메뉴 건너뛰기




Volumn 18, Issue 11, 1998, Pages 6457-6473

The human ARF cell cycle regulatory gene promoter is a CPG island which can be silenced by DNA methylation and down-regulated by wild-type p53

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; TRANSCRIPTION FACTOR SP1;

EID: 0031771497     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.11.6457     Document Type: Article
Times cited : (334)

References (78)
  • 1
    • 0027459198 scopus 로고
    • Mdm2 expression is induced by wild type p53 activity
    • Barak, Y., T. Juven, R. Haffner, and M. Oren. 1993. Mdm2 expression is induced by wild type p53 activity. EMBO J. 12:461-468.
    • (1993) EMBO J. , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 2
    • 0031964055 scopus 로고    scopus 로고
    • Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines
    • Bender, C. M., M. M. Pao, and P. A. Jones. 1998. Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res. 58:95-101.
    • (1998) Cancer Res. , vol.58 , pp. 95-101
    • Bender, C.M.1    Pao, M.M.2    Jones, P.A.3
  • 3
    • 0022540321 scopus 로고
    • CpG-Rich islands and the function of DNA methylation
    • Bird, A. 1986. CpG-Rich islands and the function of DNA methylation. Nature 321:209-213.
    • (1986) Nature , vol.321 , pp. 209-213
    • Bird, A.1
  • 5
    • 0025808136 scopus 로고
    • The initiator directs the assembly of a transcription factor IID-dependent transcription complex
    • Carcamo, J., L. Buckbinder, and D. Reinberg. 1991. The initiator directs the assembly of a transcription factor IID-dependent transcription complex. Proc. Natl. Acad. Sci. USA 88:8052-8056.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8052-8056
    • Carcamo, J.1    Buckbinder, L.2    Reinberg, D.3
  • 6
    • 0026555717 scopus 로고
    • Modulation of activity of the promoter of the human MDR1 gene by ras and p53
    • Chin, K.-V., K. Ueda, I. Pastan, and M. M. Gottesman. 1992. Modulation of activity of the promoter of the human MDR1 gene by ras and p53. Nature 255:459-462.
    • (1992) Nature , vol.255 , pp. 459-462
    • Chin, K.-V.1    Ueda, K.2    Pastan, I.3    Gottesman, M.M.4
  • 7
    • 0024973729 scopus 로고
    • Role of transcriptional interference in the Drosophila melanogaster Adh promoter switch
    • Corbin, V., and T. Maniatis. 1989. Role of transcriptional interference in the Drosophila melanogaster Adh promoter switch. Nature 337:279-282.
    • (1989) Nature , vol.337 , pp. 279-282
    • Corbin, V.1    Maniatis, T.2
  • 8
    • 0028131554 scopus 로고
    • Transcriptional activation by p53 correlates with suppression of growth but not transformation
    • Crook, T., N. J. Marston, E. A. Sara, and K. H. Vousden. 1994. Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell 79:817-827.
    • (1994) Cell , vol.79 , pp. 817-827
    • Crook, T.1    Marston, N.J.2    Sara, E.A.3    Vousden, K.H.4
  • 10
    • 0028218938 scopus 로고
    • Parental imprinting of autosomal mammalian genes
    • Efstratiadis, A. 1994. Parental imprinting of autosomal mammalian genes. Curr. Opin. Genet. Dev. 4:265-280.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 265-280
    • Efstratiadis, A.1
  • 12
    • 0023216891 scopus 로고
    • CpG islands in vertebrate genomes
    • Gardiner-Garden, M., and M. Frommer. 1987. CpG islands in vertebrate genomes. J. Mol. Biol. 196:261-282.
    • (1987) J. Mol. Biol. , vol.196 , pp. 261-282
    • Gardiner-Garden, M.1    Frommer, M.2
  • 13
    • 0025887476 scopus 로고
    • Wild-type p53 can down-regulate the activity of various promoters
    • Ginsberg, D., F. Mechta, M. Yaniv, and M. Oren. 1991. Wild-type p53 can down-regulate the activity of various promoters. Proc. Natl. Acad. Sci. USA 88:9979-9983.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 9979-9983
    • Ginsberg, D.1    Mechta, F.2    Yaniv, M.3    Oren, M.4
  • 14
    • 0028875205 scopus 로고
    • Methylation of the CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
    • Gonzalez-Zulueta, M., C. M. Bender, A. S. Yang, T.-D. Nguyen, R. W. Beart, J. M. VanTornout, and P. A. Jones. 1995. Methylation of the CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res. 55: 4531-4535.
