Heat shock genes - Integrating cell survival and death

Journal of Biosciences

Volumn 32, Issue 3, 2007, Pages 595-610

  Arya, Richa ^a   Mallik, Moushami ^a   Lakhotia, Subhash C ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Caspases; Hsp27; Hsp60; Hsp70; Hsp90; hsr omega

Indexed keywords

APOPTOSOME; CARRIER PROTEIN; CASPASE; CASPASE 3; CASPASE 8; CRYSTALLIN; CYTOCHROME C; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROCASPASE 3; PROTEIN BAX; PROTEIN KINASE B; RECEPTOR INTERACTING PROTEIN; RNA BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

APOPTOSIS; CYTOCHROME; FLY; GENE; GENE EXPRESSION; HEAT SHOCK; INHIBITION; MITOCHONDRION; PROTEIN; RNA;

APOPTOSIS; CELL DAMAGE; CELL DEATH; CELL REGENERATION; CELL STRESS; CELL SURVIVAL; DROSOPHILA MELANOGASTER; ENZYME INHIBITION; ENZYME REGULATION; GENE EXPRESSION; HEAT SHOCK RESPONSE; MITOCHONDRION; NONHUMAN; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN SECRETION; REVIEW; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL SURVIVAL; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS;

DROSOPHILA MELANOGASTER;

EID: 34248176724     PISSN: 02505991     EISSN: 02505991     Source Type: Journal    
DOI: 10.1007/s12038-007-0059-3     Document Type: Review

References (130)

