Retinal pigment epithelium is protected against apoptosis by αB-crystallin

Investigative Ophthalmology and Visual Science

Volumn 43, Issue 11, 2002, Pages 3575-3582

  Alge, Claudia S ^a   Priglinger, Siegfried G ^a   Neubauer, Aljoscha S ^a   Kampik, Anselm ^a   Zillig, Markus ^a   Bloemendal, Hans ^a   Welge Lussen, Ulrich ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; BETA CRYSTALLIN; CASPASE 3; COMPLEMENTARY DNA; HEAT SHOCK PROTEIN; HOE 33342; MESSENGER RNA; PROPIDIUM IODIDE;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; HEAT SHOCK; HUMAN; HUMAN CELL; NORTHERN BLOTTING; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RETINA DEGENERATION; RETINA INJURY; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA LUTEA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADOLESCENT; ADULT; AGED; ALPHA-CRYSTALLIN B CHAIN; APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELLS, CULTURED; CYTOPROTECTION; HEAT; HUMANS; HYDROGEN PEROXIDE; MIDDLE AGED; OXIDATIVE STRESS; PIGMENT EPITHELIUM OF EYE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION;

EID: 0036847441     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Hawkins BS, Bird A, Klein R, West SK. Epidemiology of age-related macular degeneration. Mol Vis. 1999;5:26.
2. Vingerling JR, Dielemans I, Hofman A, et al. The prevalence of age-related maculopathy in the Rotterdam Study. Ophthalmology. 1995;102:205-210.
3. Xu GZ, Li WW, Tso MO. Apoptosis in human retinal degenerations. Trans Am Ophthalmol Soc. 1996;94:411-430.
4. Jin GF, Hurst JS, Godley BF. Rod outer segments mediate mitochondrial DNA damage and apoptosis in human retinal pigment epithelium. Curr Eye Res. 2001;23:11-19.
5. Sparrow JR, Nakanishi K, Parish CA. The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci. 2000;41:1981-1989.
6. Sparrow JR, Cai B. Blue light-induced apoptosis of A2E-containing RPE: Involvement of caspase-3 and protection by Bcl-2. Invest Ophthalmol Vis Sci. 2001;42:1356-1362.
7. Seko Y, Pang J, Tokoro T, Ichinose S, Mochizuki M. Blue lightinduced apoptosis in cultured retinal pigment epithelium cells of the rat. Graefes Arch Clin Exp Ophthalmol. 2001;239:47-52.
8. Wood JP, Osborne NN. The influence of zinc on caspase-3 and DNA breakdown in cultured human retinal pigment epithelial cells. Arch Ophthalmol. 2001;119:81-88.
9. Cai J, Wu M, Nelson KC, Sternberg P Jr, Jones DP. Oxidant-induced apoptosis in cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1999;40:959-966.
10. Suter M, Reme C, Grimm C, et al. Age-related macular degeneration: The lipofusion component N-retinyl-N-retinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells. J Biol Chem. 2000;275:39625-39630.
11. Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem. 1999;68:383-424.
12. Stennicke HR, Salvesen GS. Caspases: Controlling intracellular signals by protease zymogen activation. Biochim Biophys Acta. 2000;1477:299-306.
13. Miller DK. Activation of apoptosis and its inhibition. Ann NY Acad Sci. 1999;886:132-157.
14. Wolf BB, Green DR. Suicidal tendencies: Apoptotic cell death by caspase family proteinases. J Biol Chem. 1999;274:20049-20052.
15. Garrido C, Gurbuxani S, Ravagnan L, Kroemer G. Heat shock proteins: Endogenous modulators of apoptotic cell death. Biochem Biophys Res Commun. 2001;286:433-442.
16. Ritossa F. A new puffering pattern induced by temperature and DNP in Drosophila. Experimentia. 1962;18:571-573.
17. Wong CG, Lin NG. Induction of stress proteins in cultured human RPE-derived cells. Curr Eye Res. 1989;8:537-545.
18. Piatigorsky J. Lens crystallins and their genes: Diversity and tissue-specific expression. FASEB J. 1989;3:1933-1940.
19. Sax CM, Piatigorsky J. Expression of the α-crystallin/small heatshock protein/molecular chaperone genes in the lens and other tissues. Adv Enzymol Relat Areas Mol Biol. 1994;69:155-201.
20. Horwitz J. The function of α-crystallin in vision. Semin Cell Dev Biol. 2000;11:53-60.
21. Fluegel C, Liebe S, Voorter C, Bloemendal H, Lütjen-Drecoll E. Distribution of αB-crystallin in the anterior segment of primate and bovine eyes. Curr Eye Res. 1993;12:871-876.
22. Kato K, Shinohara H, Kurobe N, Inaguma Y, Shimizu K, Ohshima K. Tissue distribution and developmental profiles of immunoreactive αB-crystallin in the rat determined with a sensitive immunoassay system. Biochim Biophys Acta. 1991;1074:201-208.
23. Iwaki T, Kume-Iwaki A, Goldman JE. Cellular distribution of αB-crystallin in non-lenticular tissues. J Histochem Cytochem. 1990;38:31-39.
24. Horwitz J. α-crystallin can function as a molecular chaperone. Proc Natl Acad Sci USA. 1992;89:10449-10453.
25. Bennardini F, Wrzosek A, Chiesi M. αB-crystallin in cardiac tissue: Association with actin and desmin filaments. Circ Res. 1992;71:288-294.
26. Nicholl ID, Quinlan RA. Chaperone activity of α-crystallins modulates intermediate filament assembly. EMBO J 1994;13:945-953.
27. Mehlen P, Schulze-Osthoff K, Arrigo AP. Small stress proteins as novel regulators of apoptosis: Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death. J Biol Chem. 1996;271:16510-16514.
