메뉴 건너뛰기




Volumn 212, Issue 2, 2007, Pages 330-344

Epigenetic drugs as pleiotropic agents in cancer treatment: Biomolecular aspects and clinical applications

Author keywords

[No Author keywords available]

Indexed keywords

3 PHENYLSULFAMOYLCINNAMOHYDROXAMIC ACID; 5 AZA 2' DEOXYCYTIDINE; 5,6 DIHYDROAZACITIDINE; AZACITIDINE; DNA; FLUCYTOSINE DEOXYRIBOSIDE; NUCLEOSIDE DERIVATIVE; VORINOSTAT; ZEBULARINE;

EID: 34347375106     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21066     Document Type: Review
Times cited : (137)

References (206)
  • 2
    • 3542998048 scopus 로고    scopus 로고
    • Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells
    • Ammanamanchi S, Brattain MG. 2004. Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells. J Biol Chem 279:32620-32625.
    • (2004) J Biol Chem , vol.279 , pp. 32620-32625
    • Ammanamanchi, S.1    Brattain, M.G.2
  • 3
    • 0032568956 scopus 로고    scopus 로고
    • Induction of transforming growth factor-beta receptor type II expression in estrogen receptor-positive breast cancer cells through SP1 activation by 5-aza-2′-deoxycytidine
    • Ammanamanchi S, Kim SJ, Sun LZ, Brattain MG. 1998. Induction of transforming growth factor-beta receptor type II expression in estrogen receptor-positive breast cancer cells through SP1 activation by 5-aza-2′-deoxycytidine. J Biol Chem 273:16527-16534.
    • (1998) J Biol Chem , vol.273 , pp. 16527-16534
    • Ammanamanchi, S.1    Kim, S.J.2    Sun, L.Z.3    Brattain, M.G.4
  • 6
    • 0035798454 scopus 로고    scopus 로고
    • Reduced expression of intercellular adhesion molecule-1 in ovarian adenocarcinomas
    • Arnold JM, Cummings M, Purdie D, Chenevix-Trench G. 2001. Reduced expression of intercellular adhesion molecule-1 in ovarian adenocarcinomas. Br J Cancer 85:1351-1358.
    • (2001) Br J Cancer , vol.85 , pp. 1351-1358
    • Arnold, J.M.1    Cummings, M.2    Purdie, D.3    Chenevix-Trench, G.4
  • 7
    • 29244453281 scopus 로고    scopus 로고
    • Methylation of tumor suppressor genes p16(INK4a), p27(Kip1) and E-cadherin in carcinogenesis
    • Auerkari EI. 2006. Methylation of tumor suppressor genes p16(INK4a), p27(Kip1) and E-cadherin in carcinogenesis. Oral Oncol 42:5-13.
    • (2006) Oral Oncol , vol.42 , pp. 5-13
    • Auerkari, E.I.1
  • 8
    • 0033558192 scopus 로고    scopus 로고
    • Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers
    • Bachman KE, Herman JG, Corn PG, Merlo A, Costello JF, Cavenee WK, Baylin SB, Graff JR. 1999. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res 59:798-802.
    • (1999) Cancer Res , vol.59 , pp. 798-802
    • Bachman, K.E.1    Herman, J.G.2    Corn, P.G.3    Merlo, A.4    Costello, J.F.5    Cavenee, W.K.6    Baylin, S.B.7    Graff, J.R.8
  • 9
    • 0037124164 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers
    • 6-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers. Br J Cancer 86:1888-1892.
    • (2002) Br J Cancer , vol.86 , pp. 1888-1892
    • Bae, S.I.1    Lee, H.S.2    Kim, S.H.3    Kim, W.H.4
  • 10
    • 31344466008 scopus 로고    scopus 로고
    • DNA methylation and gene silencing in cancer
    • Baylin SB. 2005. DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol 2:S4-11-S4-11.
    • (2005) Nat Clin Pract Oncol , vol.2
    • Baylin, S.B.1
  • 12
    • 0031964055 scopus 로고    scopus 로고
    • Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines
    • Bender CM, Pao MM, Jones PA. 1998. Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res 58:95-101.
    • (1998) Cancer Res , vol.58 , pp. 95-101
    • Bender, C.M.1    Pao, M.M.2    Jones, P.A.3
  • 13
    • 0034917318 scopus 로고    scopus 로고
    • Antineoplastic action of 5-aza-2′-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells
    • Bovenzi V, Momparler RL. 2001. Antineoplastic action of 5-aza-2′-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells. Cancer Chemother Pharmacol 48:71-76.
    • (2001) Cancer Chemother Pharmacol , vol.48 , pp. 71-76
    • Bovenzi, V.1    Momparler, R.L.2
  • 16
    • 0242442595 scopus 로고    scopus 로고
    • Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas
    • Byun DS, Cho K, Ryu BK, Lee MG, Kang MJ, Kim HR, Chi SG. 2003. Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas. Cancer Res 63:7068-7075.
    • (2003) Cancer Res , vol.63 , pp. 7068-7075
    • Byun, D.S.1    Cho, K.2    Ryu, B.K.3    Lee, M.G.4    Kang, M.J.5    Kim, H.R.6    Chi, S.G.7
  • 18
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron EE, Bachman KE, Myohanen S, Herman JG, Baylin SB. 1999. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21:103-107.
    • (1999) Nat Genet , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 19
    • 4644259264 scopus 로고    scopus 로고
    • Enhancement of xenograft tumor radiosensitivity by the histone deacetylase inhibitor MS-275 and correlation with histone hyperacetylation
    • Camphausen K, Scott T, Sproull M, Tofilon PJ. 2004. Enhancement of xenograft tumor radiosensitivity by the histone deacetylase inhibitor MS-275 and correlation with histone hyperacetylation. Clin Cancer Res 10:6066-6071.
    • (2004) Clin Cancer Res , vol.10 , pp. 6066-6071
    • Camphausen, K.1    Scott, T.2    Sproull, M.3    Tofilon, P.J.4
  • 20
    • 0017886958 scopus 로고
    • Sodium butyrate inhibits histone deacetylation in cultured cells
    • Candido EP, Reeves R, Davie JR. 1978. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell 14:105-113.
    • (1978) Cell , vol.14 , pp. 105-113
    • Candido, E.P.1    Reeves, R.2    Davie, J.R.3
  • 22
    • 26444561533 scopus 로고    scopus 로고
    • Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family
    • Chen ZX, Mann JR, Hsieh CL, Riggs AD, Chedin F. 2005. Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family. J Cell Biochem 95:902-917.
    • (2005) J Cell Biochem , vol.95 , pp. 902-917
    • Chen, Z.X.1    Mann, J.R.2    Hsieh, C.L.3    Riggs, A.D.4    Chedin, F.5
  • 24
    • 14844307097 scopus 로고    scopus 로고
    • Epigenetic regulation by histone methylation and histone variants
    • Cheung P, Lau P. 2005. Epigenetic regulation by histone methylation and histone variants. Mol Endocrinol 19:563-573.
    • (2005) Mol Endocrinol , vol.19 , pp. 563-573
    • Cheung, P.1    Lau, P.2
  • 26
    • 0032920527 scopus 로고    scopus 로고
    • Prolonged upregulation of the expression of HLA class I antigens and costimulatory molecules on melanoma cells treated with 5-aza-2′-deoxycytidine (5-AZA-CdR)
    • Coral S, Sigalotti L, Gasparollo A, Cattarossi I, Visintin A, Cattelan A, Altomonte M, Maio M. 1999. Prolonged upregulation of the expression of HLA class I antigens and costimulatory molecules on melanoma cells treated with 5-aza-2′-deoxycytidine (5-AZA-CdR). J Immunother 22:16-24.
