The C5a receptor is expressed in normal renal proximal tubular but not in normal pulmonary or hepatic epithelial cells

Immunology

Volumn 99, Issue 1, 2000, Pages 38-45

  Fayyazi, A ^a   Scheel, O ^a   Werfel, T ^b   Schweyer, S ^a   Oppermann, M ^a   Gotze O ^a   Radzun, H J ^a   Zwirner, J ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C5A RECEPTOR;

ARTICLE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY TUBULE CELL; LIVER CELL; LUNG ALVEOLUS CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RECEPTOR DENSITY; TISSUE DISTRIBUTION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; COMPLEMENT C5A; EPITHELIUM; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINE, SMALL; KIDNEY TUBULES, PROXIMAL; KUPFFER CELLS; LUNG; MACROPHAGES; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, COMPLEMENT;

EID: 0033978132     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2000.00911.x     Document Type: Article

References (31)

1. 1. GoldStein I.M. (1992) Complement: biologically active products. In: Inflammation: Basic Principles and Clinical Correlates (eds. J.I. Gallin, I.M. Goldstein & R. Snyderman), 2nd edn. p. 63. Raven Press, Ltd., New York.
2. 2. Wetsel R.A. (1995) Structure, function and cellular expression of complement anaphylatoxin receptors. Curr Opin Immunol 7, 48.
3. 3. Chenoweth D.E. & Hugli T.E. (1978) Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes. Proc Natl Acad Sci USA 75, 3943.
4. 4. Gerard N.P., Hodges M.K., Drazen J.M., Weller P.F. & Gerard C. (1989) Characterization of a receptor for C5a anaphylatoxin on human eosinophils. J Biol Chem 264, 1760.
5. 5. Kurimoto Y., De Weck A.L. & Dahinden C.A. (1989) Interleukin 3-dependent mediator release in basophils triggered by C5a. J Exp Med 170, 467.
6. 6. Werfel T., Oppermann M., Schulze M., Krieger G., Weber M. & Götze O. (1992) Binding of fluorescein-labeled anaphylatoxin C5a to human peripheral blood, spleen, and bone marrow leukocytes. Blood 79, 151.
7. 7. Boulay F., Mery L., Tardif M., Brouchon L. & Vignais P. (1991) Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells. Biochemistry 30, 2993.
8. 8. Gerard N.P. & Gerard C. (1991) The chemotactic receptor for human C5a anaphylatoxin. Nature 349, 614.
9. 2-terminal domain. J Immunol 151, 3785.
10. 10. Werfel T., Zwirner J., Oppermann M. et al. (1996) CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin. J Immunol 157, 1729.
11. 11. Gasque P., Chan P., Fontaine M. et al. (1995) Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes. J Immunol 155, 4882.
12. 12. Haviland D.L., McCoy R.L., Whitehead W.T. et al. (1995) Cellular expression of the C5a unaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung. J Immunol 154, 1861.
13. 13. Schieferdecker H.L., Rothermel E., Timmermann A., Götze O. & Jungermann K. (1997) Anaphylatoxin C5a receptor mRNA is strongly expressed in Kupffer and stellate cells and weakly in sinusoidal endothelial cells but not in hepatocytes of normal rat liver. FEBS Lett 406, 305.
14. 14. Radzun H.J., Hansmann M.L., Heidebrecht H.J. et al. (1991) Detection of a monocyte/macrophage differentiation antigen in routinely processed paraffin-embedded tissues by monoclonal antibody Ki-MIP. Lab Invest 65, 306.
15. 15. Logel J., Dill D. & Leonard S. (1992) Synthesis of cRNA probes from PCR-generated DNA. Biotechniques 13, 604.
16. 16. Breitschopf H., Suchanek G., Gould R.M., Colman D.R. & Lassmann H. (1992) In situ hybridization with digoxigcnin-labeled probes: sensitive and reliable detection method applied to myelinating rat brain. Acta Neuropathol 84, 581.
17. 17. Zahn S., Zwirner J., Spengler H.-P. & Götze O. (1997) Chemoattractant receptors for interleukin-8 and C5a: expression on peripheral blood leukocytes and differential regulation on HL-60 and AML-193 cells by vitamin D3 and all-trans relinoic acid. Eur J Immunol 27, 935.
18. 18. Wetsel R.A. (1995) Expression of the complement C5a anaphylatoxin receptor (C5aR) on non-myeloid cells. Immunol Lett 44, 183.
19. 19. Gasque P., Singhrao S.K., Neal J.W., Götze O. & Morgan B.P. (1997) Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system. Am J Pathol 150, 31.
20. 20. McCoy R., Haviland D.L., Molmenti E.P., Ziambaras T., Wetsel R.A. & Perlmutter D.H. (1995) N-Formylpeptide and complement C5a receptors are expressed in liver cells and mediate hepatic acute phase gene regulation. J Exp Med 182, 207.
21. 21. Floreani A.A., Heires A.J., Welniak L.A. et al. (1998) Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke. J Immunol 160, 5073.
22. 22. Fayyazi A., Sandau R., Duong L.Q. et al. (1999) C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells. Am J Pathol 154, 495.
23. 23. Prodjosudjadi W., Gerritsma J.S., Klar-Mohamad N. et al. (1995) Production and cytokine-mediated regulation of monocyte chemoattractant protein-1 by human proximal tubular epithelial cells. Kidney Int 48, 1477.
24. 24. Gerritsma J.S., Hiemstra P.S., Gerritsen A.F. et al. (1996) Regulation and production of IL-8 by human proximal tubular epithelial cells in vitro. Clin Exp Immunol 103, 289.
25. 25. Gerritsma J.S., Van Kooten C., Gerritsen A.F., Mommaas A.M., Van Es L.A. & Daha M.R. (1998) Production of inflammatory mediators and cytokine responsiveness of an SV40-transformed human proximal tubular epithelial cell line. Exp Nephrol 6, 208.
26. 26. Cavaillon J.M., Fitting C. & Haeffner-Cavaillon N. (1990) Recombinant C5a enhances interleukin 1 and tumor necrosis factor release by lipopolysaccharide-stimulated monocytes and macrophages. Eur J Immunol 20, 253.
27. 27. Schindler R., Gelfand J.A. & Dinarello C.A. (1990) Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysaccharide or IL-1 itself. Blood 76, 1631.
28. 28. Montz H., Koch K.C., Ziers R. & Götze O. (1991) The role of C5a in interleukin-6 production induced by lipopolysaccharide or interleukin-1. Immunology 74, 373.
29. 29. Ember J.A., Sanderson S.D., Hugli T.E. & Morgan E.L. (1994) Induction of interleukin-8 synthesis from monocytes by human C5a anaphylatoxin. Am J Pathol 144, 393.
30. 30. McLean R.H. (1993) Complement and glomerulonephritis - an update. Pediatr Nephrol 7, 226.
31. 31. Johnson R.J. (1997) Involvement of complement in renal disease. Curr Opin Nephrol Hypertens 6, 120.