28. Li DW, Xiang H, Mao YW, et al. Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis. Exp Cell Res. 2001;266:279-291.
29. Andley UP, Song Z, Wawrousek EF, Fleming TP, Bassnett S. Differential protective activity of αA- and αB-crystallin in lens epithelial cells. J Biol Chem. 2000;275:36823-36831.
30. van Rijk AF, Bloemendal H. αB-crystallin in neuropathology. Ophthalmologica. 2000;214:7-12.
31. van Noort JM, van Sechel AC, Bajramovic JJ, et al. The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis. Nature. 1995;375:798-801.
32. Bajramovic JJ, Lassmann H, van Noort JM. Expression of αB-crystallin in glia cells during lesional development in multiple sclerosis. J Neuroimmunol. 1997;78:143-151.
33. Strik HM, Weller M, Frank B, et al. Heat shock protein expression in human gliomas. Anticancer Res. 2000;20:4457-4462.
34. Hermisson M, Strik H, Rieger J, Dichgans J, Meyermann R, Weller M. Expression and functional activity of heat shock proteins in human glioblastoma multiforme. Neurology. 2000;54:1357-1365.
35. Jones SE, Jomary C, Grist J, Thomas MR, Neal MJ. Expression of αB-crystallin in a mouse model of inherited retinal degeneration. Neuroreport. 1998;9:4161-4165.
36. Campochiaro PA, Jerdon JA, Glaser BM. The extracellular matrix of human retinal pigment epithelial cells in vivo and its synthesis in vitro. Invest Ophthalmol Vis Sci. 1986;27:1615-1621.
37. Leschey KH, Hackett SF, Singer JH, Campochiaro PA. Growth factor responsiveness of human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1990;31:839-846.
38. Dunn KC, Aotaki-Keen AE, Putkey FR, Hjelmeland LM. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp Eye Res. 1996;62:155-169.
39. Welge-Lussen U, Eichhorn M, Bloemendal H, Lütjen-Drecoll E. Classification of human scleral spur cells in monolayer culture. Eur J Cell Biol. 1998;75:78-84.
40. Welge-Lussen U, May CA, Eichhorn M, Bloemendal H, LütjenDrecoll E. αB-crystallin in the trabecular meshwork is inducible by transforming growth factor-beta. Invest Ophthalmol Vis Sci. 1999;40:2235-2241.
41. Kamradt MC, Chen F, Cryns VL. The small heat shock protein αB-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation. J Biol Chem. 2001;276:16059-16063.
42. Feeney-Burns L, Hilderbrand ES, Eldridge S. Ageing human RPE: Morphometric analysis of macular, equatorial, and peripheral cells. Invest Ophthalmol Vis Sci. 1984;25:195-200.
43. Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ. Cell loss in the ageing retina: Relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci. 1989;30:1691-1699.
44. Welge-Lussen U, Bloemendal H, Lütjen-Drecoll E. Transforming growth factor-beta: A growth factor inducing αB-crystallin expression in ciliary muscle cells. Graefes Arch Clin Exp Ophthalmol. 2000;238:993-997.
45. Van de Klundert FA, Gijsen ML, van den IJssel PR, Snoeckx LH, de Jong WW. αB-crystallin and hsp25 in neonatal cardiac cells: Differences in cellular localization under stress conditions. Eur J Cell Biol. 1998;75:38-45.
46. Xanthoudakis S, Nicholson DW. Heat-shock proteins as death determinants. Nat Cell Biol. 2000;2:E163-E165.
47. Beere HM, Wolf BB, Cain K, et al. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol. 2000 Aug;2:469-475.
48. Pandey P, Saleh A, Nakazawa A, et al. Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO J. 2000;19:4310-4322.
49. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000;2:476-483.
50. Bruey JM, Ducasse C, Bonniaud P, et al. Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol. 2000;2:645-652.
51. Mao YW, Xiang H, Wang J, Korsmeyer S, Reddan J, Li DW. Human bcl-2 gene attenuates the ability of rabbit lens epithelial cells against H2O2-induced apoptosis through down-regulation of the αB-crystallin gene. J Biol Chem. 2001;276:43435-43445.
52. Ray PS, Martin JL, Swanson EA, Otani H, Dillmann WH, Das DK. Transgene overexpression of αB-crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion. FASEB J. 2001;15:393-402.
53. Jin GF, Hurst JS, Godley BF. Hydrogen peroxide stimulates apoptosis in cultured human retinal pigment epithelial cells. Curr Eye Res. 2001;22:165-173.
54. Liles MR, Newsome DA, Oliver PD. Antioxidant enzymes in the ageing human retinal pigment epithelium. Arch Ophthalmol. 1991;109:1285-1288.
55. De La Paz MA, Zhang J, Fridovich I. Antioxidant enzymes of the human retina: Effect of age on enzyme activity of macula and periphery. Curr Eye Res. 1996;15:273-278.
56. Cohen SM, Olin KL, Feuer WJ, Hjelmeland L, Keen CL, Morse LS. Low glutathione reductase and peroxidase activity in age-related macular degeneration. Br J Ophthalmol. 1994;78:791-794.
57. Frank RN, Amin RH, Puklin JE. Antioxidant enzymes in the macular retinal pigment epithelium of eyes with neovascular age-related macular degeneration. Am J Ophthalmol. 1999;127:694-709.
58. Gaillard ER, Atherton SJ, Eldred G, Dillon J. Photophysical studies on human retinal lipofuscin. Photochem Photobiol. 1995;61:448-453.