    • (1999) J Immunother , vol.22 , pp. 16-24
    • Coral, S.1    Sigalotti, L.2    Gasparollo, A.3    Cattarossi, I.4    Visintin, A.5    Cattelan, A.6    Altomonte, M.7    Maio, M.8
  • 29
    • 0033565514 scopus 로고    scopus 로고
    • Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation
    • Corn PG, Kuerbitz SJ, van Noesel MM, Esteller M, Compitello N, Baylin SB, Herman JG. 1999. Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation. Cancer Res 59:3352-3356.
    • (1999) Cancer Res , vol.59 , pp. 3352-3356
    • Corn, P.G.1    Kuerbitz, S.J.2    van Noesel, M.M.3    Esteller, M.4    Compitello, N.5    Baylin, S.B.6    Herman, J.G.7
  • 31
    • 0031731906 scopus 로고    scopus 로고
    • Demethylation by 5-aza-2′-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor beta gene in human colon carcinoma cells
    • Cote S, Sinnett D, Momparler RL. 1998. Demethylation by 5-aza-2′-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor beta gene in human colon carcinoma cells. Anticancer Drugs 9:743-750.
    • (1998) Anticancer Drugs , vol.9 , pp. 743-750
    • Cote, S.1    Sinnett, D.2    Momparler, R.L.3
  • 32
    • 0033918563 scopus 로고    scopus 로고
    • Epigeneticinactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
    • Dammann R, Li C, Yoon JH, Chin PL, Bates S, Pfeifer GP. 2000. Epigeneticinactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet 25:315-319.
    • (2000) Nat Genet , vol.25 , pp. 315-319
    • Dammann, R.1    Li, C.2    Yoon, J.H.3    Chin, P.L.4    Bates, S.5    Pfeifer, G.P.6
  • 33
    • 13944267211 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins
    • 6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins. Mol Cancer Ther 4:61-69.
    • (2005) Mol Cancer Ther , vol.4 , pp. 61-69
    • Danam, R.P.1    Howell, S.R.2    Brent, T.P.3    Harris, L.C.4
  • 35
  • 36
    • 0032694084 scopus 로고    scopus 로고
    • DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter
    • De Smet C, Lurquin C, Lethe B, Martelange V, Boon T. 1999. DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol Cell Biol 19:7327-7335.
    • (1999) Mol Cell Biol , vol.19 , pp. 7327-7335
    • De Smet, C.1    Lurquin, C.2    Lethe, B.3    Martelange, V.4    Boon, T.5
  • 37
    • 0030843274 scopus 로고    scopus 로고
    • Methylation of the BRCA1 gene in sporadic breast cancer
    • Dobrovic A, Simpfendorfer D. 1997. Methylation of the BRCA1 gene in sporadic breast cancer. Cancer Res 57:3347-3350.
    • (1997) Cancer Res , vol.57 , pp. 3347-3350
    • Dobrovic, A.1    Simpfendorfer, D.2
  • 39
    • 0033680062 scopus 로고    scopus 로고
    • Epigenetic lesions causing genetic lesions in human cancer: Promoter hypermethylation of DNA repair genes
    • Esteller M. 2000. Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes. Eur J Cancer 36:2294-2300.
    • (2000) Eur J Cancer , vol.36 , pp. 2294-2300
    • Esteller, M.1
  • 40
    • 0942279488 scopus 로고    scopus 로고
    • 6-methylguanine DNA methyltransferase in human cancer
    • 6-methylguanine DNA methyltransferase in human cancer. Oncogene 23:1-8.
    • (2004) Oncogene , vol.23 , pp. 1-8
    • Esteller, M.1    Herman, J.G.2
  • 41
    • 0032487831 scopus 로고    scopus 로고
    • MLHI promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas
    • Esteller M, Levine R, Baylin SB, Ellenson LH, Herman JG. 1998. MLHI promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. Oncogene 17:2413-2417.
    • (1998) Oncogene , vol.17 , pp. 2413-2417
    • Esteller, M.1    Levine, R.2    Baylin, S.B.3    Ellenson, L.H.4    Herman, J.G.5
  • 42
    • 0033557903 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
    • 6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 59:793-797.
    • (1999) Cancer Res , vol.59 , pp. 793-797
    • Esteller, M.1    Hamilton, S.R.2    Burger, P.C.3    Baylin, S.B.4    Herman, J.G.5
  • 47
    • 0345275879 scopus 로고    scopus 로고
    • Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
    • Fang MZ, Wang Y, Ai N, Hou Z, Sun Y, Lu H, Welsh W, Yang CS. 2003. Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res 63:7563-7570.
    • (2003) Cancer Res , vol.63 , pp. 7563-7570
    • Fang, M.Z.1    Wang, Y.2    Ai, N.3    Hou, Z.4    Sun, Y.5    Lu, H.6    Welsh, W.7    Yang, C.S.8
  • 48
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg AP, Tycko B. 2004. The history of cancer epigenetics. Nat Rev Cancer 4:143-153.
    • (2004) Nat Rev Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 49
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg AP, Vogelstein B. 1983. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301:89-92.
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 50
    • 0036392059 scopus 로고    scopus 로고
    • DNA methylation and genomic imprinting: Insights from cancer into epigenetic mechanisms
    • Feinberg AP, Cui H, Ohlsson R. 2002. DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms. Semin Cancer Biol 12:389-398.
    • (2002) Semin Cancer Biol , vol.12 , pp. 389-398
    • Feinberg, A.P.1    Cui, H.2    Ohlsson, R.3
  • 51
    • 0029002319 scopus 로고
    • Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression
    • Ferguson AT, Lapidus RG, Baylin SB, Davidson NE. 1995. Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression. Cancer Res 55:2279-2283.
    • (1995) Cancer Res , vol.55 , pp. 2279-2283
    • Ferguson, A.T.1    Lapidus, R.G.2    Baylin, S.B.3    Davidson, N.E.4
  • 52
    • 0031434813 scopus 로고    scopus 로고
    • Role of estrogen receptor gene demethylation and DNA methyltransferase. DNA adduct formation in 5-aza-2′deoxycytidine-induced cytotoxicity in human breast cancer cells
    • Ferguson AT, Vertino PM, Spitzner JR, Baylin SB, Muller MT, Davidson NE. 1997. Role of estrogen receptor gene demethylation and DNA methyltransferase. DNA adduct formation in 5-aza-2′deoxycytidine-induced cytotoxicity in human breast cancer cells. J Biol Chem 272:32260-32266.
    • (1997) J Biol Chem , vol.272 , pp. 32260-32266
    • Ferguson, A.T.1    Vertino, P.M.2    Spitzner, J.R.3    Baylin, S.B.4    Muller, M.T.5    Davidson, N.E.6
  • 55
    • 0035855626 scopus 로고    scopus 로고
    • Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
    • Fulda S, Kufer MU, Meyer E, van Valen F, Dockhorn-Dworniczak B, Debatin KM. 2001. Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene 20:5865-5877.
    • (2001) Oncogene , vol.20 , pp. 5865-5877
    • Fulda, S.1    Kufer, M.U.2    Meyer, E.3    van Valen, F.4    Dockhorn-Dworniczak, B.5    Debatin, K.M.6
  • 57
    • 0037358032 scopus 로고    scopus 로고
    • Interaction of 5-aza-2′-deoxycytidine and depsipeptide on antineoplastic activity and activation of 14-3-3sigma, E-cadherin and tissue inhibitor of metalloproteinase 3 expression in human breast carcinoma cells
    • Gagnon J, Shaker S, Primeau M, Hurtubise A, Momparler RL. 2003. Interaction of 5-aza-2′-deoxycytidine and depsipeptide on antineoplastic activity and activation of 14-3-3sigma, E-cadherin and tissue inhibitor of metalloproteinase 3 expression in human breast carcinoma cells. Anticancer Drugs 14:193-202.
