Anti-C5a monoclonal antibody reduces cardiopulmonary bypass and cardioplegia-induced coronary endothelial dysfunction

Journal of Thoracic and Cardiovascular Surgery

Volumn 116, Issue 6, 1998, Pages 1060-1068

  Tofukuji, M ^a   Stahl, G L ^a   Agah, A ^a   Metais, C ^a   Simons, M ^a   Sellke, F W ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; CLONIDINE; COMPLEMENT COMPONENT C5A; COMPLEMENT INHIBITOR; DRUG VEHICLE; ISOPRENALINE; MONOCLONAL ANTIBODY; MYELOPEROXIDASE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; COMPLEMENT INHIBITION; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; ENDOTHELIUM INJURY; FEMALE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE REPERFUSION; INTRAVENOUS DRUG ADMINISTRATION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; SWINE;

EID: 0031757369     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5223(98)70059-5     Document Type: Article

References (27)

1. 2-plasmin-inhibitor complexes during cardiopulmonary bypass Blood 73 1989 468 471
2. JB Steinberg DP Kapelanski JD Olson JM. Weiler Cytokines and complement levels in patients undergoing cardiopulmonary bypass J Thorac Cardiovasc Surg 106 1993 1008 1016
3. RE Kalfin RM Engelman JA Rousou Induction of interleukin-8 expression during cardiopulmonary bypass Circulation 88 Suppl 1993 II401 II406
4. J Butler GM Rocker S. Westaby Inflammatory response to cardiopulmonary bypass Ann Thorac Surg 55 1993 552 559
5. AM Gillinov JM Redmond JA Winkelstein Complement and neutrophil activation during cardiopulmonary bypass: a study in the complement-deficient dog Ann Thorac Surg 57 1994 345 352
6. MG Tonnesen DC Anderson TA Springer A Knedler N Avdi PM. Henson Adherence of neutrophils to cultured human microvascular endothelial cells: stimulation by chemotactic peptides and lipid mediators and dependence upon the Mac-1, LFA-1, p150,95 glycoprotein family J Clin Invest 83 1989 637 646
7. MP Fletcher GL Stahl JC. Longhurst C5a-induced myocardial ischemia: role for CD18-dependent PMN localization and PMN-platelet interactions Am J Physiol 265 1993 H1750 H1761
8. R Hattori KK Hamilton RD Fugate RP McEver PJ. Sims Complement proteins C5b-9 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane protein GMP-140 to the cell surface J Biol Chem 264 1989 9053 9060
9. KE Foreman AA Vaporciyan BK Bonish C5a-induced expression of P-selectin in endothelial cells J Clin Invest 94 1994 1147 1155
10. HF Weisman T Bartow MK Leppo Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis Science 249 1990 146 151
11. GL Stahl WR Reemstra G. Frendl Complement-mediated loss of endothelium-dependent relaxation of porcine coronary arteries: role of the terminal membrane attack complex Circ Res 76 1995 575 583
12. CS Rinder HM Rinder BR Smith Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation J Clin Invest 96 1995 1564 1572
13. GL Stahl MP Fletcher EA Amsterdam JC. Longhurst Role of granulocytes and C5a in myocardial response to zymosan-activated serum Am J Physiol 261 1991 H29 H37
14. A Vakeva A Agah SA Rollins LA Matis L Li GL. Stahl Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy Circulation 97 1998 2259 2267
15. EA Amsterdam GL Stahl H-L Pan SV Rendig MP Fletcher JC. Longhurst Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs Am J Physiol 268 1995 H448 H457
16. JL Zhang JM Patel ER. Block Molecular cloning, characterization and expression of a nitric oxide form porcine pulmonary artery endothelial cells Comp Biochem Physiol B Mol Biol 116 1997 485 491
17. DA Geller CJ Lowenstein RA Shapiro Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes Proc Natl Acad Sci U S A 90 1993 3491 3495
18. EA Amsterdam GL Stahl HL Pan SV Rendig MP Fletcher JC. Longhurst Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs Am J Physiol 268 1995 H448 H457
19. SE Martin DE Chenoweth RL Engler DM Roth JC. Longhurst C5a decreases regional coronary blood flow and myocardial function in pigs: implications for a granulocyte mechanism Circ Res 63 1988 483 491
20. A Finn BP Morgan N Rebuck Effect of inhibition of complement activation using recombinant soluble receptor 1 on neutrophil CD11b/CD18 and L-selectin expression and release of interleukin-8 and elastase in simulated cardiopulmonary bypass J Thorac Cardiovasc Surg 111 1996 451 459
21. JW Homeister P Satoh BR. Lucchesi Effects of complement activation in the isolated heart: role of the terminal complement components Circ Res 71 1992 303 319
22. MH Crawford FL Grover WP Kolb Complement and neutrophil activation in the pathogenesis of ischemic myocardial injury Circulation 78 1988 1449 1458
23. 2 in the cardiovascular response to intracoronary C5a Circ Res 66 1990 1103 1111
24. RD Rossen LH Michael A Kagiyama Mechanism of complement activation after coronary artery occlusion: evidence that myocardial ischemia in dogs causes release of constituents of myocardial subcellular origin that complex with human C1q in vivo Circ Res 62 1988 572 584
25. JK Kirklin DE Chenoweth DC Naftel Effects of protamine administration after cardiopulmonary bypass on complement, blood elements, and the hemodynamic state Ann Thorac Surg 41 1986 193 199
26. FW Sellke T Shafique FJ Schoen RM. Weintraub Impaired endothelium-dependent coronary microvascular relaxation after cold potassium cardioplegia and reperfusion J Thorac Cardiovasc Surg 105 1993 52 58
27. FW Sellke EM Boyle ED. Verrier Endothelial cell injury in cardiovascular surgery: the pathophysiology of vasomotor dysfunction Ann Thorac Surg 62 1996 1222 1228