Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggests a suppressor role in kidney, brain, and other human cancers

Cancer Research

Volumn 59, Issue 4, 1999, Pages 798-802

  Bachman, Kurtis E ^a,b   Herman, James G ^a   Corn, Paul G ^a   Merlo, Adrian ^c   Costello, Joseph F ^d   Cavenee, Webster K ^d   Baylin, Stephen B ^a   Graff, Jeremy R ^a,e  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF BASEL   (Switzerland)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

^e ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX METALLOPROTEINASE; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE;

ANGIOGENESIS; ARTICLE; CANCER INHIBITION; CANCER INVASION; CONTROLLED STUDY; DISEASE MARKER; ENZYME ACTIVITY; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KIDNEY CANCER; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AZACITIDINE; BRAIN NEOPLASMS; CPG ISLANDS; DNA METHYLATION; HUMANS; KIDNEY NEOPLASMS; TISSUE INHIBITOR OF METALLOPROTEINASE-3;

EID: 0033558192     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Chambers, A. F., and Matrisian, L. M. Changing views of the role of matrix metalloproteinases in metastasis. J. Natl. Cancer Inst., 89, 1260-1270, 1997.
2. Gomez, D. E., Alonso, D. F., Yoshiji, H., and Thorgeirsson, U. P. Tissue inhibitors of metalloproteinases: structure, regulation and biological functions. Eur. J. Cell Biol., 74: 111-122, 1997.
3. Wang, M., Liu, Y. E., Greene, J., Sheng, S., Fuchs, A., Rosen, E. M., and Shi, Y. E. Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4. Oncogene, 14: 2767-2774, 1997.
4. DeClerck, Y. A., Perez, N., Shimada, H., Boone, T. C., Langley, K. E., and Taylor, S. M. Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases. Cancer Res., 52: 701-708, 1992.
5. Mohanam, S., Wang, S. W., Rayford, A., Yamamoto, M., Sawaya, R., Nakajima, M., Liotta, L. A., Nicolson, G. L., Stetler-Stevenson, W. G., and Rao, J. S. Expression of tissue inhibitors of metalloproteinases: negative regulators of human glioblastoma invasion in vivo. Clin. Exp. Metastasis, 13: 57-62, 1995.
6. Ahonen, M., Baker, A. H., and Kahari, V. M. Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells. Cancer Res., 58: 2310-2315, 1998.
7. Airola, K., Ahonen, M., Johansson, N., Heikkila, P., Kere, J., Kahari, V. M., and Saarialho-Kere, U. K. Human TIMP-3 is expressed during fetal development, hair growth cycle, and cancer progression. J. Histochem. Cytochem., 46: 437-447, 1998.
8. Anand-Apte, B., Pepper, M. S., Voest, E., Montesano, R., Olsen, B., Murphy, G., Apte, S. S., and Zetter, B. Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3. Invest. Ophthalmol. Vis. Sci., 38: 817-823, 1997.
9. Anand-Apte, B., Bao, L., Smith, R., Iwata, K., Olsen, B. R., Zetter, B., and Apte, S. S. A review of tissue inhibitor of metalloproteinases-3 (TIMP-3) and experimental analysis of its effect on primary tumor growth. Biochem. Cell Biol., 74: 853-862, 1996.
10. Bian, J., Wang, Y., Smith, M. R., Kim, H., Jacobs, C., Jackman, J., Kung, H. F., Colburn, N. H., and Sun, Y. Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3. Carcinogenesis (Lond.), 17: 1805-1811, 1996.
11. Powe, D. G., Brough, J. L., Carter, G. I., Bailey, E. M., Stetler-Stevenson, W. G., Turner, D. R., and Hewitt, R. E. TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma. Br. J. Cancer, 75: 1678-1683, 1997.
12. Sun, Y., Hegamyer, G., Kim, H., Sithanandam, K., Li, H., Watts, R., and Colburn, N. H. Molecular cloning of mouse tissue inhibitor of metalloproteinases-3 and its promoter. Specific lack of expression in neoplastic JB6 cells may reflect altered gene methylation. J. Biol. Chem., 270: 19312-19319, 1995.
13. Graff, J. R., Herman, J. G., Lapidus, R. G., Chopra, H., Xu, R., Jarrard, D. F., Issacs, W. B., Pitha, P. M., Davidson, N. E., and Baylin, S. B. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res., 55: 5195-5199, 1995.
14. Herman, J. G., Graff, J. R., Myohanen, S., Nelkin, B. D., and Baylin, S. B. Methylation-specific PCR. A novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA, 93: 9821-9826, 1996.
15. Graff, J. R., De Benedetti, A., Olsen, J. W., Tamez, P., Casero, R. A., Jr., and Zimmer, S. G. Translation of ODC mRNA and polyamine transport are suppressed in ras-transformed CREF cells by depleting translation initiation factor 4E. Biochem. Biophys. Res Commun., 240: 15-20, 1997.
16. Herman, J. G., Merlo, A., Mao, L., Lapidus, R. G., Issa, J. P., Davidson, N. E., Sidransky, D., and Baylin, S. B. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res., 55: 4525-4530, 1995.
17. Wong, H., Anderson, W. D., Cheng, T., and Riabowol, K. T. Monitoring mRNA expression by polymerase chain reaction: the "primer-dropping" method. Anal. Biochem., 223: 251-258, 1994.
18. Wick, M., Haronen, R., Mumberg, D., Burger, C., Olsen, B. R., Budarf, M. L., Apte, S. S., and Muller, R. Structure of the human TIMP-3 gene and its cell cycle-regulated promoter. Biochem J., 311: 549-554, 1995.
19. Graff, J. R., Greenberg, V. E., Herman, J. G., Westra, W. H., Boghaert, E. R., Ain, K. B., Saji, M., Zeiger, M. A., Zimmer, S. G., and Baylin, S. B. Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma. Cancer Res., 58: 2063-2066, 1998.
20. 0 6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res., 59: 793-797, 1999.
21. McElligott, A. M., Baker, A. H., and McGlynn, H. Matrix metalloproteinase and tissue inhibitor of metalloproteinase regulation of the invasive potential of a metastatic renal cell line. Biochem. Soc. Trans., 25: 147S, 1997.
22. Andreu, T., Beckers, T., Thoenes, E., Hilgard, P., and von Melchner, H. Gene trapping identifies inhibitors of oncogenic transformation. The tissue inhibitor of metalloproteinases-3 (timp3) and collagen type 1 α2 (colla2) are epidermal growth factor-regulated growth repressors. J. Biol. Chem., 273: 13848-13854, 1998.
23. Rasheed, B. K. A., and Bigner, S. H. Genetic alterations in glioma and medulloblastoma. Cancer Metastasis Rev., 10: 289-299, 1991.
24. Eble, J. N. Diseases of the urogenital and reproductive systems. In: I. Damjanov and J. Linder (eds.), Anderson's Pathology, pp. 2138-2142. St. Louis, MO: Mosby, 1996.