    • (2003) Anticancer Drugs , vol.14 , pp. 193-202
    • Gagnon, J.1    Shaker, S.2    Primeau, M.3    Hurtubise, A.4    Momparler, R.L.5
  • 58
    • 0038784365 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma
    • Galm O, Yoshikawa H, Esteller M, Osieka R, Herman JG. 2003. SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood 101:2784-2788.
    • (2003) Blood , vol.101 , pp. 2784-2788
    • Galm, O.1    Yoshikawa, H.2    Esteller, M.3    Osieka, R.4    Herman, J.G.5
  • 59
    • 23044495284 scopus 로고    scopus 로고
    • Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies
    • Galm O, Suzuki H, Akiyama Y, Esteller M, Brock MV, Osieka R, Baylin SB, Herman JG. 2005. Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies. Oncogene 24:4799-4805.
    • (2005) Oncogene , vol.24 , pp. 4799-4805
    • Galm, O.1    Suzuki, H.2    Akiyama, Y.3    Esteller, M.4    Brock, M.V.5    Osieka, R.6    Baylin, S.B.7    Herman, J.G.8
  • 61
    • 33344456652 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: A review of their clinical status as antineoplastic agents
    • Garcia-Manero G, Issa JP. 2005. Histone deacetylase inhibitors: a review of their clinical status as antineoplastic agents. Cancer Invest 23:635-642.
    • (2005) Cancer Invest , vol.23 , pp. 635-642
    • Garcia-Manero, G.1    Issa, J.P.2
  • 65
    • 0036861629 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors-state of the art
    • Goffin J, Eisenhauer E. 2002. DNA methyltransferase inhibitors-state of the art. Ann Oncol 13:1699-1716.
    • (2002) Ann Oncol , vol.13 , pp. 1699-1716
    • Goffin, J.1    Eisenhauer, E.2
  • 66
    • 33748046812 scopus 로고    scopus 로고
    • Phase I trial of sequential low-dose 5-aza-2′-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma
    • Gollob JA, Sciambi CJ, Peterson BL, Richmond T, Thoreson M, Moran K, Dressman HK, Jelinek J, Issa JP. 2006. Phase I trial of sequential low-dose 5-aza-2′-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma. Clin Cancer Res 12:4619-4627.
    • (2006) Clin Cancer Res , vol.12 , pp. 4619-4627
    • Gollob, J.A.1    Sciambi, C.J.2    Peterson, B.L.3    Richmond, T.4    Thoreson, M.5    Moran, K.6    Dressman, H.K.7    Jelinek, J.8    Issa, J.P.9
  • 68
    • 0842277812 scopus 로고    scopus 로고
    • Histone deacetylase (HDAC) inhibitor activation of p2IWAFI involves changes in promoter-associated proteins, including HD AC1
    • Gui CY, Ngo L, Xu WS, Richon VM, Marks PA. 2004. Histone deacetylase (HDAC) inhibitor activation of p2IWAFI involves changes in promoter-associated proteins, including HD AC1. Proc Natl Acad Sci USA 101:1241-1246.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1241-1246
    • Gui, C.Y.1    Ngo, L.2    Xu, W.S.3    Richon, V.M.4    Marks, P.A.5
  • 70
    • 0037310198 scopus 로고    scopus 로고
    • Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma
    • Gupta A, Godwin AK, Vanderveer L, Lu A, Liu J. 2003. Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma. Cancer Res 63:664-673.
    • (2003) Cancer Res , vol.63 , pp. 664-673
    • Gupta, A.1    Godwin, A.K.2    Vanderveer, L.3    Lu, A.4    Liu, J.5
  • 72
    • 0038243168 scopus 로고    scopus 로고
    • The role of DNA methylation in setting up chromatin structure during development
    • Hashimshony T, Zhang J, Keshet I, Bustin M, Cedar H. 2003. The role of DNA methylation in setting up chromatin structure during development. Nat Genet 34:187-192.
    • (2003) Nat Genet , vol.34 , pp. 187-192
    • Hashimshony, T.1    Zhang, J.2    Keshet, I.3    Bustin, M.4    Cedar, H.5
  • 74
    • 0030046322 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B
    • Herman JG, Jen J, Merlo A, Baylin SB. 1996. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res 56:722-727.
    • (1996) Cancer Res , vol.56 , pp. 722-727
    • Herman, J.G.1    Jen, J.2    Merlo, A.3    Baylin, S.B.4
  • 76
    • 9744251005 scopus 로고    scopus 로고
    • Biochemistry and biology of mammalian DNA methyltransferases
    • Hermann A, Gowher H, Jeltsch A. 2004. Biochemistry and biology of mammalian DNA methyltransferases. Cell Mol Life Sci 61:2571-2587.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 2571-2587
    • Hermann, A.1    Gowher, H.2    Jeltsch, A.3
  • 77
    • 0034662625 scopus 로고    scopus 로고
    • Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
    • Hopkins-Donaldson S, Bodmer JL, Bourloud KB, Brognara CB, Tschopp J, Gross N. 2000. Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Res 60:4315-4319.
    • (2000) Cancer Res , vol.60 , pp. 4315-4319
    • Hopkins-Donaldson, S.1    Bodmer, J.L.2    Bourloud, K.B.3    Brognara, C.B.4    Tschopp, J.5    Gross, N.6
  • 78
    • 33746679765 scopus 로고    scopus 로고
    • Effect of histone deacetylase inhibitor LAQ824 on antineoplastic action of 5-Aza-2′-deoxycytidine (decitabine) on human breast carcinoma cells
    • Hurtubise A, Momparler RL. 2006. Effect of histone deacetylase inhibitor LAQ824 on antineoplastic action of 5-Aza-2′-deoxycytidine (decitabine) on human breast carcinoma cells. Cancer Chemother Pharmacol S8:618-625.
    • (2006) Cancer Chemother Pharmacol S8 , pp. 618-625
    • Hurtubise, A.1    Momparler, R.L.2
  • 80
    • 10344260184 scopus 로고    scopus 로고
    • CpG island methylator phenotype in cancer
    • Issa JP. 2004. CpG island methylator phenotype in cancer. Nat Rev Cancer 4:988-993.
    • (2004) Nat Rev Cancer , vol.4 , pp. 988-993
    • Issa, J.P.1
  • 81
    • 31344460650 scopus 로고    scopus 로고
    • Optimizing therapy with methylation inhibitors in myelodysplastic syndromes: Dose, duration, and patient selection
    • Issa JP. 2005. Optimizing therapy with methylation inhibitors in myelodysplastic syndromes: dose, duration, and patient selection. Nat Clin Pract Oncol 2:S24-S29.
    • (2005) Nat Clin Pract Oncol , vol.2
    • Issa, J.P.1
  • 85
    • 0041347519 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer therapy: Is transcription the primary target?
    • Johnstone RW, Licht JD. 2003. Histone deacetylase inhibitors in cancer therapy: is transcription the primary target? Cancer Cell 4:13-18.
    • (2003) Cancer Cell , vol.4 , pp. 13-18
    • Johnstone, R.W.1    Licht, J.D.2
  • 87
    • 0028151343 scopus 로고
    • Toxicity of 5-aza-2′- deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
    • Juttermann R, Li E, Jaenisch R. 1994. Toxicity of 5-aza-2′- deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci USA 91:11797-11801.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11797-11801
    • Juttermann, R.1    Li, E.2    Jaenisch, R.3
  • 88
    • 3042584653 scopus 로고    scopus 로고
    • Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
    • Kaneda M, Okano M, Hata K, Sado T, Tsujimoto N, Li E, Sasaki H. 2004. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature 429:900-903.
