Generating mutations but providing chemosensitivity: The role of O 6-methylguanine DNA methyltransferase in human cancer

Oncogene

Volumn 23, Issue 1, 2004, Pages 1-8

  Esteller, Manel ^a   Herman, James G ^b  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Alkylating agents; CpG island hypermethylation; MGMT; O6 methylguanine DNA methyltransferase; Transition mutations

Indexed keywords

ALKYLATING AGENT; CARCINOGEN; CARMUSTINE; CYCLOPHOSPHAMIDE; DNA POLYMERASE; ENZYME INHIBITOR; K RAS PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLNITROSOUREA; MUTAGENIC AGENT; NIMUSTINE; O 6 BENZYLGUANINE; PROCARBAZINE; PROTEIN BAX; PROTEIN P53; STREPTOZOCIN; TEMOZOLOMIDE; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

BODY FLUID; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RESEARCH; CARCINOGENESIS; CHROMATIN; COLON CANCER; COLORECTAL CANCER; CPG ISLAND; DEMETHYLATION; DNA REPAIR; DNA SYNTHESIS; ENZYME ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE OVEREXPRESSION; GENE SILENCING; GENOMICS; GLIOMA; HEAD AND NECK CANCER; HUMAN; LUNG NON SMALL CELL CANCER; LYMPHOMA; METHYLATION; MISMATCH REPAIR; ONCOGENE; ONCOGENE K RAS; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; TUMOR CELL CULTURE; TUMOR SUPPRESSOR GENE;

ANTINEOPLASTIC AGENTS, ALKYLATING; DNA METHYLATION; GENE SILENCING; HUMANS; MUTATION; NEOPLASMS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROMOTER REGIONS (GENETICS);

EID: 0942279488     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207316     Document Type: Review

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