 로고    scopus 로고
    • Overview of QTL mapping software and introduction to Map Manager QT Mamm
    • Manly, K.F. & Olson, J.M. Overview of QTL mapping software and introduction to Map Manager QT Mamm. Genome 10, 327-334 (1999).
    • (1999) Genome , vol.10 , pp. 327-334
    • Manly, K.F.1    Olson, J.M.2
  • 42
    • 33646942472 scopus 로고
    • A simple regression method for mapping quantitative trait loci in line crosses using flanking markers
    • Haley, C.S. & Knott, S.A. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69, 315-324 (1992).
    • (1992) Heredity , vol.69 , pp. 315-324
    • Haley, C.S.1    Knott, S.A.2
  • 43
    • 0242691208 scopus 로고    scopus 로고
    • A comparison of Bayesian methods for haplotype reconstruction from population genotype data
    • Stephens, M. & Donnelly, P. A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am. J. Hum. Genet. 73, 1162-1169 (2003).
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 1162-1169
    • Stephens, M.1    Donnelly, P.2
  • 44
    • 0041691044 scopus 로고    scopus 로고
    • Minimal haplotype tagging
    • Sebastiani, P. et al. Minimal haplotype tagging. Proc. Natl. Acad. Sci. USA 100, 9900-9905 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9900-9905
    • Sebastiani, P.1
  • 45
    • 0028235641 scopus 로고
    • Classification of chronic hepatitis: Diagnosis, grading and staging
    • Desmet, V.J., Gerber, M., Hoofnagle, J.H., Manns, M. & Scheuer, P.J. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 19, 1513-1520 (1994).
    • (1994) Hepatology , vol.19 , pp. 1513-1520
    • Desmet, V.J.1    Gerber, M.2    Hoofnagle, J.H.3    Manns, M.4    Scheuer, P.J.5
  • 46
    • 0035820265 scopus 로고    scopus 로고
    • For the MULTIVIRC group. Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: A prospective study
    • Imbert-Bismut, F. et al. for the MULTIVIRC group. Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Lancet 357, 1069-1075 (2001).
    • (2001) Lancet , vol.357 , pp. 1069-1075
    • Imbert-Bismut, F.1
  • 47
    • 0034768777 scopus 로고    scopus 로고
    • Up-regulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts
    • Fehrenbach, H., Weiskirchen, R., Kasper, M. & Gressner, A.M. Up-regulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts. Hepatology 34, 943-952 (2001).
    • (2001) Hepatology , vol.34 , pp. 943-952
    • Fehrenbach, H.1    Weiskirchen, R.2    Kasper, M.3    Gressner, A.M.4
  • 48
    • 0036304968 scopus 로고    scopus 로고
    • Increased C5a receptor expression in sepsis
    • Riedemann, N.C. et al. Increased C5a receptor expression in sepsis. J. Clin. Invest. 110, 101-108 (2002).
    • (2002) J. Clin. Invest. , vol.110 , pp. 101-108
    • Riedemann, N.C.1
  • 49
    • 0031466983 scopus 로고    scopus 로고
    • From genotypes to genes: Doubling the sample size
    • Sasieni, P.D. From genotypes to genes: doubling the sample size. Biometrics 53, 1253-1261 (1997).
    • (1997) Biometrics , vol.53 , pp. 1253-1261
    • Sasieni, P.D.1
  • 50
    • 0017659970 scopus 로고
    • Testing for Hardy-Weinberg equilibrium in small samples
    • Elston, R.C. & Forthofer, R. Testing for Hardy-Weinberg equilibrium in small samples. Biometrics 33, 536-542 (1977).
    • (1977) Biometrics , vol.33 , pp. 536-542
    • Elston, R.C.1    Forthofer, R.2


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