    • (2004) Nature , vol.429 , pp. 900-903
    • Kaneda, M.1    Okano, M.2    Hata, K.3    Sado, T.4    Tsujimoto, N.5    Li, E.6    Sasaki, H.7
  • 92
    • 0035057219 scopus 로고    scopus 로고
    • Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2′-deoxycytidine
    • Karpf AR, Moore BC, Ririe TO, Jones DA. 2001. Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2′-deoxycytidine. Mol Pharmacol 59:751-757.
    • (2001) Mol Pharmacol , vol.59 , pp. 751-757
    • Karpf, A.R.1    Moore, B.C.2    Ririe, T.O.3    Jones, D.A.4
  • 93
    • 0033564351 scopus 로고    scopus 로고
    • Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies
    • Katzenellenbogen RA, Baylin SB, Herman JG. 1999. Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies. Blood 93:4347-4353.
    • (1999) Blood , vol.93 , pp. 4347-4353
    • Katzenellenbogen, R.A.1    Baylin, S.B.2    Herman, J.G.3
  • 94
    • 0242610850 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA
    • Kim MS, Blake M, Baek JH, Kohlhagen G, Pommier Y, Carrier F. 2003. Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. Cancer Res 63:7291-7300.
    • (2003) Cancer Res , vol.63 , pp. 7291-7300
    • Kim, M.S.1    Blake, M.2    Baek, J.H.3    Kohlhagen, G.4    Pommier, Y.5    Carrier, F.6
  • 95
    • 33747889966 scopus 로고    scopus 로고
    • Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma
    • Kim TY, Zhong S, Fields CR, Kim JH, Robertson KD. 2006. Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. Cancer Res 66:7490-7501.
    • (2006) Cancer Res , vol.66 , pp. 7490-7501
    • Kim, T.Y.1    Zhong, S.2    Fields, C.R.3    Kim, J.H.4    Robertson, K.D.5
  • 96
    • 0030757685 scopus 로고    scopus 로고
    • DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: Possible implications for role as tumor suppressor gene
    • Kissil JL, Feinstein E, Cohen O, Jones PA, Tsai YC, Knowles MA, Eydmann ME, Kimchi A. 1997. DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene. Oncogene 15:403-407.
    • (1997) Oncogene , vol.15 , pp. 403-407
    • Kissil, J.L.1    Feinstein, E.2    Cohen, O.3    Jones, P.A.4    Tsai, Y.C.5    Knowles, M.A.6    Eydmann, M.E.7    Kimchi, A.8
  • 97
    • 20544473454 scopus 로고    scopus 로고
    • Depsipeptide inhibits migration of primary and metastatic uveal melanoma cell lines in vitro: A potential strategy for uveal melanoma
    • Klisovic DD, Klisovic MI, Effron D, Liu S, Marcucci G, Katz SE. 2005. Depsipeptide inhibits migration of primary and metastatic uveal melanoma cell lines in vitro: a potential strategy for uveal melanoma. Melanoma Res 15:147-153.
    • (2005) Melanoma Res , vol.15 , pp. 147-153
    • Klisovic, D.D.1    Klisovic, M.I.2    Effron, D.3    Liu, S.4    Marcucci, G.5    Katz, S.E.6
  • 98
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: The mark and its mediators
    • Klose RJ, Bird AP. 2006. Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 31:89-97.
    • (2006) Trends Biochem Sci , vol.31 , pp. 89-97
    • Klose, R.J.1    Bird, A.P.2
  • 102
    • 0038118337 scopus 로고    scopus 로고
    • Effects of methylation on expression of TMSI/ASC in human breast cancer cells
    • Levine JJ, Stimson-Crider KM, Vertino PM. 2003. Effects of methylation on expression of TMSI/ASC in human breast cancer cells. Oncogene 22:3475-3488.
    • (2003) Oncogene , vol.22 , pp. 3475-3488
    • Levine, J.J.1    Stimson-Crider, K.M.2    Vertino, P.M.3
  • 103
    • 0033609371 scopus 로고    scopus 로고
    • Methylation and silencing of the Thrombospondin-1 promoter in human cancer
    • Li Q, Ahuja N, Burger PC, Issa JP. 1999. Methylation and silencing of the Thrombospondin-1 promoter in human cancer. Oncogene 18:3284-3289.
    • (1999) Oncogene , vol.18 , pp. 3284-3289
    • Li, Q.1    Ahuja, N.2    Burger, P.C.3    Issa, J.P.4
  • 104
    • 0036171225 scopus 로고    scopus 로고
    • Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2′-deoxycytidine
    • Liang G, Gonzales FA, Jones PA, Orntoft TF, Thykjaer T. 2002. Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2′-deoxycytidine. Cancer Res 62:961-966.
    • (2002) Cancer Res , vol.62 , pp. 961-966
    • Liang, G.1    Gonzales, F.A.2    Jones, P.A.3    Orntoft, T.F.4    Thykjaer, T.5
  • 106
    • 0038408486 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion
    • Liu LT, Chang HC, Chiang LC, Hung WC. 2003. Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. Cancer Res 63:3069-3072.
    • (2003) Cancer Res , vol.63 , pp. 3069-3072
    • Liu, L.T.1    Chang, H.C.2    Chiang, L.C.3    Hung, W.C.4
  • 107
    • 33645950778 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Multifunctional anticancer agents
    • Liu T, Kuljaca S, Tee A, Marshall GM. 2006. Histone deacetylase inhibitors: multifunctional anticancer agents. Cancer Treat Rev 32:157-165.
    • (2006) Cancer Treat Rev , vol.32 , pp. 157-165
    • Liu, T.1    Kuljaca, S.2    Tee, A.3    Marshall, G.M.4
  • 108
    • 20144383392 scopus 로고    scopus 로고
    • Functional epigenomics identifies genes frequently silenced in prostate cancer
    • Lodygin D, Epanchintsev A, Menssen A, Diebold J, Hermeking H. 2005. Functional epigenomics identifies genes frequently silenced in prostate cancer. Cancer Res 65:4218-4227.
    • (2005) Cancer Res , vol.65 , pp. 4218-4227
    • Lodygin, D.1    Epanchintsev, A.2    Menssen, A.3    Diebold, J.4    Hermeking, H.5
  • 110
    • 1442330508 scopus 로고    scopus 로고
    • Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo
    • Luo J, Li M, Tang Y, Laszkowska M, Roeder RG, Gu W. 2004. Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci USA 101:2259-2264.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2259-2264
    • Luo, J.1    Li, M.2    Tang, Y.3    Laszkowska, M.4    Roeder, R.G.5    Gu, W.6
  • 111
    • 33646709661 scopus 로고    scopus 로고
    • Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells
    • Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S. 2006. Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells. Oncogene 25:2873-2884.
    • (2006) Oncogene , vol.25 , pp. 2873-2884
    • Luo, W.1    Wang, X.2    Kageshita, T.3    Wakasugi, S.4    Karpf, A.R.5    Ferrone, S.6
  • 112
    • 0034548836 scopus 로고    scopus 로고
    • Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells
    • Maeda T, Towatari M, Kosugi H, Saito H. 2000. Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells. Blood 96:3847-3856.
    • (2000) Blood , vol.96 , pp. 3847-3856
    • Maeda, T.1    Towatari, M.2    Kosugi, H.3    Saito, H.4
  • 113
    • 0034671618 scopus 로고    scopus 로고
    • Magner WJ, Kazim AL, Stewart C, Romano MA, Catalano G, Grande C, Keiser N, Santaniello F, Tomasi TB. 2000. Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors. J Immunol 165:7017-7024.
    • Magner WJ, Kazim AL, Stewart C, Romano MA, Catalano G, Grande C, Keiser N, Santaniello F, Tomasi TB. 2000. Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors. J Immunol 165:7017-7024.
