Induction of anaphylatoxin C5a receptors in rat hepatocytes by lipopolysaccharide in vivo: Mediation by interleukin-6 from Kupffer cells

Gastroenterology

Volumn 122, Issue 3, 2002, Pages 697-708

  Koleva, Milena ^a   Schlaf, Gerald ^a   Landmann, Regine ^b   Götze, Otto ^a   Jungermann, Kurt ^a   Schieferdecker, Henrike L ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHYLATOXIN; COMPLEMENT COMPONENT C5A RECEPTOR; GLUCOSE; GLYCOGEN PHOSPHORYLASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROSTANOID;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTER; IMMUNOCYTOCHEMISTRY; KUPFFER CELL; LIVER CELL; LIVER CELL CULTURE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

EID: 0036180753     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.31883     Document Type: Article

References (57)

1. Colitis and colonic mucosal barrier dysfunction
2. Endotoxin levels measured by a chromogenic assay in portal, hepatic and peripheral venous blood in patients with cirrhosis
3. Purification, characterization, and amino acid sequence of rat anaphylatoxin (C3a)
4. Primary structure and functional characterization of rat C5a: An anaphylatoxin with unusually high potency
5. Nucleoticle and corrected amino acid sequence of the functional recombinant rat anaphylatoxin C5a
6. Anaphylatoxin C5a receptor mRNA is strongly expressed in Kupffer and stellate cells and weakly in sinusoidal endothelial cells but not in hepatocytes of normal rat liver
7. 2+ release
8. Analysis of the tissue distribution of the rat C5a receptor and inhibition of C5a-mediated effects through the use of two MOABs
9. Stimulation of glycogen phosphorylase in rat hepatocytes via prostanoid release from Kupffer cells by recombinant rat anaphylatoxin C5a but not by native human C5a in hepatocyte/Kupffer cell co-cultures
10. 2-macroglobulin formation during the acute phase response of the liver
11. cDNA cloning and characterization of rat C5a anaphylatoxin receptor
12. Cellular expression of the C5a anaphylatoxin receptor (C5aR): Demonstration of C5aR on nonmyeloid cells of the liver and lung
13. Cloning and characterization of rat C3a receptor: Differential expression of rat C3a and C5a receptors by LPS stimulation
14. Induction of functional anaphylatoxin C5a receptors on hepatocytes by in vivo treatment of rats with interleukin-6
15. The acute phase response
16. Cytokines and the hepatic acute-phase response
17. Kupffer and sinusoidal endothelial cells
18. In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects
19. Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis
20. Rat hepatocytes prepared with collagenase: Prolonged retention of differentiated characteristics in culture
21. Phosphatidylinositol 3-kinase and protein kinase C contribute to the inhibition by interleukin 6 of phosphoenolpyruvate carboxykinase gene expression in cultured rat hepatocytes
22. Impairment by interleukin 1 beta and tumour necrosis factor alpha of the glucagon-induced increase in phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis in cultured rat hepatocytes
23. Centrifugal separation of mammalian cells
24. The effect of glucose and of potassium ions on the interconversion of two forms of glycogen phosphorylase and of glycogen synthetase in isolated rat liver preparations
25. Stimulation by anaphylatoxin C5a of glycogen phosphorylase in rat hepatocytes via prostanoid release from hepatic stellate cells but not sinusoidal endothelial cells
26. 2 on hepatocytes
27. Interleukin-6 and the acute phase response
28. Regulation of interleukin-6 receptor expression in human monocytes and hepatocytes
29. Augmentation of type I IL-1 receptor expression and IL-1 signaling by IL-6 and glucocorticoid in murine hepatocytes
30. Tumor necrosis factor: Receptor binding and expression of receptors in cultured mouse hepatocytes
31. Biologically active products of stimulated liver macrophages (Kupffer cells)
32. Activation of the gene for the type-1 acute phase protein hempoexin in hepatocytes by Kupffer cell-derived IL-6 but not IL-1β following stimulation with C5a or LPS: Lack of posttranslational processing of II-1β
33. Viable rat Kupffer cells synthesize but do not secrete interleukin-1: Indications for necrosis-induced maturation of interleukin-1α, but not of interleukin1β
34. C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells
35. Kinetics of anaphylatoxin C5a receptor expression during experimental allergic encephalomyelitis
36. Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system
37. Expression of C5a receptor in mouse brain: Role in signal transduction and neurodegeneration
38. Experimental diffuse axonal injury induces enhanced neuronal C5a receptor mRNA expression in rats
39. TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis
40. Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's disease
41. Elevated complement C5a receptor expression on neurons and glia in astrocyte-targeted interleukin-3 transgenic mice
42. Expression of functional receptors for human C5a anaphylatoxin (CD88) on the human hepatocellular carcinoma cell line HepG2. Stimulation of acute-phase protein-specific mRNA and protein synthesis by human C5a anaphylatoxin
43. N-formylpeptide and complement C5a receptors are expressed in liver cells and mediate hepatic acute phase gene regulation
44. The C5a receptor is expressed in normal renal proximal tubular but not in pulmonary or hepatic epithelial cells
45. Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism
46. Kupffer cell depletion partially prevents hepatic heme oxygenase 1 messenger RNA accumulation in systemic inflammation in mice: Role of interleukin 1beta
47. Activation of Kupffer cells and caspase-3 involved in rat hepatocyte apoptosis induced by endotoxin
48. Inactivation of interleukin-6 in vitro by monoblastic U937 cell plasma membranes involves both protease and peptidyl-transferase activities
49. Evidence for a crucial role of neutrophil-derived serine proteases in the inactivation of interleukin-6 at sites of inflammation
50. Antibodies chaperone circulating IL-6. Paradoxical effects of antiIL-6 "neutralizing" antibodies in vivo
51. Inhibition of anaphylatoxin C3a- and C5a- but not nerve stimulation- or Noradrenaline-dependent increase in glucose output and reduction of flow in Kupffer cell-depleted perfused rat livers
52. Anaphylatoxin C5a actions in rat liver: Synergistic enhancement by C5a of lipopolysaccharide-dependent alpha(2)-macroglobulin gene expression in hepatocytes via IL-6 release from Kupffer cells
53. Characterization of complement anaphylatoxins and their biological responses
54. A novel rote of complement: Mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration
55. Protective effects of C5a blockade in sepsis
56. Role of C5a in multiorgan failure during sepsis
57. Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis