Neutrophils stimulated with a variety of chemoattractants exhibit rapid activation of p21-activated kinases (Paks): Separate signals are required for activation and inactivation of Paks

Molecular and Cellular Biology

Volumn 18, Issue 12, 1998, Pages 7130-7138

  Huang, Riyun ^a   Lian, Jian P ^b   Robinson, Dwight ^a   Badwey, John A ^b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHYLATOXIN; CHEMOATTRACTANT; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 8; LEUKOTRIENE B4; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; PROTEIN P21; RANTES; SULFATIDE; THROMBOCYTE ACTIVATING FACTOR;

ANIMAL CELL; ARTICLE; CELL CULTURE; CHEMOTAXIS; ENZYME ACTIVATION; ENZYME INACTIVATION; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0031724925     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.12.7130     Document Type: Article

References (69)

1. Amatruda, T. T., III, N. P. Gerard, C. Gerard, and M. I. Simon. 1993. Specific interactions of chemoattractant factor receptors with G-proteins. J. Biol. Chem. 268:10139-10144.
2. Avdi, N. J., B. W. Winston, M. Russel, S. K. Young, G. L. Johnson, and G. S. Worthen. 1996. Activation of MEKK by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation. J. Biol. Chem. 52:33598-33606.
3. Badwey, J. A., and M. L. Karnovsky. 1986. NADH-oxidase and aldehyde oxidase from polymorphonuclear leukocytes. Methods Enzymol. 132:365-368.
4. Bagrodia, S., B. Derijard, R. J. Davis, and R. A. Cerione. 1995. Cdc42 and Pak-mediated signaling leads to JUN kinase and p38 MAP kinase activation. J. Biol. Chem. 270:22731-22737.
5. Bokoch, G. M., A. M. Reilly, R. H. Daniels, C. C. King, A. Olivera, S. Spiegel, and U. G. Knaus. 1998. A GTPase-independent mechanism of Pak activation: regulation hy sphingosine and other biologically active lipids. J. Biol. Chem. 273:8137-8144.
6. Bokoch, G. M., Y. Wang, B. P. Bohl, M. A. Sells, L. A. Quilliam, and U. G. Knaus. 1996. Interaction of the Nck adapter protein with p21-activated kinase (Pak1). J. Biol. Chem. 271:25746-25749.
7. Brumell, J. H., and S. Grinstein. 1994. Serine/threonine kinase activation in human neutrophils: relationship to tyrosine phosphorylation. Am. J. Physiol. 267:C1574-C1581.
8. Brzeska, H., U. G. Knaus, Z.-Y. Wang, G. M. Bokoch, and E. D. Korn. 1997. p21-Activated kinase has substrate specificity similar to Acanthamoeba myosin-1 heavy chain kinase and activates Acanthamoeba myosin-1. Proc. Natl. Acad. Sci. USA 94:1092-1095.
9. Butcher, E. C. 1991. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67:1033-1036.
10. Didsbury, J. R., R. J. Uhing, E. Tomhave, C. Gerard, N. Gerard, and R. Snyderman. 1991. Receptor class desensitization of leukocyte chemoattractant receptors. Proc. Natl. Acad. Sci. USA 88:11564-11568.
11. Ding, J., and J. A. Badwey. 1993. Neutrophils stimulated with a chemotactic peptide or a phorbol ester exhibit different alterations in the activities of a battery of protein kinases. J. Biol. Chem. 268:5234-5240.
12. Ding, J., and J. A. Badwey. 1993. Stimulation of neutrophils with a chemoattractant activates several novel protein kinases that can catalyze the phosphorylation of peptides derived from p47-phox and MARKS. J. Biol. Chem. 268:17326-17333.
13. Ding, J., U. G. Knaus, J. P. Lian, G. M. Bokoch, and J. A. Badwey. 1996. The renaturable 69 and 63 kDa protein kinases that undergo rapid activation in chemoattractant-stimulated guinea pig neutrophils are p21-activated kinases (Paks). J. Biol. Chem. 271:24869-24873.
14. Ding, J., C. J. Vlahos, R. Liu, R. F. Brown, and J. A. Badwey. 1995. Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils. J. Biol. Chem. 270:11684-11691.