  • 114
    • 0242539831 scopus 로고    scopus 로고
    • Epigenetic targets for immune intervention in human malignancies
    • Maio M, Coral S, Fratta E, Altomonte M, Sigalotti L. 2003. Epigenetic targets for immune intervention in human malignancies. Oncogene 22:6484-6488.
    • (2003) Oncogene , vol.22 , pp. 6484-6488
    • Maio, M.1    Coral, S.2    Fratta, E.3    Altomonte, M.4    Sigalotti, L.5
  • 115
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D. 1995. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1:686-692.
    • (1995) Nat Med , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 116
    • 0026584248 scopus 로고
    • Human high molecular weight melanoma-associated antigen (HMW-MAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: Induction of humoral anti-HMW-MAA immunity and prolongation of survival in patients with stage IV melanoma
    • Mittelman A, Chen ZJ, Yang H, Wong GY, Ferrone S. 1992. Human high molecular weight melanoma-associated antigen (HMW-MAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: induction of humoral anti-HMW-MAA immunity and prolongation of survival in patients with stage IV melanoma. Proc Natl Acad Sci USA 89:466-470.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 466-470
    • Mittelman, A.1    Chen, Z.J.2    Yang, H.3    Wong, G.Y.4    Ferrone, S.5
  • 117
    • 25844465921 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer with 5-aza-2′-deoxycytidine (decitabine)
    • Momparler RL. 2005. Epigenetic therapy of cancer with 5-aza-2′-deoxycytidine (decitabine). Semin Oncol 32:443-451.
    • (2005) Semin Oncol , vol.32 , pp. 443-451
    • Momparler, R.L.1
  • 118
  • 119
    • 17444409344 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammals. Hum Mol Genet 14:R47-R58
    • Morgan HD, Santos F, Green K, Dean W, Reik W. 2005. Epigenetic reprogramming in mammals. Hum Mol Genet 14:R47-R58. Spec No 1:R47-R58.
    • (2005) Spec No , vol.1
    • Morgan, H.D.1    Santos, F.2    Green, K.3    Dean, W.4    Reik, W.5
  • 120
    • 33748360764 scopus 로고    scopus 로고
    • Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci
    • Munshi A, Tanaka T, Hobbs ML, Tucker SL, Richon VM, Meyn RE. 2006. Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Mol Cancer Ther 5:1967-1974.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1967-1974
    • Munshi, A.1    Tanaka, T.2    Hobbs, M.L.3    Tucker, S.L.4    Richon, V.M.5    Meyn, R.E.6
  • 121
    • 0032468051 scopus 로고    scopus 로고
    • Hypomethylation of the metastasis- associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines
    • Nakamura N, Takenaga K. 1998. Hypomethylation of the metastasis- associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines. Clin Exp Metastasis 16:471-479.
    • (1998) Clin Exp Metastasis , vol.16 , pp. 471-479
    • Nakamura, N.1    Takenaga, K.2
  • 122
    • 4344666663 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells
    • Nakata S, Yoshida T, Horinaka M, Shiraishi T, Wakada M, Sakai T. 2004. Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells. Oncogene 23:6261-6271.
    • (2004) Oncogene , vol.23 , pp. 6261-6271
    • Nakata, S.1    Yoshida, T.2    Horinaka, M.3    Shiraishi, T.4    Wakada, M.5    Sakai, T.6
  • 123
    • 1642289104 scopus 로고    scopus 로고
    • 5-aza-2′-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis
    • Nam JS, Ino Y, Kanai Y, Sakamoto M, Hirohashi S. 2004. 5-aza-2′-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis. Clin Exp Metastasis 21:49-56.
    • (2004) Clin Exp Metastasis , vol.21 , pp. 49-56
    • Nam, J.S.1    Ino, Y.2    Kanai, Y.3    Sakamoto, M.4    Hirohashi, S.5
  • 124
    • 0034794672 scopus 로고    scopus 로고
    • DNA hypermethylation is a mechanism for loss of expression of the HLA class I genes in human esophageal squamous cell carcinomas
    • Nie Y, Yang G, Song Y, Zhao X, So C, Liao J, Wang LD, Yang CS. 2001. DNA hypermethylation is a mechanism for loss of expression of the HLA class I genes in human esophageal squamous cell carcinomas. Carcinogenesis 22:1615-1623.
    • (2001) Carcinogenesis , vol.22 , pp. 1615-1623
    • Nie, Y.1    Yang, G.2    Song, Y.3    Zhao, X.4    So, C.5    Liao, J.6    Wang, L.D.7    Yang, C.S.8
  • 125
    • 18844397298 scopus 로고    scopus 로고
    • De novo DNA methytransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2′-deoxycytidine
    • Oka M, Meacham AM, Hamazaki T, Rodic N, Chang LJ, Terada N. 2005. De novo DNA methytransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2′-deoxycytidine. Oncogene 24:3091-3099.
    • (2005) Oncogene , vol.24 , pp. 3091-3099
    • Oka, M.1    Meacham, A.M.2    Hamazaki, T.3    Rodic, N.4    Chang, L.J.5    Terada, N.6
  • 126
    • 0035890776 scopus 로고    scopus 로고
    • Heterogeneous transforming growth factor (TGF)-beta unresponsiveness and loss of TGF-beta receptor type II expression caused by histone deacetylation in lung cancer cell lines
    • Osada H, Tatematsu Y, Masuda A, Saito T, Sugiyama M, Yanagisawa K, Takahashi T. 2001. Heterogeneous transforming growth factor (TGF)-beta unresponsiveness and loss of TGF-beta receptor type II expression caused by histone deacetylation in lung cancer cell lines. Cancer Res 61:8331-8339.
    • (2001) Cancer Res , vol.61 , pp. 8331-8339
    • Osada, H.1    Tatematsu, Y.2    Masuda, A.3    Saito, T.4    Sugiyama, M.5    Yanagisawa, K.6    Takahashi, T.7
  • 127
    • 0037709969 scopus 로고    scopus 로고
    • Methylation status of uPA promoter as a molecular mechanism regulating prostate cancer invasion and growth in vitro and in vivo
    • Pakneshan P, Xing RH, Rabbani SA. 2003. Methylation status of uPA promoter as a molecular mechanism regulating prostate cancer invasion and growth in vitro and in vivo. FASEB J 17:1081-1088.
    • (2003) FASEB J , vol.17 , pp. 1081-1088
    • Pakneshan, P.1    Xing, R.H.2    Rabbani, S.A.3
  • 129
    • 0021160287 scopus 로고
    • 5-Aza-2′-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias
    • Pinto A, Attadia V, Fusco A, Ferrara F, Spada OA, Di Fiore PP. 1984. 5-Aza-2′-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias. Blood 64:922-929.
    • (1984) Blood , vol.64 , pp. 922-929
    • Pinto, A.1    Attadia, V.2    Fusco, A.3    Ferrara, F.4    Spada, O.A.5    Di Fiore, P.P.6
  • 130
    • 0034326784 scopus 로고    scopus 로고
    • Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine- induced demethylation of the hMLH1 gene promoter
    • Plumb JA, Strathdee G, Sludden J, Kaye SB, Brown R. 2000. Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine- induced demethylation of the hMLH1 gene promoter. Cancer Res 60:6039-6044.
    • (2000) Cancer Res , vol.60 , pp. 6039-6044
    • Plumb, J.A.1    Strathdee, G.2    Sludden, J.3    Kaye, S.B.4    Brown, R.5
  • 131
    • 22844437430 scopus 로고    scopus 로고
    • Activation of p53/p2IWafI/Cip1 pathway by 5-aza-2′-deoxycytidine inhibits cell proliferation, induces pro-apoptotic genes and mitogen-activated protein kinases in human prostate cancer cells
    • Pulukuri SM, Rao JS. 2005. Activation of p53/p2IWafI/Cip1 pathway by 5-aza-2′-deoxycytidine inhibits cell proliferation, induces pro-apoptotic genes and mitogen-activated protein kinases in human prostate cancer cells. Int J Oncol 26:863-871.