1. Alge C S, Priglinger S G, Neubauer A S, Kampik A, Zillig M, Bloemendal H and Welge-Lussen U 2002 Retinal pigment epithelium is protected against apoptosis by alphaB-crystallin; Invest. Ophthalmol. Vis.Sci.43 3575-3582
2. Arya R and Lakhotia S C 2006 A simple nail polish imprint technique for examination of external morphology of Drosophila eyes; Curr. Sci. 90 1179-1180
3. Basso A D, Solit D B, Chiosis G, Giri B, Tsichlis P and Rosen N 2002 Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function; J. Biol. Chem. 277 39858-39866
4. Beere H M 2001 Stressed to death: regulation of apoptotic signaling pathways by the heat shock proteins; Sci. STKE 2001 RE1
5. Beere H M 2005 Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways; J. Clin. Invest. 115 2633-2639
6. Beere H M, Wolf B B, Cain K, Mosser D D, Mahboubi A, Kuwana T, Tailor P, Morimoto R I, Cohen G M and Green D R 2000 Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome; Nat. Cell Biol. 2 469-475
7. Boellmann F, Guettouche T, Guo Y, Fenna M, Mnayer L and Voellmy R 2004 DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity; Proc Natl Acad Sci USA 101 4100-4105
8. Brand A H and Perrimon N 1993 Targeted gene expression as a means of altering cell fates and generating dominant phenotypes; Development 118 401-415
9. Bruey J M, Ducasse C, Bonniaud P, Ravagnan L, Susin S A, Diaz-Latoud C, Gurbuxani S, Arrigo A P, Kroemer G, Solary E and Garrido C 2000 Hsp27 negatively regulates cell death by interacting with cytochrome c; Nat. Cell Biol. 2 645-652
10. Budihardjo I, Oliver H, Lutter M, Luo X and Wang X 1999 Biochemical pathways of caspase activation during apoptosis; Annu. Rev. Cell Dev. Biol. 15 269-290
11. Chang H Y, Nishitoh H, Yang X, Ichijo H and Baltimore D 1998 Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx; Science 281 1860-1863
12. Charette S J, Lavoie J N, Lambert H and Landry J 2000 Inhibition of Daxx-mediated apoptosis by heat shock protein 27; Mol. Cell Biol. 20 7602-7612
13. Charroux B, Angelats C, Fasano L, Kerridge S and Vola C 1999 The levels of the bancal product, a Drosophila homologue of vertebrate hnRNP K protein, affect cell proliferation and apoptosis in imaginal disc cells; Mol. Cell. Biol. 19 7846-7856
14. Chen G, Cao P and Goeddel D V 2002 TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90; Mol. Cell 9 401-410
15. Chen Z J, Parent L and Maniatis T 1996 Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity; Cell 84 853-862
16. Concannon C G, Gorman A M and Samali A 2003 On the role of Hsp27 in regulating apoptosis; Apoptosis 8 61-70
17. Concannon C G, Orrenius S and Samali A 2001 Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c; Gene Expr. 9 195-201
18. Csermely P 2004 Strong links are important, but weak links stabilize them; Trends Biochem. Sci. 29 331-334
19. Deveraux Q L and Reed J C 1999 IAP family proteins - suppressors of apoptosis; Genes Dev. 13 239-252
20. Devin A, Cook A, Lin Y, Rodriguez Y, Kelliher M and Liu Z 2000 The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation; Immunity 12 419-429
21. Didelot C, Schmitt E, Brunet M, Maingret L, Parcellier A and Garrido C 2006 Heat shock proteins: endogenous modulators of apoptotic cell death; Handb. Exp. Pharmacol. 171-198
22. DiDonato J A, Hayakawa M, Rothwarf D M, Zandi E and Karin M 1997 A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB; Nature (London) 388 548-554
23. Eddy S R 2001 Non-coding RNA genes and the modern RNA world; Nat. Rev. Genet. 2 919-929
24. Faber P W, Alter J R, MacDonald M E and Hart A C 1999 Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron; Proc. Natl. Acad. Sci. USA 96 179-184
25. Faried A, Sohda M, Nakajima M, Miyazaki T, Kato H and Kuwano H 2004 Expression of heat-shock protein Hsp60 correlated with the apoptotic index and patient prognosis in human oesophageal squamous cell carcinoma; Eur. J. Cancer 40 2804-2811
26. Fink A L 1999 Chaperone-mediated protein folding; Physiol. Rev. 79 425-449
27. Gabai V L, Mabuchi K, Mosser D D and Sherman M Y 2002 Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis; Mol. Cell. Biol. 22 3415-3424