    • (1995) Cancer Res. , vol.55 , pp. 4531-4535
    • Gonzalez-Zulueta, M.1    Bender, C.M.2    Yang, A.S.3    Nguyen, T.-D.4    Beart, R.W.5    VanTornout, J.M.6    Jones, P.A.7
  • 16
    • 0030778842 scopus 로고    scopus 로고
    • ARF
    • ARF. Cell 91:555-558.
    • (1997) Cell , vol.91 , pp. 555-558
    • Haber, D.A.1
  • 17
    • 0029921317 scopus 로고    scopus 로고
    • Genetic alterations of cyclins, cyclin-dependent kinases, and cdk inhibitors in human cancer
    • Hall, M., and G. Peters. 1996. Genetic alterations of cyclins, cyclin-dependent kinases, and cdk inhibitors in human cancer. Adv. Cancer Res. 68:67-108.
    • (1996) Adv. Cancer Res. , vol.68 , pp. 67-108
    • Hall, M.1    Peters, G.2
  • 19
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt, Y., R. Maya, A. Kazaz, and M. Oren. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387:296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 21
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman, J. G., A. Merlo, L. Mao, R. G. Lapidus, J. P. Issa, N. E. Davidson, D. Sidransky, and S. B. Baylin. 1995. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res. 55:4525-4530.
    • (1995) Cancer Res. , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.P.5    Davidson, N.E.6    Sidransky, D.7    Baylin, S.B.8
  • 24
    • 0023974472 scopus 로고
    • Trans-acting protein factors and the regulation of eukaryotic transcription: Lessons from studies on DNA tumor viruses
    • Jones, N. C., P. W. Rigby, and E. B. Ziff. 1988. Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses. Genes Dev. 2:267-281.
    • (1988) Genes Dev. , vol.2 , pp. 267-281
    • Jones, N.C.1    Rigby, P.W.2    Ziff, E.B.3
  • 29
    • 0029972806 scopus 로고    scopus 로고
    • P53: Puzzle and paradigm
    • Ko, L. J., and C. Prives. 1996. p53: Puzzle and paradigm. Genes Dev. 10: 1054-1072.
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 30
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by mdm2
    • Kubbutat, M. H. G., S. N. Jones, and K. H. Vousden. 1997. Regulation of p53 stability by mdm2. Nature 387:299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.G.1    Jones, S.N.2    Vousden, K.H.3
  • 31
    • 0029664483 scopus 로고    scopus 로고
    • INK4a: A gene with a dual capacity to encode unrelated proteins that inhibit cell cycle progression
    • INK4a: a gene with a dual capacity to encode unrelated proteins that inhibit cell cycle progression. Oncogene 12:2041-2044.
    • (1996) Oncogene , vol.12 , pp. 2041-2044
    • Larsen, C.-J.1
  • 32
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 33
    • 9544251503 scopus 로고    scopus 로고
    • P16 and p16β are potent growth suppressors of head and neck squamous carcinoma cells in vitro
    • Liggett, W. H., D. A. Sewell, J. Rocco, S. A. Ahrendt, W. Koch, and D. Sidransky. 1996. p16 and p16β are potent growth suppressors of head and neck squamous carcinoma cells in vitro. Cancer Res. 56:4119-4123.
    • (1996) Cancer Res. , vol.56 , pp. 4119-4123
    • Liggett, W.H.1    Sewell, D.A.2    Rocco, J.3    Ahrendt, S.A.4    Koch, W.5    Sidransky, D.6
  • 34
    • 0027318117 scopus 로고
    • Specific repression of TATA-mediated but not initiator-mediated transcription repression by wild-type p53
    • Mack, D. H., J. Vartikar, J. M. Pipas, and L. A. Laimins. 1993. Specific repression of TATA-mediated but not initiator-mediated transcription repression by wild-type p53. Nature 363:281-283.