    • (2005) Int J Oncol , vol.26 , pp. 863-871
    • Pulukuri, S.M.1    Rao, J.S.2
  • 132
    • 0032168678 scopus 로고    scopus 로고
    • CpG methylation, chromatin structure and gene silencing-a three-way connection
    • Razin A. 1998. CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J 17:4905-4908.
    • (1998) EMBO J , vol.17 , pp. 4905-4908
    • Razin, A.1
  • 133
    • 0035234557 scopus 로고    scopus 로고
    • Genomic imprinting: Parental influence on the genome
    • Reik W, Walter J. 2001. Genomic imprinting: parental influence on the genome. Nat Rev Genet 2:21-32.
    • (2001) Nat Rev Genet , vol.2 , pp. 21-32
    • Reik, W.1    Walter, J.2
  • 136
    • 0034730127 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor selectively induces p2IWAFI expression and gene-associated histone acetylation
    • Richon VM, Sandhoff TW, Rifkind RA, Marks PA. 2000. Histone deacetylase inhibitor selectively induces p2IWAFI expression and gene-associated histone acetylation. Proc Natl Acad Sci USA 97:10014-10019.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10014-10019
    • Richon, V.M.1    Sandhoff, T.W.2    Rifkind, R.A.3    Marks, P.A.4
  • 137
    • 0031771497 scopus 로고    scopus 로고
    • The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53
    • Robertson KD, Jones PA. 1998. The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol Cell Biol 18:6457-6473.
    • (1998) Mol Cell Biol , vol.18 , pp. 6457-6473
    • Robertson, K.D.1    Jones, P.A.2
  • 138
    • 0036525616 scopus 로고    scopus 로고
    • 5′ CpG island hypermethylation is associated with transcriptional silencing of the p21 (CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia
    • Roman-Gomez J, Castillejo JA, Jimenez A, Gonzalez MG, Moreno F, Rodriguez MC, Barrios M, Maldonado J, Torres A. 2002. 5′ CpG island hypermethylation is associated with transcriptional silencing of the p21 (CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia. Blood 99:2291-2296.
    • (2002) Blood , vol.99 , pp. 2291-2296
    • Roman-Gomez, J.1    Castillejo, J.A.2    Jimenez, A.3    Gonzalez, M.G.4    Moreno, F.5    Rodriguez, M.C.6    Barrios, M.7    Maldonado, J.8    Torres, A.9
  • 139
    • 33646051586 scopus 로고    scopus 로고
    • Superiority of prolonged low-dose azanucleoside administration? Results of S-aza-2′-deoxycytidine retreatment in high-risk myelodysplasia patients
    • Ruter B, Wijermans PW, Lubbert M. 2006. Superiority of prolonged low-dose azanucleoside administration? Results of S-aza-2′-deoxycytidine retreatment in high-risk myelodysplasia patients. Cancer 106:1744-1750.
    • (2006) Cancer , vol.106 , pp. 1744-1750
    • Ruter, B.1    Wijermans, P.W.2    Lubbert, M.3
  • 140
    • 12344330351 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines
    • Sakajiri S, Kumagai T, Kawamata N, Saitoh T, Said JW, Koeffler HP. 2005. Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines. Exp Hematol 33:53-61.
    • (2005) Exp Hematol , vol.33 , pp. 53-61
    • Sakajiri, S.1    Kumagai, T.2    Kawamata, N.3    Saitoh, T.4    Said, J.W.5    Koeffler, H.P.6
  • 142
    • 0035799382 scopus 로고    scopus 로고
    • Changes in DNA methylation in neoplasia: Pathophysiology and therapeutic implications
    • Santini V, Kantarjian HM, Issa JP. 2001. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann Intern Med 134:573-586.
    • (2001) Ann Intern Med , vol.134 , pp. 573-586
    • Santini, V.1    Kantarjian, H.M.2    Issa, J.P.3
  • 143
    • 0035139039 scopus 로고    scopus 로고
    • Progesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer
    • Sasaki M, Dharia A, Oh BR, Tanaka Y, Fujimoto S, Dahiya R. 2001. Progesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer. Cancer Res 61:97-102.
    • (2001) Cancer Res , vol.61 , pp. 97-102
    • Sasaki, M.1    Dharia, A.2    Oh, B.R.3    Tanaka, Y.4    Fujimoto, S.5    Dahiya, R.6
  • 144
    • 0037453906 scopus 로고    scopus 로고
    • Effects of 5-aza-2′-deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness
    • Sato N, Maehara N, Su GH, Goggins M. 2003. Effects of 5-aza-2′-deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness. J Natl Cancer Inst 95:327-330.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 327-330
    • Sato, N.1    Maehara, N.2    Su, G.H.3    Goggins, M.4
  • 145
    • 13444291198 scopus 로고    scopus 로고
    • Epigenetic inactivation of TFP1-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma
    • Sato N, Parker AR, Fukushima N, Miyagi Y, Iacobuzio-Donahue CA, Eshleman JR, Goggins M. 2005. Epigenetic inactivation of TFP1-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. Oncogene 24:850-858.
    • (2005) Oncogene , vol.24 , pp. 850-858
    • Sato, N.1    Parker, A.R.2    Fukushima, N.3    Miyagi, Y.4    Iacobuzio-Donahue, C.A.5    Eshleman, J.R.6    Goggins, M.7
  • 147
    • 2942591945 scopus 로고    scopus 로고
    • The cancer/testis genes: Review, standardization, and commentary
    • Scanlan MJ, Simpson AJ, Old LJ. 2004. The cancer/testis genes: review, standardization, and commentary. Cancer Immun 4:1.
    • (2004) Cancer Immun , vol.4 , pp. 1
    • Scanlan, M.J.1    Simpson, A.J.2    Old, L.J.3
  • 148
    • 14844313747 scopus 로고    scopus 로고
    • 5-Aza-2′-deoxycytidine induces p2IWAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia
    • Schmelz K, Wagner M, Dorken B, Tamm I. 2005. 5-Aza-2′-deoxycytidine induces p2IWAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia. Int J Cancer 114:683-695.
    • (2005) Int J Cancer , vol.114 , pp. 683-695
    • Schmelz, K.1    Wagner, M.2    Dorken, B.3    Tamm, I.4
  • 149
    • 24744456138 scopus 로고    scopus 로고
    • Targeting the epigenome for the treatment and prevention of lung cancer
    • Schrump DS, Nguyen DM. 2005. Targeting the epigenome for the treatment and prevention of lung cancer. Semin Oncol 32:488-502.
    • (2005) Semin Oncol , vol.32 , pp. 488-502
    • Schrump, D.S.1    Nguyen, D.M.2
  • 152
    • 0035886022 scopus 로고    scopus 로고
    • Reexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2′- deoxycytidine treatment
    • Serrano A, Tanzarella S, Lionello I, Mendez R, Traversari C, Ruiz-Cabello F, Garrido F. 2001. Reexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2′- deoxycytidine treatment. Int J Cancer 94: 243-251.
    • (2001) Int J Cancer , vol.94 , pp. 243-251
    • Serrano, A.1    Tanzarella, S.2    Lionello, I.3    Mendez, R.4    Traversari, C.5    Ruiz-Cabello, F.6    Garrido, F.7
  • 153
    • 33745685866 scopus 로고    scopus 로고
    • Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: Tamoxifen-bound reactivated ER recruits distinctive corepressor complexes
    • Sharma D, Saxena NK, Davidson NE, Vertino PM. 2006. Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. Cancer Res 66:6370-6378.
