Hypermethylation of XIAP-associated Factor 1, a Putative Tumor Suppressor Gene from the 17p13.2 Locus, in Human Gastric Adenocarcinomas

Cancer Research

Volumn 63, Issue 21, 2003, Pages 7068-7075

  Byun, Do Sun ^a,b   Cho, Kyucheol ^a   Ryu, Byung Kyu ^a   Lee, Min Goo ^a   Kang, Min Ju ^a   Kim, Hak Ryul ^b   Chi, Sung Gil ^a  

^a Kyung Hee University Hospital   (South Korea)

^b Korea University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; APOPTOSIS INHIBITOR; CASPASE; MITOCHONDRIAL PROTEIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SERINE PROTEINASE OMI; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS ASSOCIATED FACTOR 1;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GRADING; CANCER STAGING; CONTROLLED STUDY; CPG ISLAND; DNA SEQUENCE; ENZYME ACTIVITY; GENE EXPRESSION; GENE INACTIVATION; GENE LOCUS; GENE MUTATION; GENE SILENCING; GENETIC TRANSCRIPTION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; SOMATIC MUTATION; STOMACH ADENOCARCINOMA; STOMACH CARCINOGENESIS; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ALLELES; CARRIER PROTEINS; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 17; DNA METHYLATION; DOWN-REGULATION; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIAL PROTEINS; MUTATION; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SERINE ENDOPEPTIDASES; STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0242442595     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease. Science (Wash. DC), 267: 1456-1462, 1995.
2. Deveraux, Q. L., and Reed, J. C. IAP family proteins-suppressors of apoptosis. Genes Dev., 13: 239-252, 1999.
3. Miller, L. K. An exegesis of IAPs: salvation and surprises from BIR motifs. Trends Cell Biol., 9: 323-328, 1999.
4. Tamm, I., Wang, Y., Sausville, E., Scudiero, D. A., Vigna, N., Oltersdorf, T., and Reed, J. C. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res., 58: 5315-5320, 1998.
5. Sasaki, H., Sheng, Y., Kotsuji, F., and Tsang, B. K. Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res., 60: 5659-5666, 2000.
6. Deveraux, Q. L., Takahashi, R., Salvesen, G. S., and Reed, J. C. X-linked IAP is a direct inhibitor of cell-death proteases. Nature (Lond.), 388: 300-304, 1997.
7. Roy, N., Deveraux, Q. L., Takahashi, R., Salvesen, G. S., and Reed, J. C. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J., 16: 6914-6925, 1997.
8. Holcik, M., Gibson, H., and Korneluk, R. G. XIAP: apoptotic brake and promising therapeutic target. Apoptosis, 6: 253-261, 2001.
9. Holcik, M., and Korneluk, R. G. XIAP, the guardian angel. Nat. Rev. Mol. Cell. Biol., 2: 550-556, 2001.
10. Fong, W. G., Liston, P., Rajcan-Separovic, E., St. Jean, M., Craig, C., and Korneluk, R. G. Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines. Genomics, 70: 113-122, 2000.
11. Tamm, I., Kornblau, S. M., Segall, H., Krajewski, S., Welsh, K., Kitada, S., Scudiero, D. A., Tudor, G., Qui, Y. H., Monks, A., Andreeff, M., and Reed, J. C. Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin. Cancer Res., 6: 1796-1803, 2001.
12. Du, C., Fang, M., Li, Y., Li, L., and Wang, X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell, 102: 33-42, 2000.
13. Verhagen, A. M., Ekert, P. G., Pakusch, M., Silke, J., Connolly, L. M., Reid, G. E., Moritz, R. L., Simpson, R. J., and Vaux, D. L. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell, 102: 43-53, 2000.
