A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia - Like syndrome in BXH-2 mice

Journal of Experimental Medicine

Volumn 201, Issue 6, 2005, Pages 881-890

  Turcotte, Karine ^a,b   Gauthier, Susan ^a,b   Tuite, Ashleigh ^a,b   Mullick, Alaka ^c   Malo, Danielle ^b   Gros, Philippe ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CYSTEINE; GAMMA INTERFERON; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN 1; INTERLEUKIN 12; MESSENGER RNA; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CHROMOSOME 8; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXPERIMENTAL MODEL; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE INACTIVATION; GENE INSERTION; GENE LOCUS; GENE MAPPING; GENE MUTATION; IMMUNE DEFICIENCY; INFECTION RESISTANCE; INFECTION SENSITIVITY; LEUKEMIA CELL; MALE; MOUSE; MOUSE STRAIN; MYCOBACTERIUM BOVIS; MYELOPROLIFERATIVE DISORDER; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DOMAIN; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SPLEEN CELL; TUMOR SUPPRESSOR GENE; VIRUS REPLICATION;

EID: 17144424686     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20042170     Document Type: Article

References (47)

1. National Cancer Institute. "Chronic myelogenous leukemia." http:// www.nci.nih.gov/cancerinfo/pdq/treatment/cml.
2. Cortes, J., and M.E. O'Dwyer. 2004. Clonal evolution in chronic myelogenous leukemia. Hematol. Oncol. Clin. North Am. 18:671-684.
3. Beutler, E., M.A. Lichtman, B.S. Coller, T.J. Kipps, and U. Seligsohn. 2001. Williams Hematology. McGraw-Hill Medical Publishing Division, New York. 1941 pp.
4. Deininger, M.W., J.M. Goldman, and J.V. Melo. 2000. The molecular biology of chronic myeloid leukemia. Blood. 96:3343-3356.
5. Sill, H., J.M. Goldman, and N.C. Cross. 1995. Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia. Blood. 85:2013-2016.
6. Towatari, M., K. Adachi, H. Kato, and H. Saito. 1991. Absence of the human retinoblastoma gene product in the megakaryoblastic crisis of chronic myelogenous leukemia. Blood. 78:2178-2181.
7. Ogawa, S., K. Mitani, M. Kurokawa, Y. Matsuo, J. Minowada, J. Inazawa, N. Kamada, T. Tsubota, Y. Yazaki, and H. Hirai. 1996. Abnormal expression of Evi-1 gene in human leukemias. Hum. Cell. 9:323-332.
8. Taylor, B.A. 1978. Recombinant inbred strains: use in gene mapping. In Origins of Inbred Mice. Herbert C. Morse III, editor. Academic Press, New York. 423-438.
9. Jenkins, N.A., N.G. Copeland, B.A. Taylor, H.G. Bedigian, and B.K. Lee. 1982. Ecotropic murine leukemia virus DNA content of normal and lymphomatous tissues of BXH-2 recombinant inbred mice. J. Virol. 42:379-388.
10. Bedigian, H.G., D.A. Johnson, N.A. Jenkins, N.G. Copeland, and R. Evans. 1984. Spontaneous and induced leukemias of myeloid origin in recombinant inbred BXH mice. J. Virol. 51:586-594.
11. Bedigian, H.G., L.A. Shepel, and P.C. Hoppe. 1993. Transplacental transmission of a leukemogenic murine leukemia virus. J. Virol. 67: 6105-6109.
12. Bedigian, H.G., B.A. Taylor, and H. Meier. 1981. Expression of murine leukemia viruses in the highly lymphomatous BXH-2 recombinant inbred mouse strain. J. Virol. 39:632-640.
13. Lilly, F., and T. Pincus. 1973. Genetic control of murine viral leukemogenesis. Advances in Cancer Research, vol. 17, Georges Klein and Sidney Weinhouse, editors. New York: Academic Press.
14. Li, J., H. Shen, K.L. Himmel, A.J. Dupuy, D.A. Largaespada, T. Nakamura, J.D. Shaughnessy Jr., N.A. Jenkins, and N.G. Copeland. 1999. Leukaemia disease genes: large-scale cloning and pathway predictions. Nat. Genet. 23:348-353.
15. Skamene, E., P. Gros, A. Forget, P.A. Kongshavn, C. St. Charles, and B.A. Taylor. 1982. Genetic regulation of resistance to intracellular pathogens. Nature. 297:506-509.
16. Turcotte, K., S. Gauthier, L.M. Mitsos, C. Shustik, N.G. Copeland, N.A. Jenkins, J.C. Fournet, P. Jolicoeur, and P. Gros. 2004. Genetic control of myeloproliferation in BXH-2 mice. Blood. 103:2343-2350.
17. Jolicoeur, P. 1979. The Fv-1 gene of the mouse and its control of murine leukemia virus replication. Curr. Top. Microbiol. Immunol. 86:67-122.
18. Chesi, M., P.L. Bergsagel, O.O. Shonukan, M.L. Martelli, L.A. Brents, T. Chen, E. Schrock, T. Ried, and W.M. Kuehl. 1998. Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma. Blood. 91:4457-4463.
19. Chesi, M., W.M. Kuehl, and P.L. Bergsagel. 2000. Recurrent immunoglobulin gene translocations identify distinct molecular subtypes of myeloma. Ann. Oncol. 11(Suppl):131-135.
20. Tamura, T., and K. Ozato. 2002. ICSBP/IRF-8: its regulatory roles in the development of myeloid cells. J. Interferon Cytokine Res. 22:145-152.
21. Levi, B.Z., S. Hashmueli, M. Gleit-Kielmanowicz, A. Azriel, and D. Meraro. 2002. ICSBP/IRF-8 transactivation: a tale of protein-protein interaction. J. Interferon Cytokine Res. 22:153-160.