15. Downey, G. P., J. R. Butler, H. Tapper, L. Fialkow, A. R. Saltiel, B. R. Rubin, and S. Grinstein. 1997. Importance of MEK in neutrophil microbicidal responsiveness. J. Immunol. 160:434-443.
16. El Benna, J., L. P. Faust, and B. M. Babior. 1994: The phosphorylation of the respiratory burst oxidase component p47-phox durirm neutrophil activation. J. Biol. Chem. 269:23431-23436.
17. Foxman, E. F., J. J. Campbell, and E. C. Butcher. 1997. Multistep navigation and the combinatorial control of leukocyte chemotaxis. J. Cell Biol. 139: 1349-1360.
18. Frost, J. A., H. Steen, P. Shapiro, T. Lewis, N. Ahn, P. E. Shaw, and M. H. Cobb. 1997. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J. 16:6426-6438.
19. Frost, J. A., S. C. Xu, M. R. Hutchison, S. Marcus, and M. H. Cobb. 1996. Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol. Cell. Biol. 16:3707-3713.
20. Galisteo, M. L., J. Chernoff, Y.-C. Su, E. Skolnick, and J. Schlessinger. 1996. The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak 1. J. Biol. Chem. 271:20997-21000.
21. Gerard, C., and N. P. Gerard. 1994. C5a anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 12:775-808.
22. Goldman, D. W., F.-H. Chang, L. A. Gifford, E. J. Goetzyl, and H. R. Bourne. 1985. Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes. J. Exp. Med. 162:145-156.
23. Grigoriadis, G., and A. G. Stewart. 1991. 1-O-Hexadecyl-2-acetyI-sn-glycero-3-phospho(N,N,N-trimethyl)hexanolamine: an analogue of platelet-activating factor with partial agonist activity. Br. J. Pharmacol. 104:171-177.
24. Grinstein, S., W. Furuya, J. R. Butler, and J. Tseng. 1993. Receptor mediated activation of multiple serine/threonine kinases in human neutrophils. J. Biol. Chem. 268:20223-20231.
25. Hanahan, D. J. 1986. Platelet activating factor: a biologically active phosphoglyceride. Annu. Rev. Biochem. 55:483-509.
26. Huang, C.-K., G. F. Laramee, M. Yamazaki, and R. I. Sha'afi. 1990. Stimulation of a histone H4 protein kinase in Triton X-100 lysates of rabbit peritoneal neutrophils treated with chemotactic factors. Lack of requirements of calcium mobilization and protein kinase C activation. J. Cell. Biochem. 44:221-228.
27. MEL, a lymphocyte homing receptor. J. Cell Biol. 111:1225-1232.
28. Kaga, S., S. Ragg, K. A. Rogers, and A. Ochi. 1998. Activation of p21-Cdc42/Rac-activated kinases by CD28 signalling: p21-activated kinase (PAK) and MEK kinase 1 (MEKK1) may mediate the interplay between CD3 and CD28 signals. J. Immunol. 160:4182-4189.
29. Kansas, G. S., K. Ley, J. M. Munro, and T. F. Tedder. 1993. Regulation of leukocyte rolling and adhesion to high endothelial venules through the cytoplasmic domain of L-selectin. J. Exp. Med. 177:833-838.
30. Kitayama, J., M. W. Carr, S. J. Roth, J. Buccola, and T. A. Springer. 1997. Contrasting responses to multiple chemotactic stimuli in transendothelial migration. Heterologous desensitization in neutrophils and augmentation of migration in eosinophils. J. Immunol. 158:2340-2349.
31. Knall, C., G. S. Worthen, and G. L. Johnson. 1997. Interleukin-8 stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen activated protein kinases. Proc. Natl. Acad. Sci. USA 94:3052-3057.
32. Knaus, U. G., S. Morris, H.-J. Dong, J. Chernoff, and G. M. Bokoch. 1995. Regulation of human leukocyte p21-activated kinases through G-protein coupled receptors. Science 269:221-223.
33. Kreienbuhl, P., H. U. Keller, and V. Niggli. 1992. Protein phosphatase inhibitors okadaic acid and calyculin A alter cell shape and F-actin distribution and inhibit stimulus-dependent increases in cytoskeletal actin of human neutrophils. Blood 80:2911-2919.