28. Garrido C, Gurbuxani S, Ravagnan L and Kroemer G 2001 Heat shock proteins: endogenous modulators of apoptotic cell death; Biochem. Biophys. Res. Commun. 286 433-442
29. Ghosh S 1999 Regulation of inducible gene expression by the transcription factor NF-kB. Immunol.; Immunol. Res. 19 183-189
30. Giordano E, Rendina R, Peluso I and Furia M 2002 RNAi triggered by symmetrically transcribed transgenes in Drosophila melanogaster; Genetics 160 637-648
31. Gotoh T, Terada K, Oyadomari S and Mori M 2004 hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria; Cell Death Differ. 11 390-402
32. Green D R and Reed J C 1998 Mitochondria and apoptosis; Science 281 1309-1312
33. Grether M E, Abrams J M, Agapite J, White K and Steller H 1995 The head involution defective gene of Drosophila melanogaster functions in programmed cell death; Genes Dev. 9 1694-1708
34. Gross A, McDonnell J M and Korsmeyer S J 1999 BCL-2 family members and the mitochondria in apoptosis; Genes Dev. 13 1899-1911
35. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G and Garrido C 2003 Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor; Oncogene 22 6669-6678
36. Hartl F U and Hayer-Hartl M 2002 Molecular chaperones in the cytosol: from nascent chain to folded protein; Science 295 1852-1858
37. Hawkins C J, Yoo S J, Peterson E P, Wang S L, Vernooy S Y and Hay B A 2000 The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM; J. Biol. Chem. 275 27084-27093
38. Hay B A and Guo M 2006 Caspase-dependent cell death in Drosophila; Annu. Rev. Cell Dev. Biol. 22 623-650
39. Hayashida N, Inouye S, Fujimoto M, Tanaka Y, Izu H, Takaki E, Ichikawa H, Rho J and Nakai A 2006 A novel HSF1-mediated death pathway that is suppressed by heat shock proteins; EMBO J. 25 4773-4783
40. Hermann R, Hensel F, Muller E C, Keppler M, Souto-Carneiro M, Brandlein S, Muller-Hermelink H K and Vollmers H P 2001 Deactivation of regulatory proteins hnRNP A1 and A2 during SC-1 induced apoptosis; Hum. Antibodies 10 83-90
41. Ingolia T D and Craig E A 1982 Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin; Proc. Natl. Acad. Sci. USA 79 2360-2364
42. Jaattela M and Wissing D 1993 Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection; J. Exp. Med. 177 231-236
43. Jaattela M, Wissing D, Bauer P A and Li G C 1992 Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity; EMBO J. 11 3507-3512
44. Jaattela M, Wissing D, Kokholm K, Kallunki T and Egeblad M 1998 Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases; EMBO J. 17 6124-6134
45. Jacobson M D, Weil M and Raff M C 1997 Programmed cell death in animal development; Cell 88 347-354
46. Jiang Z H, Zhang W J, Rao Y and Wu J Y 1998 Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors; Proc. Natl. Acad. Sci. USA 95 9155-9160
47. Jolly C and Lakhotia S C 2006 Human sat III and Drosophila hsr omega transcripts: a common paradigm for regulation of nuclear RNA processing in stressed cells; Nucleic Acids Res. 34 5508-5514
48. Kammanadiminti S J and Chadee K 2006 Suppression of NF-κB activation by Entameba histolytica in intestinal epithelial cells is mediated by heat shock protein 27; J. Biol. Chem. 281 26029-26080
49. Kamradt M C, Chen F and Cryns V L 2001 The small heat shock protein alpha B-crystallin negatively regulates cytochrome c-and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation; J. Biol. Chem. 276 16059-16063
50. Karlseder J, Wissing D, Holzer G, Orel L, Sliutz G, Auer H, Jaattela M and Simon M M 1996 HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest; Biochem. Biophys. Res. Commun. 220 153-159
51. Kerr J F, Wyllie A H and Currie A R 1972 Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics; Br. J. Cancer 26 239-257
52. Kim H P, Morse D and Choi A M 2006a Heat-shock proteins: new keys to the development of cytoprotective therapies; Expert Opin. Ther. Targets 10 759-769
53. Kim J Y, Kim S M, Ko J H, Yim J H and Park J H 2006b Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades; FEBS Lett. 580 3270-3275
54. Kirchhoff S R, Gupta S and Knowlton A A 2002 Cytosolic heat shock protein 60, apoptosis, and myocardial injury; Circulation 105 2899-2904
