Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine

Journal of Surgical Research

Volumn 103, Issue 2, 2002, Pages 260-267

  Arumugam, Thiruma V ^a   Shiels, Ian A ^a   Woodruff, Trent M ^a   Reid, Robert C ^a   Fairlie, David P ^a   Taylor, Stephen M ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

AcF (OPdChaWR); Aspartate amino transferase; C5a receptor antagonist; Edema; Gut ischemia reperfusion; Haptoglobin; Polymorphonuclear leukocytes; Tumor necrosis factor

Indexed keywords

ACETYLPHENYLALANINE(ORNITHYLPROLYL DEXTRO CYCLOHEXYLALANYLTRYPTOPHYLARGININE); ASPARTATE AMINOTRANSFERASE; COMPLEMENT COMPONENT C5A RECEPTOR; HAPTOGLOBIN; RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CLAMP; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; EDEMA; ENZYME BLOOD LEVEL; FEMALE; HISTOPATHOLOGY; INTESTINE ISCHEMIA; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; REPERFUSION INJURY; SUPERIOR MESENTERIC ARTERY OBSTRUCTION;

EID: 0036351871     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.2002.6369     Document Type: Article

References (39)

1. Increased levels of platelet-activating factor in blood following intestinal ischemia in the dog
2. Platelet-activating factor mediates pulmonary macromolecular leak following intestinal ischemia-reperfusion
3. Evidence for tumor necrosis factor-induced pulmonary microvascular injury after intestinal ischemia-reperfusion injury
4. The potential etiologic role of tumor necrosis factor in mediating multiple organ dysfunction in rats following intestinal-reperfusion injury
5. Gut ischemia and mesenteric synthesis of inflammatory cytokines after hemorrhagic or endotoxic shock
6. Ischemic injury in the cat small intestine: Role of superoxide radicals
7. Ischemia-reperfusion-induced mucosal dysfunction: Role of neutrophils
8. Soluble complement receptor type 1 ameliorates the local and remote organ injury after intestinal ischemia-reperfusion in the rat
9. A blockade of complement activation prevents rapid intestinal ischaemia-reperfusion injury by modulating mucosal mast cell degranulation in rats
10. Antiinflammatory effects of soluble complement receptor type 1 promote rapid recovery of ischemia/reperfusion injury in rat small intestine
11. Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury
12. Role of complement activation and mast cell degranulation in the pathogenesis of rapid intestinal ischemia/reperfusion injury in rats
13. Inhibition of complement C5 reduces local and remote organ injury after intestinal ischemia/reperfusion in the rat
14. Intestinal reperfusion injury is mediated by IgM and complement
15. Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a
16. Inhibition of immune-complex mediated dermal inflammation following either oral or topical administration of a small molecule C5a receptor antagonist
17. Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat
18. A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats
19. Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal
20. Xanthine oxidase and neutrophil infiltration in intestinal ischemia
21. Vascular insufficiency of the intestines
22. Acute necrosis of the intestinal mucosa
23. Gut ischemia mediates lung injury by a xanthine oxidase-dependent neutrophil mechanism
24. Neutrophil depletion attenuates human intestinal reperfusion injury
25. Neutrophils, host defense, and inflammation: A double-edged sword
26. Regulation of the complement membrane attack pathway
27. Regulators of the anaphylatoxin C5a
28. C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1beta and interleukin 1 alpha
29. Recombinant C5a enhances interleukin 1 and tumor necrosis factor release by lipopolysaccharide-stimulated monocytes and macrophages
30. Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production in vitro by a new C5a receptor antagonist
31. Role of cytokines in the pathogenesis of inflammatory bowel disease
32. Proinflammatory cytokines
33. Bovine and canine acute phase proteins
34. Interaction of cytokine- and glucocorticoid-response elements of acute-phase plasma protein genes. Importance of glucocorticoid receptor level and cell type for regulation of the elements from rat alpha 1-acid glycoprotein and beta-fibrinogen genes
35. Expression of functional receptors for human C5a anaphylatoxin (CD88) on the human hepatocellular carcinoma cell line HepG2. Stimulation of acute-phase protein-specific mRNA and protein synthesis by human C5a anaphylatoxin
36. Complement-dependent acute-phase expression of C-reactive protein and serum amyloid P-component
37. Bile analysis as a tool for assessing integrity of biliary epithelial cells after cold ischemia-reperfusion of rat livers
38. Pharmacological characterization of antagonists of the C5a receptor
39. Species dependence for binding of small molecule agonist and antagonists to the C5a receptor on polymorphonuclear leukocytes