34. Krump, E., J. S. Sanghera, S. L. Pelech, W. Furuya, and S. Grinstein. 1997. Chemotactic peptide N-formyl-Met-Leu-Phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils. J. Biol. Chem. 272:937-944.
35. Kuroki, M., and J. T. O'Flaherty. 1997. Differential effects of a mitogen-activated protein kinase inhibitor on human neutrophil responses to chemotactic factors. Biochem. Biophys. Res. Commun. 232:474-477.
36. Lawrence, M. B., and T. A. Springer. 1991. Leukocytes roll on a selectin at physiologic flow rates: dissociation from a prerequisite for adhesion through integrins. Cell 65:859-873.
37. Leeuw, T., C. Wu. J. D. Shrag, M. Whiteway, D. Y. Thomas, and E. Leberer. 1998. Interaction of a G-protein β-subunit with a conserved sequence in Ste20/PAK family protein kinases. Nature 391:191-198.
38. Lian, J. P., and J. A. Badwey. 1997. Activation of the p21-activated protein kinases from neutrophils with an antibody that reacts with the N-terminal region of Pak 1. FEBS Lett. 404:211-215.
39. Lian, J. P., R.-Y. Huang, D. R. Robinson, and J. A. Badwey. 1998. Products of sphingolipid catabolism block activation of the p21-activated protein kinases in neutrophils. J. Immunol. 161:4375-4381.
40. Lu, W., S. Katz, R. Gupta, and B. J. Mayer. 1997. Activation of Pak by membrane localization mediated by Nck. Curr. Biol. 7:85-94.
41. Manser, E., C. Chong, Z.-S. Zhao, T. Leung, G. Michael, C. Hall, and L. Lun. 1995. Molecular cloning of a new member of the p21-Cdc42/Rac activated kinase (PAK) family. J. Biol. Chem. 270:25070-25078.
42. Manser, E., H.-Y. Huang, T.-H. Loo, X.-Q. Chen, J.-M. Dong, T. Leung, and L. Lim. 1997. Expression of constitutively active αPak reveals effects of the kinase on actin and focal complexes. Mol. Cell. Biol. 17:1129-1143.
43. Manser, E., H.-Y. Huang, T.-H. Loo, X.-Q. Chen, J.-M. Dong, T. Leung, and L. Lim. 1997. Regulation of phosphorylation pathways by p21-GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways. Eur. J. Biochem. 242:171-185.
44. Manser, E., T. Leung, H. Salihuddin, Z.-S. Zhao, and L. Lim. 1994. A brain serine/threonine protein kinase activated by Cdc42 and Rac 1. Nature 367: 40-46.
45. Manser, E., T.-H. Loo, C.-G. Koh, Z.-S. Zhao, X.-Q. Chen, L. Tan, I. Tan, T. Leung, and L. Lim. 1998. Pak kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol. Cell 1:183-192.
46. Martin, G. A., G. Bollag, F. McCormick, and A. Abo. 1995. A novel serine kinase activated by Rac1/Cdc42 Hs-dependent autophosphorylation is related to Pak 65 and STE 20. EMBO J. 14:1970-1978.
47. McWhinney, C. D., R. A. Hunt, K. M. Conrad, D. E. Dostal, and K. M. Baker. 1997. The type 1 angiotensin II receptor couples to Stat1 and Stat3 activation through Jak2 kinase in neonatal rat cardiac myocytes. J. Mol. Cell. Cardiol. 29:2513-2524.
48. Mitchell, R., D. McCulloch, E. Lutz, M. Johnson, C. MacKenzie, M. Fennell, G. Fink, W. Zhou, and S. C. Sealfon. 1998. Rhodopsin-family receptors associate with small G proteins to activate phospholipase D. Nature 392:411-414.
49. Nahas, N., T. F. P. Molski, G. A. Fernandez, and R. I. Sha'afi. 1996. Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists. Biochem. J. 318:247-253.
50. Nick, J. A., N. J. Avdi, S. K. Young, C. Knall, P. Gerwins, G. L. Johnson, and G. S. Worthen. 1997. Common and distinct intracellular signalling pathways in human neutrophils utilized by platelet activating factor and fMLP. J. Clin. Investig. 99:975-986.