14. Suzuki, Y., Imai, Y., Nakayama, H., Takahashi, K., Takio, K., and Takahashi, R. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol. Cell, 8: 613-621, 2001.
15. Wu, G., Chai, J., Suber, T. L., Wu, J. W., Du, C., Wang, X., and Shi, Y. Structural basis of IAP recognition by Smac/DIABLO. Nature (Lond.), 408: 1008-1012, 2000.
16. Liu, Z., Sun, C., Olejniczak, E. T., Meadows, R. P., Betz, S. F., Oost, T., Herrmann, J., Wu, J. C., and Fesik, S. W. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature (Lond.), 408: 1004-1008, 2000.
17. Liston, P., Fong, W. G., Kelly, N. L., Toji, S., Miyazaki, T., Conte, D., Tamai, K., Craig, C. G., McBurney, M. W., and Korneluk, R. G. Identification of XAF1 as an antagonist of XIAP anti-caspase activity. Nat. Cell Biol., 3: 128-133, 2001.
18. Fuchs, C. S., and Mayer, R. J. Gastric carcinoma. N. Engl. J. Med., 333: 32-41, 1995.
19. Werner, M., Becker, K. F., Keller, G., and Hofler, H. Gastric adenocarcinoma: pathomorphology and molecular pathology. J. Cancer Res. Clin. Oncol., 127: 207-216, 2001.
20. Yustein, A. S., Harper, J. C., Petroni, G. R., Cummings, O. W., Moskaluk, C. A., and Powell, S. M. Allelotype of gastric adenocarcinoma. Cancer Res., 59: 1437-1441, 1999.
21. Kim, J. H., Takahashi, T., Chiba, I., Park, J. G., Birrer, M. J., Roh, J. K., Lee, H., Kim, J. P., Minna, J. D., and Gazdar, A. F. Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines. J. Natl. Cancer Inst., 83: 938-943, 1991.
22. Yokozaki, H. Molecular characteristics of eight gastric cancer cell lines established in Japan. Pathol. Int., 50: 767-777, 2000.
23. Gardiner-Garden, M., and Frommer, M. CpG islands in vertebrate genomes. J. Mol. Biol., 196: 261-282, 1987.
24. Shen, L., Kondo, Y., Hamilton, S. R., Rashid, A., and Issa, J. P. P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53. Gastroenterology, 124: 626-633, 2003.
25. Nasr, A. F., Nutini, M., Palombo, B., Guerra, E., and Alberti, S. Mutations of TP53 induce loss of DNA methylation and amplification of the TROP1 gene. Oncogene, 22: 1668-1677, 2003.
26. Ehrlich, M., Jiang, G., Fiala, E., Dome, J. S., Yu, M. C., Long, T. I., Youn, B., Sohn, O. S., Widschwendter, M., Tomlinson, G. E., Chintagumpala, M., Champagne, M., Parham, D., Liang, G., Malik, K., and Laird, P. W. Hypomethylation and hypermethylation of DNA in Wilms tumors. Oncogene, 21: 6694-6702, 2002.
27. Takai, D., and Jones, P. A. Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc. Natl. Acad. Sci. USA, 99: 3740-3745, 2002.
28. Harada, K., Toyooka, S., Shivapurkar, N., Maitra, A., Reddy, J. L., Matta, H., Miyajima, K., Timmons, C. F., Tomlinson, G. E., Mastrangelo, D., Hay, R. J., Chaudhary, P. M., and Gazdar, A. F. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. Cancer Res., 62: 5897-5901, 2002.
29. Leaman, D. W., Chawla-Sarkar, M., Vyas, K., Reheman, M., Tamai, K., Toji, S., and Borden, E. C. Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis. J. Biol. Chem., 277: 28504-28511, 2002.
30. Shyu, R., Su, H., Yu, J., and Jiang, S. Direct growth suppressive activity of interferon-α and -γ on human gastric cancer cells. J. Surg. Oncol., 75: 122-130, 2000.
31. Kubota, T., Kase, S., Otani, Y., Watanabe, M., Teramoto, T., and Kitajima, M. Interferons α-2a and β increase the antitumor activity, detected by MTT assay, of 5-fluorouracil against experimental and clinical human gastrointestinal carcinomas. Anticancer Res., 17: 725-728, 1997.