55. Korcsmáros T, Kovács I A , Szalay M S, and Csermely P 2007 Molecular chaperones: The modular evolution of cellular networks.; J. Biosci. 32 441-446
56. Kornbluth S and White K 2005 Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm); J. Cell. Sci. 118 1779-1787
57. Kramer J M and Staveley B E 2003 GAL4 causes developmental defects and apoptosis when expressed in the developing eye of Drosophila melanogaster; Genet. Mol. Res. 2 43-47
58. Lakhotia S C 1996 RNA polymerase II dependent genes that do not code for protein; Indian J. Biochem. Biophys. I33 93-102
59. Lakhotia S C 2003 The noncoding developmentally active and stress-inducible hsrω gene of Drosophila melanogaster integrates Post-transcriptional processing of other nuclear transcripts; in Noncoding RNAs: Molecular biology and molecular medicine (eds) J Barciszewski and VA Erdmann (New York: Kluwer Academic/ Plenum Publishers) pp 209-219
60. Lakhotia S C, Ray P, Rajendra, T K and Prasanth K V 1999 The non-coding transcripts of hsrω gene in Drosophila: Do they regulate trafficking and availability of nuclear RNA processing factors?; Curr. Sci. 77 553-563
61. Lewis J, Devin A, Miller A, Lin Y, Rodriguez Y, Neckers L and Liu Z G 2000 Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation; J. Biol. Chem. 275 10519-10526
62. Li D W, Liu J P, Mao Y W, Xiang H, Wang J, Ma W Y, Dong Z, Pike H M, Brown R E and Reed J C 2005 Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation; Mol. Biol. Cell. 16 4437-4453
63. Li H, Zhu H, Xu C J and Yuan J 1998 Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis; Cell 94 491-501
64. Lin K M, Lin B, Lian I Y, Mestril R, Scheffler I E and Dillmann W H 2001 Combined and individual mitochondrial HSP60 and HSP10 expression in cardiac myocytes protects mitochondrial function and prevents apoptotic cell deaths induced by simulated ischemia-reoxygenation; Circulation 103 1787-1792
65. Liossis S N, Ding X Z, Kiang J G and Tsokos G C 1997 Overexpression of the heat shock protein 70 enhances the TCR/CD3- and Fas/Apo-1/CD95-mediated apoptotic cell death in Jurkat T cells; J. Immunol. 158 5668-5675
66. Locksley R M, Killeen N and Lenardo M J 2001 The TNF and TNF receptor superfamilies: integrating mammalian biology; Cell 104 487-501
67. Lund P A 1995 The roles of molecular chaperones in vivo; Essays Biochem. 29 113-123
68. Luo X, Budihardjo I, Zou H, Slaughter C and Wang X 1998 Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors; Cell 94 481-490
69. Mao Y W, Liu J P, Xiang H and Li D W 2004 Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis; Cell Death Differ. 11 512-526
70. Mao Y W, Xiang H, Wang J, Korsmeyer S, Reddan J and Li D W 2001 Human bcl-2 gene attenuates the ability of rabbit lens epithelial cells against H2O2-induced apoptosis through down-regulation of the alpha B-crystallin gene; J. Biol. Chem. 276 43435-43445
71. Mattick J S 2004 RNA regulation: a new genetics? Nat. Rev. Genet. 5 316-323
72. Mayer M P and Bukau B 2005 Hsp70 chaperones: cellular functions and molecular mechanism; Cell Mol. Life Sci. 62 670-684
73. Meriin A B, Yaglom J A, Gabai V L, Zon L, Ganiatsas S, Mosser D D and Sherman M Y 1999 Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72; Mol. Cell Biol. 19 2547-2555
74. Mosser D D, Caron A W, Bourget L, Denis-Larose C and Massie B 1997 Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis; Mol. Cell Biol. 17 5317-5327
75. Mosser D D, Caron A W, Bourget L, Meriin A B, Sherman M Y, Morimoto R I and Massie B 2000 The chaperone function of hsp70 is required for protection against stress-induced apoptosis; Mol. Cell Biol. 20 7146-7159
76. Nover L 1984 Heat shock response of eucaryotic cells (Berlin: Springer-Verlag)
77. Nylandsted J, Gyrd-Hansen M, Danielewicz A, Fehrenbacher N, Lademann U, Hoyer-Hansen M, Weber E, Multhoff G, Rohde M and Jaattela M 2004 Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization; J. Exp. Med. 200 425-435
78. Ozes O N, Mayo L D, Gustin J A, Pfeffer S R, Pfeffer L M and Donner D B 1999 NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase; Nature (London) 401 82-85
79. Paez J and Sellers W R 2003 PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling; Cancer Treat. Res.115 145-167
