Complement C5a receptor antagonist attenuates multiple organ injury in a model of ruptured abdominal aortic aneurysm

Journal of Vascular Surgery

Volumn 39, Issue 1, 2004, Pages 196-206

  Harkin, Denis W ^a,b,d   Romaschin, Alex ^a   Taylor, Stephen M ^c   Rubin, Barry B ^a   Lindsay, Thomas F ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b ROYAL VICTORIA HOSPITAL   (United Kingdom)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLPHENYLALANINE (ORNITHINE PROLYL DEXTRO CYCLOHEXYLALANYLTRYPTOPHYLARGININE); ALBUMIN; COMPLEMENT COMPONENT C5 INHIBITOR; COMPLEMENT COMPONENT C5A RECEPTOR; CYCLOPEPTIDE; CYTOKINE; IODINE 125; MESSENGER RNA; MYELOPEROXIDASE; PEPTIDE DERIVATIVE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ABDOMINAL AORTA ANEURYSM; ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CLAMPING; AORTA RUPTURE; ARTICLE; BLOOD VESSEL PERMEABILITY; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME ASSAY; EXPERIMENTAL MODEL; GENE EXPRESSION REGULATION; HEMORRHAGIC SHOCK; INFLAMMATION; INTESTINE MUCOSA PERMEABILITY; ISOTOPE LABELING; MALE; MULTIPLE ORGAN FAILURE; NEUTROPHIL; NONHUMAN; ORGAN INJURY; PARAMETER; PRIORITY JOURNAL; PROTECTION; RAT; REGULATORY MECHANISM; REPERFUSION; RESUSCITATION; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TISSUE INJURY; TISSUE LEVEL;

EID: 0347595295     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2003.07.001     Document Type: Article

References (38)

