Antineoplastic action of 5-aza-2′-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor β and estrogen receptor α genes in breast carcinoma cells

Cancer Chemotherapy and Pharmacology

Volumn 48, Issue 1, 2001, Pages 71-76

  Bovenzi, Veronica ^a   Momparler, Richard L ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

Author keywords

5 Aza 2 deoxycytidine; Breast cancer; DNA methylation; Estrogen receptor ; Retinoic acid receptor ; Trichostatin A

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ESTROGEN RECEPTOR ALPHA; HISTONE DEACETYLASE INHIBITOR; NUCLEOTIDE; PRIMER DNA; RETINOIC ACID RECEPTOR; RNA; TRICHOSTATIN A;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CHEMOTHERAPY; CARCINOMA CELL; CELL KILLING; CLONOGENIC ASSAY; CONTROLLED STUDY; DNA METHYLATION; DRUG EFFECT; DRUG POTENTIATION; GENE ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; METHYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; BREAST NEOPLASMS; ENZYME INHIBITORS; ESTROGEN RECEPTOR ALPHA; FEMALE; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; RECEPTORS, ESTROGEN; RECEPTORS, RETINOIC ACID; TUMOR CELLS, CULTURED;

EID: 0034917318     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800100294     Document Type: Article

References (38)

1. Specific protection of methylated CpGs in mammalian nuclei
2. Alterations in DNA methylation: A fundamental aspect of neoplasia
3. Methylation-induced repression-belts, braces, and chromatin
4. DNA methylation of retinoic acid receptor β in breast cancer and possible therapeutic role of 5-aza-2′-deoxycytidine
5. Chemotherapy of breast cancer with inhibitor of DNA methylation 5-aza-2′-deoxycytidine and histone deacetylation trichostatin A
6. Quantitation of the inhibition of DNA methylation of retinoic acid receptor β gene by 5-aza-2′-deoxycytidine in tumor cells using single nucleotide primer extension assay
7. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
8. Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene
9. Activation of the retinoic acid receptor β gene by 5-aza-2′-deoxycytidine in human DLD-1 colon carcinoma cells
10. Demethylation by 5-aza-2′-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor β gene in human colon carcinoma cells
11. Expression of estrogen receptor-α in human breast tumors
12. DNA methylation models histone acetylation
13. Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells
14. Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression
15. A direct link between core histone acetylation and transcriptionally active chromatin
16. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
17. Cancer epigenetics comes of age
18. Cellular differentiation, cytidine analogs and DNA methylation
19. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
20. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
21. Sin meets NuRD and other tails of repression
22. Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: A new approach to anti-leukemia therapy
23. Mapping of ER gene CpG island methylation by methylation-specific polymerase chain reaction
24. A positive role for histone acetylation in transcription factor access to nucleosomal DNA
25. DNA methylation and cancer
26. Induction of differentiation and inhibition of DNA methylation in HL-60 myeloid leukemic cells by 5-aza-2′-deoxycytidine
27. Pilot phase I-II study on 5-aza-2′-deoxycytidine (Decitabine) in patients with metastatic lung cancer
28. FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor
29. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
30. Phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia
31. Estrogen receptor gene analysis in estrogen receptor-positive and receptor-negative primary breast cancer
32. Hi-stone deacetylase inhibitors as potential anti-skin cancer agents
33. Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor β2 promoter in breast cancer cells
34. Down-regulation of retinoic acid receptor β in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells
35. Synergistic interaction of anti-cancer agents: A cellular perspective
36. Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase
37. Loss of retinoic acid receptor β expression in breast cancer and morphologically normal adjacent tissue but not in the normal breast tissue distant from the cancer
38. Inhibition of DNA methylation in L1210 leukemic cells by 5-aza-2′-deoxycytidine as a possible mechanism of chemotherapeutic action