Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system

American Journal of Pathology

Volumn 150, Issue 1, 1997, Pages 31-41

  Gasque, Philippe ^a   Singhrao, Sim K ^a   Neal, James W ^a   Götze, Otto ^b   Morgan, B Paul ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A RECEPTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ASTROCYTE; BRAIN DISEASE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DEMYELINATING DISEASE; ENDOTHELIUM CELL; FETUS; GLIOSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; HUNTINGTON CHOREA; IMMUNOHISTOCHEMISTRY; MICROGLIA; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; VIRUS ENCEPHALITIS;

ADULT; ANTIGENS, CD; ASTROCYTES; BRAIN; CELLS, CULTURED; COMPLEMENT C5A; ENDOTHELIUM, VASCULAR; FETUS; HUMANS; IMMUNOHISTOCHEMISTRY; MICROGLIA; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, COMPLEMENT; STAINING AND LABELING; TISSUE FIXATION; UP-REGULATION;

EID: 0031031213     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Gerard C, Gerard NP: C5a anaphylatoxin, and its seven transmembrane-segment receptor. Annu Rev Immunol 1994, 12:775-808
2. Wetsel RA: Structure, function, and cellular expression of complement anaphylatoxin receptors. Curr Opin Immunol 1995, 1:48-53
3. Gerard NP, Hodges MK, Drazen JM, Weller PF, Gerard C: Characterization of a receptor for C5a anaphylatoxin on human eosinophils. J Biol Chem 1989, 264:1760-1766
4. Oppermann M, Raedt U, Hebell T, Schmidt B, Zimmermann B, Götze O: Probing the human receptor for C5a anaphylatoxin with site-directed antibodies. J Immunol 1993, 151:3785-3794
5. Morgan EL, Ember JA, Sanderson SD, Scholz W, Buchner R, Ye RD, Hugli TE: Anti-C5a receptor antibodies: characterization of neutralizing antibodies specific for a peptide, C5aR-(9-29), derived from the predicted amino-terminal sequence of the human C5a receptor. J Immunol 1993, 151:377-388
6. Okusawa S, Dinarello CA, Yancy KB, Endres S, Lawley TJ, Frank MM, Burke JF, Gelfand JA: C5a induction of human interleukin 1 : synergistic effect with endotoxin or Interferon γ. J Immunol 1987, 139:2635-2640
7. Schindler R, Gelfand JA, Dinarello CA: Recombinant C5a stimulates transcription rather than translation of interleukin 1 (IL-1), and tumor necrosis factor: translational signal provided by liposaccharide or IL-1 itself. Blood 1990, 76:1631-1638
8. Scholz W, McClurg MR, Cardenas GJ, Smith M, Noonan DJ, Hugli TE, Morgan EL: C5a-mediated release of interleukin by human monocytes. Clin Immunol Immunopathol 1990, 57:297-307
9. Morgan EL, Sanderson S, Scholz W, Noonan DJ, Weigle WO, Hugli, TE: Identification and characterization of the effector region within human C5a responsible for the stimulation of IL-6 synthesis. J Immunol 1992, 148:3937-3942
10. Ember JA, Sanderson SD, Hugli TE, Morgan EL: Induction of interleukin-8 synthesis from human C5a anaphylatoxin. Am J Pathol 1994, 144:393-403
11. Hopken U, Mohr M, Struber A, Montz H, Burchardi H, Gotze O, Oppermann M: Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies. Eur J Irnmunol 1996, 26:1103-1109
12. Haviland DL, McCoy RL, Whitehead WT, Akama H, Molmenti EP, Brown A, Haviland JC, Parks WC, Perlmutter DH, Wetsel RA: Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung. J Immunol 1995, 154:1861-1869
13. Buchner RR, Hugli TE, Ember JA, Morgan, EL: Expression of functional receptors for human C5a anaphylatoxin (CD88) on the human hepatocellular carcinoma cell line HepG2. Stimulation of the acute-phase protein specific mRNA and protein synthesis by human C5a anaphylatoxin. J Immunol 1995, 155:308-315
14. Fureder W, Agis H, Willheim M, Bankl HC, Maier U, Kishi K, Muller MR, Czerwenka K, Radaszkiewicz T, Butterfield JH, Klappacher GW, Sperr WR, Oppermann M, Lechner K, Valent P: Differential expression of complement receptors on human basophils and mast cells. Evidence for mast cell heterogeneity and CD88/C5aR expression on skin mast cells. J Immunol 1995, 155: 3152-3160
15. Foreman KE, Vaporciyan AA, Bonish BK, Jones ML, Johnson KJ, Glovski MM, Eddy SM, Ward PA: C5a-induced expression of P-selectin in endothelial cells. J Clin Invest 1994, 94:1147-1155
16. Gasque P, Chan P, Fontaine M, IschenkoA, Lamacz M, Götze O, Morgan BP: Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes. J Immunol 1995, 155:4882-4889
17. Morgan BP: Complement in diseases of the nervous system. Complement in Health and Disease. Edited by K Whaley, M Loos, JM Weiler. Dordrecht, The Netherlands, Kluwer Academic Publishers, 1993, pp 353-375
18. Morgan BP, Gasque P: Expression of complement in the brain: role in health and disease. Immunol Today 1996, 17:461-466
19. Ranscht B, Clapshaw PA, Price J, Noble M, Seifert W: Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside. Proc Natl Acad Sci USA 1982, 79:2709-2713
20. Singhrao SK, Neal JW, Gasque P, Morgan BP, Newman GR: Role of complement in the aetiology of Pick's disease. J Neuropathol Exp Neurol 1996, 55:578-593
21. Peudenier S, Hery C, Montagnier L, Tardieu M: Human microglial cells: characterization in cerebral tissue and primary culture and study of their susceptibility to HIV-1 infection. Ann Neurol 1991, 29:152-161
22. Armstrong RC, Dorn HH, Kufta CV, Friedman E, Dubois-Dalcq ME: Pre-oligodendrocytes from adult human CNS. J Neurosci 1992, 12:1538-1547
23. Williams CA, Schupf N, Hugli TE: Anaphylatoxin C5a modulation of an α-adrenergic system in the rat hypothalamus. J Neuroimmunol 1985, 9:29-40
24. Schupf N, Williams CA, Berkman A, Cattell WS, Kerper L: Binding specificity of presynaptic action of anaphylatoxin C5a in rat brain. Brain Behav Immun 1989, 3:28-38
25. Armstrong RC, Harvath L, Dubois-Dalcq ME: Type 1 astrocytes, and oligodendrocyte-type 2 astrocyte glial progenitors migrate toward distinct molecules. J Neurosci Res 1990, 27:400-407
26. Lacy M, Whittemore SR, Haviland DL, Wetsel RA, Barnum SR Expression of the receptor for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia. J Neuroimmunol 1995, 61:71-78