51. Niggli, V., and H. Keller. 1997. The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils. Eur. J. Pharmacol. 335: 43-52.
52. Novak, K. D., and M. A. Titus. 1997. Myosin I overexpression impairs cell migration. J. Cell Biol. 136:633-647.
53. Okada, T., O. Hazeki, M. Ui, and T. Katada. 1996. Synergistic activation of Ptdlns 3-kinase by tyrosine-phosphorylated peptide and βγ-subunits of GTP-binding proteins. Biochem. J. 317:475-480.
54. Pierce Chemical Co. 1996. SuperSignal substrate Western blotting kits. No. 34081-34086. Pierce Chemical Co., Rockford. Ill.
55. Promega. 1998. Promega technical bulletin no. 262. Promega, Madison, Wis.
56. Sells, M. A., U. G. Knaus, S. Bagrodia, D. M. Ambrose, G. M. Bokoch, and J. Chernoff. 1997. Human p21-activated kinase (Pakl) regulates actin organization in mammalian cells. Curr. Biol. 7:202-210.
57. Tapson, N., K.-I. Nagata, N. Lamarche, and A. Hall. 1998. A new Rac target POSH is an SH3-containing scaffold protein involved in JNK and NE-κB signalling pathways. EMBO J. 17:1395-1404.
58. Thompson, H. L., C. J. Marshall, and J. Saklatvala. 1994. Characterization of two different forms of mitogen-activated protein kinase in polymorphonuclear leukocytes following stimulation by N-formylmethionyl-leucyl-phenylalanine or granulocyte-macrophage colony-stimulating factor. J. Biol. Chem. 269:9486-9492.
59. Toker, A., and L. C. Cantley. 1997. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387:673-676.
60. Uehara, Y., H. Fukazawa, Y. Murakami, and S. Mizuno. 1989. Irreversible inhibition of the v-src tyrosine kinase activity by herbimycin A and its abrogation by sulfhydryl compounds. Biochem. Biophys. Res. Commun. 163:803-809.
61. Umezawa, K., T. Hori, H. Tajima, M. Imoto, K. lsshiki, and T. Takeuchi. 1990. Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors. FEBS Lett. 260:198-200.
62. Waddell, T. K., L. Fialkow, C. K. Chan, T. K. Kishimoto, and G. P. Downey. 1995. Signaling functions of L-selectin. Enhancement of tyrosine phosphorylation and activation of MAP kinase. J. Biol. Chem. 270:15403-15411.
63. Wilde, M. W., K. E. Carlson, D. R. Manning, and S. H. Zigmond. 1989. Chemoattractant-stimulated GTPase activity is decreased on membranes from polymorphonuclear leukocytes incubated in chemoattractant. J. Biol. Chem. 264:190-196.
64. Wu, C., S.-F. Lee, E. Furmaniak-Kazmierczak, G. P. Cote, D. Y. Thomas, and E. Leberer. 1996. Activation of myosin-1 by members of the Ste20p protein kinase family. J. Biol. Chem. 271:31787-31790.
65. 4 that mediates chemotaxis. Nature 387:620-624.
66. Zhang, S., J. Han, M. A. Sells, J. Chernoff, U. G. Knaus, R. J. Ulevitch. and G. M. Bokoch. 1995. Rho family GTPases regulate p38 MAP kinase through the downstream mediator Pak 1. J. Biol. Chem. 270:23934-23936.
67. Zhao, Z.-S., E. Manser, X.-Q. Chen, C. Chong, T. Leung, and L. Lim. 1998. A conserved negative regulatory region in aPak: inhibition of Pak kinases reveals their morphological roles downstream of Cdc42 and Rac1. Mol. Cell. Biol. 18:2153-2163.
68. Zigmond, S. H. 1996. Signal transduction and actin filament organization. Curr. Opin. Cell Biol. 8:66-73.
69. Zu, Y.-L., J. Qi, A. Gilchrist, G. A. Fernandez, D. Vazquez-Abad, D. L. Kreutzer, C.-K. Huang, and R. I. Sha'afi. 1998. p38-mitogen activated protein kinase activation is required for human neutrophil function triggered by TNF-α or fMLP stimulation. J. Immunol. 160:1982-1989.