5′ CpG island hypermethylation is associated with transcriptional silencing of the p21CIP1/WAF1/SD11 gene and confers poor prognosis in acute lymphoblastic leukemia

Blood

Volumn 99, Issue 7, 2002, Pages 2291-2296

  Roman Gomez, Jose ^a,b   Castillejo, Juan Antonio ^a,b   Jimenez, Antonio ^a,b   Gonzalez, Maria Gracia ^a,b   Moreno, Fernanda ^a,b   Del Carmen Rodriguez, Maria ^b   Barrios, Manuel ^a,b   Maldonado, Juan ^a,b   Torres, Antonio ^a,b  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P21; PROTEIN P53; PROTEIN P73; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; CYTIDYLYL 3' 5' GUANOSINE; CYTIDYLYL-3'-5'-GUANOSINE; DINUCLEOSIDE PHOSPHATE; ENZYME INHIBITOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CPG ISLAND; CYTOGENETICS; FEMALE; GENETIC TRANSCRIPTION; HUMAN; INFANT; LEUKEMOGENESIS; MAJOR CLINICAL STUDY; MALE; METHYLATION; MULTIVARIATE ANALYSIS; MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; TUMOR SUPPRESSOR GENE; ACUTE LYMPHOCYTIC LEUKEMIA; CHILD; DNA METHYLATION; GENE SILENCING; GENETICS; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; PRESCHOOL CHILD; RESTRICTION MAPPING; RETROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL RATE; TIME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DINUCLEOSIDE PHOSPHATES; DNA METHYLATION; ENZYME INHIBITORS; GENE SILENCING; HUMANS; INFANT; LEUKEMIA, LYMPHOCYTIC, ACUTE; MIDDLE AGED; PROGNOSIS; RESTRICTION MAPPING; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL RATE; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 0036525616     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.7.2291     Document Type: Article

References (40)

1. CDK inhibitors: Positive and negative regulators of G1 phase progression
2. Braking the cell cycle
3. Role of the cyclin-dependent kinase inhibitors in the development of cancer
4. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
5. kip1 cyclin-dependent kinase inhibitors during human hematopoiesis
6. Tumor suppression by p21WAF1
7. Relationships between G1 arrest and stability of the p53 and p21cip1/waf1 proteins following γ-irradiation of human lymphoma cells
8. Acute lymphoblastic leukemia
9. Clinical and biologic relevance of immunologic marker studies in childhood acute lymphoblastic leukemia
10. Post-transcriptional stabilization underlies p53-independent induction of p21 WAF1/CIP1/SDI1 in differentiating human leukemic cells
11. H-, K-and N-Ras inhibit myeloid leukemia cell proliferation by a p21WAF1-dependent mechanism
12. Proteasome inhibitors induced caspase-dependent apoptosis and accumulation of p21WAF1/CIP1 in human immature leukemic cells
13. DNA methylation
14. ABL1 methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia
15. Distinct patterns of inactivation of p151NK4b and p161NK4a characterize the major types of hematological malignancies
16. Methylation of the p15 (INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression
17. WAF1/CIP1 expression on tumor progression in bladder cancer
18. WAF1 genes are associated with aggressive variants of mantle cell lymphomas
19. (WAF1/CIP1) gene
20. Absence of WAF1 mutations in a variety of human malignancies
21. Hypermethylation of the calcitonin gene in acute lymphoblastic leukaemia is associated with unfavourable clinical outcome
22. Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia
23. Spanish acute lymphoblastic leukemia trials
24. Treatment of high-risk acute lymphoblastic leukemia: Preliminary results of the protocol PETHEMA ALL-93
25. Late intensification chemotherapy has not improved the results of intensive chemotherapy in adult acute lymphoblastic leukemia: Results of a prospective multicenter randomized trial (PETHEMA ALL-89)
26. Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate-risk acute lymphoblastic leukemia: Final results of the prospective randomized PETHEMA ALL-89 TRIAL
27. WAF1 promoter region
28. Diagnosis of acute promyelocytic leukemia by RT-PCR: Detection of PML-RARA and RARA-PML fusion transcripts
29. Prognostic relevance of ALL-1 gene rearrangement in infant acute leukemias
30. Consistent amounts of acute leukemia-associated p190BCR/ABL transcripts are expressed by chronic myelogenous leukemia patients at diagnosis
31. Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model
32. p53 mutations in human cancers
33. Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood
34. Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation
35. Mechanism for inactivation of the kip family cyclin-dependent kinase inhibitor genes in gastric cancer cells
36. WAF1
37. CpG island methylator phenotype in colorectal cancer
38. Methylation profiling in acute myeloid leukemia
39. Cell cycle regulatory gene abnormalities are important determinants of leukemogenesis and disease biology in adult acute lymphoblastic leukemia
40. Overall survival in aggressive B-cell lymphomas is dependent on the accumulation of alterations in p53, p16 and p27