The role of DNA methylation in setting up chromatin structure during development

Nature Genetics

Volumn 34, Issue 2, 2003, Pages 187-192

  Hashimshony, Tamar ^a   Zhang, Jianmin ^a   Keshet, Ilana ^a   Bustin, Michael ^b   Cedar, Howard ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DNA; HISTONE; LYSINE;

ANIMAL CELL; ARTICLE; CELL TYPE; CHROMATIN STRUCTURE; DEACETYLATION; DNA METHYLATION; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; GENOME; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; TRANSGENE;

ACETYLATION; ANIMALS; CHROMATIN; CPG ISLANDS; DNA METHYLATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLOBINS; HISTONES; HUMANS; LYSINE; METHYLATION; MICE; MICE, TRANSGENIC; MODELS, GENETIC; TRANSFECTION;

ANIMALIA;

EID: 0038243168     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1158     Document Type: Article

References (24)

1. Razin, A. CpG methylation, chromatin structure and gene silencing - a three-way connection. EMBO J. 17, 4905-4908 (1998).
2. Siegfried, Z. et al. DNA methylation represses transcription in vivo. Nat. Genet. 22, 203-206 (1999).
3. Kafri, T. et al. Developmental pattern of gene-specific DNA methylation in the mouse embryo and germline. Genes Dev. 6, 705-714 (1992).
4. Monk, M., Boubelik, M. & Lehnert, S. Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development 99, 371-382 (1987).
5. Brandeis, M. et al. Sp1 elements protect a CpG island from de novo methylation. Nature 371, 435-438 (1994).
6. Strahl, B.D. & Allis, C.D. The language of covalent histone modifications. Nature 403, 41-45 (2000).
7. Litt, M.D., Simpson, M., Gaszner, M., Allis, C.D. & Felsenfeld, G. Correlation between histone lysine methylation and developmental changes at the chicken β-globin locus. Science 293, 2453-2455 (2001).
8. Wolffe, A.P. Histone H1. Int. J. Biochem. Cell Biol. 29, 1463-1466 (1997).
9. Wolffe, A.P., Khochbin, S. & Dimitrov, S. What do linker histones do in chromatin? Bioessays 19, 249-255 (1997).
10. Renz, M. Preferential and cooperative binding of histone I to chromosomal mammalian DNA. Proc. Natl. Acad. Sci. USA 72, 733-736 (1975).
11. Misteli, T., Gunjan, A., Hock, R., Bustin, M. & Brown, D.T. Dynamic binding of histone H1 to chromatin in living cells. Nature 408, 877-881 (2000).
12. Cameron, E.E., Bachman, K.E., Myohanen, S., Herman, J.G. & Baylin, S.B. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat. Genet. 21, 103-107 (1999).
13. Nan, X. et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386-389 (1998).
14. Jones, P.L. et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat. Genet. 19, 187-191 (1998).
15. Fuks, F et al. The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J. Biol. Chem. (2002).
16. Wang, H. et al. Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol. Cell 8, 1207-1217 (2001).
17. Briggs, S.D. et al. Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes Dev. 15, 3286-3295 (2001).
18. Zegerman, P., Canas, B., Pappin, D. & Kouzarides, T. Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex. J. Biol. Chem. 277, 11621-11624 (2002).
19. Nishioka, K. et al. Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev. 16, 479-489 (2002).
20. Lallemand, Y., Luria, V., Haffner-Krausz, R. & Lonai, P. Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site specific recombinase. Transgenic Res. 7, 105-112 (1998).
21. Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427-1429 (1995).
22. Eden, S., Hashimshony, T., Keshet, I., Thorne, A.W. & Cedar, H. DNA methylation models histone acetylation. Nature 394, 842-843 (1998).
23. Bustin, M. Preparation and application of immunological probes for nucleosomes. Methods Enzymol. 170, 214-251 (1989).
24. Hebbes, T.R., Clayton, A.L., Thorne, A.W. & Crane-Robinson, C. Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken β-globin chromosomal domain. EMBO J. 13, 1823-1830 (1994).