22. Kanno, Y., C.A. Kozak, C. Schindler, P.H. Driggers, D.L. Ennist, S.L. Gleason, J.E. Darnell Jr., and K. Ozato. 1993. The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds. Mol. Cell. Biol. 13:3951-3963.
23. Nguyen, H., J. Hiscott, and P.M. Pitha. 1997. The growing family of interferon regulatory factors. Cytokine Growth Factor Rev. 8:293-312.
24. Ortiz, M.A., J. Light, R.A. Maki, and N. Assa-Munt. 1999. Mutation analysis of the Pip interaction domain reveals critical residues for protein-protein interactions. Proc. Natl. Acad. Sci. USA. 96:2740-2745.
25. Tsujimura, H., T. Tamura, C. Gongora, J. Aliberti, C. Reis e Sousa, A. Sher, and K. Ozato. 2003. ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro. Blood. 101:961-969.
26. Holtschke, T., J. Lohler, Y. Kanno, T. Fehr, N. Giese, F. Rosenbauer, J. Lou, K.P. Knobeloch, L. Gabriele, J.F. Waring, et al. 1996. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell. 87:307-317.
27. Jabado, N., A. Jankowsky, S. Dougaparsad, V. Picard, S. Grinstein, and P. Gros. 2000. Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane. J. Exp. Med. 192:1237-1248.
28. Skamene, E., E. Schurr, and P. Gros. 1998. Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections. Annu. Rev. Med. 49:275-287.
29. Malo, D., K. Vogan, S. Vidal, J. Hu, M. Cellier, E. Schurr, A. Fuks, N. Bumstead, K. Morgan, and P. Gros. 1994. Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites. Genomics. 23:51-61.
30. King, S.R., B.J. Berson, and R. Risser. 1988. Mechanism of interaction between endogenous ecotropic murine leukemia viruses in (BALB/c X C57BL/6) hybrid cells. Virology. 162:1-11.
31. Li, M., X. Huang, Z. Zhu, and E. Gorelik. 1999. Sequence and insertion sites of murine melanoma-associated retrovirus. J. Virol. 73:9178-9186.
32. Hurt, E.M., A. Wiestner, A. Rosenwald, A.L. Shaffer, E. Campo, T. Grogan, P.L. Bergsagel, W.M. Kuehl, and L.M. Staudt. 2004. Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma. Cancer Cell. 5:191-199.
33. Scharton-Kersten, T., C. Contursi, A. Masumi, A. Sher, and K. Ozato. 1997. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J. Exp. Med. 186:1523-1534.
34. Giese, N.A., L. Gabriele, T.M. Doherty, D.M. Klinman, L. Tadesse-Heath, C. Contursi, S.L. Epstein, and H.C. Morse III. 1997. Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression. J. Exp. Med. 186:1535-1546.
35. Schmidt, M., S. Nagel, J. Proba, C. Thiede, M. Ritter, J.F. Waring, F. Rosenbauer, D. Huhn, B. Wittig, I. Horak, and A. Neubauer. 1998. Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias. Blood. 91:22-29.
36. Deng, M., and G.Q. Daley. 2001. Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ ABL-induced leukemia. Blood. 97:3491-3497.
37. Hao, S.X., and R. Ren. 2000. Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder. Mol. Cell. Biol. 20:1149-1161.
38. Schwieger, M., J. Lohler, J. Friel, M. Scheller, I. Horak, and C. Stocking. 2002. AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency. J. Exp. Med. 196:1227-1240.
39. Suzuki, T., H. Shen, K. Akagi, H.C. Morse, J.D. Malley, D.Q. Naiman, N.A. Jenkins, and N.G. Copeland. 2002. New genes involved in cancer identified by retroviral tagging. Nat. Genet. 32:166-174.
40. Kanazawa, N., M. Kurosaki, N. Sakamoto, N. Enomoto, Y. Itsui, T. Yamashiro, Y. Tanabe, S. Maekawa, M. Nakagawa, C.H. Chen, et al. 2004. Regulation of hepatitis C virus replication by interferon regulatory factor 1. J. Virol 78:9713-9720.
41. Morse, H.C., III, C.F. Qi, S.K. Chattopadhyay, M. Hori, L. Taddesse-Heath, K. Ozato, J.W. Hartley, B.A. Taylor, J.M. Ward, N.A. Jenkins, et al. 2001. Combined histologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice. Leuk. Res. 25:719-733.
42. Mitsos, L.M., L.R. Cardon, A. Fortin, L. Ryan, R. LaCourse, R.J. North, and P. Gros. 2000. Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice. Genes Immun. 1:467-477.
43. Min-Oo, G., A. Fortin, M.F. Tam, A. Nantel, M.M. Stevenson, and P. Gros. 2003. Pyruvate kinase deficiency in mice protects against malaria. Nat. Genet. 35:357-362.
44. Hanna, Z., D.G. Kay, N. Rebai, A. Guimond, S. Jothy, and P. Jolicoeur. 1998. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell. 95:163-175.
45. Epstein, D.J., M. Vekemans, and P. Gros. 1991. Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell. 67:767-774.
46. Gros, P., E. Skamene, and A. Forget. 1981. Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. J. Immunol. 127:2417-2421.
47. Forget, A., E. Skamene, P. Gros, A.C. Miailhe, and R. Turcotte. 1981. Differences in response among inbred mouse strains to infection with small doses of Mycobacterium bovis BCG. Infect. Immun. 32:42-47.