G protein-coupled receptor drug discovery: Implications from the crystal structure of rhodopsin

Current Opinion in Drug Discovery and Development

Volumn 4, Issue 5, 2001, Pages 561-574

  Ballesteros, J ^a   Palczewski, K ^a  

^a Novasite Pharmaceuticals Inc   (United States)

Author keywords

Agonist; Antagonist; Drug discovery and design; G protein; G protein coupled receptors (GPCRs); Rhodopsin; Signal transduction

Indexed keywords

BACTERIAL PROTEIN; BACTERIORHODOPSIN; G PROTEIN COUPLED RECEPTOR; MEMBRANE PROTEIN; POLYPEPTIDE; RETINOID BINDING PROTEIN; RHODOPSIN; DRUG RECEPTOR; GTP BINDING PROTEINS; GUANINE NUCLEOTIDE BINDING PROTEIN;

AGONIST; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DRUG DESIGN; HUMAN; MODEL; PROTEIN PROCESSING; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; MOLECULAR GENETICS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; GTP-BINDING PROTEINS; HUMAN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RECEPTORS, DRUG; RHODOPSIN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0034801665     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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