80. Pandey P, Saleh A, Nakazawa A, Kumar S, Srinivasula S M, Kumar V, Weichselbaum R, Nalin C, Alnemri E S, Kufe D and Kharbanda S 2000a Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90; EMBO J. 19 4310-4322
81. Pandey P, Farber R, Nakazawa A, Kumar S, Bharti A, Nalin C, Weichselbaum R, Kufe D and Kharbanda S 2000b Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3; Oncogene 19 1975-1981
82. Park H S, Cho S G, Kim C K, Hwang H S, Noh K T, Kim M S, Huh S H, Kim M J, Ryoo K, Kim E K, Kang W J, Lee J S, Seo J S, Ko Y G, Kim S and Choi E J 2002 Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1; Mol. Cell Biol. 22 7721-7730
83. Paul C, Manero F, Gonin S, Kretz-Remy C, Virot S and Arrigo A P 2002 Hsp27 as a negative regulator of cytochrome C release; Mol. Cell Biol. 22 816-834
84. Paulson H L, Bonini N M and Roth K A 2000 Polyglutamine disease and neuronal cell death; Proc. Natl. Acad. Sci. USA 97 12957-12958
85. Pirkkala L, Nykanen P and Sistonen L 2001 Roles of the heat shock transcription factors in regulation of the heat shock response and beyond; Faseb J. 15 1118-1131
86. Prasanth K V and Spector D L 2007 Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum; Genes Dev. 21 11-42
87. Prasanth K V, Rajendra T K, Lal A K and Lakhotia S C 2000 Omega speckles - a novel class of nuclear speckles containing hnRNPs associated with noncoding hsr-omega RNA in Drosophila; J. Cell Sci. 113 3485-3497
88. Pratt W B 1998 The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors; Proc. Soc. Exp. Biol. Med. 217 420-434
89. Rane M J, Pan Y, Singh S, Powell D W, Wu R, Cummins T, Chen Q, McLeish K R and Klein J B 2003 Heat shock protein 27 controls apoptosis by regulating Akt activation; J. Biol. Chem. 278 27828-27835
90. Ravagnan L, Gurbuxani S, Susin S A, Maisse C, Daugas E, Zamzami N, Mak T, Jaattela M, Penninger J M, Garrido C and Kroemer G 2001 Heat-shock protein 70 antagonizes apoptosis-inducing factor; Nat. Cell. Biol. 3 839-843
91. Regnier C H, Song H Y, Gao X, Goeddel D V, Cao Z and Rothe M 1997 Identification and characterization of an IkappaB kinase; Cell 90 373-383
92. Riedl S J and Shi Y 2004 Molecular mechanisms of caspase regulation during apoptosis; Nat. Rev. Mol. Cell Biol. 5 897-907
93. Romashkova J A and Makarov S S 1999 NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling; Nature (London) 401 86-90
94. Rutherford S L and Lindquist S 1998 Hsp90 as a capacitor for morphological evolution; Nature (London) 396 336-342
95. Saleh A, Srinivasula S M, Balkir L, Robbins P D and Alnemri E S 2000 Negative regulation of the Apaf-1 apoptosome by Hsp70; Nat. Cell. Biol. 2 476-483
96. Samali A and Orrenius S 1998 Heat shock proteins: regulators of stress response and apoptosis; Cell Stress Chaperones 3 228-236
97. Samali A, Cai J, Zhivotovsky B, Jones D P and Orrenius S 1999 Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells; EMBO J. 18 2040-2048
98. Sarkar S and Lakhotia S C 2005 The Hsp60C gene in the 25F cytogenetic region in Drosophila melanogaster is essential for tracheal development and fertility; J. Genet. 84 265-281
99. Sarkar S, Arya R and Lakhotia S C 2006 Chaperonins: In life and death; in Stress Response: A Molecular Biology Approach (eds) A S Sreedhar and U K Srinivas (Kerala, India: Research Signpost) pp 43-60
100. Sato S, Fujita N and Tsuruo T 2000 Modulation of Akt kinase activity by binding to Hsp90; Proc. Natl. Acad. Sci. USA 97 10832-10837
101. Schlesinger M J, Ashburner M and Tissiers A 1982 Heat shock proteins: from bacteria to man; (New York: Cold Spring Harbor Laboratory Press)
102. Schwerk C and Schulze-Osthoff K 2005 Regulation of apoptosis by alternative pre-mRNA splicing; Mol. Cell 19 1-13
103. Screaton G and Xu X N 2000 T cell life and death signalling via TNF-receptor family members; Curr. Opin. Immunol. 12 316-322
104. Sengupta S and Lakhotia S C 2006 Altered Expressions of the Noncoding hsromega Gene Enhances poly-Q-Induced Neurotoxicity in Drosophila; RNA Biol. 3 28-35
105. Shan Y X, Liu T J, Su H F, Samsamshariat A, Mestril R and Wang P H 2003 Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells; J. Mol. Cell. Cardiol. 35 1135-1143