    • (1993) Nature , vol.363 , pp. 281-283
    • Mack, D.H.1    Vartikar, J.2    Pipas, J.M.3    Laimins, L.A.4
  • 35
    • 0027960055 scopus 로고
    • Sp1 sites in the mouse Aprt gene promoter are required to prevent methylation of the CpG island
    • Macleod, D., J. Charlton, J. Mullins, and A. P. Bird. 1994. Sp1 sites in the mouse Aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev. 8:2282-2292.
    • (1994) Genes Dev. , vol.8 , pp. 2282-2292
    • Macleod, D.1    Charlton, J.2    Mullins, J.3    Bird, A.P.4
  • 37
    • 0025034666 scopus 로고
    • Transcriptional initiation from the dihydrofolate reductase promoter is positioned by HIP-1 binding at the initiation site
    • Means, A. L., and P. J. Farnham. 1990. Transcriptional initiation from the dihydrofolate reductase promoter is positioned by HIP-1 binding at the initiation site. Mol. Cell. Biol 10:653-661.
    • (1990) Mol. Cell. Biol , vol.10 , pp. 653-661
    • Means, A.L.1    Farnham, P.J.2
  • 38
    • 0026065497 scopus 로고
    • Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression
    • Mercer, W. E., M. T. Shields, D. Lin, E. Appella, and S. J. Ullrich. 1991. Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression. Proc. Natl. Acad. Sci. USA 88:1958-1962.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 1958-1962
    • Mercer, W.E.1    Shields, M.T.2    Lin, D.3    Appella, E.4    Ullrich, S.J.5
  • 39
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo, A., J. G. Herman, L. Mao, D. J. Lee, E. Gabrielson, P. C. Burger, S. B. Baylin, and D. Sidransky. 1995. 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med. 1:686-692.
    • (1995) Nat. Med. , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 40
    • 0027408679 scopus 로고
    • DNA tumor virus transforming proteins and the cell cycle
    • Moran, E. 1993. DNA tumor virus transforming proteins and the cell cycle. Curr. Opin. Genet. Dev. 3:63-70.
    • (1993) Curr. Opin. Genet. Dev. , vol.3 , pp. 63-70
    • Moran, E.1
  • 41
    • 0028204160 scopus 로고
    • DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways
    • Nelson, W. G., and M. B. Kastan. 1994. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14:1815-1823.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1815-1823
    • Nelson, W.G.1    Kastan, M.B.2
  • 42
    • 0026740449 scopus 로고
    • Amplification of a gene encoding a p53-associated protein in human sarcomas
    • Oliner, J. D., K. W. Kinzler, P. S. Meltzer, D. L. George, and B. Vogelstein. 1992. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358:80-83.
    • (1992) Nature , vol.358 , pp. 80-83
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 44
    • 0028869884 scopus 로고
    • Lack of cyclin D-cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumor suppressor gene product
    • Parry, D., S. Bates, D. J. Mann, and G. Peters. 1995. Lack of cyclin D-cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumor suppressor gene product. EMBO J. 14:503-511.
    • (1995) EMBO J. , vol.14 , pp. 503-511
    • Parry, D.1    Bates, S.2    Mann, D.J.3    Peters, G.4
  • 45
    • 0027447696 scopus 로고
    • Tumor-suppressor p53 and the cell cycle
    • Perry, M. E., and A. J. Levine. 1993. Tumor-suppressor p53 and the cell cycle. Curr. Opin. Genet. Dev. 3:50-54.
    • (1993) Curr. Opin. Genet. Dev. , vol.3 , pp. 50-54
    • Perry, M.E.1    Levine, A.J.2
  • 47
    • 0029811984 scopus 로고    scopus 로고
    • Genetic determinants of p53-induced apoptosis and growth arrest
    • Polyak, K., T. Waldman, T.-C. He, K. W. Kinzler, and B. Vogelstein. 1996. Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev. 10:1945-1952.
    • (1996) Genes Dev. , vol.10 , pp. 1945-1952
    • Polyak, K.1    Waldman, T.2    He, T.-C.3    Kinzler, K.W.4    Vogelstein, B.5
  • 49
    • 0022533498 scopus 로고
    • Transcriptional interference and termination between duplicated α-globin gene constructs suggests a novel mechanism for gene regulation
    • Proudfoot, N. J. 1986. Transcriptional interference and termination between duplicated α-globin gene constructs suggests a novel mechanism for gene regulation. Nature 322:562-565.