    • (2006) Cancer Res , vol.66 , pp. 6370-6378
    • Sharma, D.1    Saxena, N.K.2    Davidson, N.E.3    Vertino, P.M.4
  • 154
    • 0034650338 scopus 로고    scopus 로고
    • Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells
    • Shin JY, Kim HS, Park J, Park JB, Lee JY. 2000. Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells. Cancer Res 60:262-265.
    • (2000) Cancer Res , vol.60 , pp. 262-265
    • Shin, J.Y.1    Kim, H.S.2    Park, J.3    Park, J.B.4    Lee, J.Y.5
  • 155
    • 33749483782 scopus 로고    scopus 로고
    • Alteration of the methylation status of tumor-promoting genes decreases prostate cancer cell invasiveness and tumorigenesis in vitro and in vivo
    • Shukeir N, Pakneshan P, Chen G, Szyf M, Rabbani SA. 2006. Alteration of the methylation status of tumor-promoting genes decreases prostate cancer cell invasiveness and tumorigenesis in vitro and in vivo. Cancer Res 66:9202-9210.
    • (2006) Cancer Res , vol.66 , pp. 9202-9210
    • Shukeir, N.1    Pakneshan, P.2    Chen, G.3    Szyf, M.4    Rabbani, S.A.5
  • 158
    • 0038142344 scopus 로고    scopus 로고
    • 5-Aza-2′-deoxycytidine (decitabine) treatment of hematopoietic malignancies: A multimechanism therapeutic approach?
    • Sigalotti L, Altomonte M, Colizzi F, Degan M, Rupolo M, Zagonel V, Pinto A, Gattei V, Maio M. 2003. 5-Aza-2′-deoxycytidine (decitabine) treatment of hematopoietic malignancies: a multimechanism therapeutic approach? Blood 101:4644-4646.
    • (2003) Blood , vol.101 , pp. 4644-4646
    • Sigalotti, L.1    Altomonte, M.2    Colizzi, F.3    Degan, M.4    Rupolo, M.5    Zagonel, V.6    Pinto, A.7    Gattei, V.8    Maio, M.9
  • 159
    • 10844289762 scopus 로고    scopus 로고
    • Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is rnethylation-regulated and functionally reverted by 5-aza-2′- deoxycytidine
    • Sigalotti L, Fratta E, Coral S, Tanzarella S, Danielli R, Colizzi F, Fonsatti E, Traversari C, Altomonte M, Maio M. 2004. Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is rnethylation-regulated and functionally reverted by 5-aza-2′- deoxycytidine. Cancer Res 64:9167-9171.
    • (2004) Cancer Res , vol.64 , pp. 9167-9171
    • Sigalotti, L.1    Fratta, E.2    Coral, S.3    Tanzarella, S.4    Danielli, R.5    Colizzi, F.6    Fonsatti, E.7    Traversari, C.8    Altomonte, M.9    Maio, M.10
  • 161
    • 0035874991 scopus 로고    scopus 로고
    • Cytosine methylation represses glutathione S-transferase P1 (GSTP1) gene expression in human prostate cancer cells
    • Singal R, van Wert J, Bashambu M. 2001. Cytosine methylation represses glutathione S-transferase P1 (GSTP1) gene expression in human prostate cancer cells. Cancer Res 61:4820-4826.
    • (2001) Cancer Res , vol.61 , pp. 4820-4826
    • Singal, R.1    van Wert, J.2    Bashambu, M.3
  • 166
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl BD, Allis CD. 2000. The language of covalent histone modifications. Nature 403: 41-45.
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 167
    • 33645086120 scopus 로고    scopus 로고
    • Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines
    • Stresemann C, Brueckner B, Musch T, Stopper H, Lyko F. 2006. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res 66:2794-2800.
    • (2006) Cancer Res , vol.66 , pp. 2794-2800
    • Stresemann, C.1    Brueckner, B.2    Musch, T.3    Stopper, H.4    Lyko, F.5
  • 168
    • 16344380408 scopus 로고    scopus 로고
    • Involvement of the tumor necrosis factor (TNF)/TNF receptor system in leukemic cell apoptosis induced by histone deacetylase inhibitor depsipeptide (FK228)
    • Sutheesophon K, Nishimura N, Kobayashi Y, Furukawa Y, Kawano M, Itoh K, Kano Y, Ishii H, Furukawa Y. 2005. Involvement of the tumor necrosis factor (TNF)/TNF receptor system in leukemic cell apoptosis induced by histone deacetylase inhibitor depsipeptide (FK228). J Cell Physiol 203:387-397.
    • (2005) J Cell Physiol , vol.203 , pp. 387-397
    • Sutheesophon, K.1    Nishimura, N.2    Kobayashi, Y.3    Furukawa, Y.4    Kawano, M.5    Itoh, K.6    Kano, Y.7    Ishii, H.8    Furukawa, Y.9
  • 170
    • 12144291274 scopus 로고    scopus 로고
    • Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van EM, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB. 2004. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 36:417-422.
    • Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van EM, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB. 2004. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 36:417-422.
  • 171
    • 29144500326 scopus 로고    scopus 로고
    • Decitabine activates specific caspases downstream of p73 in myeloid leukemia
    • Tamm J, Wagner M, Schmelz K. 2005. Decitabine activates specific caspases downstream of p73 in myeloid leukemia. Ann Hematol 84 Suppl 13:47-53.
    • (2005) Ann Hematol , vol.84 , Issue.SUPPL. 13 , pp. 47-53
    • Tamm, J.1    Wagner, M.2    Schmelz, K.3
  • 172
    • 0032145266 scopus 로고    scopus 로고
    • Methylation of the 5′ CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas
    • Tanaka H, Shimada Y, Harada H, Shinoda M, Hatooka S, Imamura M, Ishizaki K. 1998. Methylation of the 5′ CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas. Cancer Res 58:3429-3434.
    • (1998) Cancer Res , vol.58 , pp. 3429-3434
    • Tanaka, H.1    Shimada, Y.2    Harada, H.3    Shinoda, M.4    Hatooka, S.5    Imamura, M.6    Ishizaki, K.7
  • 173
    • 12744280832 scopus 로고    scopus 로고
    • Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cells
    • Tang X, Wu W, Sun SY, Wistuba II, Hong WK, Mao L. 2004. Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cells. Mol Cancer Res 2:685-691.
    • (2004) Mol Cancer Res , vol.2 , pp. 685-691
    • Tang, X.1    Wu, W.2    Sun, S.Y.3    Wistuba, I.I.4    Hong, W.K.5    Mao, L.6
  • 175
  • 176
    • 0029774145 scopus 로고    scopus 로고
    • Reduced expression of the cyclin-dependent kinase inhibitor gene p57KIP2 in Wilms' tumor
    • Thompson JS, Reese KJ, DeBaun MR, Perlman EJ, Feinberg AP. 1996. Reduced expression of the cyclin-dependent kinase inhibitor gene p57KIP2 in Wilms' tumor. Cancer Res 56:5723-5727.
    • (1996) Cancer Res , vol.56 , pp. 5723-5727
    • Thompson, J.S.1    Reese, K.J.2    DeBaun, M.R.3    Perlman, E.J.4    Feinberg, A.P.5
  • 177
    • 26944458941 scopus 로고    scopus 로고
    • Tosi GM, Trimarchi C, Macaluso M. La 5D. Ciccodicola A, Lazzi S, Massaro-Giordano M, Caporossi A, Giordano A, Cinti C. 2005. Genetic and epigenetic alterations of RB2/p130 tumor suppressor gene in human sporadic retinoblastoma: implications for pathogenesis and therapeutic approach. Oncogene 24:5827-5836.