1. Adam DJ, Mohan IV, Stuart WP, Bain M, Bradbury AW. Community and hospital outcome from ruptured abdominal aortic aneurysm within the catchment area of a regional vascular surgical service. J Vasc Surg 1999;30:922-8.
2. Lindsay TF, Luo XP, Lehotay DC, Rubin BB, Anderson M, Walker PM, et al. Ruptured abdominal aortic aneurysm, a "two hit" ischemia/reperfusion injury: evidence from an analysis of oxidative products. J Vasc Surg 1999;30:219-28.
3. Groeneveld AB, Raijmakers PG, Rauwerda JA, Hack CE. The inflammatory response to vascular surgery-associated ischaemia and reperfusion in man: effect on postoperative pulmonary function. Eur J Vasc Endovasc Surg 1997;14:351-9.
4. Huber TS, Harward TK, Flynn TC, Albright JL, Seeger JM. Operative mortality rates after elective infrarenal aortic reconstructions. J Vasc Surg 1995;22:287-93.
5. Paterson IS, Klausner JM, Pugatch R, Allen P, Mannick JA, Shepro D, et al. Noncardiogenic pulmonary edema after abdominal aortic aneuism surgery. Ann Surg 1989;209:231-6.
6. Roumen RM, Hendriks T, van der Vliet JA, Nieuwenhuijzen GA, Sauerwein RW, van der Meer JW, et al. Cytokine patterns in patients after major vascular surgery, hemorrhagic shock and severe blunt trauma: relation with subsequent adult respiratory distress syndrome and multiple organ failure. Ann Surg 1993;218:769-76.
7. Lindsay TF, Memari N, Ghanekar A, Walker P, Romaschin A. Rupture of an abdominal aortic aneurysm causes priming of phagocytic oxidative burst. J Vasc Surg 1997;25:599-610.
8. Fantini GA, Conte MS. Pulmonary failure following lower torso ischemia: clinical evidence for a remote effect of reperfusion injury. Am Surg 1995;61:316-9.
9. Welbourn R, Goldman G, Kobzik L, Paterson IS, Valeri CR, Shepro D, et al. Role of neutrophil adherence receptors (CD 18) in lung permeability following lower torso ischemia. Circ Res 1992;71:82-6.
10. Paterson IS, Klausner JM, Pugatch R, Allen P, Mannick JA, Shepro D, et al. Noncardiogenic pulmonary edema after abdominal aortic aneurysm surgery. Ann Surg 1989;209:231-6.
11. Rubin BB, Smith A, Liauw S, Isenman D, Romaschin AD, Walker PM. Complement activation and white cell sequestration in postischemic skeletal muscle. Am J Physiol 1990;259:H525-31.
12. Williams JP, Pechet TT, Weiser MR, Reid R, Kobzik L, Moore FD Jr, et al. Intestinal reperfusion injury is mediated by IgM and complement. J Appl Physiol 1999;86:938-42.
13. Kawatsu R, Sanderson SD, Blanco I, Kendall N, Finch AM, Taylor SM, et al. Conformationally biased analogs of human C5a mediate changes in vascular permeability. J Pharmacol Exp Ther 1996;278:432-40.
14. Sanderson SD, Kirnarsky L, Sherman SA, Vogen SM, Prakash O, Ember JA, et al. Decapeptide agonists of human C5a: the relationship between conformation and neutrophil response. J Med Chem 1995;38:3669-75.
15. Goldman G, Welbourn R, Klausner JM, Kobzik L, Valeri CR, Shepro D, et al. Intravascular chemoattractants inhibit diapedesis by selective receptor occupancy. Am J Physiol 1991;260:H465-72.
16. Morgan EL, Ember JA, Sanderson SD, Scholz W, Buchner R, Ye RD, et al. Anti-C5a receptor antibodies: characterization of neutralizing antibodies specific for a peptide, C5aR-(9-29), derived from the predicted amino-terminal sequence of the human C5a receptor. J Immunol 1993;151:377-88.
17. Arumugam TV, Shiels IA, Strachan AJ, Abbenante G, Fairlie DP, Taylor SM. A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats. Kidney Int 2003;63:134-42.
18. Boyd AJ, Rubin BB, Walker PM, Romaschin A, Issckutz TB, Lindsay TF. A CD18 monoclonal antibody reduces multiple organ injury in a model of ruptured abdominal aortic aneurysm. Am J Physiol 1999;277: H172-82.
19. Riedemann NC, Ward PA. Complement in ischemia reperfusion injury. Am J Pathol 2003;162:363-7.
20. Hill J, Lindsay TF, Ortiz F, Yeh CG, Hechtman HB, Moore FD Jr. Soluble complement receptor type 1 ameliorates the local and remote organ injury after intestinal ischemia-reperfusion in the rat. J Immunol 1992;149:1723-8.
21. Roumen RM, van der Vliet JA, Wevers RA, Goris RJ. Intestinal permeability is increased after major vascular surgery. J Vasc Surg 1993;17: 734-7.
22. Harward TK, Welborn MB III, Martin TD, Flynn TC, Huber TS, Moldawer LL, et al. Visceral ischemia and organ dysfunction after thoracoabdominal aortic aneurysm repair: a clinical and cost analysis. Ann Surg 1996;223:729-34.
23. Hernandez LA, Grisham MB, Twohig B, Arfors KE, Harlan JM, Granger DN. Role of neutrophils in ischemia-reperfusion-induced microvascular injury. Am J Physiol 1987;253:H699-703.
24. Harkin DW, Barros D'Sa AA, Yassin MM, Hoper M, Halliday MI. Gut mucosal injury is attenuated by recombinant bactericidal/permeability-increasing protein in hind limb ischemia-reperfusion injury. Ann Vasc Surg 2001;15:326-31.
25. Harkin DW, Barros D'Sa AA, Yassin MM, Hoper M, Halliday MI, Parks TG, et al. Recombinant bactericidal/permeability-increasing protein attenuates the systemic inflammatory response syndrome in lower limb ischemia-reperfusion injury. J Vasc Surg 2001;33:840-6.
26. Baue AE. Multiple organ failure, multiple organ dysfunction syndrome, and systemic inflammatory response syndrome: why no magic bullets? [Comments]. Arch Surg 1997;132:703-7.
27. Deitch EA. Multiple organ failure: pathophysiology and potential future therapy [comments]. Ann Surg 1992;216:117-34.
28. van Deventer SJ, Hack CE, Wolbink CE, Voermans HJ, Strack van Schijindel RJ, ten Cate JW, et al. Endotoxin-induced neutrophil activation: the role of complement revisited. Prog Clin Biol Res 1991;367: 101-9.
29. Lindsay TF, Hill J, Ortiz F, Rudolph A, Valeri CR, Hechtman HB, et al. Blockade of complement activation prevents local and pulmonary albumin leak after lower torso ischemia-reperfusion. Ann Surg 1992;216: 677-83.
30. Bless NM, Warner RL, Padgaonkar VA, Lentsch AB, Czermak BJ, Schmal H, et al. Roles for C-X-C chemokines and C5a in lung injury after hindlimb ischemia-reperfusion. Am J Physiol 1999;276:L57-63.
31. Kilgore KS, Flory CM, Miller BF, Evans VM, Warren JS. The membrane attack complex of complement induces interleukin-8 and monocyte chemoattractant protein-1 secretion from human umbilical vein endothelial cells. Am J Pathol 1996;149:953-61.
32. Pierre AF, Xavier AM, Liu M, Cassivi SD, Lindsay TF, Marsh HC, et al. Effect of complement inhibition with soluble complement receptor 1 on pig allotransplant lung function. Transplantation 1998;66: 723-32.
33. Welbourn R, Goldman G, O'Riordain M, Lindsay TF, Paterson IS, Kobzik L, et al. Role for tumor necrosis factor as mediator of lung injury following lower torso ischemia. J Appl Physiol 1991;70:2645-9.
34. Becker LC. Do neutrophils contribute to myocardial stunning? Cardiovasc Drugs Ther 1991;5:909-13.
35. Barry MC, Kelly C, Burke P, Sheehan S, Redmond HP, Bouchier-Hayes D. Immunological and physiological responses to aortic surgery: effect of reperfusion on neutrophil and monocyte activation and pulmonary function. Br J Surg 1997;84:513-9.
36. Abraham E. Effects of stress on cytokine production. Methods Achiev Exp Pathol 1991;14:45-62.
37. Collard CD, Lekowski R, Jordan JE, Agah A, Stahl GL. Complement activation following oxidative stress. Mol Immunol 1999;36:941-8.
38. Stahl GL, Reenstra WR, Frendl G. Complement-mediated loss of endothelium-dependent relaxation of porcine coronary arteries: role of the terminal membrane attack complex. Circ Res 1995;76:575-83.