106. Shchors K, Yehiely F, Kular R K, Kotlo K U, Brewer G and Deiss L P 2002 Cell death inhibiting RNA (CDIR) derived from a 3′-untranslated region binds AUF1 and heat shock protein 27; J. Biol. Chem. 277 47061-47072
107. Simon M M, Reikerstorfer A, Schwarz A, Krone C, Luger T A, Jaattela M and Schwarz T 1995 Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine release; J. Clin. Invest. 95 926-933
108. Sreedhar A S and Csermely P 2004 Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review; Pharmacol. Ther. 101 227-257
109. Srivastava P 2004 Studies on the constitutively expressed members of Hsp60 anf Hsp70 gene families in Drosophila melanogaster, PhD. Dissertation, Banaras Hindu University, Varanasi, India
110. Staal S P 1987 Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma; Proc. Natl. Acad. Sci. USA 84 5034-5037
111. Stankiewicz A R, Lachapelle G, Foo C P, Radicioni S M and Mosser D D 2005 Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation; J. Biol. Chem. 280 38729-38739
112. Stokoe D, Stephens L R, Copeland T, Gaffney P R, Reese C B, Painter G F, Holmes A B, McCormick F and Hawkins P T 1997 Dual role of phosphatidylinositol- 3,4,5-trisphosphate in the activation of protein kinase B; Science 277 567-570
113. Van Gurp M, Festjens N, van Loo G, Saelens X and Vandenabeele P 2003 Mitochondrial intermembrane proteins in cell death; Biochem. Biophys. Res. Commun. 304 487-497
114. Veereshwarayya V, Kumar P, Rosen K M, Mestril R and Querfurth H W 2006 Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular beta-amyloid-induced inhibition of complex IV and limit apoptosis; J. Biol. Chem. 281 29468-29478
115. Volker U, Mach H, Schmid R and Hecker M 1992 Stress proteins and cross-protection by heat shock and salt stress in Bacillus subtilis; J. Gen. Microbiol. 138 2125-2135
116. Volloch V, Gabai V L, Rits S and Sherman M Y 1999 ATPase activity of the heat shock protein hsp72 is dispensable for its effects on dephosphorylation of stress kinase JNK and on heat-induced apoptosis; FEBS Lett. 461 73-76
117. Vydra N, Malusecka E, Jarzab M, Lisowska K, Glowala-Kosinska M, Benedyk K, Widlak P, Krawczyk Z and Widlak W 2006 Spermatocyte-specific expression of constitutively active heat shock factor 1 induces HSP70i-resistant apoptosis in male germ cells; Cell Death Differ. 13 212-222
118. Wang C Y, Mayo M W, Korneluk R G, Goeddel D V and Baldwin A S, Jr. 1998 NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation; Science 281 1680-1683
119. Warrick J M, Paulson H L, Gray-Board G L, Bui Q T, Fischbeck K H, Pittman R N and Bonini N M 1998 Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila; Cell 93 939-949
120. White K, Tahaoglu E and Steller H 1996 Cell killing by the Drosophila gene reaper; Science 271 805-807
121. Willis S, Day C L, Hinds M G and Huang D C 2003 The Bcl-2-regulated apoptotic pathway; J. Cell Sci. 116 4053-4056
122. Wyllie A H, Kerr J F and Currie A R 1980 Cell death: the significance of apoptosis; Int. Rev. Cytol. 68 251-306
123. Xanthoudakis S, Roy S, Rasper D, Hennessey T, Aubin Y, Cassady R, Tawa P, Ruel R, Rosen A and Nicholson D W 1999 Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis; EMBO J. 18 2049-2056
124. Xia W, Voellmy R and Spector N L 2000 Sensitization of tumor cells to fas killing through overexpression of heat-shock transcription factor 1; J Cell Physiol 183 425-431
125. Yan N and Shi Y 2005 Mechanisms of apoptosis through structural biology; Annu. Rev. Cell Dev. Biol. 21 35-56
126. Yang X, Khosravi-Far R, Chang H Y and Baltimore D 1997 Daxx, a novel Fas-binding protein that activates JNK and apoptosis; Cell 89 1067-1076
127. Zha J, Harada H, Yang E, Jockel J and Korsmeyer S J 1996 Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L); Cell 87 619-628
128. Zhang R, Luo D, Miao R, Bai L, Ge Q, Sessa W C and Min W 2005 Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis; Oncogene 24 3954-3963
129. Zhang S Q, Kovalenko A, Cantarella G and Wallach D 2000 Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation; Immunity 12 301-311
130. Zou H, Li Y, Liu X and Wang X 1999 An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9; J. Biol. Chem. 274 11549-11556