Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand

Biochemistry

Volumn 38, Issue 30, 1999, Pages 9712-9717

  Crass, Torsten ^a   Bautsch, Wilfried ^a   Cain, Stuart A ^b   Pease, James E ^c   Monk, Peter N ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASPARTIC ACID; CARBOXYL GROUP; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A [DEARGININE]; COMPLEMENT COMPONENT C5A RECEPTOR; GLUCOSAMINIDASE; GLUTAMIC ACID; LYSINE; SEROTONIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING COMPETITION; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME RELEASE; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; RECEPTOR BINDING; SEROTONIN RELEASE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIGENS, CD; ARGININE; ASPARTIC ACID; COMPLEMENT C5A, DES-ARGININE; GLUTAMIC ACID; HEXOSAMINIDASES; HUMANS; IODINE RADIOISOTOPES; LIGANDS; LYSINE; MONOCYTES; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; RATS; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, COMPLEMENT; RECOMBINANT PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED; U937 CELLS;

ANIMALIA;

EID: 0033609445     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990139q     Document Type: Article

References (28)

1. Gallin, J. I., Goldstein, I. M., and Snyderman, R. (1992) Inflammation: Basic Principles and Clinical Correlates, 1st ed.; Raven Press, New York.
2. Zuiderweg, E. R., and Fesik, S. W. (1989) Biochemistry 28, 2387-2391.
3. Zhang, X. L., Boyar, W., Toth, M. J., Wennogle, L., and Gonnella, N. C. (1997) Proteins: Struct., Funct., Genet. 28, 261-267.
4. Mollison, K. W., Mandecki, W., Zuiderweg, E. P., Fayer, L., Fey, T. A., Krause, R. A., Conway, R. G., Miller, L., Edalji, R. P., Shalcross, M. A., Lane, B., Fox, J. L., Greer, J., and Carter, G. W. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 292-296.
5. Bubeck, P., Grotzinger, J., Winkler, M., Kohl, J., Wollmer, A., Klos, A., and Bautsch, W. (1994) Eur. J. Biochem. 219, 897-904.
6. Toth, M. J., Huwyler, L., Boyar, W. C., Braunwalder, A. F., Yarwood, D., Hadala, J., Haston, W. O., Sills, M. A., Seligmann, B., Galakatos, N. (1994) Protein Sci. 3, 1159-1168.
7. Bokisch, V. A., and Muller-Eberhardt, H. J. (1970) J. Clin. Invest. 49, 2427-2434.
8. Yancey, K. B., Lawley, T. J., Dersookian, M., and Harvath, L. (1989) J. Invest. Dermatol. 92, 184-189.
9. Marder, S. R., Chenoweth, D. E., Goldstein, I. M., and Perez, H. D. (1985) J. Immunol. 134, 3325-3331.
10. Burgi, B., Brunner, T., and Dahinden, C. A. (1994) Eur. J. Immunol. 24, 1583-1589.
11. Fureder, W., Agis, H., Willhein, M., Bankl, H. C., Maier, U., Kishi, K., Muller, M. R., Czerwenka, K., Radaszkiewicz, T., Butterfield, J. H., Klappacher, G. W., Sperr, W. R., Oppermann, M., Lechner, K., and Valent, P. (1995) J. Immunol. 155, 3152-3160.
12. Werfel, T., Oppermann, M., Butterfield, J. H., Begemann, G., Elsner, J., Gotze, O., and Zwirner, J. (1996) Scand. J. Immunol. 44, 30-36.
13. El-Lati, S. G., Dahinden, C. A., and Church, M. K. (1994) J. Invest. Dermatol. 103, 803-806.
14. Senior, R. M., Griffin, G. L., Perez, H. D., and Webster, R. O. (1988) J. Immunol. 141, 3570-3574.
15. Gerard, C., Chenoweth, D. E., and Hugli, T. (1981) J. Immunol. 127, 1978-1982.
16. Gerard, C., and Gerard, N. P. (1991) Nature 349, 614-617.
17. Boulay, F., Tardif, M., Brouchon, L., and Vignais, P. (1991) Biochemistry 30, 2993-2999.
18. Pease, J. E., Burton, D. R., and Barker, M. D. (1994) Eur. J. Immunol. 24, 211-215.
19. De Martino, J. A., Van Riper, G., Siciliano, S. J., Molineaux, C. J., Knoteatis, Z. D., Rosen, H., and Springer, M. (1994) J. Biol. Chem. 269, 14446-14450.
20. Mery, L., and Boulay, F. (1994) J. Biol. Chem. 269, 3457-3463.
21. Opperman, M., Raedt, U., Hebell, T., Schmidt, B., Zimmerman, B., and Gotze, O. (1993) J. Immunol. 151, 3785-3794.
22. Morgan, E. L., Ember, J. A., Sanderson, S. D., Scholz, W., Buchner, R., Ye, R. D., and Hugli, T. E. (1993) J. Immunol. 151, 377-388.
23. Monk, P. N., Barker, M. D., Partridge, L. J., and Pease, J. E. (1995). J. Biol. Chem. 270, 16625-16629.
24. Raffetseder, U., Roper, F., Mery, L., Gietz, C., Klos, A., Grotzinger, J., Wollmer, A., Boulay, F., Kohl, J., and Bautsch, W. (1996) Eur. J. Biochem. 235, 82-90.
25. DeMartino, J. A., Konteatis, Z. D., Siciliano, S. J., Van Riper, G., Underwood, D. J., Fischer, P. A., and Springer, M. S. (1995) J. Biol. Chem. 270, 15966-15969.
26. Siciliano, S. J., Rollins, T. E., DeMartino, J., Konteatis, Z., Malkowitz, L., VanRiper, G., Bondy, S., Rosen, H., and Springer, M. S. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 1241-1218.
27. Monk, P. N., Pease, J. E., Marland, G., and Barker, M. D. (1994) Eur. J. Immunol. 24, 2922-2925.
28. Vogen, S. M., Finch, A. M., Wadi, S. K., Thatcher, J., Monk, P. N., Sanderson, S. D., and Taylor, S. M. (1999) J. Pept. Res. 53, 8-17.