    • (1986) Nature , vol.322 , pp. 562-565
    • Proudfoot, N.J.1
  • 50
    • 0031060288 scopus 로고    scopus 로고
    • Regulation of EBNA gene transcription in lymphoblastoid cell lines: Characterization of sequences downstream of BCR2 (Cp)
    • Puglielli, M. T., N. Desai, and S. H. Speck. 1997. Regulation of EBNA gene transcription in lymphoblastoid cell lines: characterization of sequences downstream of BCR2 (Cp). J. Virol. 71:120-128.
    • (1997) J. Virol. , vol.71 , pp. 120-128
    • Puglielli, M.T.1    Desai, N.2    Speck, S.H.3
  • 52
    • 0029587551 scopus 로고
    • Alternative reading frames of the INKAa tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
    • Quelle, D. E., F. Zindy, R. A. Ashmun, and C. J. Sherr. 1995. Alternative reading frames of the INKAa tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83:993-1000.
    • (1995) Cell , vol.83 , pp. 993-1000
    • Quelle, D.E.1    Zindy, F.2    Ashmun, R.A.3    Sherr, C.J.4
  • 53
    • 0017173272 scopus 로고
    • Mechanism of DNA synthesis inhibition by arabinosyl cytosine and arabinosyl adenine
    • Rashbaum, S. A., and N. R. Cozzarelli. 1976. Mechanism of DNA synthesis inhibition by arabinosyl cytosine and arabinosyl adenine. Nature 264:679.
    • (1976) Nature , vol.264 , pp. 679
    • Rashbaum, S.A.1    Cozzarelli, N.R.2
  • 54
    • 0021228029 scopus 로고
    • Growth regulation of a cellular tumor antigen. p53, in nontransformed cells
    • Reich, N. C., and A. J. Levine. 1984. Growth regulation of a cellular tumor antigen. p53, in nontransformed cells. Nature 308:199-201.
    • (1984) Nature , vol.308 , pp. 199-201
    • Reich, N.C.1    Levine, A.J.2
  • 55
    • 0030860852 scopus 로고    scopus 로고
    • Mapping promoter regions that are hypersensitive to methylation-mediated inhibition of transcription: Application of the methylation cassette assay to the Epstein-Barr virus major latency promoter
    • Robertson, K. D., and R. F. Ambinder. 1997. Mapping promoter regions that are hypersensitive to methylation-mediated inhibition of transcription: application of the methylation cassette assay to the Epstein-Barr virus major latency promoter. J. Virol. 71:6445-6454.
    • (1997) J. Virol. , vol.71 , pp. 6445-6454
    • Robertson, K.D.1    Ambinder, R.F.2
  • 56
    • 0028840682 scopus 로고
    • Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: Evidence that demethylation at a single CpG site is crucial
    • Robertson, K. D., S. D. Hayward, P. D. Ling, D. Samid, and R. F. Ambinder. 1995. Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial. Mol. Cell. Biol. 15:6150-6159.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6150-6159
    • Robertson, K.D.1    Hayward, S.D.2    Ling, P.D.3    Samid, D.4    Ambinder, R.F.5
  • 58
    • 0025775929 scopus 로고
    • Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product
    • Santhanam, U., A. Ray, and P. B. Sehgal. 1991. Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product. Proc. Natl. Acad. Sci. USA 88:7605-7609.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7605-7609
    • Santhanam, U.1    Ray, A.2    Sehgal, P.B.3
  • 60
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano, M., G. J. Hannon, and D. Beach. 1993. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 63
    • 0009573792 scopus 로고    scopus 로고
    • Human p16β encodes a novel 14 kD protein and suppresses growth in vitro independently from pRb
    • Sewell, D. A., W. H. Liggett, Jr., W. G. Yarbrough, and D. Sidransky. 1997. Human p16β encodes a novel 14 kD protein and suppresses growth in vitro independently from pRb. Proc. Am. Assoc Cancer Res. 38:80.