    • Tosi GM, Trimarchi C, Macaluso M. La 5D. Ciccodicola A, Lazzi S, Massaro-Giordano M, Caporossi A, Giordano A, Cinti C. 2005. Genetic and epigenetic alterations of RB2/p130 tumor suppressor gene in human sporadic retinoblastoma: implications for pathogenesis and therapeutic approach. Oncogene 24:5827-5836.
  • 180
    • 0041939756 scopus 로고    scopus 로고
    • Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells
    • Villar-Garea A, Fraga MF, Espada J, Esteller M. 2003. Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res 63:4984-4989.
    • (2003) Cancer Res , vol.63 , pp. 4984-4989
    • Villar-Garea, A.1    Fraga, M.F.2    Espada, J.3    Esteller, M.4
  • 181
    • 17844395749 scopus 로고    scopus 로고
    • Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer
    • Wang W, Huper G, Guo Y, Murphy SK, Olson JAJr, Marks JR. 2005. Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer. Oncogene 24:2705-2714.
    • (2005) Oncogene , vol.24 , pp. 2705-2714
    • Wang, W.1    Huper, G.2    Guo, Y.3    Murphy, S.K.4    JAJr, O.5    Marks, J.R.6
  • 183
    • 23044514626 scopus 로고    scopus 로고
    • Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
    • Weber M, Davies JJ, Wittig D, Oakeley EJ, Haase M, Lam WL, Schubeler D. 2005. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet 37:853-862.
    • (2005) Nat Genet , vol.37 , pp. 853-862
    • Weber, M.1    Davies, J.J.2    Wittig, D.3    Oakeley, E.J.4    Haase, M.5    Lam, W.L.6    Schubeler, D.7
  • 187
    • 0037068360 scopus 로고    scopus 로고
    • DNA methylation and breast carcinogenesis
    • Widschwendter M, Jones PA. 2002. DNA methylation and breast carcinogenesis. Oncogene 21:5462-5482.
    • (2002) Oncogene , vol.21 , pp. 5462-5482
    • Widschwendter, M.1    Jones, P.A.2
  • 189
    • 17444452612 scopus 로고    scopus 로고
    • Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients
    • Wijermans P, Lubbert M, Verhoef G, Bosly A, Ravoet C, Andre M, Ferrant A. 2000. Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J Clin Oncol 18:956-962.
    • (2000) J Clin Oncol , vol.18 , pp. 956-962
    • Wijermans, P.1    Lubbert, M.2    Verhoef, G.3    Bosly, A.4    Ravoet, C.5    Andre, M.6    Ferrant, A.7
  • 190
    • 33744829728 scopus 로고    scopus 로고
    • Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells
    • Wischnewski F, Pantel K, Schwarzenbach H. 2006. Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells. Mol Cancer Res 4:339-349.
    • (2006) Mol Cancer Res , vol.4 , pp. 339-349
    • Wischnewski, F.1    Pantel, K.2    Schwarzenbach, H.3
  • 191
    • 0032940478 scopus 로고    scopus 로고
    • Transcriptional regulation of urokinase (uPA) gene expression in breast cancer cells: Role of DNA methylation
    • Xing RH, Rabbani SA. 1999. Transcriptional regulation of urokinase (uPA) gene expression in breast cancer cells: role of DNA methylation. Int J Cancer 81:443-450.
    • (1999) Int J Cancer , vol.81 , pp. 443-450
    • Xing, R.H.1    Rabbani, S.A.2
  • 192
    • 0035477320 scopus 로고    scopus 로고
    • Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells
    • Yang X, Phillips DL, Ferguson AT, Nelson WG, Herman JG, Davidson NE. 2001. Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells. Cancer Res 61:7025-7029.
    • (2001) Cancer Res , vol.61 , pp. 7025-7029
    • Yang, X.1    Phillips, D.L.2    Ferguson, A.T.3    Nelson, W.G.4    Herman, J.G.5    Davidson, N.E.6
  • 194
    • 0030840954 scopus 로고    scopus 로고
    • Cytosine methylation and the ecology of intragenomic parasites
    • Yoder JA, Walsh CP, Bestor TH. 1997. Cytosine methylation and the ecology of intragenomic parasites. Trends Genet 13:335-340.
    • (1997) Trends Genet , vol.13 , pp. 335-340
    • Yoder, J.A.1    Walsh, C.P.2    Bestor, T.H.3
  • 195
    • 0031000513 scopus 로고    scopus 로고
    • Dihydro-5-azacytidine in malignant mesothelioma. A phase II trial demonstrating activity accompanied by cardiac toxicity. Cancer and Leukemia Group B
    • Yogelzang NJ, Herndon JE, Cirrincione C, Harmon DC, Antman KH, Corson JM, Suzuki Y, Citron ML, Green MR. 1997. Dihydro-5-azacytidine in malignant mesothelioma. A phase II trial demonstrating activity accompanied by cardiac toxicity. Cancer and Leukemia Group B. Cancer 79:2237-2242.
    • (1997) Cancer , vol.79 , pp. 2237-2242
    • Yogelzang, N.J.1    Herndon, J.E.2    Cirrincione, C.3    Harmon, D.C.4    Antman, K.H.5    Corson, J.M.6    Suzuki, Y.7    Citron, M.L.8    Green, M.R.9
  • 196
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: Past, present and future
    • S
    • Yoo CB, Jones PA. 2006. Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov S:37-50.
    • (2006) Nat Rev Drug Discov , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2
  • 197
    • 1942506634 scopus 로고    scopus 로고
    • Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers
    • Youssef EM, Chen XQ, Higuchi E, Kondo Y, Garcia-Manero G, Lotan R, Issa JP. 2004a. Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers. Cancer Res 64:2411-2417.
    • (2004) Cancer Res , vol.64 , pp. 2411-2417
    • Youssef, E.M.1    Chen, X.Q.2    Higuchi, E.3    Kondo, Y.4    Garcia-Manero, G.5    Lotan, R.6    Issa, J.P.7
  • 201
    • 0033809993 scopus 로고    scopus 로고
    • Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter
    • Zhang Q, Raghunath PN, Vonderheid E, Odum N, Wasik MA. 2000. Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter. Am J Pathol 157:1137-1146.
    • (2000) Am J Pathol , vol.157 , pp. 1137-1146
    • Zhang, Q.1    Raghunath, P.N.2    Vonderheid, E.3    Odum, N.4    Wasik, M.A.5
  • 202
    • 2342564962 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl) aminomethyl]benzamide and m-carboxycinnamic acid bis-hydroxamide augment radiation-induced cell death in gastrointestinal adenocarcinoma cells
    • Zhang Y, Adachi M, Zhao X, Kawamura R, Imai K. 2004. Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl) aminomethyl]benzamide and m-carboxycinnamic acid bis-hydroxamide augment radiation-induced cell death in gastrointestinal adenocarcinoma cells. Int J Cancer 110:301-308.
    • (2004) Int J Cancer , vol.110 , pp. 301-308
    • Zhang, Y.1    Adachi, M.2    Zhao, X.3    Kawamura, R.4    Imai, K.5
  • 204
    • 0036965821 scopus 로고    scopus 로고
    • Zebularine: A novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases
    • Zhou L, Cheng X, Connolly BA, Dickman MJ, Hurd PJ, Hornby DP. 2002. Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. J Mol Biol 321:591-599.
    • (2002) J Mol Biol , vol.321 , pp. 591-599
    • Zhou, L.1    Cheng, X.2    Connolly, B.A.3    Dickman, M.J.4    Hurd, P.J.5    Hornby, D.P.6
  • 205
    • 0035866353 scopus 로고    scopus 로고
    • DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors
    • Zhu WG, Lakshmanan RR, Beal MD, Otterson GA. 2001. DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. Cancer Res 61:1327-1333.
    • (2001) Cancer Res , vol.61 , pp. 1327-1333
    • Zhu, W.G.1    Lakshmanan, R.R.2    Beal, M.D.3    Otterson, G.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.