    • (1997) Proc. Am. Assoc Cancer Res. , vol.38 , pp. 80
    • Sewell, D.A.1    Liggett Jr., W.H.2    Yarbrough, W.G.3    Sidransky, D.4
  • 64
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr, C. J. 1996. Cancer cell cycles. Science 276:1672-1677.
    • (1996) Science , vol.276 , pp. 1672-1677
    • Sherr, C.J.1
  • 66
    • 0028639172 scopus 로고
    • An analysis of genes regulated by the multi-functional transcriptional regulator Yin Yang-1
    • Shrivastava, A., and K. Calame. 1994. An analysis of genes regulated by the multi-functional transcriptional regulator Yin Yang-1. Nucleic Acids Res. 22:5151-5155.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 5151-5155
    • Shrivastava, A.1    Calame, K.2
  • 67
    • 0024557039 scopus 로고
    • The "initiator" as a transcriptional control element
    • Smale, S. T., and D. Baltimore. 1989. The "initiator" as a transcriptional control element. Cell 57:103-113.
    • (1989) Cell , vol.57 , pp. 103-113
    • Smale, S.T.1    Baltimore, D.2
  • 69
    • 0026642078 scopus 로고
    • Inhibition of viral and cellular promoters by human wild-type p53
    • Subler, M. A., D. W. Martin, and S. Deb. 1992. Inhibition of viral and cellular promoters by human wild-type p53. J. Virol. 66:4757-4762.
    • (1992) J. Virol. , vol.66 , pp. 4757-4762
    • Subler, M.A.1    Martin, D.W.2    Deb, S.3
  • 71
    • 0031035027 scopus 로고    scopus 로고
    • Multiple types of aberrations in the p16(INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines
    • Tanaka, H., Y. Shimada, M. Imamura, I. Shabagaki, and K. Ishizaki. 1997. Multiple types of aberrations in the p16(INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines. Int. J. Cancer 70:437-442.
    • (1997) Int. J. Cancer , vol.70 , pp. 437-442
    • Tanaka, H.1    Shimada, Y.2    Imamura, M.3    Shabagaki, I.4    Ishizaki, K.5
  • 73
    • 0024573893 scopus 로고
    • Characterization of the human p53 gene promoter
    • Tuck, S. P., and L. Crawford. 1989. Characterization of the human p53 gene promoter. Mol. Cell. Biol. 9:2163-2172.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 2163-2172
    • Tuck, S.P.1    Crawford, L.2
  • 74
    • 0024574584 scopus 로고
    • Promoter occlusion prevents transcription of Adenovirus polypeptide IX mRNA until after DNA replication
    • Vales, L. D., and J. E. Darnell. 1989. Promoter occlusion prevents transcription of Adenovirus polypeptide IX mRNA until after DNA replication. Genes Dev. 3:49-59.
    • (1989) Genes Dev. , vol.3 , pp. 49-59
    • Vales, L.D.1    Darnell, J.E.2
  • 75
    • 0025186517 scopus 로고
    • Negative regulation of the human ε-globin gene by transcriptional interference: Role of an Alu repetitive element
    • Wu, J., G. J. Grindlay, P. Bushel, L. Mendelsohn, and M. Allan. 1990. Negative regulation of the human ε-globin gene by transcriptional interference: role of an Alu repetitive element. Mol. Cell. Biol. 10:1209-1216.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 1209-1216
    • Wu, J.1    Grindlay, G.J.2    Bushel, P.3    Mendelsohn, L.4    Allan, M.5
  • 76
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulatory feedback loop
    • Wu, X., J. H. Bayle, D. Olsen, and A. J. Levine. 1993. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 7:1126-1132.
    • (1993) Genes Dev. , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olsen, D.3    Levine, A.J.4
  • 77
    • 0031023518 scopus 로고    scopus 로고
    • Transcriptional regulation of the human PAX6 gene promoter
    • Xu, Z.-P., and G. F. Saunders. 1997. Transcriptional regulation of the human PAX6 gene promoter. J. Biol. Chem. 272:3430-3436.
    • (1997) J. Biol. Chem. , vol.272 , pp. 3430-3436
    • Xu, Z.-P.1    Saunders, G.F.2
  • 78
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang, Y., Y. Xiong, and W. G. Yarbrough. 1998. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92:725-734.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.